Published in Hum Gene Ther on August 10, 1997
New pathophysiological insights and modern treatment of IBD. J Gastroenterol (2010) 1.31
Gene transfer to hemophilia A mice via oral delivery of FVIII-chitosan nanoparticles. J Control Release (2008) 1.00
In vitro and in vivo models for the study of oral delivery of nanoparticles. Adv Drug Deliv Rev (2013) 0.92
Gene and cell therapy based treatment strategies for inflammatory bowel diseases. World J Gastrointest Pathophysiol (2011) 0.91
Efficient gene delivery to the inflamed colon by local administration of recombinant adenoviruses with normal or modified fibre structure. Gut (1999) 0.86
Function and immunolocalization of overexpressed human intestinal H+/peptide cotransporter in adenovirus-transduced Caco-2 cells. AAPS PharmSci (1999) 0.84
Efficient directional cloning of recombinant adenovirus vectors using DNA-protein complex. Nucleic Acids Res (1998) 0.82
Targeting the gastrointestinal tract with viral vectors: state of the art and possible applications in research and therapy. Histochem Cell Biol (2016) 0.80
Effective in vivo and ex vivo gene transfer to intestinal mucosa by VSV-G-pseudotyped lentiviral vectors. BMC Gastroenterol (2010) 0.79
The sequence of the human genome. Science (2001) 101.55
A whole-genome assembly of Drosophila. Science (2000) 38.48
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med (1999) 16.91
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc Natl Acad Sci U S A (2001) 7.12
The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90
Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci U S A (1994) 5.74
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J (1999) 5.49
Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med (1990) 5.27
NF-AT components define a family of transcription factors targeted in T-cell activation. Nature (1994) 4.90
The Human Connectome Project: a data acquisition perspective. Neuroimage (2012) 4.64
Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat Genet (1992) 4.12
B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol (2001) 4.10
A transcriptional hierarchy involved in mammalian cell-type specification. Nature (1992) 4.08
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med (1997) 3.89
A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A (1996) 3.89
T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years. Science (1995) 3.87
Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. J Virol (1993) 3.68
Rad23 links DNA repair to the ubiquitin/proteasome pathway. Nature (1998) 3.54
Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res (1998) 3.44
Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections. Science (1996) 3.38
Establishment and characterization of a cell line of human breast carcinoma origin. Eur J Cancer (1979) 3.37
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell (2001) 3.37
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell (2001) 3.30
TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol (2001) 3.22
The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Cell (1995) 3.17
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A (2001) 2.93
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. Proc Natl Acad Sci U S A (1994) 2.91
A pilot study of aerosolized amiloride for the treatment of lung disease in cystic fibrosis. N Engl J Med (1990) 2.83
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci U S A (1999) 2.81
Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers. Br J Cancer (2006) 2.67
Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses. Nat Genet (1993) 2.67
ATP is essential for protein translocation into Escherichia coli membrane vesicles. Proc Natl Acad Sci U S A (1985) 2.65
Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Nature (1994) 2.57
Mutation of the Bacillus subtilis alkyl hydroperoxide reductase (ahpCF) operon reveals compensatory interactions among hydrogen peroxide stress genes. J Bacteriol (1996) 2.57
Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot. Nat Struct Biol (1999) 2.57
A prospective 4-year follow-up study of attention-deficit hyperactivity and related disorders. Arch Gen Psychiatry (1996) 2.55
Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children? Am J Psychiatry (1996) 2.54
Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice. Proc Natl Acad Sci U S A (1994) 2.53
dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference. Gene (2000) 2.52
The complete DNA sequence of myxoma virus. Virology (1999) 2.44
Xa21D encodes a receptor-like molecule with a leucine-rich repeat domain that determines race-specific recognition and is subject to adaptive evolution. Plant Cell (1998) 2.43
A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol (1994) 2.42
SecA protein is required for secretory protein translocation into E. coli membrane vesicles. Cell (1988) 2.41
A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene (1998) 2.39
Solution structure of a bovine immunodeficiency virus Tat-TAR peptide-RNA complex. Science (1995) 2.35
Primitive deuterostomes from the Chengjiang Lagerstätte (Lower Cambrian, China). Nature (2001) 2.31
Seventh cervical nerve root transfer from the contralateral healthy side for treatment of brachial plexus root avulsion. J Hand Surg Br (1992) 2.30
LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J Immunol (2000) 2.27
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Mol Cell Biol (2000) 2.27
Survival time comparison between Hawley and clear overlay retainers: a randomized trial. J Dent Res (2011) 2.26
Nontuberculous mycobacteria in adult patients with cystic fibrosis. Chest (1992) 2.25
Predictors of persistence and remission of ADHD into adolescence: results from a four-year prospective follow-up study. J Am Acad Child Adolesc Psychiatry (1996) 2.24
Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nat Med (2000) 2.18
Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China. Infection (2013) 2.18
NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell Immunol (1998) 2.11
Evidence for reduced Cl- and increased Na+ permeability in cystic fibrosis human primary cell cultures. J Physiol (1988) 2.10
Effect of ADP and ionic strength on the kinetic and motile properties of recombinant mouse myosin V. J Biol Chem (2000) 2.09
ADHD is associated with early initiation of cigarette smoking in children and adolescents. J Am Acad Child Adolesc Psychiatry (1997) 2.09
The DNA repair protein rad23 is a negative regulator of multi-ubiquitin chain assembly. Nat Cell Biol (2000) 2.07
RNA recognition by an isolated alpha helix. Cell (1993) 2.05
PPARalpha agonist fenofibrate improves diabetic nephropathy in db/db mice. Kidney Int (2006) 2.05
Rapid angiographic progression of coronary artery disease in patients with angina pectoris. The role of complex stenosis morphology. Circulation (1995) 2.04
MDM2 suppresses p73 function without promoting p73 degradation. Mol Cell Biol (1999) 2.00
Epitope mapping of human anti-adeno-associated virus type 2 neutralizing antibodies: implications for gene therapy and virus structure. J Virol (2000) 1.98
Chinese Hemophilia Joint Health Score 2.1 reliability study. Haemophilia (2013) 1.98
Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy. J Exp Med (1997) 1.96
Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population: the Shanghai Diabetes Studies, a cross-sectional 3-year follow-up study in Shanghai urban communities. Diabetologia (2006) 1.96
Progenitor cells of the adult human airway involved in submucosal gland development. Development (1995) 1.95
Role of RNA structure in arginine recognition of TAR RNA. Proc Natl Acad Sci U S A (1993) 1.94
Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition. Gene Ther (2008) 1.94
How safe is bilateral internal iliac artery embolization prior to EVAR? Cardiovasc Intervent Radiol (2007) 1.93
Nucleotide sequence of a multiple-copy gene for the B protein of photosystem II of a cyanobacterium. Proc Natl Acad Sci U S A (1984) 1.92
LIPSIA--a new software system for the evaluation of functional magnetic resonance images of the human brain. Comput Med Imaging Graph (2001) 1.90
Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers. Cancer Epidemiol Biomarkers Prev (1998) 1.87
Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes. Science (1990) 1.85
Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. J Biol Chem (1994) 1.85
Clathrin self-assembly is mediated by a tandemly repeated superhelix. Nature (1999) 1.84
The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J Clin Invest (2001) 1.82
Elements regulating cell- and stage-specific expression of the C. elegans MyoD family homolog hlh-1. Dev Biol (1994) 1.82
Alkaline phosphatase and OmpA protein can be translocated posttranslationally into membrane vesicles of Escherichia coli. J Bacteriol (1985) 1.82
Effects of PMP22 duplication and deletions on the axonal cytoskeleton. Ann Neurol (1999) 1.81
Pleiotropic defects caused by loss of the proteasome-interacting factors Rad23 and Rpn10 of Saccharomyces cerevisiae. Genetics (1999) 1.81
Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood (2000) 1.76
Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005-2007. Clin Microbiol Infect (2009) 1.76
Improvement in retinal image quality with dynamic correction of the eye's aberrations. Opt Express (2001) 1.76
On pelvic reference lines and the MR evaluation of genital prolapse: a proposal for standardization using the Pelvic Inclination Correction System. Int Urogynecol J (2013) 1.74
Effects of angiotensin-converting enzyme inhibition on exercise-induced angina and ST segment depression in patients with microvascular angina. J Am Coll Cardiol (1994) 1.74
Head and backbone of the Early Cambrian vertebrate Haikouichthys. Nature (2003) 1.73
A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Hum Mol Genet (1999) 1.72
Neuropathy progression in Charcot-Marie-Tooth disease type 1A. Neurology (2008) 1.70
Adenovirus-mediated expression of human coagulation factor IX in the rhesus macaque is associated with dose-limiting toxicity. Blood (1999) 1.70
Expression of the cystic fibrosis gene in adult human lung. J Clin Invest (1994) 1.70
Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol Biomarkers Prev (1995) 1.70
EMBRYONIC FLOWER2, a novel polycomb group protein homolog, mediates shoot development and flowering in Arabidopsis. Plant Cell (2001) 1.69
B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood (2001) 1.69
Dynamics of ferroelastic domains in ferroelectric thin films. Nat Mater (2003) 1.69
Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected. J Immunol (1995) 1.68
Field observations on the antimalarial piperaquine. Chin Med J (Engl) (1982) 1.68