D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele.

PubWeight™: 2.28‹?› | Rank: Top 2%

🔗 View Article (PMID 9429233)

Published in Pharmacogenetics on December 01, 1997


J Thompson1, N Thomas, A Singleton, M Piggott, S Lloyd, E K Perry, C M Morris, R H Perry, I N Ferrier, J A Court

Author Affiliations

1: MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, UK.

Associated clinical trials:

The Gut-brain Axis: a Novel Target for Treating Behavioral Alterations in Obesity (CIDO OEA) | NCT01976156

Articles citing this

(truncated to the top 100)

Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele. Science (2008) 4.94

Tobacco addiction. Lancet (2008) 3.65

Candidate gene studies of ADHD: a meta-analytic review. Hum Genet (2009) 3.56

Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens. Arch Gen Psychiatry (2006) 2.00

Examining impulsivity as an endophenotype using a behavioral approach: a DRD2 TaqI A and DRD4 48-bp VNTR association study. Behav Brain Funct (2007) 1.83

Dorsal striatal D2-like receptor availability covaries with sensitivity to positive reinforcement during discrimination learning. J Neurosci (2011) 1.82

Relation of obesity to consummatory and anticipatory food reward. Physiol Behav (2009) 1.52

Dopamine DRD2 polymorphism alters reversal learning and associated neural activity. J Neurosci (2009) 1.37

D2 dopamine receptor Taq1A polymorphism, body weight, and dietary intake in type 2 diabetes. Nutrition (2008) 1.35

Dopaminergic control of cognitive flexibility in humans and animals. Front Neurosci (2013) 1.28

Genetics of nicotine dependence and pharmacotherapy. Biochem Pharmacol (2007) 1.21

Association of the DRD2 gene Taq1A polymorphism and smoking behavior: a meta-analysis and new data. Nicotine Tob Res (2009) 1.11

Genetic determinants of time perception mediated by the serotonergic system. PLoS One (2010) 1.10

Season of birth and dopamine receptor gene associations with impulsivity, sensation seeking and reproductive behaviors. PLoS One (2007) 1.09

Reduced nucleus accumbens and caudate nucleus activation to a pleasant taste is associated with obesity in older adults. Brain Res (2011) 1.08

The reinforcement-enhancing effects of nicotine: implications for the relationship between smoking, eating and weight. Physiol Behav (2011) 1.07

Dopamine and binge eating behaviors. Pharmacol Biochem Behav (2010) 1.06

Neurobiological processes in adolescent addictive disorders. Am J Addict (2008) 1.06

Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity. Neuroendocrinology (2008) 1.05

Genetic variation in the human brain dopamine system influences motor learning and its modulation by L-Dopa. PLoS One (2013) 1.02

Personality traits and vulnerability or resilience to substance use disorders. Trends Cogn Sci (2014) 1.01

Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study. Brain Inj (2008) 1.01

Changes in food reward following smoking cessation: a pharmacogenetic investigation. Psychopharmacology (Berl) (2004) 0.97

Dopamine receptor genetic polymorphisms and body composition in undernourished pastoralists: an exploration of nutrition indices among nomadic and recently settled Ariaal men of northern Kenya. BMC Evol Biol (2008) 0.97

Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations. Psychopharmacology (Berl) (2005) 0.97

Leptin increases striatal dopamine D2 receptor binding in leptin-deficient obese (ob/ob) mice. Synapse (2010) 0.97

Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study. Behav Brain Funct (2007) 0.96

Neurotransmission-related genetic polymorphisms, negative affectivity traits, and gender predict tobacco abstinence symptoms across 44 days with and without nicotine patch. J Abnorm Psychol (2009) 0.94

Behavioral phenotypes of impulsivity related to the ANKK1 gene are independent of an acute stressor. Behav Brain Funct (2008) 0.94

The dopamine D2 receptor gene and depressive and anxious symptoms in childhood: associations and evidence for gene-environment correlation and gene-environment interaction. Psychiatr Genet (2010) 0.93

Gene-environment interactions across development: Exploring DRD2 genotype and prenatal smoking effects on self-regulation. Dev Psychol (2009) 0.92

Pharmacogenetics of antipsychotic-induced side effects. Dialogues Clin Neurosci (2009) 0.92

Polymorphisms in the DBH and DRD2 gene regions and smoking behavior. Eur Arch Psychiatry Clin Neurosci (2005) 0.91

Role of dopamine D2 receptors in human reinforcement learning. Neuropsychopharmacology (2014) 0.91

Deficient dopamine D2 receptor function causes renal inflammation independently of high blood pressure. PLoS One (2012) 0.90

Addictive genes and the relationship to obesity and inflammation. Mol Neurobiol (2011) 0.89

Genetics of dopamine receptors and drug addiction. Hum Genet (2012) 0.89

Polymorphisms in dopamine system genes are associated with individual differences in attention in infancy. Dev Psychol (2010) 0.89

Sex heterogeneity in pharmacogenetic smoking cessation clinical trials. Drug Alcohol Depend (2009) 0.89

The renal dopaminergic system: novel diagnostic and therapeutic approaches in hypertension and kidney disease. Transl Res (2014) 0.88

Dopaminergic mutations: within-family association and linkage in multiplex alcohol dependence families. Am J Med Genet B Neuropsychiatr Genet (2008) 0.88

Behavioral economics of food reinforcement and the effects of prefeeding, extinction, and eticlopride in dopamine D2 receptor mutant mice. Psychopharmacology (Berl) (2011) 0.88

Hemoglobin, lead exposure, and intelligence quotient: effect modification by the DRD2 Taq IA polymorphism. Environ Health Perspect (2011) 0.88

The genetics of nicotine dependence: relationship to pancreatic cancer. World J Gastroenterol (2006) 0.88

Single-nucleotide polymorphisms of the dopamine D2 receptor increase inflammation and fibrosis in human renal proximal tubule cells. Hypertension (2013) 0.88

Genetic variations in human G protein-coupled receptors: implications for drug therapy. AAPS PharmSci (2001) 0.86

DRD2 and DRD4 in relation to regular alcohol and cannabis use among adolescents: does parenting modify the impact of genetic vulnerability? The TRAILS study. Drug Alcohol Depend (2010) 0.86

Allelic and genotypic associations of DRD2 TaqI A polymorphism with heroin dependence in Spanish subjects: a case control study. Behav Brain Funct (2007) 0.85

Polymorphisms in genes modulating the dopamine system: do they inf luence outcome and response to medication after traumatic brain injury? J Head Trauma Rehabil (2009) 0.85

Response inhibition and interference control in obsessive-compulsive spectrum disorders. Front Hum Neurosci (2014) 0.85

A dopamine receptor (DRD2) but not dopamine transporter (DAT1) gene polymorphism is associated with neurocognitive development of Mexican preschool children with lead exposure. J Pediatr (2011) 0.84

Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population. BMC Neurol (2011) 0.83

Smoking-specific parenting and smoking onset in adolescence: the role of genes from the dopaminergic system (DRD2, DRD4, DAT1 genotypes). PLoS One (2013) 0.83

Motivational salience and genetic variability of dopamine D2 receptor expression interact in the modulation of interference processing. Front Hum Neurosci (2013) 0.83

DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder. Int J Neuropsychopharmacol (2013) 0.83

Dopamine genetic risk score predicts depressive symptoms in healthy adults and adults with depression. PLoS One (2014) 0.83

Biomarkers to optimize the treatment of nicotine dependence. Biomark Med (2011) 0.83

Valenced action/inhibition learning in humans is modulated by a genetic variant linked to dopamine D2 receptor expression. Front Syst Neurosci (2014) 0.83

Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients. Behav Brain Funct (2010) 0.83

Influences of polymorphic variants of DRD2 and SLC6A3 genes, and their combinations on smoking in Polish population. BMC Med Genet (2009) 0.83

Linguistic grammar learning and DRD2-TAQ-IA polymorphism. PLoS One (2013) 0.83

Brain-derived neurotropic factor polymorphisms, traumatic stress, mild traumatic brain injury, and combat exposure contribute to postdeployment traumatic stress. Brain Behav (2015) 0.83

Posttraumatic Brain Injury Cognitive Performance Is Moderated by Variation Within ANKK1 and DRD2 Genes. J Head Trauma Rehabil (2015) 0.82

Effect of the TaqIA polymorphism on ethanol response in the brain. Psychiatry Res (2009) 0.82

Pharmacogenomics in psychiatry: the relevance of receptor and transporter polymorphisms. Br J Clin Pharmacol (2014) 0.82

Antipsychotic-induced extrapyramidal symptoms in patients with schizophrenia: associations with dopamine and serotonin receptor and transporter polymorphisms. Eur J Clin Pharmacol (2007) 0.82

Basolateral amygdala response to food cues in the absence of hunger is associated with weight gain susceptibility. J Neurosci (2015) 0.82

Serotonin and dopamine receptor gene polymorphisms and the risk of extrapyramidal side effects in perphenazine-treated schizophrenic patients. Psychopharmacology (Berl) (2006) 0.81

Dopamine D2 receptor Taq IA polymorphism is associated with postoperative nausea and vomiting. J Anesth (2008) 0.81

Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies. Transl Psychiatry (2016) 0.80

COMT and ANKK1 Genetics Interact With Depression to Influence Behavior Following Severe TBI: An Initial Assessment. Neurorehabil Neural Repair (2016) 0.79

A variant in ANKK1 modulates acute subjective effects of cocaine: a preliminary study. Genes Brain Behav (2014) 0.79

ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. Pharmacogenet Genomics (2013) 0.79

Multigene interactions and the prediction of depression in the Wisconsin Longitudinal Study. BMJ Open (2012) 0.79

Association of dopamine receptor gene polymorphisms with the clinical course of Wilson disease. JIMD Rep (2012) 0.79

Common variants in DRD2 are associated with sleep duration: the CARe consortium. Hum Mol Genet (2015) 0.79

Effects of nicotine on emotional distraction of attentional orienting: evidence of possible moderation by dopamine type 2 receptor genotype. Pharmacol Biochem Behav (2013) 0.78

The D2 dopamine receptor gene and nicotine dependence among bladder cancer patients and controls. Behav Genet (2009) 0.78

The TaqIA RFLP is associated with attenuated intervention-induced body weight loss and increased carbohydrate intake in post-menopausal obese women. Appetite (2012) 0.78

An association study of DRD2 and COMT polymorphisms with novelty seeking and harm avoidance scores, in two independent samples of depressed patients. Behav Brain Funct (2007) 0.78

Polymorphisms of DRD2 and DRD3 genes and Parkinson's disease: A meta-analysis. Biomed Rep (2014) 0.77

An association study on the polymorphisms of dopaminergic genes with working memory in a healthy Chinese Han population. Cell Mol Neurobiol (2012) 0.77

Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset. Neurogenetics (2013) 0.77

The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood. Dev Psychopathol (2012) 0.77

Prediction of striatal D2 receptor binding by DRD2/ANKK1 TaqIA allele status. Synapse (2016) 0.77

Genetic analysis of polymorphisms in dopamine receptor and transporter genes for association with smoking among cancer patients. Eur Addict Res (2012) 0.77

Dopamine in socioecological and evolutionary perspectives: implications for psychiatric disorders. Front Neurosci (2015) 0.77

Genetic influences on delay discounting in smokers: examination of a priori candidates and exploration of dopamine-related haplotypes. Psychopharmacology (Berl) (2015) 0.77

The associations among the dopamine D2 receptor Taq1, emotional intelligence, creative potential measured by divergent thinking, and motivational state and these associations' sex differences. Front Psychol (2015) 0.77

Genetic variations in COMT and DRD2 modulate attentional bias for affective facial expressions. PLoS One (2013) 0.77

Excessive state switching underlies reversal learning deficits in cocaine users. Drug Alcohol Depend (2013) 0.76

Child maltreatment, impulsivity, and antisocial behavior in African American children: Moderation effects from a cumulative dopaminergic gene index. Dev Psychopathol (2015) 0.76

Between- and within-family association test of the dopamine receptor D2 TaqIA polymorphism and alcohol abuse and dependence in a general population sample of adults. J Stud Alcohol Drugs (2007) 0.76

The significant association of Taq1A genotypes in DRD2/ANKK1 with smoking cessation in a large-scale meta-analysis of Caucasian populations. Transl Psychiatry (2015) 0.76

Alcohol abuse and HIV infection: role of DRD2. Curr HIV Res (2014) 0.76

A Nested Allele-Specific Multiplex Polymerase Chain Reaction Method for the Detection of DRD2 Polymorphisms. Malays J Med Sci (2011) 0.75

Genetic Variation and Neuroplasticity: Role in Rehabilitation After Stroke. J Neurol Phys Ther (2017) 0.75

Fuel not fun: Reinterpreting attenuated brain responses to reward in obesity. Physiol Behav (2016) 0.75

Altered brain activation in a reversal learning task unmasks adaptive changes in cognitive control in writer's cramp. Neuroimage Clin (2015) 0.75

The Association of DRD2 with Insight Problem Solving. Front Psychol (2016) 0.75

Articles by these authors

Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology (2005) 21.67

alpha-Synuclein locus triplication causes Parkinson's disease. Science (2003) 20.20

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology (1996) 12.33

Genealogies of mouse inbred strains. Nat Genet (2000) 8.06

Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. N Engl J Med (2009) 7.53

Human gene mutation database-a biomedical information and research resource. Hum Mutat (2000) 6.87

Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS): a phase II, double-blind, randomised trial. Lancet (2009) 6.83

QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients. Lancet (2000) 6.78

Matching using estimated propensity scores: relating theory to practice. Biometrics (1996) 6.73

Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity. Science (2011) 4.72

Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophy. Nature (1986) 4.13

X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat Genet (1996) 3.90

Lithium neurotoxicity at normal therapeutic levels. Br J Psychiatry (1993) 3.76

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br Med J (1978) 3.59

Widespread geographic distribution of oral Candida dubliniensis strains in human immunodeficiency virus-infected individuals. J Clin Microbiol (1997) 3.54

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease. Nat Genet (2001) 3.15

Nurses taking on junior doctors' work: a confusion of accountability. BMJ (1996) 2.88

MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily. Nat Struct Biol (1998) 2.70

Thioridazine and sudden unexplained death in psychiatric in-patients. Br J Psychiatry (2002) 2.69

Staging and natural history of cerebrovascular pathology in dementia. Neurology (2012) 2.61

Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration. J Med Genet (2005) 2.56

Interpreting hospital mortality data. The role of clinical risk adjustment. JAMA (1989) 2.53

Lewy bodies and parkinsonism in families with parkin mutations. Ann Neurol (2001) 2.50

Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur. J Bone Joint Surg Am (1986) 2.49

Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease. J Neurol Neurosurg Psychiatry (1985) 2.47

Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Mol Psychiatry (2008) 2.38

Treatment of acute myocardial infarction with anisoylated plasminogen streptokinase activator complex. Br Med J (Clin Res Ed) (1986) 2.33

Association between mortality from ischaemic heart-disease and rainfall in South Wales and in the county boroughs of England and Wales. Lancet (1972) 2.26

Autobiographical memory in depression: state or trait marker? Br J Psychiatry (1993) 2.24

Senile dementia of Lewy body type. A clinically and neuropathologically distinct form of Lewy body dementia in the elderly. J Neurol Sci (1990) 2.24

An absence of cutaneous neurofibromas associated with a 3-bp inframe deletion in exon 17 of the NF1 gene (c.2970-2972 delAAT): evidence of a clinically significant NF1 genotype-phenotype correlation. Am J Hum Genet (2006) 2.23

Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease. Neurology (2004) 2.23

Computer-assisted total knee replacement. A controlled cadaver study using a multi-parameter quantitative CT assessment of alignment (the Perth CT Protocol). J Bone Joint Surg Br (2004) 2.21

Validation of the functional assessment of multiple sclerosis quality of life instrument. Neurology (1996) 2.20

General practitioners' continuing education: a review of policies, strategies and effectiveness, and their implications for the future. Br J Gen Pract (1998) 2.20

In vitro differentiation of Trypanosoma cruzi under chemically defined conditions. Mol Biochem Parasitol (1985) 2.20

Autism as a disorder of neural information processing: directions for research and targets for therapy. Mol Psychiatry (2004) 2.19

Predicting hospital-associated mortality for Medicare patients. A method for patients with stroke, pneumonia, acute myocardial infarction, and congestive heart failure. JAMA (1989) 2.19

Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2000 British Association for Psychopharmacology guidelines. J Psychopharmacol (2008) 2.11

alpha-Synuclein gene haplotypes are associated with Parkinson's disease. Hum Mol Genet (2001) 2.07

Report of the second dementia with Lewy body international workshop: diagnosis and treatment. Consortium on Dementia with Lewy Bodies. Neurology (1999) 2.00

Necropsy evidence of central cholinergic deficits in senile dementia. Lancet (1977) 1.97

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease. Hum Mol Genet (2005) 1.94

Malformations of central nervous system and softness of local water supplies. Br Med J (1971) 1.92

Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma. Cancer Res (1997) 1.91

Letter: Unusual cardiac and neurological reactions to narcotics. Lancet (1973) 1.90

The effect of oxytocin and adrenaline on blood flow in the hind limb of the dog following chronic lumbar sympathectomy. J Physiol (1967) 1.89

Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies. Neurology (2000) 1.85

A rapid method for preparing synaptosomes: comparison, with alternative procedures. Brain Res (1981) 1.85

Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue. J Neurol Sci (1977) 1.83

Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis. Brain (2008) 1.83

Changes in brain cholinesterases in senile dementia of Alzheimer type. Neuropathol Appl Neurobiol (1978) 1.82

The impact of genetic counselling on risk perception and mental health in women with a family history of breast cancer. Br J Cancer (1999) 1.80

Effect of silicon on gastrointestinal absorption of aluminium. Lancet (1993) 1.80

Raised levels of plasma interleukin-1beta in major and postviral depression. Acta Psychiatr Scand (2001) 1.80

SPG11 mutations are common in familial cases of complicated hereditary spastic paraplegia. Neurology (2008) 1.79

Apolipoprotein E genes in Lewy body and Parkinson's disease. Lancet (1994) 1.77

A closer look at water-related geologic activity on Mars. Science (2007) 1.71

Mineralization of linear alkylbenzene sulfonate by a four-member aerobic bacterial consortium. Appl Environ Microbiol (1991) 1.68

Risk factors associated with human cystic echinococcosis in Florida, Uruguay: results of a mass screening study using ultrasound and serology. Am J Trop Med Hyg (1998) 1.68

Radiation myelitis of the dorsolumbar spinal cord. Radiology (1969) 1.64

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry (2010) 1.63

Long-read sequence analysis of the MECP2 gene in Rett syndrome patients: correlation of disease severity with mutation type and location. Hum Mol Genet (2000) 1.61

A relationship between adrenaline and the mode of action of oxytocin and oestrogen on vascular smooth muscle. J Physiol (1965) 1.61

Clinical effectiveness of pneumococcal vaccine. Meta-analysis. Can Fam Physician (1999) 1.60

Optical observations of comet Hale-Bopp (C/1995 O1) at large heliocentric distances before perihelion. Science (1997) 1.58

Genome-wide association study of obsessive-compulsive disorder. Mol Psychiatry (2012) 1.57

LRRK2 gene in Parkinson disease: mutation analysis and case control association study. Neurology (2005) 1.56

Simple keel fixation technique for endoscopic repair of anterior glottic stenosis. J Laryngol Otol (2006) 1.53

Relapse in chronic depressives on withdrawal of L-tryptophan. Lancet (1990) 1.53

Genomic diversity correlates with clinical variation in Ph'-negative chronic myeloid leukaemia. Nature (1986) 1.53

A neuropathological study of vascular factors in late-life depression. J Neurol Neurosurg Psychiatry (2001) 1.53

Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis. Acta Psychiatr Scand (2013) 1.52

Pathological changes in the nucleus of Meynert in Alzheimer's and Parkinson's diseases. J Neurol Sci (1983) 1.51

The neurocognitive performance of drug-free and medicated euthymic bipolar patients do not differ. Acta Psychiatr Scand (2009) 1.51

Area differences in prevalence of neural tube malformations in South Wales. A study of possible demographic determinants. Br J Prev Soc Med (1972) 1.50

Operational criteria for senile dementia of Lewy body type (SDLT). Psychol Med (1992) 1.49

Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution. Brain (1999) 1.48

Cutting needle biopsy in the diagnosis of clinically suspected non-carcinomatous disease of the lung. Br J Radiol (2000) 1.47

Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. Br J Psychiatry (2009) 1.45

Microbial DNA profiling by multiplex terminal restriction fragment length polymorphism for forensic comparison of soil and the influence of sample condition. J Appl Microbiol (2008) 1.45

Cholinergic activity in autism: abnormalities in the cerebral cortex and basal forebrain. Am J Psychiatry (2001) 1.44