Published in J Biol Chem on August 21, 1998
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets. Pharmacol Rev (2011) 1.98
Retracted Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proc Natl Acad Sci U S A (2007) 1.14
Recognition in the face of diversity: interactions of heterotrimeric G proteins and G protein-coupled receptor (GPCR) kinases with activated GPCRs. J Biol Chem (2011) 1.07
Functional reconstitution of an atypical G protein heterotrimer and regulator of G protein signaling protein (RGS1) from Arabidopsis thaliana. J Biol Chem (2011) 1.06
A Gsalpha mutant designed to inhibit receptor signaling through Gs. Proc Natl Acad Sci U S A (1999) 1.05
Two Galpha(i1) rate-modifying mutations act in concert to allow receptor-independent, steady-state measurements of RGS protein activity. J Biomol Screen (2009) 1.03
A conserved phenylalanine as a relay between the α5 helix and the GDP binding region of heterotrimeric Gi protein α subunit. J Biol Chem (2014) 0.94
A sweet cycle for Arabidopsis G-proteins: Recent discoveries and controversies in plant G-protein signal transduction. Plant Signal Behav (2008) 0.93
A high throughput screen for RGS proteins using steady state monitoring of free phosphate formation. PLoS One (2013) 0.90
Activated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange. Eukaryot Cell (2010) 0.84
Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans. J Biol Chem (2008) 0.84
Different biochemical properties explain why two equivalent Gα subunit mutants cause unrelated diseases. J Biol Chem (2014) 0.83
Mutation of cysteine 214 in Gi1 alpha subunit abolishes its endogenous GTPase activity. Biochem J (2004) 0.80
Exploring the correlation between the sequence composition of the nucleotide binding G5 loop of the FeoB GTPase domain (NFeoB) and intrinsic rate of GDP release. Biosci Rep (2014) 0.78
Characterization of subcellular localization and stability of a splice variant of G alpha i2. BMC Cell Biol (2002) 0.77
A constitutively active Gα subunit provides insights into the mechanism of G protein activation. Biochemistry (2012) 0.77
Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis. Biopolymers (2016) 0.77
A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1. J Biol Chem (2014) 0.77
A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor. J Biol Chem (2016) 0.76
Mechanism of the intrinsic arginine finger in heterotrimeric G proteins. Proc Natl Acad Sci U S A (2016) 0.75
Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses. Nat Commun (2017) 0.75
Elucidation of Single Hydrogen Bonds in GTPases via Experimental and Theoretical Infrared Spectroscopy. Biophys J (2017) 0.75
Molecular Cloning and Characterization of G Alpha Proteins from the Western Tarnished Plant Bug, Lygus hesperus. Insects (2014) 0.75
A GTPase chimera illustrates an uncoupled nucleotide affinity and release rate, providing insight into the activation mechanism. Biophys J (2014) 0.75
The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer. Acta Pharmacol Sin (2016) 0.75
G proteins: transducers of receptor-generated signals. Annu Rev Biochem (1987) 27.41
A protein binding assay for adenosine 3':5'-cyclic monophosphate. Proc Natl Acad Sci U S A (1970) 23.79
Cyclic adenosine monophosphate and alteration of Chinese hamster ovary cell morphology: a rapid, sensitive in vitro assay for the enterotoxins of Vibrio cholerae and Escherichia coli. Infect Immun (1974) 12.51
G proteins and dual control of adenylate cyclase. Cell (1984) 11.05
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell (1995) 7.66
Regulation of axon formation by clonal lines of a neural tumor. Proc Natl Acad Sci U S A (1970) 5.12
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. Cell (1996) 4.76
Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Cell (1997) 4.74
Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science (1998) 4.62
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science (1997) 4.52
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science (1994) 4.43
p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Science (1998) 4.32
Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold. Cell (1995) 3.94
Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP. Cell (1993) 3.93
Homologies between signal transducing G proteins and ras gene products. Science (1984) 3.85
Biochemical properties of hormone-sensitive adenylate cyclase. Annu Rev Biochem (1980) 3.79
G proteins. Trends Biochem Sci (1992) 3.79
Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride. Proc Natl Acad Sci U S A (1982) 3.73
Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature (1994) 3.54
The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein. J Biol Chem (1986) 3.54
Purification and characterization of smooth muscle cell caveolae. J Cell Biol (1994) 3.18
Identification of the predominant substrate for ADP-ribosylation by islet activating protein. J Biol Chem (1983) 3.11
The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding. J Biol Chem (1982) 3.09
Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase. Eur J Biochem (1985) 3.04
Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. Science (1991) 3.00
Relationship between the beta-adrenergic receptor and adenylate cyclase. J Biol Chem (1977) 2.99
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Cell (1984) 2.96
Mammalian membrane-bound adenylyl cyclases. J Biol Chem (1995) 2.93
Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins. Proc Natl Acad Sci U S A (1987) 2.93
Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins. Proc Natl Acad Sci U S A (1986) 2.87
Purification of the regulatory component of adenylate cyclase. Proc Natl Acad Sci U S A (1980) 2.81
Complexity and diversity of mammalian adenylyl cyclases. Annu Rev Pharmacol Toxicol (1996) 2.70
The regulatory component of adenylate cyclase. Purification and properties. J Biol Chem (1981) 2.69
Crystal structure of the adenylyl cyclase activator Gsalpha. Science (1997) 2.68
Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme. J Biol Chem (1978) 2.64
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis. Science (1995) 2.64
Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z. J Biol Chem (1995) 2.61
Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure. Science (1989) 2.59
The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding. J Biol Chem (1989) 2.58
Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. J Biol Chem (1984) 2.56
The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis. J Biol Chem (1996) 2.48
Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin. J Biol Chem (1984) 2.43
Expression of G-protein alpha subunits in Escherichia coli. Methods Enzymol (1994) 2.39
Three-dimensional structure of a complex between the death domains of Pelle and Tube. Cell (1999) 2.39
G protein involvement in receptor-effector coupling. J Biol Chem (1988) 2.38
A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS). J Biol Chem (1998) 2.36
Molecular basis for two forms of the G protein that stimulates adenylate cyclase. J Biol Chem (1986) 2.35
Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase. Science (1985) 2.35
Mammalian RGS proteins: barbarians at the gate. J Biol Chem (1998) 2.34
Lipid modifications of G proteins: alpha subunits are palmitoylated. Proc Natl Acad Sci U S A (1993) 2.32
G protein gamma subunits contain a 20-carbon isoprenoid. Proc Natl Acad Sci U S A (1990) 2.32
Two-metal-Ion catalysis in adenylyl cyclase. Science (1999) 2.31
G proteins control diverse pathways of transmembrane signaling. FASEB J (1989) 2.21
Resolution of some components of adenylate cyclase necessary for catalytic activity. J Biol Chem (1977) 2.20
RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha. Proc Natl Acad Sci U S A (1997) 2.14
G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells. Proc Natl Acad Sci U S A (1990) 2.13
Synthesis in Escherichia coli of GTPase-deficient mutants of Gs alpha. J Biol Chem (1989) 2.12
The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins. J Biol Chem (1983) 2.12
Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity. Proc Natl Acad Sci U S A (2000) 2.11
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit. J Biol Chem (1983) 2.06
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein. J Biol Chem (1984) 2.05
Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins. J Biol Chem (1987) 2.02
Adenylyl cyclases. Cell (1992) 1.96
Expression and characterization of calmodulin-activated (type I) adenylylcyclase. J Biol Chem (1991) 1.94
A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. Proc Natl Acad Sci U S A (1998) 1.94
Receptor regulation of G-protein palmitoylation. Proc Natl Acad Sci U S A (1994) 1.93
Inhibition of adenylyl cyclase by Gi alpha. Science (1993) 1.87
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Proc Natl Acad Sci U S A (1986) 1.86
The effect of GTP and Mg2+ on the GTPase activity and the fluorescent properties of Go. J Biol Chem (1987) 1.85
The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins. J Biol Chem (1986) 1.83
ADP-ribosylation of transducin by islet-activation protein. Identification of asparagine as the site of ADP-ribosylation. J Biol Chem (1984) 1.83
Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2. J Biol Chem (1999) 1.82
G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma. J Biol Chem (1992) 1.75
Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity. J Biol Chem (1989) 1.75
Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits. J Biol Chem (1993) 1.74
Expression of Gs alpha in Escherichia coli. Purification and properties of two forms of the protein. J Biol Chem (1989) 1.73
Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta. Proc Natl Acad Sci U S A (1991) 1.73
Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells. J Biol Chem (1977) 1.71
Lipid modifications of G protein subunits. Myristoylation of Go alpha increases its affinity for beta gamma. J Biol Chem (1991) 1.70
Binding of (125I)iodohydroxybenzylpindolol to putative beta-adrenergic receptors of rat glioma cells and other cell clones. J Biol Chem (1976) 1.69
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition. J Biol Chem (1984) 1.69
Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli. J Biol Chem (1990) 1.69
Gz, a guanine nucleotide-binding protein with unique biochemical properties. J Biol Chem (1990) 1.67
Reconstitution of catecholamine-sensitive adenylate cyclase. Association of a regulatory component of the enzyme with membranes containing the catalytic protein and beta-adrenergic receptors. J Biol Chem (1979) 1.67
Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases. J Biol Chem (1998) 1.66
Effect of catecholamines on the adenosine 3':5'-cyclic monophosphate concentrations of clonal satellite cells of neurons. Proc Natl Acad Sci U S A (1971) 1.65
Autoacylation of G protein alpha subunits. J Biol Chem (1996) 1.64
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes. J Biol Chem (1984) 1.62
Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity. J Neurosci (1998) 1.62
The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins. J Biol Chem (1987) 1.61
Guanine nucleotide-binding regulatory proteins and dual control of adenylate cyclase. J Clin Invest (1984) 1.60