Published in Proc Natl Acad Sci U S A on July 20, 1999
Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. Biochemistry (2002) 2.42
The nitrilase superfamily: classification, structure and function. Genome Biol (2001) 2.19
FHIT gene therapy prevents tumor development in Fhit-deficient mice. Proc Natl Acad Sci U S A (2001) 1.67
Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. J Biol Chem (2002) 1.58
The histidine triad superfamily of nucleotide-binding proteins. J Cell Physiol (1999) 1.38
High-resolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss of heterozygosity and a discontinuous pattern of allele loss. Am J Pathol (2001) 1.36
Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines. Proc Natl Acad Sci U S A (2002) 1.27
Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates. J Biol Chem (2000) 1.25
Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding. Proc Natl Acad Sci U S A (2003) 1.14
Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic. Proc Natl Acad Sci U S A (2003) 1.09
Tumor suppressor and hepatocellular carcinoma. World J Gastroenterol (2008) 1.09
The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation. Mol Cell Biol (2010) 1.07
Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant. Br J Cancer (2004) 1.02
Increased sensitivity to cisplatin in non-small cell lung cancer cell lines after FHIT gene transfer. Neoplasia (2006) 0.91
Fhit deficiency-induced global genome instability promotes mutation and clonal expansion. PLoS One (2013) 0.91
FHIT protein expression and its relation to apoptosis, tumor histologic grade and prognosis in colorectal adenocarcinoma: an immunohistochemical and image analysis study. Clin Exp Metastasis (2002) 0.90
DNA methylation in promoter region as biomarkers in prostate cancer. Methods Mol Biol (2012) 0.88
The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. Cell Signal (2013) 0.87
Loss of FHIT protein expression correlates with disease progression and poor differentiation in gastric cancer. J Cancer Res Clin Oncol (2003) 0.85
Fragile histidine triad protein: structure, function, and its association with tumorogenesis. J Cancer Res Clin Oncol (2009) 0.85
Frequent epigenetic silencing of the FHIT gene in penile squamous cell carcinomas. Virchows Arch (2008) 0.84
Disruption and overexpression of the Schizosaccharomyces pombe aph1 gene and the effects on intracellular diadenosine 5',5'''-P1, P4-tetraphosphate (Ap4A), ATP and ADP concentrations. Biochem J (2000) 0.84
A hybrid machine learning-based method for classifying the Cushing's Syndrome with comorbid adrenocortical lesions. BMC Genomics (2008) 0.83
Expression of fragile histidine triad in primary hepatocellular carcinoma and its relation with cell proliferation and apoptosis. World J Gastroenterol (2005) 0.82
Impaired FHIT expression characterizes serous ovarian carcinoma. Br J Cancer (2001) 0.82
Frequent allelic deletion at the FHIT locus associated with p53 overexpression in squamous cell carcinoma subtype of Taiwanese non-small-cell lung cancers. Br J Cancer (2004) 0.81
Chromosomal and genomic changes in lung cancer. Cell Adh Migr (2010) 0.81
The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions. Br J Cancer (2004) 0.80
A novel approach to simultaneously scan genes at fragile sites. BMC Cancer (2006) 0.79
Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement. BMC Chem Biol (2001) 0.78
Effect of eradication of Helicobacter pylori on expression levels of FHIT, IL-8 and P73 in gastric mucosa of first-degree relatives of gastric cancer patients. PLoS One (2015) 0.78
Regions of variable DNA methylation in human placenta associated with newborn neurobehavior. Epigenetics (2016) 0.77
P53 nuclear stabilization is associated with FHIT loss and younger age of onset in squamous cell carcinoma of oral tongue. BMC Clin Pathol (2014) 0.76
Fhit loss-associated initiation and progression of neoplasia in vitro. Cancer Sci (2016) 0.75
Methylation status of the FHIT gene in the transformed human mesenchymal F6 stem cell line. Oncol Lett (2015) 0.75
Immunohistochemical characterization of FHIT expression in normal human tissues. Interv Med Appl Sci (2016) 0.75
A novel independence test for somatic alterations in cancer shows that biology drives mutual exclusivity but chance explains most co-occurrence. Genome Biol (2016) 0.75
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell (1993) 33.20
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods (1991) 16.64
p21 is a universal inhibitor of cyclin kinases. Nature (1993) 15.55
The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell (1996) 15.19
Induction of apoptosis by the Bcl-2 homologue Bak. Nature (1995) 3.56
Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase. Biochemistry (1996) 2.46
Replacement of Fhit in cancer cells suppresses tumorigenicity. Proc Natl Acad Sci U S A (1997) 2.36
Simultaneous visualization of seven different DNA probes by in situ hybridization using combinatorial fluorescence and digital imaging microscopy. Proc Natl Acad Sci U S A (1992) 2.32
Loss of FHIT function in lung cancer and preinvasive bronchial lesions. Cancer Res (1998) 1.96
Structure and expression of the human FHIT gene in normal and tumor cells. Cancer Res (1997) 1.76
The FHIT gene at 3p14.2 is abnormal in breast carcinomas. Cancer Res (1996) 1.75
Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit. Proc Natl Acad Sci U S A (1998) 1.68
Diadenosine oligophosphates (Ap(n)A), a novel class of signalling molecules? FEBS Lett (1998) 1.59
Loss of FHIT expression in cervical carcinoma cell lines and primary tumors. Cancer Res (1997) 1.42
Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities. Cancer Res (1997) 1.18
Absence or reduction of Fhit expression in most clear cell renal carcinomas. Cancer Res (1998) 1.18
The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell (1996) 15.19
Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci U S A (1982) 11.15
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science (1984) 8.80
Involvement of the bcl-2 gene in human follicular lymphoma. Science (1985) 8.19
Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun (2005) 7.50
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science (1985) 6.63
Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature (1984) 5.85
Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci U S A (1986) 5.54
The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell (1992) 5.39
Nucleotide sequence of cloned cDNA of human c-myc oncogene. Nature (1983) 4.83
Chromosomal location of the genes for human immunoglobulin heavy chains. Proc Natl Acad Sci U S A (1979) 4.52
Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin. Proc Natl Acad Sci U S A (1981) 4.50
Expression of the CD34 gene in vascular endothelial cells. Blood (1990) 4.41
Production of antibodies against influenza virus by somatic cell hybrids between mouse myeloma and primed spleen cells. Proc Natl Acad Sci U S A (1977) 4.30
MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene (2008) 4.11
MicroRNA deregulation in human thyroid papillary carcinomas. Endocr Relat Cancer (2006) 4.11
Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. Blood (1998) 4.07
PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell (1990) 3.98
miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. Cell Death Differ (2009) 3.94
Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia. Proc Natl Acad Sci U S A (1983) 3.90
Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas. Science (1983) 3.82
Translocation of an immunoglobulin kappa locus to a region 3' of an unrearranged c-myc oncogene enhances c-myc transcription. Proc Natl Acad Sci U S A (1983) 3.75
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci U S A (2000) 3.69
Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science (1984) 3.64
Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt. Proc Natl Acad Sci U S A (1983) 3.53
P53 expression in breast cancer. Int J Cancer (1988) 3.51
Transcriptional activation of the translocated c-myc oncogene in burkitt lymphoma. Proc Natl Acad Sci U S A (1983) 3.46
Assignment of the genes for human lambda immunoglobulin chains to chromosome 22. Nature (1981) 3.43
Differential expression of the normal and of the translocated human c-myc oncogenes in B cells. Proc Natl Acad Sci U S A (1983) 3.43
Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphoma. Science (1983) 3.40
Translocation of immunoglobulin VH genes in Burkitt lymphoma. Proc Natl Acad Sci U S A (1982) 3.30
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas. Oncogene (2007) 3.29
Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO J (1999) 3.22
Inactivation of Bcl-2 by phosphorylation. Proc Natl Acad Sci U S A (1995) 3.13
microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. Oncogene (2011) 3.02
Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient. Science (1984) 2.97
The intriguing role of polymorphonuclear neutrophils in antitumor reactions. Blood (2001) 2.92
Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation. Nature (1985) 2.91
MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene (2007) 2.79
PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann Oncol (2008) 2.75
Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax. Oncogene (1997) 2.69
DNA vaccination against rat her-2/Neu p185 more effectively inhibits carcinogenesis than transplantable carcinomas in transgenic BALB/c mice. J Immunol (2000) 2.65
Assignment of the T-antigen gene of simian virus 40 to human chromosome C-7. Proc Natl Acad Sci U S A (1973) 2.63
Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene. Science (2001) 2.61
FRA3B and other common fragile sites: the weakest links. Nat Rev Cancer (2001) 2.61
A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases. Nature (1987) 2.60
The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. Cancer Res (1999) 2.56
Localization of gene for human p53 tumour antigen to band 17p13. Nature (1986) 2.56
The alpha-spectrin gene is on chromosome 1 in mouse and man. Proc Natl Acad Sci U S A (1985) 2.53
The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex. Proc Natl Acad Sci U S A (1998) 2.52
Bcl2 is the guardian of microtubule integrity. Cancer Res (1997) 2.51
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. Proc Natl Acad Sci U S A (2000) 2.48
elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. Science (1989) 2.48
Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res (1995) 2.47
MicroRNAs and chromosomal abnormalities in cancer cells. Oncogene (2006) 2.47
Somatic cell hybrids producing antibodies specific for the tumor antigen of simian virus 40. Proc Natl Acad Sci U S A (1978) 2.47
Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase. Biochemistry (1996) 2.46
Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc Natl Acad Sci U S A (1989) 2.45
bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood (1993) 2.45
MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer. Oncogene (2008) 2.44
Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality. Oncogene (2001) 2.42
Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene. Cancer Res (2001) 2.41
Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas. Proc Natl Acad Sci U S A (1987) 2.40
Effect of environmental pH on the efficiency of cellular hybridization. Proc Natl Acad Sci U S A (1972) 2.39
Repertoire of antiviral antibodies expressed by somatic cell hybrids. Proc Natl Acad Sci U S A (1978) 2.38
A potential role for interleukin-15 in the regulation of human natural killer cell survival. J Clin Invest (1997) 2.37
The FHIT gene 3p14.2 is abnormal in lung cancer. Cell (1996) 2.36
Replacement of Fhit in cancer cells suppresses tumorigenicity. Proc Natl Acad Sci U S A (1997) 2.36
Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation. Science (1987) 2.36
Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms. Science (1985) 2.33
Production of human hybridomas secreting antibodies to measles virus. Nature (1980) 2.32
Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo. J Exp Med (1996) 2.32
Down-regulation of bcl-2 by p53 in breast cancer cells. Cancer Res (1994) 2.31
Antitumor vaccination: where we stand. Haematologica (2000) 2.30
Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells. Proc Natl Acad Sci U S A (1992) 2.28
Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene. Science (1982) 2.27
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22. Proc Natl Acad Sci U S A (1988) 2.26
Control of expression of histocompatibility antigens (H-2) and beta 2-microglobulin in F9 teratocarcinoma stem cells. Proc Natl Acad Sci U S A (1981) 2.22
Selective suppression of the transcription of ribosomal genes in mouse-human hybrid cells. J Cell Physiol (1979) 2.21
Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis. Am J Pathol (1997) 2.19
Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. J Biol Chem (2001) 2.19
Muir-Torre-like syndrome in Fhit-deficient mice. Proc Natl Acad Sci U S A (2000) 2.15
Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth. Ann Oncol (2002) 2.14
Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell (1987) 2.12
Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features. Am J Pathol (1999) 2.11
Activation of MYC in a masked t(8;17) translocation results in an aggressive B-cell leukemia. Proc Natl Acad Sci U S A (1989) 2.11
GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development. Cancer Res (1997) 2.11
Taxol induces bcl-2 phosphorylation and death of prostate cancer cells. Cancer Res (1996) 2.09
Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A. Mol Cell Biol (1993) 2.08
Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms. Oncogene (2000) 2.08
Role of the high mobility group A proteins in human lipomas. Carcinogenesis (2001) 2.08
A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. J Biol Chem (2000) 2.08
The gene encoding the T-cell surface protein T4 is located on human chromosome 12. Proc Natl Acad Sci U S A (1986) 2.08
Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice. J Exp Med (1998) 2.08
The t(8; 14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V-D-J joining. Nature (1986) 2.07