Published in Cancer Res on March 15, 1996
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol (1999) 4.00
Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer. Cancer Res (2010) 2.42
Inhibition of the androgen receptor as a novel mechanism of taxol chemotherapy in prostate cancer. Cancer Res (2009) 1.80
Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Mol Cell Biol (1998) 1.70
Hypoxia-ischemia and retinal ganglion cell damage. Clin Ophthalmol (2008) 1.44
An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. Clin Cancer Res (2009) 1.36
Targeting prostate cancer based on signal transduction and cell cycle pathways. Cell Cycle (2008) 1.25
miR-135a contributes to paclitaxel resistance in tumor cells both in vitro and in vivo. Oncogene (2011) 1.20
Multimodality therapy: potentiation of high linear energy transfer radiation with paclitaxel for the treatment of disseminated peritoneal disease. Clin Cancer Res (2008) 1.14
Bcl-2 expression identifies an early stage of myogenesis and promotes clonal expansion of muscle cells. J Cell Biol (1998) 1.09
Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment. Biochim Biophys Acta (2015) 1.05
Synergy of Taxol and radioimmunotherapy with yttrium-90-labeled chimeric L6 antibody: efficacy and toxicity in breast cancer xenografts. Proc Natl Acad Sci U S A (1997) 1.04
Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1. Neoplasia (2002) 1.04
Glycomic analysis using glycoprotein immobilization for glycan extraction. Anal Chem (2013) 1.03
Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines. Br J Cancer (1999) 0.99
DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis. J Zhejiang Univ Sci B (2007) 0.99
Modulation of docetaxel-induced apoptosis and cell cycle arrest by all- trans retinoic acid in prostate cancer cells. Br J Cancer (2001) 0.99
Mitogenic action of the androgen receptor sensitizes prostate cancer cells to taxane-based cytotoxic insult. Cancer Res (2006) 0.99
Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation. J Biol Chem (2011) 0.97
Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy. BMC Cancer (2012) 0.97
Raf kinase inhibitor protein (RKIP) blocks signal transducer and activator of transcription 3 (STAT3) activation in breast and prostate cancer. PLoS One (2014) 0.95
Proteasomal degradation of human peptidyl prolyl isomerase pin1-pointing phospho Bcl2 toward dephosphorylation. Neoplasia (2002) 0.91
Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1. Neoplasia (2001) 0.91
Chemotherapy for androgen-independent prostate cancer. World J Urol (2005) 0.89
Activation of SAPK/JNK by camptothecin sensitizes androgen-independent prostate cancer cells to Fas-induced apoptosis. Br J Cancer (2000) 0.89
Connective tissue growth factor (CTGF) promotes activated mesangial cell survival via up-regulation of mitogen-activated protein kinase phosphatase-1 (MKP-1). Biochem J (2007) 0.89
Induction of apoptosis by taxol and cisplatin and effect on cell cycle-related proteins in cisplatin-sensitive and -resistant human ovarian cells. Br J Cancer (1998) 0.89
Therapy effect of either paclitaxel or cyclophosphamide combination treatment in patients with epithelial ovarian cancer and relation to TP53 gene status. Br J Cancer (1998) 0.88
Malate dehydrogenase 2 confers docetaxel resistance via regulations of JNK signaling and oxidative metabolism. Prostate (2013) 0.88
Concurrent administration of Docetaxel and Stealth liposomal doxorubicin with radiotherapy in non-small cell lung cancer : excellent tolerance using subcutaneous amifostine for cytoprotection. Br J Cancer (2002) 0.88
JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis. Exp Mol Med (2009) 0.87
Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation. Biochem Pharmacol (2009) 0.86
The mechanism of action of docetaxel (Taxotere) in xenograft models is not limited to bcl-2 phosphorylation. Invest New Drugs (2003) 0.86
Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions. Br J Cancer (2001) 0.86
Key regulators in prostate cancer identified by co-expression module analysis. BMC Genomics (2014) 0.86
Src tyrosine kinase augments taxotere-induced apoptosis through enhanced expression and phosphorylation of Bcl-2. Br J Cancer (2002) 0.85
Long circulating lectin conjugated paclitaxel loaded magnetic nanoparticles: a new theranostic avenue for leukemia therapy. PLoS One (2011) 0.85
Targeting the Androgen Receptor by Taxol in Castration-Resistant Prostate Cancer. Mol Cell Pharmacol (2010) 0.84
Prediction of functional phosphorylation sites by incorporating evolutionary information. Protein Cell (2012) 0.84
Combination effects of docetaxel and Doxorubicin in hormone-refractory prostate cancer cells. Biochem Res Int (2012) 0.83
Taxol-mediated augmentation of CD95 ligand-induced apoptosis of human malignant glioma cells: association with bcl-2 phosphorylation but neither activation of p53 nor G2/M cell cycle arrest. Br J Cancer (1998) 0.83
GLIPR1-ΔTM synergizes with docetaxel in cell death and suppresses resistance to docetaxel in prostate cancer cells. Mol Cancer (2015) 0.83
Role of the Bcl-2 gene family in prostate cancer progression and its implications for therapeutic intervention. Environ Health Perspect (1999) 0.83
Apoptosis induction via microtubule disassembly by an antitumour compound, pironetin. Biochem J (1999) 0.82
Docetaxel for the treatment of hormone-refractory prostate cancer. Rev Urol (2003) 0.81
Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cells. Br J Cancer (2001) 0.81
A phase I pharmacokinetic and pharmacodynamic correlative study of the antisense Bcl-2 oligonucleotide g3139, in combination with carboplatin and paclitaxel, in patients with advanced solid tumors. Clin Cancer Res (2008) 0.81
Ethanol extract of Forsythia suspensa root induces apoptosis of esophageal carcinoma cells via the mitochondrial apoptotic pathway. Mol Med Rep (2014) 0.81
BCL-2, p53 and HLA-DR antigen expression in surgically treated parotid cancer patients. Eur Arch Otorhinolaryngol (2008) 0.81
Novel suicide ligands of tubulin arrest cancer cells in S-phase. Neoplasia (1999) 0.81
The X-linked inhibitor of apoptosis protein inhibits taxol-induced apoptosis in LNCaP cells. Urol Res (2003) 0.81
Methyl sulfone induces loss of metastatic properties and reemergence of normal phenotypes in a metastatic cloudman S-91 (M3) murine melanoma cell line. PLoS One (2010) 0.80
Docetaxel for the treatment of hormone-refractory prostate cancer. Rev Urol (2003) 0.79
Concurrent conventionally factionated radiotherapy and weekly docetaxel in the treatment of stage IIIb non-small-cell lung carcinoma. Br J Cancer (1999) 0.79
MiRNA-149 modulates chemosensitivity of ovarian cancer A2780 cells to paclitaxel by targeting MyD88. J Ovarian Res (2015) 0.79
MicroRNA-16 sensitizes breast cancer cells to paclitaxel through suppression of IKBKB expression. Oncotarget (2016) 0.79
Elevated prx1 provides resistance to docetaxel, but is not associated with predictive significance in lung cancer. Tuberc Respir Dis (Seoul) (2013) 0.78
Drug interactions of paclitaxel and docetaxel and their relevance for the design of combination therapy. Invest New Drugs (2001) 0.77
N52 monodeamidated Bcl‑xL shows impaired oncogenic properties in vivo and in vitro. Oncotarget (2016) 0.77
Caveolin-1 Modulates Docetaxel-Induced Cell Death in Breast Cancer Cell Subtypes through Different Mechanisms. Cancer Res Treat (2015) 0.76
Histone deacetylase inhibitor-induced cell death in bladder cancer is associated with chromatin modification and modifying protein expression: A proteomic approach. Int J Oncol (2016) 0.76
Mimicking Cdk2 phosphorylation of Bcl-xL at Ser73 results in caspase activation and Bcl-xL cleavage. Cell Death Discov (2016) 0.75
Restricted mobility of specific functional groups reduces anti-cancer drug activity in healthy cells. Sci Rep (2016) 0.75
The chemomodulatory effects of glufosfamide on docetaxel cytotoxicity in prostate cancer cells. PeerJ (2016) 0.75
Protein kinase A type II-α regulatory subunit regulates the response of prostate cancer cells to taxane treatment. Cell Cycle (2014) 0.75
Protection of hybridoma cells against apoptosis by a loop domain-deficient Bcl-xL protein. Cytotechnology (2001) 0.75
Microtubule-stabilizing properties of the avocado-derived toxins (+)-(R)-persin and (+)-(R)-tetrahydropersin in cancer cells and activity of related synthetic analogs. Invest New Drugs (2016) 0.75
Sulforaphane sensitizes human breast cancer cells to paclitaxel-induced apoptosis by downregulating the NF-κB signaling pathway. Oncol Lett (2017) 0.75
Anti-apoptotic effect of nerve growth factor is lost in congenital insensitivity to pain with anhidrosis (CIPA) B lymphocytes. J Clin Immunol (2004) 0.75
Retracted Gastric changes following colchicine therapy in patients with FMF. Dig Dis Sci (2007) 0.75
The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell (1996) 15.19
Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci U S A (1982) 11.15
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science (1984) 8.80
Involvement of the bcl-2 gene in human follicular lymphoma. Science (1985) 8.19
Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun (2005) 7.50
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science (1985) 6.63
Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature (1984) 5.85
Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci U S A (1986) 5.54
The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell (1992) 5.39
Nucleotide sequence of cloned cDNA of human c-myc oncogene. Nature (1983) 4.83
Chromosomal location of the genes for human immunoglobulin heavy chains. Proc Natl Acad Sci U S A (1979) 4.52
Production of antibodies against influenza virus by somatic cell hybrids between mouse myeloma and primed spleen cells. Proc Natl Acad Sci U S A (1977) 4.30
MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene (2008) 4.11
MicroRNA deregulation in human thyroid papillary carcinomas. Endocr Relat Cancer (2006) 4.11
Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. Blood (1998) 4.07
miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. Cell Death Differ (2009) 3.94
Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia. Proc Natl Acad Sci U S A (1983) 3.90
Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas. Science (1983) 3.82
Translocation of an immunoglobulin kappa locus to a region 3' of an unrearranged c-myc oncogene enhances c-myc transcription. Proc Natl Acad Sci U S A (1983) 3.75
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci U S A (2000) 3.69
Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science (1984) 3.64
Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt. Proc Natl Acad Sci U S A (1983) 3.53
Transcriptional activation of the translocated c-myc oncogene in burkitt lymphoma. Proc Natl Acad Sci U S A (1983) 3.46
Assignment of the genes for human lambda immunoglobulin chains to chromosome 22. Nature (1981) 3.43
Differential expression of the normal and of the translocated human c-myc oncogenes in B cells. Proc Natl Acad Sci U S A (1983) 3.43
Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphoma. Science (1983) 3.40
Translocation of immunoglobulin VH genes in Burkitt lymphoma. Proc Natl Acad Sci U S A (1982) 3.30
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas. Oncogene (2007) 3.29
Inactivation of Bcl-2 by phosphorylation. Proc Natl Acad Sci U S A (1995) 3.13
microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. Oncogene (2011) 3.02
Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation. Nature (1985) 2.91
MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene (2007) 2.79
Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax. Oncogene (1997) 2.69
Assignment of the T-antigen gene of simian virus 40 to human chromosome C-7. Proc Natl Acad Sci U S A (1973) 2.63
Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene. Science (2001) 2.61
FRA3B and other common fragile sites: the weakest links. Nat Rev Cancer (2001) 2.61
The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. Cancer Res (1999) 2.56
Localization of gene for human p53 tumour antigen to band 17p13. Nature (1986) 2.56
The alpha-spectrin gene is on chromosome 1 in mouse and man. Proc Natl Acad Sci U S A (1985) 2.53
The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex. Proc Natl Acad Sci U S A (1998) 2.52
Bcl2 is the guardian of microtubule integrity. Cancer Res (1997) 2.51
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. Proc Natl Acad Sci U S A (2000) 2.48
elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. Science (1989) 2.48
Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res (1995) 2.47
MicroRNAs and chromosomal abnormalities in cancer cells. Oncogene (2006) 2.47
Somatic cell hybrids producing antibodies specific for the tumor antigen of simian virus 40. Proc Natl Acad Sci U S A (1978) 2.47
Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase. Biochemistry (1996) 2.46
Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc Natl Acad Sci U S A (1989) 2.45
MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer. Oncogene (2008) 2.44
Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality. Oncogene (2001) 2.42
Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene. Cancer Res (2001) 2.41
Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas. Proc Natl Acad Sci U S A (1987) 2.40
Effect of environmental pH on the efficiency of cellular hybridization. Proc Natl Acad Sci U S A (1972) 2.39
Repertoire of antiviral antibodies expressed by somatic cell hybrids. Proc Natl Acad Sci U S A (1978) 2.38
A potential role for interleukin-15 in the regulation of human natural killer cell survival. J Clin Invest (1997) 2.37
The FHIT gene 3p14.2 is abnormal in lung cancer. Cell (1996) 2.36
Replacement of Fhit in cancer cells suppresses tumorigenicity. Proc Natl Acad Sci U S A (1997) 2.36
Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation. Science (1987) 2.36
Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms. Science (1985) 2.33
Production of human hybridomas secreting antibodies to measles virus. Nature (1980) 2.32
Down-regulation of bcl-2 by p53 in breast cancer cells. Cancer Res (1994) 2.31
Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells. Proc Natl Acad Sci U S A (1992) 2.28
Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene. Science (1982) 2.27
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22. Proc Natl Acad Sci U S A (1988) 2.26
Control of expression of histocompatibility antigens (H-2) and beta 2-microglobulin in F9 teratocarcinoma stem cells. Proc Natl Acad Sci U S A (1981) 2.22
Selective suppression of the transcription of ribosomal genes in mouse-human hybrid cells. J Cell Physiol (1979) 2.21
Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. J Biol Chem (2001) 2.19
Muir-Torre-like syndrome in Fhit-deficient mice. Proc Natl Acad Sci U S A (2000) 2.15
Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell (1987) 2.12
Activation of MYC in a masked t(8;17) translocation results in an aggressive B-cell leukemia. Proc Natl Acad Sci U S A (1989) 2.11
GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development. Cancer Res (1997) 2.11
Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms. Oncogene (2000) 2.08
Role of the high mobility group A proteins in human lipomas. Carcinogenesis (2001) 2.08
A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. J Biol Chem (2000) 2.08
The gene encoding the T-cell surface protein T4 is located on human chromosome 12. Proc Natl Acad Sci U S A (1986) 2.08
The t(8; 14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V-D-J joining. Nature (1986) 2.07
Chromosomal assignment of the human homologues of feline sarcoma virus and avian myeloblastosis virus onc genes. Proc Natl Acad Sci U S A (1982) 2.06
Characterization of the protein product of bcl-2, the gene involved in human follicular lymphoma. Oncogene (1987) 2.06
Clinical applications for microRNAs in cancer. Clin Pharmacol Ther (2012) 2.05
Identification of the TCL1 gene involved in T-cell malignancies. Proc Natl Acad Sci U S A (1994) 2.02
The role of the FHIT/FRA3B locus in cancer. Annu Rev Genet (1998) 2.01
Partial tandem duplication of ALL1 as a recurrent molecular defect in acute myeloid leukemia with trisomy 11. Cancer Res (1996) 1.99
MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways. Oncogene (2010) 1.97
Loss of FHIT function in lung cancer and preinvasive bronchial lesions. Cancer Res (1998) 1.96
Loss of mouse chromosomes in somatic cell hybrids between HT-1080 human fibrosarcoma cells and mouse peritioneal macrophages. Proc Natl Acad Sci U S A (1976) 1.96
Role of chromosome translocations in human neoplasia. Cell (1987) 1.94
Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia. Cancer Res (2001) 1.93
Oncogene activation by chromosome translocation in human malignancy. Annu Rev Genet (1987) 1.91
Somatic cell hybrids between mouse peritoneal macrophages and SV40-transformed human cells. I. Positive control of the transformed phenotype by the human chromosome 7 carrying the SV40 genome. J Exp Med (1974) 1.91
Cloning and sequencing of a c-myc oncogene in a Burkitt's lymphoma cell line that is translocated to a germ line alpha switch region. Mol Cell Biol (1985) 1.90
Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases. Proc Natl Acad Sci U S A (1993) 1.89
Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations. Cancer Res (1991) 1.88
Molecular cloning and nucleotide sequence of a full-length cDNA for human alpha enolase. Proc Natl Acad Sci U S A (1986) 1.87
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J Biol Chem (1997) 1.86
Deregulated expression of TCL1 causes T cell leukemia in mice. Proc Natl Acad Sci U S A (1998) 1.86
Molecular basis of human B cell neoplasia. Blood (1985) 1.85
Localization of the gene encoding human erythroid-potentiating activity to chromosome region Xp11.1----Xp11.4. Am J Hum Genet (1986) 1.84
The structure and nucleotide sequence of the 5' end of the human c-myc oncogene. Proc Natl Acad Sci U S A (1983) 1.84
Human regulatory gene for inducible tyrosine aminotransferase in rat-human hybrids. Proc Natl Acad Sci U S A (1973) 1.84
Human TCR-gamma+/delta+, CD8+ T lymphocytes recognize tetanus toxoid in an MHC-restricted fashion. J Exp Med (1989) 1.82