Published in Biochemistry on September 10, 1996
Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. Biochemistry (2002) 2.42
Replacement of Fhit in cancer cells suppresses tumorigenicity. Proc Natl Acad Sci U S A (1997) 2.36
Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins. Nat Struct Biol (1997) 1.96
The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. Proc Natl Acad Sci U S A (1998) 1.86
Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit. Proc Natl Acad Sci U S A (1998) 1.68
Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. J Biol Chem (2002) 1.58
The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control. Proc Natl Acad Sci U S A (1999) 1.47
The histidine triad superfamily of nucleotide-binding proteins. J Cell Physiol (1999) 1.38
Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. Proc Natl Acad Sci U S A (1998) 1.32
Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates. J Biol Chem (2000) 1.25
Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding. Proc Natl Acad Sci U S A (2003) 1.14
Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein. Protein Eng (1997) 1.07
Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin. J Biol Chem (2008) 1.06
Role of genetics in the diagnosis and prognosis of Crohn's disease. World J Gastroenterol (2012) 1.01
Disease-associated mutations inactivate AMP-lysine hydrolase activity of Aprataxin. J Biol Chem (2005) 1.00
Two hydrolase resistant analogues of diadenosine 5',5"'-P1,P3-triphosphate for studies with Fhit, the human fragile histidine triad protein. Nucleosides Nucleotides (1998) 1.00
Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions. J Biol Chem (2008) 1.00
Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. J Biol Chem (2003) 0.99
Genome-wide transcriptome analysis of hypothalamus in rats with inherited stress-induced arterial hypertension. BMC Genet (2016) 0.97
Feminizing chicks: a model for avian sex determination based on titration of Hint enzyme activity and the predicted structure of an Asw-Hint heterodimer. Genome Biol (2003) 0.96
The histidine triad protein Hint is not required for murine development or Cdk7 function. Mol Cell Biol (2003) 0.93
Isolation, cloning and characterization of a low-molecular-mass purine nucleoside- and nucleotide-binding protein. Biochem J (1997) 0.92
WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland. Mol Biol Cell (1999) 0.92
Re-splicing of mature mRNA in cancer cells promotes activation of distant weak alternative splice sites. Nucleic Acids Res (2012) 0.91
Loss of FHIT expression in transitional cell carcinoma of the urinary bladder. Am J Pathol (2000) 0.91
Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9. Biochem J (2000) 0.90
Role of 5'-CpG island hypermethylation of the FHIT gene in cervical carcinoma. J Gynecol Oncol (2008) 0.88
Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS. Nucleic Acids Res (2014) 0.88
High-resolution whole-genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesis. Neoplasia (2012) 0.87
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Aberrant FHIT transcripts in hepatocellular carcinomas. Br J Cancer (1998) 0.87
Control of 5',5'-dinucleoside triphosphate catabolism by APH1, a Saccharomyces cerevisiae analog of human FHIT. J Bacteriol (1998) 0.86
Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells. Biochem Biophys Res Commun (2007) 0.86
Cloning and expression of diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase from Lupinus angustifolius L. Biochem J (1998) 0.86
Dinucleoside polyphosphates and their interaction with other nucleotide signaling pathways. Pflugers Arch (2006) 0.85
Fragile histidine triad protein: structure, function, and its association with tumorogenesis. J Cancer Res Clin Oncol (2009) 0.85
Hits, Fhits and Nits: beyond enzymatic function. Adv Enzyme Regul (2010) 0.84
Disruption and overexpression of the Schizosaccharomyces pombe aph1 gene and the effects on intracellular diadenosine 5',5'''-P1, P4-tetraphosphate (Ap4A), ATP and ADP concentrations. Biochem J (2000) 0.84
Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel. PLoS One (2013) 0.84
Brewers' rice induces apoptosis in azoxymethane-induced colon carcinogenesis in rats via suppression of cell proliferation and the Wnt signaling pathway. BMC Complement Altern Med (2014) 0.84
Replicative Stress and the FHIT Gene: Roles in Tumor Suppression, Genome Stability and Prevention of Carcinogenesis. Cancers (Basel) (2014) 0.83
Impaired FHIT expression characterizes serous ovarian carcinoma. Br J Cancer (2001) 0.82
Expression of fragile histidine triad in primary hepatocellular carcinoma and its relation with cell proliferation and apoptosis. World J Gastroenterol (2005) 0.82
Reduced FHIT expression is associated with mismatch repair deficient and high CpG island methylator phenotype colorectal cancer. J Histochem Cytochem (2013) 0.81
The FHIT gene product is highly expressed in the cytoplasm of renal tubular epithelium and is down-regulated in kidney cancers. Am J Pathol (1997) 0.81
Adenosine 5'-tetraphosphate phosphohydrolase from yellow lupin seeds: purification to homogeneity and some properties. Biochem J (1997) 0.80
Abnormalities of the FHIT gene in human oral carcinogenesis. Br J Cancer (2000) 0.80
Aberrant transcripts of the FHIT gene are expressed in normal and leukaemic haemopoietic cells. Br J Cancer (1998) 0.80
Characterization of the role of Fhit in suppression of DNA damage. Adv Biol Regul (2012) 0.79
Control of dinucleoside polyphosphates by the FHIT-homologous HNT2 gene, adenine biosynthesis and heat shock in Saccharomyces cerevisiae. BMC Mol Biol (2002) 0.79
A Fhit-mimetic peptide suppresses annexin A4-mediated chemoresistance to paclitaxel in lung cancer cells. Oncotarget (2016) 0.79
Role of genetics in the diagnosis and prognosis of Crohn's disease. World J Gastroenterol (2011) 0.79
Evaluation of FHIT gene alterations in ovarian cancer. Br J Cancer (1998) 0.79
Quantitative assessment of the diagnostic role of FHIT promoter methylation in non-small cell lung cancer. Oncotarget (2016) 0.78
Acyl coenzyme A synthetase from Pseudomonas fragi catalyzes the synthesis of adenosine 5'-polyphosphates and dinucleoside polyphosphates. J Bacteriol (1998) 0.78
Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor. Cell Commun Signal (2013) 0.78
Ca2+ signalling in brain synaptosomes activated by dinucleotides. J Membr Biol (2003) 0.78
Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases. Biochem J (2003) 0.78
Common Variants Affecting Susceptibility to Develop Multiple Basal Cell Carcinomas. J Invest Dermatol (2015) 0.78
Identification of diadenosine triphosphate in Brugia malayi by reverse phase high performance liquid chromatography and MALDI mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2007) 0.78
Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement. BMC Chem Biol (2001) 0.78
Classification of non-small cell lung cancer based on copy number alterations. PLoS One (2014) 0.77
Effect of fragile histidine triad gene transduction on proliferation and apoptosis of human hepatocellular carcinoma cells. World J Gastroenterol (2008) 0.77
Loss of Fhit expression is associated with poorer survival in gastric cancer but is not an independent prognostic marker. J Cancer Res Clin Oncol (2005) 0.77
NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes. PLoS One (2016) 0.76
Identification of Fhit as a post-transcriptional effector of Thymidine Kinase 1 expression. Biochim Biophys Acta (2017) 0.75
Comparison of structural genetics of non-schistosoma-associated squamous cell carcinoma of the urinary bladder. Int J Clin Exp Pathol (2015) 0.75
Molecular and epigenetic analysis of the fragile histidine triad tumour suppressor gene in equine sarcoids. BMC Vet Res (2012) 0.75
Immunohistochemical characterization of FHIT expression in normal human tissues. Interv Med Appl Sci (2016) 0.75
Adenylylsulfate-ammonia adenylyltransferase activity is another inherent property of Fhit proteins. Biosci Rep (2015) 0.75
Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ. BMC Cancer (2015) 0.75
Crystallization and preliminary X-ray analysis of the diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.75
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