Published in Biochem J on December 01, 1999
Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Am J Pathol (2004) 2.15
Therapeutics for Alzheimer's disease based on the metal hypothesis. Neurotherapeutics (2008) 1.58
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am J Pathol (2004) 1.56
In vivo reduction of amyloid-beta by a mutant copper transporter. Proc Natl Acad Sci U S A (2003) 1.52
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice. Proc Natl Acad Sci U S A (2003) 1.46
Oxidative stress and the pathogenesis of Alzheimer's disease. Oxid Med Cell Longev (2013) 1.44
Copper in the brain and Alzheimer's disease. J Biol Inorg Chem (2009) 1.40
Metals and amyloid-beta in Alzheimer's disease. Int J Exp Pathol (2005) 1.19
Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice. Am J Pathol (2005) 1.15
Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein. J Biol Chem (2010) 1.14
Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance. Proc Natl Acad Sci U S A (2013) 1.11
Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease. Brain Struct Funct (2010) 1.04
Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. J Neurochem (2009) 1.03
Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer's disease. J Neural Transm (Vienna) (2006) 1.02
Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease. J Biol Chem (2009) 0.93
The role of metals in modulating metalloprotease activity in the AD brain. Eur Biophys J (2008) 0.92
Pharmacotherapeutic targets in Alzheimer's disease. J Cell Mol Med (2008) 0.91
Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial. J Neural Transm (Vienna) (2008) 0.89
Copper binding to the Alzheimer's disease amyloid precursor protein. Eur Biophys J (2007) 0.88
Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial. J Neural Transm (Vienna) (2008) 0.85
Copper promotes the trafficking of the amyloid precursor protein. J Biol Chem (2010) 0.85
Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands. Biochem J (2007) 0.83
The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxid Med Cell Longev (2012) 0.81
Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.81
Links between copper and cholesterol in Alzheimer's disease. Front Physiol (2013) 0.81
Importance and management of micronutrient deficiencies in patients with Alzheimer's disease. Clin Interv Aging (2013) 0.81
Spatial memory deficits in a mouse model of late-onset Alzheimer's disease are caused by zinc supplementation and correlate with amyloid-beta levels. Front Aging Neurosci (2014) 0.80
Neuronal and vascular oxidative stress in Alzheimer's disease. Curr Neuropharmacol (2011) 0.79
The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism. J Biol Chem (2012) 0.78
Disturbed copper bioavailability in Alzheimer's disease. Int J Alzheimers Dis (2011) 0.78
REGION-SPECIFIC NEURON AND SYNAPSE LOSS IN THE HIPPOCAMPUS OF APP(SL)/PS1 KNOCK-IN MICE. Transl Neurosci (2013) 0.77
Effects of a copper-deficient diet on the biochemistry, neural morphology and behavior of aged mice. PLoS One (2012) 0.76
Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease. Acta Crystallogr Sect F Struct Biol Cryst Commun (2004) 0.76
Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments. Front Mol Neurosci (2017) 0.75
Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production. J Biol Chem (2017) 0.75
Full-length Cellular Beta-secretase Has a Trimeric Subunit Stoichiometry, and Its Sulfur-rich Transmembrane Interaction Site Modulates Cytosolic Copper Compartmentalization. J Biol Chem (2017) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature (1992) 7.16
Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA. Biotechniques (1990) 6.90
Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science (1992) 5.22
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell (1989) 4.99
Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science (1990) 4.91
Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci (1997) 4.57
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci U S A (1998) 4.49
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med (1997) 4.10
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci U S A (1999) 3.85
Alzheimer's disease: genotypes, phenotypes, and treatments. Science (1997) 3.72
An enzyme-release assay for natural cytotoxicity. J Immunol Methods (1983) 3.36
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science (1990) 3.10
Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking. EMBO J (1996) 3.04
Membrane protein secretases. Biochem J (1997) 2.70
Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science (1992) 2.50
Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proc Natl Acad Sci U S A (1992) 2.31
The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I) Science (1996) 2.29
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med (1998) 2.20
Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide. Nature (1993) 1.85
Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease. J Neurochem (1995) 1.83
Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. Proc Natl Acad Sci U S A (1993) 1.73
Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I. J Biol Chem (1996) 1.48
Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons. J Neurosci (1996) 1.37
The beta A4 amyloid precursor protein binding to copper. FEBS Lett (1994) 1.34
A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease. J Biol Chem (1993) 1.33
Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux. Hum Mol Genet (1995) 1.29
Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein. J Biol Chem (1994) 1.25
Alzheimer's disease. BMJ (1998) 1.12
ATP-dependent copper transport by the Menkes protein in membrane vesicles isolated from cultured Chinese hamster ovary cells. FEBS Lett (1998) 1.11
Late compartments of amyloid precursor protein transport in SY5Y cells are involved in beta-amyloid secretion. J Neurosci (1997) 1.09
Reactive oxygen species and Alzheimer's disease. Biochem Pharmacol (1997) 1.09
Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion. J Biol Chem (1996) 1.08
Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide. Biochemistry (1998) 1.03
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proc Natl Acad Sci U S A (1995) 1.01
Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway. J Neurosci (1997) 0.98
The alternatively spliced Kunitz protease inhibitor domain alters amyloid beta protein precursor processing and amyloid beta protein production in cultured cells. J Biol Chem (1996) 0.96
Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease. J Neurochem (1997) 0.96
Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein. J Biol Chem (1996) 0.95
Iron levels modulate alpha-secretase cleavage of amyloid precursor protein. J Neurochem (1995) 0.94
Enhanced release of secreted form of Alzheimer's amyloid precursor protein from PC12 cells by nicotine. Mol Pharmacol (1997) 0.88
Thrombin receptor activation induces secretion and nonamyloidogenic processing of amyloid beta-protein precursor. J Biol Chem (1994) 0.87
Cholinesterase inhibitors increase secretion of APPs in rat brain cortex. Neuroreport (1995) 0.85
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A (1985) 16.10
Imaging beta-amyloid burden in aging and dementia. Neurology (2007) 7.70
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol (1999) 7.69
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J (1985) 6.24
Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease. Nature (1987) 5.88
Creutzfeldt-Jakob disease: patterns of worldwide occurrence and the significance of familial and sporadic clustering. Ann Neurol (1979) 5.53
Rapid induction of Alzheimer A beta amyloid formation by zinc. Science (1994) 5.34
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell (1989) 4.99
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci U S A (1998) 4.49
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron (2001) 4.42
The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Nature (1987) 4.15
Purification and properties of colony-stimulating factor from mouse lung-conditioned medium. J Biol Chem (1977) 3.74
How lac repressor binds to DNA. Nature (1972) 3.72
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci U S A (2001) 3.50
The amino-acid sequence of lac repressor. Proc Natl Acad Sci U S A (1973) 3.36
Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease. J Mol Biol (1991) 3.33
A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques. Neurology (1988) 3.28
Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. N Engl J Med (1989) 3.24
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci U S A (1990) 3.13
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science (1990) 3.10
Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J Biol Chem (1996) 3.10
Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking. EMBO J (1996) 3.04
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat Med (1997) 2.95
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep (2001) 2.70
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry (1999) 2.58
Abeta deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease. Neuropsychologia (2008) 2.58
[Virus proteins. IV. Constitution of the coat protein of the fd phage]. Hoppe Seylers Z Physiol Chem (1969) 2.56
A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32. EMBO J (1996) 2.55
Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease. Brain (2006) 2.54
Subacute spongiform encephalopathy (Creutzfeldt-Jakob disease). The nature and progression of spongiform change. Brain (1978) 2.49
Large amounts of neocortical beta A4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person. Neurosci Lett (1990) 2.40
Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes. EMBO J (1982) 2.31
Packaging of prions into exosomes is associated with a novel pathway of PrP processing. J Pathol (2007) 2.31
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem (1999) 2.30
The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I) Science (1996) 2.29
Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact. EMBO J (1988) 2.26
Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, NFI-B and NFI-C with homologues in mammalian genomes. Nucleic Acids Res (1990) 2.24
Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques. Acta Neuropathol (1983) 2.23
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J (1988) 2.23
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J Neurosci (1994) 2.19
In vitro and in vivo products of E. coli lactose permease gene are identical. Nature (1980) 2.18
Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes. J Exp Med (1994) 2.13
Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography. J Neurol Neurosurg Psychiatry (2008) 2.12
Amyloid, aluminium and the aetiology of Alzheimer's disease. Med J Aust (1995) 2.09
The cDNA clone for strictosidine synthase from Rauvolfia serpentina. DNA sequence determination and expression in Escherichia coli. FEBS Lett (1988) 2.05
Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia. Neurology (2010) 1.99
Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to nonhuman primates. J Infect Dis (1980) 1.96
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. J Biol Chem (2001) 1.96
Mammalian single-stranded DNA binding protein UP I is derived from the hnRNP core protein A1. EMBO J (1986) 1.94
Inhibition of 3-deoxy-d-arabinoheptulosonic acid-7-phosphate synthetase (trp) in Escherichia coli. J Bacteriol (1969) 1.93
The promoter of Alzheimer's disease amyloid A4 precursor gene. EMBO J (1988) 1.92
Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides. J Mol Biol (1992) 1.90
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease. Neuroscience (2007) 1.86
Two alleles of a neural protein gene linked to scrapie in sheep. Proc Natl Acad Sci U S A (1990) 1.84
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci Lett (2001) 1.82
The familial occurrence of Creutzfeldt-Jakob disease and Alzheimer's disease. Brain (1981) 1.80
Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease. Eur J Biochem (1995) 1.80
Molecular genetics and transport analysis of the copper-resistance determinant (pco) from Escherichia coli plasmid pRJ1004. Mol Microbiol (1995) 1.78
The protein component of scrapie-associated fibrils is a glycosylated low molecular weight protein. EMBO J (1985) 1.76
The LPS receptor (CD14) links innate immunity with Alzheimer's disease. FASEB J (2003) 1.75