Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data.

PubWeight™: 3.69‹?› | Rank: Top 1%

🔗 View Article (PMC 1378020)

Published in Am J Hum Genet on April 12, 2000

Authors

P C Sham1, S S Cherny, S Purcell, J K Hewitt

Author Affiliations

1: Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London SE5 8AF, United Kingdom. spjupcs@iop.kcl.ac.uk.

Articles citing this

Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings. PLoS Genet (2006) 7.13

Parental phenotypes in family-based association analysis. Am J Hum Genet (2004) 6.35

Powerful regression-based quantitative-trait linkage analysis of general pedigrees. Am J Hum Genet (2002) 5.20

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes (2008) 4.20

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet (2015) 3.82

Leveraging the HapMap correlation structure in association studies. Am J Hum Genet (2007) 3.57

Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am J Hum Genet (2006) 3.25

A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. Biol Psychiatry (2011) 2.87

Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height. Am J Hum Genet (2001) 2.50

Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. Am J Hum Genet (2001) 2.26

Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. Am J Med Genet B Neuropsychiatr Genet (2006) 2.09

Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays. Genes Brain Behav (2008) 2.08

Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples. Proc Natl Acad Sci U S A (2005) 2.00

Statistical power to detect genetic (co)variance of complex traits using SNP data in unrelated samples. PLoS Genet (2014) 1.92

A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples. Behav Genet (2009) 1.75

Possible association of amelogenin to high caries experience in a Guatemalan-Mayan population. Caries Res (2007) 1.67

Genetic epidemiological approaches in the study of risk factors for cardiovascular disease. Eur J Epidemiol (2004) 1.40

The IMAGE project: methodological issues for the molecular genetic analysis of ADHD. Behav Brain Funct (2006) 1.37

The power of multivariate quantitative-trait loci linkage analysis is influenced by the correlation between variables. Am J Hum Genet (2002) 1.35

Localising loci underlying complex trait variation using Regional Genomic Relationship Mapping. PLoS One (2012) 1.34

Evidence for linkage and association with reading disability on 6p21.3-22. Am J Hum Genet (2002) 1.31

Testing for genetic linkage in families by a variance-components approach in the presence of genomic imprinting. Am J Hum Genet (2002) 1.30

A kernel of truth: statistical advances in polygenic variance component models for complex human pedigrees. Adv Genet (2013) 1.25

A genome-wide linkage scan for age at menarche in three populations of European descent. J Clin Endocrinol Metab (2008) 1.19

Is replication the gold standard for validating genome-wide association findings? PLoS One (2008) 1.18

Disease model distortion in association studies. Genet Epidemiol (2011) 1.14

Mapping quantitative trait loci in humans: achievements and limitations. J Clin Invest (2005) 1.08

High-resolution association mapping of quantitative trait loci: a population-based approach. Genetics (2005) 1.05

GWAPower: a statistical power calculation software for genome-wide association studies with quantitative traits. BMC Genet (2011) 1.04

Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins. Diabetologia (2006) 1.03

Novel genetic analysis for case-control genome-wide association studies: quantification of power and genomic prediction accuracy. PLoS One (2013) 1.02

A survey of haplotype variants at several disease candidate genes: the importance of rare variants for complex diseases. J Med Genet (2005) 1.02

Recovering power in association mapping panels with variable levels of linkage disequilibrium. Genetics (2014) 1.02

The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies. Hum Genet (2006) 0.96

Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals. PLoS Genet (2011) 0.94

Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands. Arch Gen Psychiatry (2008) 0.94

Simultaneous estimation of haplotype frequencies and quantitative trait parameters: applications to the test of association between phenotype and diplotype configuration. Genetics (2004) 0.92

Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD. BMC Med Genet (2008) 0.89

Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs. J Med Genet (2005) 0.88

Dopamine genes and schizophrenia: case closed or evidence pending? Schizophr Bull (2007) 0.88

SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women. Atherosclerosis (2007) 0.88

Power calculations using exact data simulation: a useful tool for genetic study designs. Behav Genet (2007) 0.87

Genetic association tests: a method for the joint analysis of family and case-control data. Hum Genomics (2009) 0.87

Combined linkage and association mapping of quantitative trait loci by multiple markers. Genetics (2005) 0.86

Twin studies and their implications for molecular genetic studies: endophenotypes integrate quantitative and molecular genetics in ADHD research. J Am Acad Child Adolesc Psychiatry (2010) 0.86

Association mapping in outbred populations: power and efficiency when genotyping parents and phenotyping progeny. Genetics (2008) 0.84

Incorporating parental information into family-based association tests. Biostatistics (2012) 0.82

Quantitative similarity-based association tests using population samples. Am J Hum Genet (2001) 0.81

Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophr Res (2011) 0.80

Co-segregation of social cognition, executive function and local processing style in children with ASD, their siblings and normal controls. J Autism Dev Disord (2013) 0.80

Replicated analysis of the genetic architecture of quantitative traits in two wild great tit populations. Mol Ecol (2015) 0.80

Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions. Eur J Hum Genet (2012) 0.79

Theoretical and empirical power of regression and maximum-likelihood methods to map quantitative trait loci in general pedigrees. Am J Hum Genet (2004) 0.79

An unbiased index to quantify participant's phenotypic contribution to an open-access cohort. Sci Rep (2017) 0.75

Variance components linkage analysis with repeated measurements. Hum Hered (2008) 0.75

Quantitative trait locus analysis of hybrid pedigrees: variance-components model, inbreeding parameter, and power. BMC Genet (2007) 0.75

Whole genome sequence association and ancestry-informed polygenic profile of EEG alpha in a Native American population. Am J Med Genet B Neuropsychiatr Genet (2017) 0.75

Articles cited by this

Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet (1980) 75.25

The future of genetic studies of complex human diseases. Science (1996) 64.76

Sequential tests for the detection of linkage. Am J Hum Genet (1955) 43.74

Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet (1998) 40.97

Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet (1999) 25.93

The investigation of linkage between a quantitative trait and a marker locus. Behav Genet (1972) 24.92

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet (1999) 17.09

Linkage disequilibrium and homozygosity of chromosome segments in finite populations. Theor Popul Biol (1971) 13.68

Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet (1995) 12.78

Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet (1999) 11.22

Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet (1994) 10.58

Linkage disequilibrium at steady state determined by random genetic drift and recurrent mutation. Genetics (1969) 7.33

Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science (1995) 7.00

Genetic traces of ancient demography. Proc Natl Acad Sci U S A (1998) 5.48

Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure. Am J Hum Genet (1999) 4.54

Multipoint interval mapping of quantitative trait loci, using sib pairs. Am J Hum Genet (1995) 4.29

Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations. Am J Hum Genet (1993) 4.13

An improved multipoint sib-pair analysis of quantitative traits. Behav Genet (1996) 3.91

A twin-pronged attack on complex traits. Nat Genet (1997) 3.63

Genome screens using linkage disequilibrium tests: optimal marker characteristics and feasibility. Am J Hum Genet (1998) 2.86

Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region. Am J Hum Genet (1994) 2.65

Multiple phenotype modeling in gene-mapping studies of quantitative traits: power advantages. Am J Hum Genet (1998) 2.50

Locating human quantitative trait loci: guidelines for the selection of sibling pairs for genotyping. Behav Genet (1994) 2.41

Multivariate multipoint linkage analysis of quantitative trait loci. Behav Genet (1996) 2.24

Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations. Am J Hum Genet (1996) 1.90

Alternative bioassays of kinship between loci. Am J Hum Genet (1988) 1.66

The effect of marker heterozygosity on the power to detect linkage disequilibrium. Genetics (1997) 1.33

Optimal selection of sib pairs from random samples for linkage analysis of a QTL using the EDAC test. Behav Genet (1998) 1.19

Exploiting pleiotropy to map genes for oligogenic phenotypes using extended pedigree data. Genet Epidemiol (1997) 1.01

Testing causal hypotheses in multivariate linkage analysis of quantitative traits: general formulation and application to sibpair data. Genet Epidemiol (1998) 0.97

A multivariate model for the analysis of sibship covariance structure using marker information and multiple quantitative traits. Genet Epidemiol (1997) 0.88

Articles by these authors

Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics (2003) 17.92

Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet (1999) 11.22

GRR: graphical representation of relationship errors. Bioinformatics (2001) 6.09

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Mol Psychiatry (2011) 4.91

Multipoint interval mapping of quantitative trait loci, using sib pairs. Am J Hum Genet (1995) 4.29

An improved multipoint sib-pair analysis of quantitative traits. Behav Genet (1996) 3.91

Genetic and environmental influences on behavioral disinhibition. Am J Med Genet (2000) 3.61

High-resolution mapping of quantitative trait loci in outbred mice. Nat Genet (1999) 2.69

Genetics and developmental psychopathology: 2. The main effects of genes and environment on behavioral problems in the Virginia Twin Study of Adolescent Behavioral Development. J Child Psychol Psychiatry (1997) 2.65

The heritability of general cognitive ability increases linearly from childhood to young adulthood. Mol Psychiatry (2009) 2.52

Association analysis in a variance components framework. Genet Epidemiol (2001) 2.38

Quantitative-trait locus for specific language and reading deficits on chromosome 6p. Am J Hum Genet (1999) 2.26

Amisulpride augmentation of clozapine: an open non-randomized study in patients with schizophrenia partially responsive to clozapine. Acta Psychiatr Scand (2004) 2.24

Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Mol Psychiatry (2010) 2.21

Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Mol Psychiatry (2012) 2.20

Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs. Am J Hum Genet (2001) 2.16

The impact of genotyping error on family-based analysis of quantitative traits. Eur J Hum Genet (2001) 2.12

Analyzing twin resemblance in multisymptom data: genetic applications of a latent class model for symptoms of conduct disorder in juvenile boys. Behav Genet (1993) 2.07

Genetic influence on language delay in two-year-old children. Nat Neurosci (1998) 2.06

Substance use, abuse and dependence in adolescence: prevalence, symptom profiles and correlates. Drug Alcohol Depend (2002) 2.02

The Virginia Twin Study of Adolescent Behavioral Development. Influences of age, sex, and impairment on rates of disorder. Arch Gen Psychiatry (1997) 1.97

Tobacco, alcohol and drug use in eight- to sixteen-year-old twins: the Virginia Twin Study of Adolescent Behavioral Development. J Stud Alcohol (1999) 1.97

Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children. Mol Psychiatry (2005) 1.91

A genome-wide scan of 1842 DNA markers for allelic associations with general cognitive ability: a five-stage design using DNA pooling and extreme selected groups. Behav Genet (2001) 1.86

Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain. Mol Psychiatry (2011) 1.84

Developmental epidemiology of drug use and abuse in adolescence and young adulthood: Evidence of generalized risk. Drug Alcohol Depend (2009) 1.84

Assortative mating for major psychiatric diagnoses in two population-based samples. Psychol Med (1998) 1.80

Isolation and characterization of eight lipid A precursors from a 3-deoxy-D-manno-octylosonic acid-deficient mutant of Salmonella typhimurium. J Biol Chem (1985) 1.67

A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS. Neurology (2009) 1.67

Testing hypotheses about direction of causation using cross-sectional family data. Behav Genet (1993) 1.66

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry (2010) 1.63

Genome-wide association study of obsessive-compulsive disorder. Mol Psychiatry (2012) 1.57

Molecular requirements for B-lymphocyte activation by Escherichia coli lipopolysaccharide. Proc Natl Acad Sci U S A (1983) 1.51

A model system for analysis of family resemblance in extended kinships of twins. Behav Genet (1994) 1.50

Variance-Components QTL linkage analysis of selected and non-normal samples: conditioning on trait values. Genet Epidemiol (2000) 1.48

Increase in power through multivariate analyses. Behav Genet (1998) 1.46

Testing structural equation models for twin data using LISREL. Behav Genet (1989) 1.46

Support for involvement of neuregulin 1 in schizophrenia pathophysiology. Mol Psychiatry (2005) 1.44

Replication of twelve association studies for Huntington's disease residual age of onset in large Venezuelan kindreds. J Med Genet (2006) 1.42

Genome-wide association study of Tourette's syndrome. Mol Psychiatry (2012) 1.42

Analytic power calculation for QTL linkage analysis of small pedigrees. Eur J Hum Genet (2001) 1.39

Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia. Mol Psychiatry (2005) 1.34

Parent ratings of temperament in twins: explaining the 'too low' DZ correlations. Twin Res (2000) 1.26

Replication study of SNP associations for colorectal cancer in Hong Kong Chinese. Br J Cancer (2010) 1.24

Optimal sibship selection for genotyping in quantitative trait locus linkage analysis. Hum Hered (2001) 1.22

Personality and reproductive fitness. Behav Genet (1990) 1.22

Genetic and environmental structure of the Tridimensional Personality Questionnaire: three or four temperament dimensions? J Pers Soc Psychol (1996) 1.21

Evidence for independent genetic influences on obesity in middle age. Int J Obes Relat Metab Disord (1992) 1.19

Fitting genetic models with LISREL: hypothesis testing. Behav Genet (1989) 1.17

Familial association between allergic disorders and depression in adult Finnish twins. Am J Med Genet (2000) 1.17

Polygenic dissection of the bipolar phenotype. Br J Psychiatry (2011) 1.17

Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample. Mol Psychiatry (2012) 1.16

Sex differences and non-additivity in the effects of genes on personality. Twin Res (1998) 1.15

Parent-offspring resemblance for reading performance at 7, 12 and 16 years of age in the Colorado Adoption Project. J Child Psychol Psychiatry (2002) 1.13

A twin study of drinking and smoking onset and latencies from first use to regular use. Behav Genet (1999) 1.12

GENESiS: creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings. Twin Res (2000) 1.10

Prenatal life and post-natal psychopathology: evidence for negative gene-birth weight interaction. Psychol Med (2002) 1.09

Genetic contribution to risk of smoking initiation: comparisons across birth cohorts and across cultures. J Subst Abuse (1993) 1.09

A family history and direct interview study of the familial aggregation of substance abuse: the adolescent substance abuse study. Drug Alcohol Depend (1998) 1.09

Somatic mosaicism in neurofibromatosis 2: prevalence and risk of disease transmission to offspring. J Med Genet (2003) 1.07

Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4. Diabetologia (2013) 1.07

Bivariate genetic analysis of left ventricular mass and weight in pubertal twins (the Medical College of Virginia twin study). Am J Cardiol (1991) 1.07

Linkage between sexual orientation and chromosome Xq28 in males but not in females. Nat Genet (1995) 1.06

Analyzing the relationship between age at onset and risk to relatives. Am J Hum Genet (1989) 1.05

Common genetic and environmental vulnerability for alcohol and tobacco use in a volunteer sample of older female twins. J Stud Alcohol (2001) 1.05

Stability of genetic and environmental influences on reading performance at 7, 12, and 16 years of age in the Colorado Adoption Project. Behav Genet (2001) 1.05

A genome-wide association study of attempted suicide. Mol Psychiatry (2011) 1.04

The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample. Mol Psychiatry (2003) 1.03

Association at SYNE1 in both bipolar disorder and recurrent major depression. Mol Psychiatry (2012) 1.03

Environmental and genetic influences on alcohol use in a volunteer sample of older twins. J Stud Alcohol (1994) 1.02

Are vaginal and rectal pressures equivalent approximations of one another for the purpose of performing subtracted cystometry? Obstet Gynecol (1995) 1.02

Molecular genetic analysis of the NF2 gene in young patients with unilateral vestibular schwannomas. J Med Genet (2002) 1.00

Familial aggregation for conduct disorder symptomatology: the role of genes, marital discord and family adaptability. Psychol Med (2000) 1.00

Further evidence of association between two NET single-nucleotide polymorphisms with ADHD. Mol Psychiatry (2007) 0.99

Association of CD247 with systemic lupus erythematosus in Asian populations. Lupus (2011) 0.98

Urodynamic characteristics of women with complete posthysterectomy vaginal vault prolapse. Urology (1994) 0.97

Exploring the genetic and environmental etiology of high general cognitive ability in fourteen- to thirty-six-month-old twins. Child Dev (1998) 0.96

Application of genome-wide SNP data for uncovering pairwise relationships and quantitative trait loci. Genetica (2009) 0.96

Genetic and environmental influences on age at sexual initiation in the Colorado Adoption Project. Behav Genet (2006) 0.95

DeFries-Fulker multiple regression analysis of sibship QTL data: a SAS macro. Bioinformatics (2001) 0.95

Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins. Int J Obes (Lond) (2008) 0.95

Investigation of variation in SNAP-25 and ADHD and relationship to co-morbid major depressive disorder. Am J Med Genet B Neuropsychiatr Genet (2007) 0.94

OpenADAM: an open source genome-wide association data management system for Affymetrix SNP arrays. BMC Genomics (2008) 0.94

Genetic and environmental influences on lifetime alcohol-related problems in a volunteer sample of older twins. J Stud Alcohol (1994) 0.93

Genetic and environmental contributions to retrospectively reported DSM-IV childhood attention deficit hyperactivity disorder. Psychol Med (2007) 0.93

The genetics of children's oral reading performance. J Child Psychol Psychiatry (1996) 0.93

Detecting large copy number variants using exome genotyping arrays in a large Swedish schizophrenia sample. Mol Psychiatry (2013) 0.93

The Virginia Twin-Family Study of Adolescent Behavioral Development: assessing sample biases in demographic correlates of psychopathology. Psychol Med (1996) 0.92

Lipoprotein and oxygen transport alterations in passive smoking preadolescent children. The MCV Twin Study. Circulation (1990) 0.90

Genetic analysis of anthropometric measures in 11-year-old twins: the Medical College of Virginia Twin Study. Pediatr Res (1990) 0.90

The structure of schizotypy: a pilot multitrait twin study. Psychiatry Res (1991) 0.89

Univariate genetic analysis of blood pressure in children (the Medical College of Virginia Twin Study). Am J Cardiol (1989) 0.89

Genetic and developmental influences on infant mouse ultrasonic calling. I. A diallel analysis of the calls of 3-day olds. Behav Genet (1997) 0.89

Inhibition of mammalian xanthine oxidase by folate compounds and amethopterin. J Biol Chem (1984) 0.88

Life events and depression in a community sample of siblings. Psychol Med (2001) 0.87