Powerful regression-based quantitative-trait linkage analysis of general pedigrees.

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet (2007) 8.63

Handling marker-marker linkage disequilibrium: pedigree analysis with clustered markers. Am J Hum Genet (2005) 6.12

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A (2008) 5.27

Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies. Am J Hum Genet (2010) 2.57

Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information. Am J Hum Genet (2004) 2.19

Regression-based quantitative-trait-locus mapping in the 21st century. Am J Hum Genet (2002) 1.87

Forward-time simulations of human populations with complex diseases. PLoS Genet (2007) 1.87

Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples. Am J Hum Genet (2007) 1.73

A generalized family-based association test for dichotomous traits. Am J Hum Genet (2009) 1.70

Possible genomic imprinting of three human obesity-related genetic loci. Am J Hum Genet (2005) 1.54

CREB1 is a strong genetic predictor of the variation in exercise heart rate response to regular exercise: the HERITAGE Family Study. Circ Cardiovasc Genet (2010) 1.52

Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism. Am J Hum Genet (2003) 1.42

Genetic epidemiological approaches in the study of risk factors for cardiovascular disease. Eur J Epidemiol (2004) 1.40

Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia. Am J Psychiatry (2013) 1.30

A powerful and robust method for mapping quantitative trait loci in general pedigrees. Am J Hum Genet (2005) 1.29

Genomewide scan in Ashkenazi Jewish families demonstrates evidence of linkage of ocular refraction to a QTL on chromosome 1p36. Hum Genet (2006) 1.28

Estimating heritability of complex traits from genome-wide association studies using IBS-based Haseman-Elston regression. Front Genet (2014) 1.28

A kernel of truth: statistical advances in polygenic variance component models for complex human pedigrees. Adv Genet (2013) 1.25

Bias toward the null hypothesis in model-free linkage analysis is highly dependent on the test statistic used. Am J Hum Genet (2004) 1.24

Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. Drug Alcohol Depend (2007) 1.23

Genetic determination and linkage mapping of Plasmodium falciparum malaria related traits in Senegal. PLoS One (2008) 1.20

Quantitative trait linkage analysis using Gaussian copulas. Genetics (2006) 1.18

Genome scan for body mass index and height in the Framingham Heart Study. BMC Genet (2003) 1.18

Recent advances in human quantitative-trait-locus mapping: comparison of methods for discordant sibling pairs. Am J Hum Genet (2003) 1.14

Genome-wide linkage analysis of malaria infection intensity and mild disease. PLoS Genet (2007) 1.13

Normalizing a large number of quantitative traits using empirical normal quantile transformation. BMC Proc (2007) 1.12

Epistatic association mapping in homozygous crop cultivars. PLoS One (2011) 1.12

Forward-time simulation of realistic samples for genome-wide association studies. BMC Bioinformatics (2010) 1.11

Genomewide scan of ocular refraction in African-American families shows significant linkage to chromosome 7p15. Genet Epidemiol (2008) 1.10

Recent advances in human quantitative-trait-locus mapping: comparison of methods for selected sibling pairs. Am J Hum Genet (2003) 1.09

Mapping quantitative trait loci in humans: achievements and limitations. J Clin Invest (2005) 1.08

Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait. Am J Hum Genet (2008) 1.07

Genetic and environmental influences on human dental variation: a critical evaluation of studies involving twins. Arch Oral Biol (2008) 1.06

Genomewide significant linkage to migrainous headache on chromosome 5q21. Am J Hum Genet (2005) 1.04

Identifying loci for the overlap between attention-deficit/hyperactivity disorder and autism spectrum disorder using a genome-wide QTL linkage approach. J Am Acad Child Adolesc Psychiatry (2010) 1.04

Transcription activity hot spot, is it real or an artifact? BMC Proc (2007) 1.04

Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype. Mol Psychiatry (2007) 1.02

Mapping quantitative traits in unselected families: algorithms and examples. Genet Epidemiol (2009) 1.00

Genomewide linkage scans for ocular refraction and meta-analysis of four populations in the Myopia Family Study. Invest Ophthalmol Vis Sci (2009) 1.00

Genome-wide association analyses of North American Rheumatoid Arthritis Consortium and Framingham Heart Study data utilizing genome-wide linkage results. BMC Proc (2009) 0.98

A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models. Addict Biol (2010) 0.98

Linkage analysis of anorexia and bulimia nervosa cohorts using selected behavioral phenotypes as quantitative traits or covariates. Am J Med Genet B Neuropsychiatr Genet (2005) 0.98

Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings. Biol Psychiatry (2008) 0.98

Genome scans and gene expression microarrays converge to identify gene regulatory loci relevant in schizophrenia. Hum Genet (2006) 0.95

A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. Drug Alcohol Depend (2006) 0.94

A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits. PLoS One (2012) 0.94

Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands. Arch Gen Psychiatry (2008) 0.94

Mapping quantitative traits with random and with ascertained sibships. Proc Natl Acad Sci U S A (2004) 0.93

Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms. PLoS One (2011) 0.91

Robust score statistics for QTL linkage analysis. Am J Hum Genet (2008) 0.90

Sex, age and generation effects on genome-wide linkage analysis of gene expression in transformed lymphoblasts. BMC Proc (2007) 0.90

Genetic analysis of the maximum drinks phenotype. BMC Genet (2005) 0.90

Imprinting detection by extending a regression-based QTL analysis method. Hum Genet (2007) 0.89

KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. Physiol Genomics (2008) 0.89

Genome wide linkage study, using a 250K SNP map, of Plasmodium falciparum infection and mild malaria attack in a Senegalese population. PLoS One (2010) 0.88

Genome-wide linkage scan on estimated breeding values for a quantitative trait. BMC Genet (2003) 0.87

Power calculations using exact data simulation: a useful tool for genetic study designs. Behav Genet (2007) 0.87

Fine mapping of a QTL on chromosome 13 for submaximal exercise capacity training response: the HERITAGE Family Study. Eur J Appl Physiol (2011) 0.86

Joint study of genetic regulators for expression traits related to breast cancer. BMC Proc (2007) 0.86

The role of heritability in mapping expression quantitative trait loci. BMC Proc (2007) 0.86

Handling linkage disequilibrium in linkage analysis using dense single-nucleotide polymorphisms. BMC Proc (2007) 0.86

Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes? Alcohol Clin Exp Res (2009) 0.85

A survey of current software for genetic power calculations. Hum Genomics (2004) 0.84

Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances. Am J Med Genet B Neuropsychiatr Genet (2012) 0.83

The multiplicity problem in linkage analysis of gene expression data - the power of differentiating cis- and trans-acting regulators. BMC Proc (2007) 0.83

Evaluation of a bayesian model integration-based method for censored data. Hum Hered (2012) 0.83

Genetic variations in genes involved in heparan sulphate biosynthesis are associated with Plasmodium falciparum parasitaemia: a familial study in Burkina Faso. Malar J (2012) 0.83

Effects of ambient and preceding temperatures and metabolic genes on flight metabolism in the Glanville fritillary butterfly. J Insect Physiol (2015) 0.83

Genome-wide linkage scan for maximum and length-dependent knee muscle strength in young men: significant evidence for linkage at chromosome 14q24.3. J Med Genet (2008) 0.82

A survey of current software for linkage analysis. Hum Genomics (2003) 0.82

Heritability and linkage analysis of personality in bipolar disorder. J Affect Disord (2013) 0.82

Genome-wide linkage scan for contraction velocity characteristics of knee musculature in the Leuven Genes for Muscular Strength Study. Physiol Genomics (2008) 0.81

Confirmation of linkage to chromosome 1q for spine bone mineral density in southern Chinese. Hum Genet (2006) 0.81

Identification of QTL genes for BMD variation using both linkage and gene-based association approaches. Hum Genet (2011) 0.80

A whole-genome scan for 24-hour respiration rate: a major locus at 10q26 influences respiration during sleep. Am J Hum Genet (2004) 0.80

Linkage analysis of alcohol dependence symptoms in the community. Alcohol Clin Exp Res (2009) 0.79

Fine-mapping of candidate region in Amish and Ashkenazi families confirms linkage of refractive error to a QTL on 1p34-p36. Mol Vis (2009) 0.79

Theoretical and empirical power of regression and maximum-likelihood methods to map quantitative trait loci in general pedigrees. Am J Hum Genet (2004) 0.79

Genome-wide significant linkage to IgG subclass responses against Plasmodium falciparum antigens on chromosomes 8p22-p21, 9q34 and 20q13. Genes Immun (2014) 0.78

Heritability and genome-wide SNP linkage analysis of temperament in bipolar disorder. J Affect Disord (2013) 0.78

Bone mineral density is linked to 1p36 and 7p15-13 in a southern Chinese population. J Bone Miner Metab (2010) 0.78

Genetic assessment of additional endophenotypes from the Consortium on the Genetics of Schizophrenia Family Study. Schizophr Res (2015) 0.78

Two-stage study designs for analyzing disease-associated covariates: linkage thresholds and case-selection strategies. BMC Proc (2007) 0.78

Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35. Prostate (2010) 0.78

No bias in linkage analysis. Am J Hum Genet (2004) 0.77

Candidate region linkage analysis in twins discordant or concordant for depression symptomatology. Am J Med Genet B Neuropsychiatr Genet (2009) 0.77

Genome-wide linkage of cotinine pharmacokinetics suggests candidate regions on chromosomes 9 and 11. Am J Med Genet B Neuropsychiatr Genet (2009) 0.77

Quantitative linkage for autism spectrum disorders symptoms in attention-deficit/hyperactivity disorder: significant locus on chromosome 7q11. J Autism Dev Disord (2014) 0.77

A method dealing with a large number of correlated traits in a linkage genome scan. BMC Proc (2007) 0.77

A large-scale genome-wide linkage analysis to map loci linked to stature in Chinese population. J Clin Endocrinol Metab (2008) 0.76

Two-dimensional linkage analyses of rheumatoid arthritis. BMC Proc (2007) 0.76

Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait. BMC Genet (2003) 0.76

Weighting affected sib pairs by marker informativity. Am J Hum Genet (2005) 0.75

Identifying variants that contribute to linkage for dichotomous and quantitative traits in extended pedigrees. BMC Proc (2011) 0.75

Rank transformation in Haseman-Elston regression using scores for location-scale alternatives. Hum Hered (2009) 0.75

An empirical Bayes method for updating inferences in analysis of quantitative trait loci using information from related genome scans. Genetics (2006) 0.75

Linkage mapping of a complex trait in the New York population of the GAW14 simulated dataset: a multivariate phenotype approach. BMC Genet (2005) 0.75

Software for quantitative trait analysis. Hum Genomics (2005) 0.75

Heritability Estimation using Regression Models for Correlation. J Biom Biostat (2011) 0.75

Application of bivariate mixed counting process models to genetic analysis of rheumatoid arthritis severity. BMC Proc (2007) 0.75

Merlin--rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet (2001) 53.16

Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet (1998) 40.97

A general model for the genetic analysis of pedigree data. Hum Hered (1971) 40.17

Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet (1996) 39.80

Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci U S A (1987) 35.83

The investigation of linkage between a quantitative trait and a marker locus. Behav Genet (1972) 24.92

Allegro, a new computer program for multipoint linkage analysis. Nat Genet (2000) 14.00

Markov chain Monte Carlo segregation and linkage analysis for oligogenic models. Am J Hum Genet (1997) 10.86

Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet (1994) 10.58

A comparison of sib-pair linkage tests for disease susceptibility loci. Genet Epidemiol (1985) 9.70

Haseman and Elston revisited. Genet Epidemiol (2000) 7.23

Extensions to multivariate normal models for pedigree analysis. Ann Hum Genet (1982) 7.07

Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations. Am J Hum Genet (1993) 4.13

An improved multipoint sib-pair analysis of quantitative traits. Behav Genet (1996) 3.91

Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data. Am J Hum Genet (2000) 3.69

Multipoint estimation of identity-by-descent probabilities at arbitrary positions among marker loci on general pedigrees. Hum Hered (2001) 3.32

The information contained in multiple sibling pairs. Genet Epidemiol (1984) 3.10

Using risk calculation to implement an extended relative pair analysis. Ann Hum Genet (1994) 2.79

Multivariate multipoint linkage analysis of quantitative trait loci. Behav Genet (1996) 2.24

Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs. Am J Hum Genet (2001) 2.16

A unified Haseman-Elston method for testing linkage with quantitative traits. Am J Hum Genet (2000) 2.08

The phenotypic difference discards sib-pair QTL linkage information. Am J Hum Genet (1997) 2.03

How sib pairs reveal linkage. Am J Hum Genet (1998) 1.96

Multiple-trait mapping of quantitative trait loci after selective genotyping using logistic regression. Genetics (1999) 1.67

A score-statistic approach for the mapping of quantitative-trait loci with sibships of arbitrary size. Am J Hum Genet (2001) 1.67

Power of regression and maximum likelihood methods to map QTL from sib-pair and DZ twin data. Ann Hum Genet (2001) 1.55

Score test for detecting linkage to quantitative traits. Genet Epidemiol (2002) 1.53

Variance-Components QTL linkage analysis of selected and non-normal samples: conditioning on trait values. Genet Epidemiol (2000) 1.48

Weighting improves the "new Haseman-Elston" method. Hum Hered (2001) 1.43

A simulation study of the effects of assignment of prior identity-by-descent probabilities to unselected sib pairs, in covariance-structure modeling of a quantitative-trait locus. Am J Hum Genet (1999) 1.28

Methods for linkage analysis of quantitative trait loci in humans. Theor Popul Biol (2001) 1.23

Optimal sibship selection for genotyping in quantitative trait locus linkage analysis. Hum Hered (2001) 1.22

Composite statistics for QTL mapping with moderately discordant sibling pairs. Am J Hum Genet (2000) 1.18

Testing the robustness of the new Haseman-Elston quantitative-trait loci-mapping procedure. Am J Hum Genet (2000) 1.09

A score test for the linkage analysis of qualitative and quantitative traits based on identity by descent data from sib-pairs. Biostatistics (2000) 1.08

Linkage analysis of quantitative traits in randomly ascertained pedigrees: comparison of penetrance-based and variance component analysis. Genet Epidemiol (2001) 0.89

Selection and subsequent analysis of sib pair data for QTL detection. Genet Res (2001) 0.86

A map of human genome variation from population-scale sequencing. Nature (2010) 121.13

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09

Merlin--rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet (2001) 53.16

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06

Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol (2010) 26.41

Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

A genome-wide association study of global gene expression. Nat Genet (2007) 22.98

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35

METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics (2010) 21.21

Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet (2006) 17.36

Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96

Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25

Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs. Nat Genet (2008) 15.89

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43

LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics (2010) 13.54

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

A global reference for human genetic variation. Nature (2015) 12.85

Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet (2012) 11.29

Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85

Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet (2007) 8.74

Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55

Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet (2006) 8.19

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nat Genet (2006) 7.49

Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44

Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31

In silico method for inferring genotypes in pedigrees. Nat Genet (2006) 7.08

A first-generation linkage disequilibrium map of human chromosome 22. Nature (2002) 7.03

Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Am J Hum Genet (2005) 6.61

The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15

Ascertainment through family history of disease often decreases the power of family-based association studies. Behav Genet (2007) 6.06

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81

Low-coverage sequencing: implications for design of complex trait association studies. Genome Res (2011) 5.34

Synaptic, transcriptional and chromatin genes disrupted in autism. Nature (2014) 5.30

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A (2008) 5.27

PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data. Bioinformatics (2005) 5.14

Genomic inflation factors under polygenic inheritance. Eur J Hum Genet (2011) 4.89

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat Genet (2010) 4.69

Using haplotype blocks to map human complex trait loci. Trends Genet (2003) 4.61

Diabetes prevalence and therapeutic target achievement in the United States, 1999 to 2006. Am J Med (2009) 4.53

CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nat Genet (2006) 4.51

Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42

Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet (2009) 4.38

Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 4.30

Optimal designs for two-stage genome-wide association studies. Genet Epidemiol (2007) 4.22

Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet (2006) 4.22

Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet (2009) 4.10

Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08

Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes (2007) 3.84

Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81

Sequence features in regions of weak and strong linkage disequilibrium. Genome Res (2005) 3.74

Genome-wide association study of PR interval. Nat Genet (2010) 3.73

Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci U S A (2004) 3.73

GENOME: a rapid coalescent-based whole genome simulator. Bioinformatics (2007) 3.65

Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet (2011) 3.56

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A (2007) 3.50

Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet (2009) 3.38

Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals. Am J Hum Genet (2010) 3.28

Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration. Am J Hum Genet (2005) 3.19

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83

The genome-wide patterns of variation expose significant substructure in a founder population. Am J Hum Genet (2008) 2.79

Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases. Genet Epidemiol (2011) 2.78

Genome-wide association analysis identifies three psoriasis susceptibility loci. Nat Genet (2010) 2.76

Efficient study designs for test of genetic association using sibship data and unrelated cases and controls. Am J Hum Genet (2006) 2.72

Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function. PLoS Genet (2010) 2.68

Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet (2010) 2.66

Dissecting the phenotype in genome-wide association studies of psychiatric illness. Br J Psychiatry (2009) 2.65

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. Nat Genet (2012) 2.55

Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration. Annu Rev Genomics Hum Genet (2009) 2.40

Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. Hum Mol Genet (2005) 2.32

Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information. Am J Hum Genet (2004) 2.19

A comparison of approaches to account for uncertainty in analysis of imputed genotypes. Genet Epidemiol (2011) 2.19

Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol (2010) 2.17

Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2009) 2.03

Functional gene group analysis reveals a role of synaptic heterotrimeric G proteins in cognitive ability. Am J Hum Genet (2010) 2.02

Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes. Diabetes (2008) 2.01

Parental monitoring moderates the importance of genetic and environmental influences on adolescent smoking. J Abnorm Psychol (2007) 1.99