Published in J Biol Chem on July 28, 2000
LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium. Nature (2010) 1.89
Differential effects of beta 1 and beta 2 subunits on BK channel activity. J Gen Physiol (2005) 1.88
Gating and ionic currents reveal how the BKCa channel's Ca2+ sensitivity is enhanced by its beta1 subunit. J Gen Physiol (2005) 1.79
BK potassium channel modulation by leucine-rich repeat-containing proteins. Proc Natl Acad Sci U S A (2012) 1.71
BK channel activation: structural and functional insights. Trends Neurosci (2010) 1.65
Locations of the beta1 transmembrane helices in the BK potassium channel. Proc Natl Acad Sci U S A (2008) 1.34
Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel. J Gen Physiol (2006) 1.33
Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues. J Gen Physiol (2003) 1.28
Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol. Proc Natl Acad Sci U S A (2008) 1.24
Identification of large conductance calcium activated potassium channel accessory beta4 subunit in rat and mouse bladder smooth muscle. J Urol (2009) 1.19
Apical sorting of a voltage- and Ca2+-activated K+ channel alpha -subunit in Madin-Darby canine kidney cells is independent of N-glycosylation. Proc Natl Acad Sci U S A (2000) 1.19
Location of modulatory beta subunits in BK potassium channels. J Gen Physiol (2010) 1.17
Modulation of BK channel voltage gating by different auxiliary β subunits. Proc Natl Acad Sci U S A (2012) 1.17
A BK (Slo1) channel journey from molecule to physiology. Channels (Austin) (2013) 1.17
Regulation of synaptic transmission by presynaptic CaMKII and BK channels. Mol Neurobiol (2008) 1.15
Functional effects of auxiliary beta4-subunit on rat large-conductance Ca(2+)-activated K(+) channel. Biophys J (2004) 1.13
Large conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signaling. FEBS Lett (2010) 1.10
Transduction of voltage and Ca2+ signals by Slo1 BK channels. Physiology (Bethesda) (2013) 1.10
{beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia. J Physiol (2009) 1.08
Intracellular BK(Ca) (iBK(Ca)) channels. J Physiol (2012) 1.05
Modes of operation of the BKCa channel beta2 subunit. J Gen Physiol (2007) 1.04
MaxiK channel and cell signalling. Pflugers Arch (2014) 1.02
Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. Proc Natl Acad Sci U S A (2013) 1.00
Slo1 is the principal potassium channel of human spermatozoa. Elife (2013) 1.00
Interactions between beta subunits of the KCNMB family and Slo3: beta4 selectively modulates Slo3 expression and function. PLoS One (2009) 1.00
Structural basis for toxin resistance of beta4-associated calcium-activated potassium (BK) channels. J Biol Chem (2008) 1.00
α-Catulin CTN-1 is required for BK channel subcellular localization in C. elegans body-wall muscle cells. EMBO J (2010) 0.97
Direct observation of a preinactivated, open state in BK channels with beta2 subunits. J Gen Physiol (2006) 0.97
Rapidly inactivating and non-inactivating calcium-activated potassium currents in frog saccular hair cells. J Physiol (2001) 0.97
Steady-state and closed-state inactivation properties of inactivating BK channels. Biophys J (2002) 0.96
Subunit-specific effect of the voltage sensor domain on Ca2+ sensitivity of BK channels. Biophys J (2008) 0.96
Targeting BK (big potassium) channels in epilepsy. Expert Opin Ther Targets (2011) 0.95
Functional regulation of BK potassium channels by γ1 auxiliary subunits. Proc Natl Acad Sci U S A (2014) 0.94
The regulation of BK channel activity by pre- and post-translational modifications. Front Physiol (2014) 0.94
Regulation of BK channels by auxiliary γ subunits. Front Physiol (2014) 0.92
A novel auxiliary subunit critical to BK channel function in Caenorhabditis elegans. J Neurosci (2010) 0.91
Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunits. Front Physiol (2014) 0.88
Species-specific Differences among KCNMB3 BK beta3 auxiliary subunits: some beta3 N-terminal variants may be primate-specific subunits. J Gen Physiol (2008) 0.88
Molecular analysis of two cytochrome P450 monooxygenase genes required for paxilline biosynthesis in Penicillium paxilli, and effects of paxilline intermediates on mammalian maxi-K ion channels. Mol Genet Genomics (2003) 0.88
The first transmembrane domain (TM1) of β2-subunit binds to the transmembrane domain S1 of α-subunit in BK potassium channels. FEBS Lett (2012) 0.87
Positions of β2 and β3 subunits in the large-conductance calcium- and voltage-activated BK potassium channel. J Gen Physiol (2013) 0.87
Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating. Nat Commun (2015) 0.86
Modeling hair cell tuning by expression gradients of potassium channel beta subunits. Biophys J (2002) 0.85
N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity. Mol Brain (2015) 0.85
The amino terminus of Slob, Slowpoke channel binding protein, critically influences its modulation of the channel. J Gen Physiol (2005) 0.83
The beta1 subunit enhances oxidative regulation of large-conductance calcium-activated K+ channels. J Gen Physiol (2004) 0.83
Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol (2013) 0.82
N-terminal inactivation domains of beta subunits are protected from trypsin digestion by binding within the antechamber of BK channels. J Gen Physiol (2009) 0.82
Mitochondrial BKCa channel. Front Physiol (2015) 0.81
A novel genetic locus for familial febrile seizures and epilepsy on chromosome 3q26.2-q26.33. Hum Genet (2008) 0.81
Structural basis for calcium and magnesium regulation of a large conductance calcium-activated potassium channel with β1 subunits. J Biol Chem (2014) 0.81
Characterization of a functionally expressed stretch-activated BKca channel cloned from chick ventricular myocytes. J Membr Biol (2003) 0.81
Contribution of BK channels to action potential repolarisation at minimal cytosolic Ca2+ concentration in chromaffin cells. Pflugers Arch (2011) 0.79
An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron. Am J Physiol Cell Physiol (2015) 0.79
Potassium transport in the maturing kidney. Pediatr Nephrol (2007) 0.79
A fast BK-type KCa current acts as a postsynaptic modulator of temporal selectivity for communication signals. Front Cell Neurosci (2014) 0.79
Functional insights into modulation of BKCa channel activity to alter myometrial contractility. Front Physiol (2014) 0.79
Current understanding of iberiotoxin-resistant BK channels in the nervous system. Front Physiol (2014) 0.79
Intracellular Mg2+ influences both open and closed times of a native Ca2+-activated BK channel in cultured human renal proximal tubule cells. J Membr Biol (2005) 0.79
Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels. J Gen Physiol (2015) 0.79
Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits. Int Rev Neurobiol (2016) 0.78
BK channel inactivation gates daytime excitability in the circadian clock. Nat Commun (2016) 0.78
Orientations and proximities of the extracellular ends of transmembrane helices S0 and S4 in open and closed BK potassium channels. PLoS One (2013) 0.78
BKbeta1 subunits contribute to BK channel diversity in rat hypothalamic neurons. Cell Mol Neurobiol (2010) 0.78
Presynaptic BK channels control transmitter release: physiological relevance and potential therapeutic implications. J Physiol (2016) 0.78
Positions of the cytoplasmic end of BK α S0 helix relative to S1-S6 and of β1 TM1 and TM2 relative to S0-S6. J Gen Physiol (2015) 0.77
Knockout of the BK β2 subunit reveals the importance of accessorizing your channel. J Gen Physiol (2014) 0.77
Molecular mechanism underlying β1 regulation in voltage- and calcium-activated potassium (BK) channels. Proc Natl Acad Sci U S A (2015) 0.77
Mechanisms of two modulatory actions of the channel-binding protein Slob on the Drosophila Slowpoke calcium-dependent potassium channel. J Gen Physiol (2006) 0.77
Differences in ion channel phenotype and function between humans and animal models. Front Biosci (Landmark Ed) (2018) 0.77
BK channels in microglia are required for morphine-induced hyperalgesia. Nat Commun (2016) 0.76
BK Channels in the Central Nervous System. Int Rev Neurobiol (2016) 0.76
Identification and characterization of Ca2+-activated K+ channels in granulosa cells of the human ovary. Reprod Biol Endocrinol (2009) 0.76
Identity by descent fine mapping of familial adult myoclonus epilepsy (FAME) to 2p11.2-2q11.2. Hum Genet (2016) 0.75
Modulation of Ca2+ oscillation and melatonin secretion by BKCa channel activity in rat pinealocytes. Am J Physiol Cell Physiol (2016) 0.75
Alcohol modulation of BK channel gating depends on β subunit composition. J Gen Physiol (2016) 0.75
Closed state-coupled C-type inactivation in BK channels. Proc Natl Acad Sci U S A (2016) 0.75
Single Channel Recordings Reveal Differential β2 Subunit Modulations Between Mammalian and Drosophila BKCa(β2) Channels. PLoS One (2016) 0.75
The unique N-terminal sequence of the BKCa channel α-subunit determines its modulation by β-subunits. PLoS One (2017) 0.75
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity (2000) 16.03
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (1997) 13.61
Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base. Pharmacogenomics J (2001) 5.94
Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes. Biophys J (2001) 5.28
HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol (2000) 4.96
Identification of the gene responsible for Best macular dystrophy. Nat Genet (1998) 4.89
The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med (1993) 4.88
Cell fate determination in the vertebrate retina. Proc Natl Acad Sci U S A (1996) 4.81
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A (2001) 4.58
Diffusion of the Interspecies Electron Carriers H(2) and Formate in Methanogenic Ecosystems and Its Implications in the Measurement of K(m) for H(2) or Formate Uptake. Appl Environ Microbiol (1989) 4.53
In vitro and in vivo evaluation of A-56268 (TE-031), a new macrolide. Antimicrob Agents Chemother (1986) 4.51
The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-independent resistance. Plant Cell (1997) 4.47
Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity (2000) 4.44
Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol (2001) 4.39
Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques (1994) 4.24
A T cell receptor V beta segment that imparts reactivity to a class II major histocompatibility complex product. Cell (1987) 4.09
Calcium-activated potassium channels expressed from cloned complementary DNAs. Neuron (1992) 4.06
Junction adhesion molecule is a receptor for reovirus. Cell (2001) 4.00
Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Genes Dev (1998) 3.84
Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. J Biol Chem (2000) 3.75
Functional role of the beta subunit of high conductance calcium-activated potassium channels. Neuron (1995) 3.75
Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol (1985) (1999) 3.65
Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury. J Biol Chem (1996) 3.65
Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol (2001) 3.63
Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. Proc Natl Acad Sci U S A (1997) 3.59
Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature (1999) 3.57
A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genet (2001) 3.52
Response regulator output in bacterial chemotaxis. EMBO J (1998) 3.40
Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel. Science (1988) 3.38
Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY. Cell (1997) 3.32
Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors. Mol Ther (2000) 3.32
Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature (2000) 3.26
Proto-oncogene PML controls genes devoted to MHC class I antigen presentation. Nature (1998) 3.22
Subsequent pulmonary embolism: risk after a negative helical CT pulmonary angiogram--prospective comparison with scintigraphy. Radiology (2000) 3.06
IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J (1998) 2.99
Activation of a mitogen-activated protein kinase pathway is involved in disease resistance in tobacco. Proc Natl Acad Sci U S A (2001) 2.98
Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest (1997) 2.93
Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles. J Virol (1997) 2.91
Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export. EMBO J (1998) 2.90
Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem (2000) 2.89
Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene (2012) 2.82
Structure of the adenylyl cyclase catalytic core. Nature (1997) 2.81
Interlocked feedback loops contribute to the robustness of the Neurospora circadian clock. Proc Natl Acad Sci U S A (2001) 2.77
Tetraethylammonium block of Slowpoke calcium-activated potassium channels expressed in Xenopus oocytes: evidence for tetrameric channel formation. Pflugers Arch (1994) 2.75
Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol (2001) 2.73
Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem (2000) 2.71
The regulation of reactive oxygen species production during programmed cell death. J Cell Biol (1998) 2.62
Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle. J Biol Chem (1994) 2.62
Residues of the variable region of the T-cell-receptor beta-chain that interact with S. aureus toxin superantigens. Nature (1990) 2.60
The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci (1998) 2.58
The C termini of Arabidopsis cryptochromes mediate a constitutive light response. Cell (2000) 2.53
Nitric oxide and cutaneous active vasodilation during heat stress in humans. J Appl Physiol (1985) (1998) 2.53
The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J (1998) 2.50
Uncoupling PR gene expression from NPR1 and bacterial resistance: characterization of the dominant Arabidopsis cpr6-1 mutant. Plant Cell (1998) 2.48
Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway. Cell (1998) 2.48
On the use of thiol-modifying agents to determine channel topology. Neuropharmacology (1996) 2.47
Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cells. J Biol Chem (1997) 2.47
Increased thermal stability of proteins in the presence of naturally occurring osmolytes. Biochemistry (1992) 2.47
Profiling serine hydrolase activities in complex proteomes. Biochemistry (2001) 2.46
Identification of the region of T cell receptor beta chain that interacts with the self-superantigen MIs-1a. Cell (1990) 2.42
Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene (2012) 2.41
A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Neurology (2011) 2.39
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37
Establishment, maintenance and description of cell lines from the tick Ixodes scapularis. J Parasitol (1994) 2.36
Design of allele-specific inhibitors to probe protein kinase signaling. Curr Biol (1998) 2.36
Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron (1997) 2.34
The transcriptome of the arbuscular mycorrhizal fungus Glomus intraradices (DAOM 197198) reveals functional tradeoffs in an obligate symbiont. New Phytol (2011) 2.29
The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev (1997) 2.26
Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China. Ann Neurol (1993) 2.23
Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J Cell Biol (2001) 2.23
Odd-parity superconductivity in Sr2RuO4. Science (2004) 2.22
Systemic gene expression after intravenous DNA delivery into adult mice. Science (1993) 2.21
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A (2001) 2.21
Coiled-coil domain-mediated FRQ-FRQ interaction is essential for its circadian clock function in Neurospora. EMBO J (2001) 2.19
Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity (1999) 2.18
Human albumin therapy of acute ischemic stroke: marked neuroprotective efficacy at moderate doses and with a broad therapeutic window. Stroke (2001) 2.16
Characterization of apelin, the ligand for the APJ receptor. J Neurochem (2000) 2.11
Dissecting glycoprotein quality control in the secretory pathway. Trends Biochem Sci (2001) 2.08
Method for obtaining structure and interactions from oriented lipid bilayers. Phys Rev E Stat Nonlin Soft Matter Phys (2000) 2.08
Covalent catalysis in nucleotidyl transfer reactions: essential motifs in Saccharomyces cerevisiae RNA capping enzyme are conserved in Schizosaccharomyces pombe and viral capping enzymes and among polynucleotide ligases. Proc Natl Acad Sci U S A (1994) 2.07
PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. J Cell Biol (2000) 2.07
Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease. J Intern Med (2014) 2.06
Identification of a global repressor gene, rsmA, of Erwinia carotovora subsp. carotovora that controls extracellular enzymes, N-(3-oxohexanoyl)-L-homoserine lactone, and pathogenicity in soft-rotting Erwinia spp. J Bacteriol (1995) 2.06
Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol Cell Biol (2000) 2.06
Do CK-MB results affect chest pain decision making in the emergency department? Ann Emerg Med (1991) 2.04
Preconditioning protects ischemic rabbit heart by protein kinase C activation. Am J Physiol (1994) 2.04
Discovery of a receptor related to the galanin receptors. FEBS Lett (1999) 2.01
The structure of ferrocytochrome c at 2.45 A resolution. J Biol Chem (1973) 2.00
A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice. Carcinogenesis (2001) 1.99
Unnatural ligands for engineered proteins: new tools for chemical genetics. Annu Rev Biophys Biomol Struct (2000) 1.99
TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity (1997) 1.98
Investigating the hows and whys of DNA endoreduplication. J Exp Bot (2001) 1.97
Human hair follicle bulge cells are biochemically distinct and possess an epithelial stem cell phenotype. J Investig Dermatol Symp Proc (1999) 1.96
Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects. Proc Natl Acad Sci U S A (1999) 1.95