Published in J Exp Med on September 04, 2000
KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med (2004) 3.69
Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E-selectin. Hepatology (2013) 1.58
Endothelial-mesenchymal transition of brain endothelial cells: possible role during metastatic extravasation. PLoS One (2015) 1.43
The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians. Hum Genet (2003) 1.31
ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells. Am J Pathol (2006) 1.24
Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6. Mol Cell Biol (2004) 1.15
XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling. Mol Cancer (2010) 0.91
The development of the heart and microcirculation: role of shear stress. Med Biol Eng Comput (2008) 0.90
Impact of interleukin-6 promoter polymorphism and serum interleukin-6 level on the acute inflammation and neovascularization stages of patients with Eales' disease. Mol Vis (2011) 0.88
Blockade of TGF-β by catheter-based local intravascular gene delivery does not alter the in-stent neointimal response, but enhances inflammation in pig coronary arteries. Int J Cardiol (2010) 0.80
Inhibition of transforming growth factor β worsens elastin degradation in a murine model of Kawasaki disease. Am J Pathol (2011) 0.80
Association of a Large Panel of Cytokine Gene Polymorphisms with Complications and Comorbidities in Type 2 Diabetes Patients. J Diabetes Res (2015) 0.78
A Short Peptide That Mimics the Binding Domain of TGF-β1 Presents Potent Anti-Inflammatory Activity. PLoS One (2015) 0.75
Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature (1992) 16.46
A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell (1996) 11.02
Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science (1989) 10.70
Role of CBP/P300 in nuclear receptor signalling. Nature (1996) 7.36
The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell (1997) 6.34
Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J (1995) 5.59
CREB-binding protein/p300 are transcriptional coactivators of p65. Proc Natl Acad Sci U S A (1997) 4.71
Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature (1995) 4.49
Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature (1996) 3.88
TGFbeta signaling: receptors, transducers, and Mad proteins. Cell (1996) 3.31
Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J (1999) 3.28
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev (1998) 3.16
A Smad transcriptional corepressor. Cell (1999) 3.07
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev (1998) 2.82
Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300. Proc Natl Acad Sci U S A (1997) 2.63
TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev (1998) 2.40
The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression. Immunity (1995) 2.17
Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc Natl Acad Sci U S A (1997) 2.15
Differential use of CREB binding protein-coactivator complexes. Science (1998) 2.10
Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1. J Biol Chem (1998) 2.02
Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways. J Biol Chem (1997) 1.99
Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics (1995) 1.85
TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cells: transcriptional activation of I kappa B alpha. Immunity (1996) 1.81
Physical and functional interaction of SMADs and p300/CBP. J Biol Chem (1998) 1.77
A striking similarity in the organization of the E-selectin and beta interferon gene promoters. Mol Cell Biol (1994) 1.75
Transforming growth factor-beta inhibits E-selectin expression on human endothelial cells. J Immunol (1993) 1.58
CREB-binding protein is a nuclear integrator of nuclear factor-kappaB and p53 signaling. J Biol Chem (1999) 1.47
CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells. Proc Natl Acad Sci U S A (1998) 1.39
MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. J Biol Chem (1999) 1.22
Role of p300, a transcriptional coactivator, in signalling of TGF-beta. Genes Cells (1998) 1.20
Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells. J Biol Chem (1994) 1.14
TGF-beta receptors and signalling mechanisms. Miner Electrolyte Metab (1998) 1.06
Suppression of interleukin-1beta-induced nitric-oxide synthase promoter/enhancer activity by transforming growth factor-beta1 in vascular smooth muscle cells. Evidence for mechanisms other than NF-kappaB. J Biol Chem (1996) 0.90
Induction of heme oxygenase-1 during endotoxemia is downregulated by transforming growth factor-beta1. Circ Res (1998) 0.90
TGF-beta: implications for human vascular disease. J Hum Hypertens (1995) 0.81
Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science (1989) 10.70
Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acad Sci U S A (1987) 10.43
Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines. J Clin Invest (1985) 8.70
Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J Immunol (1986) 8.22
Culture of vascular endothelium. Prog Hemost Thromb (1976) 7.05
The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell (1997) 6.34
Human vascular endothelial cells in culture. Growth and DNA synthesis. J Cell Biol (1974) 5.95
Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J Exp Med (1984) 5.89
Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1. Proc Natl Acad Sci U S A (1986) 5.83
Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science (1991) 5.76
Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses. Br J Cancer (1977) 5.58
Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest (1995) 5.09
Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon. J Exp Med (1983) 4.92
Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts. Proc Natl Acad Sci U S A (1984) 4.43
Tumor dormancy in vivo by prevention of neovascularization. J Exp Med (1972) 4.34
The dynamic response of vascular endothelial cells to fluid shear stress. J Biomech Eng (1981) 4.27
MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature (1999) 4.19
Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. Nature (1983) 4.16
Tumor growth and neovascularization: an experimental model using the rabbit cornea. J Natl Cancer Inst (1974) 4.05
Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci U S A (1996) 3.93
Activated macrophages induce vascular proliferation. Nature (1977) 3.74
Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann N Y Acad Sci (2000) 3.70
Induction and detection of a human endothelial activation antigen in vivo. J Exp Med (1986) 3.66
Regulation of macrophage populations. I. Preferential induction of Ia-rich peritoneal exudates by immunologic stimuli. J Immunol (1980) 3.46
Heme oxygenase-1 protects against vascular constriction and proliferation. Nat Med (2001) 3.11
Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species. J Immunol (1987) 3.06
Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J Immunol (1991) 3.05
Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins. J Cell Biol (1994) 3.02
Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res (2001) 2.98
Macrophage-T cell interactions involving Listeria monocytogenes--role of the H-2 gene complex. J Immunol (1979) 2.93
IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J Immunol (1992) 2.89
Biomechanical activation of vascular endothelium as a determinant of its functional phenotype. Proc Natl Acad Sci U S A (2001) 2.89
A role for smad6 in development and homeostasis of the cardiovascular system. Nat Genet (2000) 2.80
Structural organization and chromosomal assignment of the gene encoding endothelin. J Biol Chem (1989) 2.77
An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb (1993) 2.77
Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. J Exp Med (1991) 2.76
Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro. Proc Natl Acad Sci U S A (1986) 2.73
Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion. Am J Pathol (1985) 2.59
The modulation of lymphocyte functions by molecules secreted by macrophages. I. Description and partial biochemical analysis. J Exp Med (1975) 2.54
Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element. Proc Natl Acad Sci U S A (1993) 2.48
Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J Clin Invest (1992) 2.45
Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Invest (1999) 2.44
Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elements. Cell (1987) 2.44
Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc Natl Acad Sci U S A (1995) 2.41
Human vascular smooth muscle in culture. Growth and ultrastructure. Lab Invest (1975) 2.41
Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells. J Clin Invest (1994) 2.35
Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells. J Biol Chem (1986) 2.33
Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem (2001) 2.31
Angiotensin II stimulation of prostaglandin production in cultured human vascular endothelium. Science (1975) 2.24
Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J (1995) 2.23
Functional angiotensin II receptors in cultured vascular smooth muscle cells. J Cell Biol (1982) 2.22
Vascular endothelium responds to fluid shear stress gradients. Arterioscler Thromb (1992) 2.21
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A (2001) 2.21
Stimulation of nonlymphoid mesenchymal cell proliferation by a macrophage-derived growth factor. J Immunol (1981) 2.18
Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium. Nature (1969) 2.16
Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc Natl Acad Sci U S A (1997) 2.15
Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J Biol Chem (1998) 2.15
Fine structure of vascular endothelium in culture. J Ultrastruct Res (1975) 2.15
Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ Res (2000) 2.14
Intravascular IL-8. Inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation. J Immunol (1991) 2.10
The RNA processing enzyme RNase MRP is identical to the Th RNP and related to RNase P. Science (1989) 2.07
Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor. J Biol Chem (1988) 2.04
Induction of cytocidal macrophages after in vitro interactions between Listeria-immune T cells and macrophages--role of H-2. J Immunol (1979) 2.00
Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res (1993) 1.98
Tumor angiogenesis: iris neovascularization at a distance from experimental intraocular tumors. J Natl Cancer Inst (1973) 1.95
Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress. J Clin Invest (1995) 1.94
Regulation of the fibrinolytic system of cultured human vascular endothelium by interleukin 1. J Clin Invest (1986) 1.89
Leukotriene B4 stimulates polymorphonuclear leukocyte adhesion to cultured vascular endothelial cells. J Clin Invest (1984) 1.88
Expression of Ia-like antigens by human vascular endothelial cells is inducible in vitro: demonstration by monoclonal antibody binding and immunoprecipitation. Proc Natl Acad Sci U S A (1982) 1.87
Role of gut-enriched Krüppel-like factor in colonic cell growth and differentiation. Am J Physiol Gastrointest Liver Physiol (2000) 1.83
Thy-1, a novel marker for angiogenesis upregulated by inflammatory cytokines. Circ Res (1998) 1.81
Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. Proc Natl Acad Sci U S A (1991) 1.79
Natriuretic peptide system in human heart failure. Circulation (1993) 1.79
Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. J Biol Chem (1995) 1.78
Influence of hemodynamic forces on vascular endothelial function. In vitro studies of shear stress and pinocytosis in bovine aortic cells. J Clin Invest (1984) 1.77
Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype. Mol Med Today (1999) 1.75
Vascular endothelial cells respond to spatial gradients in fluid shear stress by enhanced activation of transcription factors. Arterioscler Thromb Vasc Biol (1999) 1.75
Human cytolytic T lymphocyte interactions with vascular endothelium and fibroblasts: role of effector and target cell molecules. J Immunol (1984) 1.75
Characterization of resident glomerular cells in the rat expressing Ia determinants and manifesting genetically restricted interactions with lymphocytes. J Clin Invest (1981) 1.72
Erythrocyte volume, plasma volume, and lean body mass in adult men and women. Blood (1969) 1.71
Induction of vascular endothelial growth factor gene expression by interleukin-1 beta in rat aortic smooth muscle cells. J Biol Chem (1995) 1.71
Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils. J Immunol (1990) 1.69
Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci U S A (1994) 1.66
Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1. J Biol Chem (1991) 1.66