Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains.

PubWeight™: 2.15‹?› | Rank: Top 2%

🔗 View Article (PMID 9422764)

Published in J Biol Chem on January 09, 1998

Authors

S F Yet1, M M McA'Nulty, S C Folta, H W Yen, M Yoshizumi, C M Hsieh, M D Layne, M T Chin, H Wang, M A Perrella, M K Jain, M E Lee

Author Affiliations

1: Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

Articles citing this

Mammalian Krüppel-like factors in health and diseases. Physiol Rev (2010) 4.09

A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res (1999) 3.68

The biology of the mammalian Krüppel-like family of transcription factors. Int J Biochem Cell Biol (2001) 3.31

Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators. EMBO J (1998) 3.06

The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter. J Biol Chem (2000) 3.02

Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. Oncogene (2004) 2.96

KLF8 recruits the p300 and PCAF co-activators to its amino terminal activation domain to activate transcription. Cell Cycle (2010) 2.69

Gut-enriched Krüppel-like factor represses cyclin D1 promoter activity through Sp1 motif. Nucleic Acids Res (2000) 2.34

Transcriptional control of endothelial cell development. Dev Cell (2009) 2.12

Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. Oncogene (2003) 2.11

Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. Proc Natl Acad Sci U S A (1998) 2.02

down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4. J Biol Chem (2011) 1.79

Roles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cells. Acta Biochim Biophys Sin (Shanghai) (2008) 1.76

The gut-enriched Krüppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion. J Biol Chem (1998) 1.76

Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients. FEBS Lett (2000) 1.70

Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene. Nucleic Acids Res (2002) 1.64

Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction. Nucleic Acids Res (2000) 1.59

Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Krüppel-associated box protein. Mol Cell Biol (2001) 1.56

Role of Kruppel-like factors in leukocyte development, function, and disease. Blood (2010) 1.54

Kruppel-like factor 4, Elk-1, and histone deacetylases cooperatively suppress smooth muscle cell differentiation markers in response to oxidized phospholipids. Am J Physiol Cell Physiol (2008) 1.46

Kruppel-like factor KLF4 facilitates cutaneous wound healing by promoting fibrocyte generation from myeloid-derived suppressor cells. J Invest Dermatol (2015) 1.44

Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition. Proc Natl Acad Sci U S A (2006) 1.35

Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancer. World J Gastroenterol (2002) 1.34

KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol (2008) 1.33

Kruppel-like factor-4 transcriptionally regulates VE-cadherin expression and endothelial barrier function. Circ Res (2010) 1.29

Kruppel-like factor 2 cooperates with the ETS family protein ERG to activate Flk1 expression during vascular development. Development (2009) 1.20

The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells. Histol Histopathol (2009) 1.15

Kruppel-like factor 4 is a novel mediator of Kallistatin in inhibiting endothelial inflammation via increased endothelial nitric-oxide synthase expression. J Biol Chem (2009) 1.09

"Go with the flow": how Krüppel-like factor 2 regulates the vasoprotective effects of shear stress. Antioxid Redox Signal (2011) 1.07

Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9. Mol Cell Biol (2008) 1.04

Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity. J Clin Invest (2014) 1.03

Regulation of EMT by KLF4 in gastrointestinal cancer. Curr Cancer Drug Targets (2013) 1.02

Gene expression of TPA induced differentiation in HL-60 cells by DNA microarray analysis. Nucleic Acids Res (2002) 1.01

Tip60 functions as a potential corepressor of KLF4 in regulation of HDC promoter activity. Nucleic Acids Res (2007) 1.00

Metastatic progression and gene expression between breast cancer cell lines from African American and Caucasian women. J Carcinog (2007) 1.00

Induction of KLF4 in response to heat stress. Cell Stress Chaperones (2006) 0.97

The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice. Blood (2007) 0.95

Deficiency of the Kruppel-like factor KLF4 correlates with increased cell proliferation and enhanced skin tumorigenesis. Carcinogenesis (2012) 0.94

Early genetic mechanisms underlying the inhibitory effects of endostatin and fumagillin on human endothelial cells. Genome Res (2004) 0.92

Deficiency of Kruppel-like factor KLF4 in mammary tumor cells inhibits tumor growth and pulmonary metastasis and is accompanied by compromised recruitment of myeloid-derived suppressor cells. Int J Cancer (2013) 0.91

Dopamine receptor regulating factor, DRRF: a zinc finger transcription factor. Proc Natl Acad Sci U S A (2001) 0.91

Cooperative transcriptional activation by Klf4, Meis2, and Pbx1. Mol Cell Biol (2011) 0.91

Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension. Sci Transl Med (2015) 0.90

KLF3 regulates muscle-specific gene expression and synergizes with serum response factor on KLF binding sites. Mol Cell Biol (2010) 0.90

12-O-tetradecanoylphorbol-13-acetate promotes breast cancer cell motility by increasing S100A14 level in a Kruppel-like transcription factor 4 (KLF4)-dependent manner. J Biol Chem (2014) 0.86

KLF4 Expression Correlates with the Degree of Differentiation in Colorectal Cancer. Gut Liver (2011) 0.84

Kruppel-like factors and vascular inflammation: implications for atherosclerosis. Curr Atheroscler Rep (2012) 0.84

Kruppel-like factor 4 attenuates osteoblast formation, function, and cross talk with osteoclasts. J Cell Biol (2014) 0.82

Molecular mechanisms for activation of the agouti-related protein and stimulation of appetite. Diabetes (2010) 0.81

Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters. Cell Cycle (2011) 0.80

Krüppel-like factor 4 is induced by rapamycin and mediates the anti-proliferative effect of rapamycin in rat carotid arteries after balloon injury. Br J Pharmacol (2012) 0.78

c-Kit+ progenitors generate vascular cells for tissue-engineered grafts through modulation of the Wnt/Klf4 pathway. Biomaterials (2015) 0.78

Elevated Krüppel-like factor 4 transcription factor in canine mammary carcinoma. BMC Vet Res (2011) 0.78

Krüppel-like Factor 4 Blocks Hepatocellular Carcinoma Dedifferentiation and Progression through Activation of Hepatocyte Nuclear Factor-6. Clin Cancer Res (2015) 0.77

Upregulation of the constitutively expressed HSC70 by KLF4. Cell Stress Chaperones (2008) 0.76

Discovery of small molecule inhibitors to Krüppel-like factor 10 (KLF10): implications for modulation of T regulatory cell differentiation. J Med Chem (2015) 0.76

Endothelial KLF4: crippling vascular injury? J Am Heart Assoc (2014) 0.75

Krüppel-like factor 4 (KLF4): What we currently know. Gene (2017) 0.75

Role of Krüppel-like factor 5 in the maintenance of the stem cell niche in the intestinal crypt. Stem Cell Transl Investig (2015) 0.75

Kruppel-like factor4 regulates PRDM1 expression through binding to an autoimmune risk allele. JCI Insight (2017) 0.75

A novel role of Krüppel-like factor 4 in Zhikong scallop Chlamys farreri during spermatogenesis. PLoS One (2017) 0.75

Expression of Krüppel-like factor 4 in breast cancer tissues and its effects on the proliferation of breast cancer MDA-MB-231 cells. Exp Ther Med (2017) 0.75

Articles by these authors

LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature (2000) 11.49

A wireless, remote query ammonia sensor. Sens Actuators B Chem (2001) 9.00

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med (2000) 7.38

Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest (2001) 7.20

Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol (1997) 6.61

Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med (1999) 6.27

Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein. Science (1997) 6.10

Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci U S A (1996) 6.00

Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses. Br J Cancer (1977) 5.58

Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell (1996) 5.45

HMG-1 as a mediator of acute lung inflammation. J Immunol (2000) 4.78

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc Natl Acad Sci U S A (2001) 4.62

Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science (1999) 4.61

Evolutionary analyses of the human genome. Nature (2001) 4.13

Gene expression profiles during the initial phase of salt stress in rice. Plant Cell (2001) 4.11

Quantum ground state and single-phonon control of a mechanical resonator. Nature (2010) 3.71

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med (1999) 3.57

Requirement for math5 in the development of retinal ganglion cells. Genes Dev (2001) 3.26

Alternative gene form discovery and candidate gene selection from gene indexing projects. Genome Res (1998) 3.26

A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature (1997) 3.26

Hyperexpression of mitogen-activated protein kinase in human breast cancer. J Clin Invest (1997) 3.26

Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron (1998) 3.18

An association between renal cell carcinoma and lymphoid malignancies. A case series of eight patients. Cancer (1996) 3.12

Heme oxygenase-1 protects against vascular constriction and proliferation. Nat Med (2001) 3.11

Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res (2001) 2.98

A floral transmitting tissue-specific glycoprotein attracts pollen tubes and stimulates their growth. Cell (1995) 2.85

Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol (2001) 2.85

Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Intern Med J (2012) 2.81

Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity. J Virol (2001) 2.79

MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene (2007) 2.79

Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat Immunol (2000) 2.78

Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution. Acta Crystallogr D Biol Crystallogr (1999) 2.77

Structural organization and chromosomal assignment of the gene encoding endothelin. J Biol Chem (1989) 2.77

Ecology. Giant pandas in a changing landscape. Science (2001) 2.73

Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem (2000) 2.71

Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. Br J Anaesth (2013) 2.70

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene (2007) 2.68

Effect of peer led programme for asthma education in adolescents: cluster randomised controlled trial. BMJ (2001) 2.67

Adhesion formation after previous caesarean section-a meta-analysis and systematic review. BJOG (2010) 2.66

Strongly enhanced current densities in superconducting coated conductors of YBa2Cu3O7-x + BaZrO3. Nat Mater (2004) 2.61

Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res (2001) 2.53

Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature (2000) 2.51

Integrin activation by R-ras. Cell (1996) 2.50

High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum (2002) 2.45

Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Invest (1999) 2.44

Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells. FEBS Lett (1988) 2.44

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A (1999) 2.42

A theoretical solution for the frictionless rolling contact of cylindrical biphasic articular cartilage layers. J Biomech (1995) 2.42

Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc Natl Acad Sci U S A (1995) 2.41

On sample size calculation in bioequivalence trials. J Pharmacokinet Pharmacodyn (2001) 2.40

GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development (1997) 2.38

Fire and flood management of coastal swamp enabled first rice paddy cultivation in east China. Nature (2007) 2.36

Discovering molecular pathways from protein interaction and gene expression data. Bioinformatics (2003) 2.32

Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem (2001) 2.31

Phylogeny of the Simbu serogroup of the genus Bunyavirus. J Gen Virol (2001) 2.30

Mechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenet Genome Res (2004) 2.26

A PhoP-regulated outer membrane protease of Salmonella enterica serovar typhimurium promotes resistance to alpha-helical antimicrobial peptides. J Bacteriol (2000) 2.26

Changing pattern of cutaneous tuberculosis. A prospective study. Int J Dermatol (1989) 2.25

Single-molecule recognition imaging microscopy. Proc Natl Acad Sci U S A (2004) 2.25

Environmental and physiological factors affecting the succinate product ratio during carbohydrate fermentation by Actinobacillus sp. 130Z. Arch Microbiol (1997) 2.25

Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A (2001) 2.21

Pinhole collimation for ultra-high-resolution, small-field-of-view SPECT. Phys Med Biol (1994) 2.19

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP. Nature (1999) 2.18

Quality of life for children with fecal incontinence after surgically corrected anorectal malformation. J Pediatr Surg (2000) 2.17

Energy transduction in ATP synthase. Nature (1998) 2.15

Ossifying fibromas of the jaw bone: 20 cases. Dentomaxillofac Radiol (2010) 2.15

TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J Dent Res (2010) 2.14

A pollen tube growth stimulatory glycoprotein is deglycosylated by pollen tubes and displays a glycosylation gradient in the flower. Cell (1995) 2.14

Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ Res (2000) 2.14

Materials science challenges for high-temperature superconducting wire. Nat Mater (2007) 2.13

The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action. Diabetologia (2009) 2.11

CORG: a database for COmparative Regulatory Genomics. Nucleic Acids Res (2003) 2.06

Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism. Mol Cell Biol (1997) 2.04

Synthesizing arbitrary quantum states in a superconducting resonator. Nature (2009) 2.03

Regional hippocampal atrophy in multiple sclerosis. Brain (2008) 2.02

In vitro Arabidopsis pollen germination and characterization of the inward potassium currents in Arabidopsis pollen grain protoplasts. J Exp Bot (2001) 2.01

Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice. J Clin Invest (1997) 2.00

1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. J Biol Chem (2000) 2.00

Expression of ethylene biosynthetic pathway transcripts in senescing carnation flowers. Plant Physiol (1992) 1.99

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res (1993) 1.98

Identification of two factors required for transcription of the ovalbumin gene. Mol Cell Biol (1986) 1.96

Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II). Cell (1987) 1.95

Violation of Bell's inequality in Josephson phase qubits. Nature (2009) 1.92

Building a root: the control of patterning and morphogenesis during root development. Plant Cell (1997) 1.89

Transforming growth factor-beta stimulates the expression of endothelin mRNA by vascular endothelial cells. Biochem Biophys Res Commun (1989) 1.88

The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J Biol Chem (1997) 1.87