Published in Mol Cell Biol on October 01, 2000
Regulation of alternative splicing by histone modifications. Science (2010) 7.98
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev (2010) 4.75
Finding signals that regulate alternative splicing in the post-genomic era. Genome Biol (2002) 4.73
Polypyrimidine tract binding protein antagonizes exon definition. Mol Cell Biol (2001) 4.10
Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice. Mol Cell Biol (2006) 2.18
Polypyrimidine tract binding protein blocks the 5' splice site-dependent assembly of U2AF and the prespliceosomal E complex. Mol Cell (2005) 2.05
Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB). RNA (2001) 1.98
Exon repression by polypyrimidine tract binding protein. RNA (2005) 1.81
A stem structure in fibroblast growth factor receptor 2 transcripts mediates cell-type-specific splicing by approximating intronic control elements. Mol Cell Biol (2003) 1.63
Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer. Mol Cell (2014) 1.61
hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc. Mol Cell Biol (2008) 1.60
Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophy. Hum Mol Genet (2009) 1.53
The polypyrimidine tract binding protein (PTB) represses splicing of exon 6B from the beta-tropomyosin pre-mRNA by directly interfering with the binding of the U2AF65 subunit. Mol Cell Biol (2006) 1.47
Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation. Mol Cell Biol (2003) 1.44
Dichotomous splicing signals in exon flanks. Genome Res (2005) 1.42
Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity. Proc Natl Acad Sci U S A (2006) 1.36
Alternative splicing and biological heterogeneity in prostate cancer. Nat Rev Urol (2009) 1.33
Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays. BMC Genomics (2008) 1.25
Conserved sequence elements associated with exon skipping. Nucleic Acids Res (2003) 1.23
Quantification of alternatively spliced FGFR2 RNAs using the RNA invasive cleavage assay. RNA (2003) 1.23
RBFOX2 is an important regulator of mesenchymal tissue-specific splicing in both normal and cancer tissues. Mol Cell Biol (2012) 1.22
Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2. Crit Rev Biochem Mol Biol (2012) 1.20
hnRNP I/PTB can antagonize the splicing repressor activity of SRp30c. RNA (2007) 1.19
A consensus CaMK IV-responsive RNA sequence mediates regulation of alternative exons in neurons. RNA (2005) 1.19
Multiple roles for polypyrimidine tract binding (PTB) proteins in trypanosome RNA metabolism. RNA (2009) 1.19
A novel intronic cis element, ISE/ISS-3, regulates rat fibroblast growth factor receptor 2 splicing through activation of an upstream exon and repression of a downstream exon containing a noncanonical branch point sequence. Mol Cell Biol (2005) 1.19
Structure of the two most C-terminal RNA recognition motifs of PTB using segmental isotope labeling. EMBO J (2005) 1.18
Mutations in RRM4 uncouple the splicing repression and RNA-binding activities of polypyrimidine tract binding protein. RNA (2002) 1.15
Polypyrimidine track-binding protein binding downstream of caspase-2 alternative exon 9 represses its inclusion. J Biol Chem (2000) 1.09
De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function. PLoS Comput Biol (2014) 1.08
Genomic localization of RNA binding proteins reveals links between pre-mRNA processing and transcription. Genome Res (2006) 1.06
Of urchins and men: evolution of an alternative splicing unit in fibroblast growth factor receptor genes. RNA (2003) 1.03
Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein. J Biol Chem (2011) 1.01
Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing. Proc Natl Acad Sci U S A (2007) 1.00
New insights into functional roles of the polypyrimidine tract-binding protein. Int J Mol Sci (2013) 1.00
PTB regulates the processing of a 3'-terminal exon by repressing both splicing and polyadenylation. Mol Cell Biol (2005) 0.98
The role of epithelial plasticity in prostate cancer dissemination and treatment resistance. Cancer Metastasis Rev (2014) 0.94
Characterization of sequences and mechanisms through which ISE/ISS-3 regulates FGFR2 splicing. Nucleic Acids Res (2006) 0.93
The hepatitis B virus PRE contains a splicing regulatory element. Nucleic Acids Res (2006) 0.93
Chemical shift mapping of RNA interactions with the polypyrimidine tract binding protein. Nucleic Acids Res (2002) 0.92
Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection. PLoS One (2010) 0.91
CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans. PLoS Genet (2013) 0.90
Imaging the alternative silencing of FGFR2 exon IIIb in vivo. RNA (2006) 0.90
5'- and 3'-terminal nucleotides in the FGFR2 ISAR splicing element core have overlapping roles in exon IIIb activation and exon IIIc repression. Nucleic Acids Res (2001) 0.89
Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells. Oncogene (2015) 0.88
Identification of an intronic splicing enhancer essential for the inclusion of FGFR2 exon IIIc. J Biol Chem (2008) 0.88
Coupling pre-mRNA processing to transcription on the RNA factory assembly line. RNA Biol (2013) 0.87
The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Elife (2015) 0.86
The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells. Oncotarget (2015) 0.84
Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing. PLoS One (2014) 0.79
Identification of novel splice variants and exons of human endothelial cell-specific chemotaxic regulator (ECSCR) by bioinformatics analysis. Comput Biol Chem (2012) 0.78
RBM4a-regulated splicing cascade modulates the differentiation and metabolic activities of brown adipocytes. Sci Rep (2016) 0.78
Methylation profiling identified novel differentially methylated markers including OPCML and FLRT2 in prostate cancer. Epigenetics (2016) 0.77
Palifermin for the protection and regeneration of epithelial tissues following injury: new findings in basic research and pre-clinical models. J Cell Mol Med (2013) 0.77
EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression. Mol Cancer (2017) 0.75
A posttranscriptional mechanism that controls Ptbp1 abundance in the Xenopus epidermis. Mol Cell Biol (2014) 0.75
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell (1992) 7.90
Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science (1994) 7.09
Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins. Science (1995) 5.97
A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro. Cell (1990) 5.92
A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. Genes Dev (1993) 5.10
The role of exon sequences in splice site selection. Genes Dev (1993) 4.86
Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res (1993) 4.67
Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns. Genes Dev (1989) 4.53
Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci U S A (1992) 4.50
General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes Dev (1993) 4.40
Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev (1991) 4.28
SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex. Mol Cell Biol (1994) 4.25
Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA (1998) 4.05
General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proc Natl Acad Sci U S A (1992) 3.97
hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res (1992) 3.89
A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. Genes Dev (1997) 3.88
Mutation of PTB binding sites causes misregulation of alternative 3' splice site selection in vivo. RNA (1997) 3.57
Characterization of cDNAs encoding the polypyrimidine tract-binding protein. Genes Dev (1991) 3.55
The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element. Mol Cell Biol (1993) 3.48
A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer. Mol Cell Biol (1995) 3.18
Polypurine sequences within a downstream exon function as a splicing enhancer. Mol Cell Biol (1994) 3.15
A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing. Proc Natl Acad Sci U S A (2000) 3.11
hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. Mol Cell Biol (1999) 3.06
The polypyrimidine tract binding protein binds upstream of neural cell-specific c-src exon N1 to repress the splicing of the intron downstream. Mol Cell Biol (1997) 2.93
hnRNP A1 recruited to an exon in vivo can function as an exon splicing silencer. Mol Cell Biol (1999) 2.93
Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer. Genes Dev (1996) 2.90
The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event. Genes Dev (1995) 2.87
Alternative mRNA splicing. Annu Rev Cell Biol (1992) 2.74
Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene. Genes Dev (1999) 2.69
The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain. Mol Cell Biol (1991) 2.63
Synergistic interactions between two distinct elements of a regulated splicing enhancer. Genes Dev (1995) 2.56
Polypyrimidine tract binding protein interacts with sequences involved in alternative splicing of beta-tropomyosin pre-mRNA. J Biol Chem (1992) 2.53
Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction. Biochim Biophys Acta (1992) 2.41
Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing. Mol Cell (2000) 2.39
Multiple RRMs contribute to RNA binding specificity and affinity for polypyrimidine tract binding protein. Biochemistry (1997) 2.35
Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy. Mol Cell Biol (1993) 2.29
Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated alpha-tropomyosin exon. RNA (1998) 2.18
Sex-lethal autoregulation requires multiple cis-acting elements upstream and downstream of the male exon and appears to depend largely on controlling the use of the male exon 5' splice site. Mol Cell Biol (1993) 2.10
Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon. Mol Cell Biol (1999) 2.05
Polypyrimidine tract binding protein functions as a repressor to regulate alternative splicing of alpha-actinin mutally exclusive exons. Mol Cell Biol (1999) 2.02
Association of individual hnRNP proteins and snRNPs with nascent transcripts. J Cell Biol (1993) 1.95
Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon. EMBO J (1994) 1.91
Multiple interdependent sequence elements control splicing of a fibroblast growth factor receptor 2 alternative exon. Mol Cell Biol (1997) 1.83
Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB. RNA (1999) 1.78
Alternative splicing of beta-tropomyosin pre-mRNA: cis-acting elements and cellular factors that block the use of a skeletal muscle exon in nonmuscle cells. Genes Dev (1991) 1.73
Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin. Mol Endocrinol (1992) 1.71
An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing. Mol Cell Biol (1998) 1.64
Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer. Oncogene (1997) 1.63
The exon sequence TAGG can inhibit splicing. Nucleic Acids Res (1996) 1.60
Regulation of pre-mRNA splicing in metazoa. Curr Opin Genet Dev (1997) 1.59
Fibroblast growth factor receptor 2 limits and receptor 1 accelerates tumorigenicity of prostate epithelial cells. Cancer Res (1997) 1.48
Combinatorial control of a neuron-specific exon. RNA (1999) 1.48
The Sex-lethal amino terminus mediates cooperative interactions in RNA binding and is essential for splicing regulation. Genes Dev (1994) 1.44
Control of BEK and K-SAM splice sites in alternative splicing of the fibroblast growth factor receptor 2 pre-mRNA. Mol Cell Biol (1993) 1.41
Multiple mRNAs code for proteins related to the BEK fibroblast growth factor receptor. Oncogene (1991) 1.40
A pyrimidine-rich exonic splicing suppressor binds multiple RNA splicing factors and inhibits spliceosome assembly. Proc Natl Acad Sci U S A (1998) 1.37
Murine polypyrimidine tract binding protein. Purification, cloning, and mapping of the RNA binding domain. J Biol Chem (1991) 1.37
A naturally arising mutation of a potential silencer of exon splicing in human immunodeficiency virus type 1 induces dominant aberrant splicing and arrests virus production. J Virol (1997) 1.31
Inhibition of growth of malignant rat prostate tumor cells by restoration of fibroblast growth factor receptor 2. Cancer Res (1998) 1.19
A novel isoform ratio switch of the polypyrimidine tract binding protein. Electrophoresis (1999) 0.95
Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors. Nature (1994) 6.97
Polypyrimidine tract binding protein antagonizes exon definition. Mol Cell Biol (2001) 4.10
Characterization of cDNAs encoding the polypyrimidine tract-binding protein. Genes Dev (1991) 3.55
Identification and characterization of a HeLa nuclear protein that specifically binds to the trans-activation-response (TAR) element of human immunodeficiency virus. Proc Natl Acad Sci U S A (1990) 2.92
Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro. RNA (1997) 2.43
Spliceosome-mediated RNA trans-splicing as a tool for gene therapy. Nat Biotechnol (1999) 2.32
A mutational analysis of the polypyrimidine tract of introns. Effects of sequence differences in pyrimidine tracts on splicing. J Biol Chem (1993) 2.02
Co-transcriptional splicing of pre-messenger RNAs: considerations for the mechanism of alternative splicing. Gene (2001) 2.02
SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome. RNA (1995) 2.02
Messenger RNA repair and restoration of protein function by spliceosome-mediated RNA trans-splicing. Mol Ther (2001) 1.84
The spliceosome assembly pathway in mammalian extracts. Mol Cell Biol (1992) 1.78
U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements. Nucleic Acids Res (1995) 1.77
Exon circularization in mammalian nuclear extracts. RNA (1996) 1.76
The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. Mol Cell Biol (2001) 1.64
An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing. Mol Cell Biol (1998) 1.64
RNA binding by Sxl proteins in vitro and in vivo. Mol Cell Biol (1994) 1.63
Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer. Oncogene (1997) 1.63
Murine polypyrimidine tract binding protein. Purification, cloning, and mapping of the RNA binding domain. J Biol Chem (1991) 1.37
Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II. Proc Natl Acad Sci U S A (2000) 1.36
CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription. Mol Cell Biol (1997) 1.36
Coupled in vitro synthesis and splicing of RNA polymerase II transcripts. RNA (2000) 1.29
Rapid effects of estrogen to modulate G protein-coupled receptors via activation of protein kinase A and protein kinase C pathways. Steroids (1999) 1.20
Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing. Gene Ther (2000) 1.10
Computed tomographic findings in cerebral sinus and venous thrombosis. Radiology (1981) 1.09
Three tumor-suppressor regions on chromosome 11p identified by high-resolution deletion mapping in human non-small-cell lung cancer. Proc Natl Acad Sci U S A (1994) 1.08
A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding. J Biol Chem (1998) 1.08
Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner. Mol Cell Biol (1999) 1.08
Unusual structure of the human immunodeficiency virus type 1 trans-activation response element. J Virol (1992) 1.07
Regulation of DNA replication in S phase nuclei by ATP and ADP pools. Proc Natl Acad Sci U S A (1979) 1.06
An ATP-independent U2 small nuclear ribonucleoprotein particle/precursor mRNA complex requires both splice sites and the polypyrimidine tract. Proc Natl Acad Sci U S A (1992) 1.03
Estrogen rapidly attenuates a GABAB response in hypothalamic neurons. Neuroendocrinology (1996) 1.00
Structural features of an RNA containing the CUGGGA loop of the human immunodeficiency virus type 1 trans-activation response element. Biochemistry (1993) 0.98
A small circular TAR RNA decoy specifically inhibits Tat-activated HIV-1 transcription. Nucleic Acids Res (1996) 0.95
Effect of human gamma interferon on yellow fever virus infection. Am J Trop Med Hyg (1988) 0.95
A novel isoform ratio switch of the polypyrimidine tract binding protein. Electrophoresis (1999) 0.95
Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p. J Biol Chem (1998) 0.93
The 5' and 3' splice sites come together via a three dimensional diffusion mechanism. Nucleic Acids Res (1996) 0.90
A mammalian activity required for the second step of pre-messenger RNA splicing. J Biol Chem (1995) 0.87
TAR RNA decoys inhibit tat-activated HIV-1 transcription after preinitiation complex formation. Nucleic Acids Res (1997) 0.86
The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-estradiol. Am J Physiol Endocrinol Metab (2013) 0.86
Structural features of the trans-activation response RNA element of equine infectious anemia virus. Biochemistry (1993) 0.84
A functional alternative splicing mutation in human tryptophan hydroxylase-2. Mol Psychiatry (2010) 0.83
Kappa opioid receptor-mediated regulation of prolactin and alpha-melanocyte-stimulating hormone secretion in male and female rats. Life Sci (1993) 0.82
Association of chromosome 11 locus D11S12 with histology, stage, and metastases in lung cancer. Cancer Detect Prev (1998) 0.82
Downregulation of mu-opioid receptor mRNA in the mediobasal hypothalamus of the female guinea pig following morphine treatment. Neurosci Lett (1996) 0.82
Canine cyclin T1 rescues equine infectious anemia virus tat trans-activation in human cells. Virology (2000) 0.82
Transection of the pancreas. J Comput Assist Tomogr (1982) 0.80
Sexual differences in kappa opioid receptor-mediated regulation of tuberoinfundibular dopaminergic neurons. Neuroendocrinology (1992) 0.80
gamma-Aminobutyric acid receptor-mediated regulation of periventricular-hypophysial dopaminergic neurons: possible role in mediating stress- and 5-hydroxytryptamine-induced decreases in neuronal activity. J Pharmacol Exp Ther (1994) 0.80
Expression analysis and mapping of the mouse and human transcriptional regulator CA150. Mamm Genome (2000) 0.78
Biopharmaceutical approaches for developing and assessing oral peptide delivery strategies and systems: in vitro permeability and in vivo oral absorption of salmon calcitonin (sCT). Pharm Res (1999) 0.78
Gonadal steroids differentially modulate the actions of orphanin FQ/nociceptin at a physiologically relevant circuit controlling female sexual receptivity. J Neuroendocrinol (2014) 0.78
Prespliceosome and spliceosome isolation and analysis. Methods Mol Biol (1999) 0.77
The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function. RNA (2000) 0.77
Regional oral absorption, hepatic first-pass effect, and non-linear disposition of salmon calcitonin in beagle dogs. Eur J Pharm Biopharm (2000) 0.77
Human immunodeficiency virus type 1 Tat-dependent activation of an arrested RNA polymerase II elongation complex. Virology (1999) 0.77
Effects of immunoneutralization of dynorphin1-17 and dynorphin1-8 on the activity of central dopaminergic neurons in the male rat. Brain Res (1992) 0.76
Equilibrium vapor pressure of mercury from dental amalgam in vitro. Dent Mater (1996) 0.75
Renal arterial encasement: an unusual cause. Cardiovasc Intervent Radiol (1982) 0.75
Case report 230: camptomelic syndrome. Skeletal Radiol (1983) 0.75
Radiological case of the month. Bronchogenic cyst. Md State Med J (1980) 0.75
CT-angiographic correlation in Sturge-Weber syndrome. J Comput Tomogr (1981) 0.75