Published in J Biol Chem on January 04, 2001
Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev (2005) 5.69
Clostridial glucosylating toxins enter cells via clathrin-mediated endocytosis. PLoS One (2010) 1.47
Structural organization of the functional domains of Clostridium difficile toxins A and B. Proc Natl Acad Sci U S A (2010) 1.44
Identification of an Essential Region for Translocation of Clostridium difficile Toxin B. Toxins (Basel) (2016) 1.40
Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A. J Biol Chem (2009) 1.39
Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A. Proc Natl Acad Sci U S A (2005) 1.35
Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism. PLoS Pathog (2012) 1.34
Variations in TcdB activity and the hypervirulence of emerging strains of Clostridium difficile. PLoS Pathog (2010) 1.26
Toward a structural understanding of Clostridium difficile toxins A and B. Front Cell Infect Microbiol (2012) 1.22
Inositol hexakisphosphate-induced autoprocessing of large bacterial protein toxins. PLoS Pathog (2010) 1.17
Transport capabilities of eleven gram-positive bacteria: comparative genomic analyses. Biochim Biophys Acta (2007) 1.14
A novel approach to generate a recombinant toxoid vaccine against Clostridium difficile. Microbiology (2013) 1.02
Structural determinants of Clostridium difficile toxin A glucosyltransferase activity. J Biol Chem (2012) 0.99
Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity. Proc Natl Acad Sci U S A (2015) 0.97
TcdB from hypervirulent Clostridium difficile exhibits increased efficiency of autoprocessing. Mol Microbiol (2012) 0.93
Inositol hexakisphosphate-dependent processing of Clostridium sordellii lethal toxin and Clostridium novyi alpha-toxin. J Biol Chem (2011) 0.93
Targeting of the actin cytoskeleton by insecticidal toxins from Photorhabdus luminescens. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.93
Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore. Proc Natl Acad Sci U S A (2014) 0.92
Clostridium difficile infection: molecular pathogenesis and novel therapeutics. Expert Rev Anti Infect Ther (2014) 0.92
Cytotoxicity of Clostridium difficile toxin B does not require cysteine protease-mediated autocleavage and release of the glucosyltransferase domain into the host cell cytosol. Pathog Dis (2013) 0.90
pH-enhanced cytopathic effects of Clostridium sordellii lethal toxin. Infect Immun (2001) 0.89
Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis. Infect Immun (2009) 0.89
Clostridium difficile toxin A binds colonocyte Src causing dephosphorylation of focal adhesion kinase and paxillin. Exp Cell Res (2009) 0.88
Crystal structure of Clostridium difficile toxin A. Nat Microbiol (2016) 0.87
Mutational analysis of the enzymatic domain of Clostridium difficile toxin B reveals novel inhibitors of the wild-type toxin. Infect Immun (2003) 0.86
Critical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis. Infect Immun (2014) 0.86
Exposure of neutralizing epitopes in the carboxyl-terminal domain of TcdB is altered by a proximal hypervariable region. J Biol Chem (2015) 0.81
Development and optimization of a novel assay to measure neutralizing antibodies against Clostridium difficile toxins. Clin Vaccine Immunol (2013) 0.80
Autoproteolytic activation of bacterial toxins. Toxins (Basel) (2010) 0.79
The Role of Rho GTPases in Toxicity of Clostridium difficile Toxins. Toxins (Basel) (2015) 0.77
Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects. Toxins (Basel) (2016) 0.77
Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B. Toxins (Basel) (2016) 0.77
SERS nanosensors that report pH of endocytic compartments during FcεRI transit. Anal Bioanal Chem (2010) 0.77
Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis. PLoS Pathog (2016) 0.76
Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in Endothelial Cells. mSphere (2015) 0.75
Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells. Sci Rep (2017) 0.75
Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities. Infect Immun (2016) 0.75
Recombinant Mucin-Type Fusion Proteins with a Galα1,3Gal Substitution as Clostridium difficile Toxin A Inhibitors. Infect Immun (2016) 0.75
Live Cells as Dynamic Laboratories: Time Lapse Raman Spectral Microscopy of Nanoparticles with Both IgE Targeting and pH-Sensing Functions. Int J Anal Chem (2012) 0.75
Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB. Front Cell Infect Microbiol (2017) 0.75
Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue. J Struct Biol (2017) 0.75
Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature (1995) 6.08
Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature (2003) 5.84
A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell (1998) 5.78
A family of hyperpolarization-activated mammalian cation channels. Nature (1998) 4.97
Microinjection of recombinant p21rho induces rapid changes in cell morphology. J Cell Biol (1990) 4.83
Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J Exp Med (1995) 4.57
Formation of large, ion-permeable membrane channels by the matrix protein (porin) of Escherichia coli. Biochim Biophys Acta (1978) 4.55
The naming of voltage-gated calcium channels. Neuron (1994) 4.31
Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli. Biochemistry (1999) 3.88
Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature (1991) 3.77
Ionic selectivity of pores formed by the matrix protein (porin) of Escherichia coli. Biochim Biophys Acta (1979) 3.72
Electrical capacity of black lipid films and of lipid bilayers made from monolayers. Biochim Biophys Acta (1975) 3.65
Properties of the large ion-permeable pores formed from protein F of Pseudomonas aeruginosa in lipid bilayer membranes. Biochim Biophys Acta (1981) 3.65
High resolution cosmid and P1 maps spanning the 14 Mb genome of the fission yeast S. pombe. Cell (1993) 3.56
Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1. Nature (1997) 3.53
Botulinum C2 toxin ADP-ribosylates actin. Nature (1986) 3.16
Nomenclature of voltage-gated sodium channels. Neuron (2000) 3.10
Nomenclature of voltage-gated calcium channels. Neuron (2000) 3.09
The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins. J Biol Chem (1995) 3.02
Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science (1996) 3.01
The roles of the subunits in the function of the calcium channel. Science (1991) 2.97
Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. Proc Natl Acad Sci U S A (2004) 2.97
Defective smooth muscle regulation in cGMP kinase I-deficient mice. EMBO J (1998) 2.96
Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Nat Cell Biol (2001) 2.94
On the mechanism of beta-adrenergic regulation of the Ca channel in the guinea-pig heart. Pflugers Arch (1985) 2.93
Ion selectivity of gram-negative bacterial porins. J Bacteriol (1985) 2.87
Serum antibodies to L-type calcium channels in patients with amyotrophic lateral sclerosis. N Engl J Med (1992) 2.86
The N-terminal domain of Pseudomonas aeruginosa exoenzyme S is a GTPase-activating protein for Rho GTPases. J Biol Chem (1999) 2.78
Outer membrane protein P of Pseudomonas aeruginosa: regulation by phosphate deficiency and formation of small anion-specific channels in lipid bilayer membranes. J Bacteriol (1982) 2.73
Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O. Proc Natl Acad Sci U S A (2001) 2.67
The preprotein translocation channel of the outer membrane of mitochondria. Cell (1998) 2.65
GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure. Mol Microbiol (2000) 2.56
Reversible electrical breakdown of lipid bilayer membranes: a charge-pulse relaxation study. J Membr Biol (1979) 2.52
Two pacemaker channels from human heart with profoundly different activation kinetics. EMBO J (1999) 2.51
Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. Eur J Biochem (2001) 2.47
Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. Proc Natl Acad Sci U S A (1999) 2.46
New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis. Nat Genet (2001) 2.44
Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel. Nature (1986) 2.41
Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization. Am J Pathol (2000) 2.41
Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle. Science (1989) 2.40
The resealing process of lipid bilayers after reversible electrical breakdown. Biochim Biophys Acta (1981) 2.35
Dual function of protein confinement in chaperonin-assisted protein folding. Cell (2001) 2.33
Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current. Nature (1982) 2.33
The repeat domain of Escherichia coli haemolysin (HlyA) is responsible for its Ca2+-dependent binding to erythrocytes. Mol Gen Genet (1988) 2.29
Voltage-dependent depolarization of bacterial membranes and artificial lipid bilayers by the peptide antibiotic nisin. Arch Microbiol (1987) 2.26
Deamidation of Cdc42 and Rac by Escherichia coli cytotoxic necrotizing factor 1: activation of c-Jun N-terminal kinase in HeLa cells. Infect Immun (1999) 2.26
Modulation of Ca current during the phosphorylation cycle in the guinea pig heart. Pflugers Arch (1986) 2.26
Chaperonin-mediated protein folding: GroES binds to one end of the GroEL cylinder, which accommodates the protein substrate within its central cavity. EMBO J (1992) 2.20
Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta. Nature (2000) 2.17
Mode of action of the staphylococcinlike peptide Pep 5: voltage-dependent depolarization of bacterial and artificial membranes. J Bacteriol (1988) 2.10
Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse. J Biol Chem (2000) 2.09
Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel. Nature (1991) 2.09
Clostridium difficile toxin B acts on the GTP-binding protein Rho. J Biol Chem (1994) 2.09
A giant protease with potential to substitute for some functions of the proteasome. Science (1999) 2.08
Primary structure and functional expression of a high voltage activated calcium channel from rabbit lung. FEBS Lett (1990) 2.08
A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins. J Biol Chem (1998) 2.08
Determination of ion permeability through the channels made of porins from the outer membrane of Salmonella typhimurium in lipid bilayer membranes. J Membr Biol (1980) 2.07
Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells. EMBO J (1995) 2.06
Regional expression and cellular localization of the alpha1 and beta subunit of high voltage-activated calcium channels in rat brain. J Neurosci (1997) 2.05
Comparison of adenosine 3':5'-monophosphate-dependent protein kinases from rabbit skeletal and bovine heart muscle. J Biol Chem (1975) 2.03
Pore formation by LamB of Escherichia coli in lipid bilayer membranes. J Bacteriol (1986) 2.02
Porin from bacterial and mitochondrial outer membranes. CRC Crit Rev Biochem (1985) 2.02
Temporally controlled somatic mutagenesis in smooth muscle. Genesis (2000) 2.01
Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. J Cell Biol (2000) 1.94
Calcium channel beta subunit heterogeneity: functional expression of cloned cDNA from heart, aorta and brain. EMBO J (1992) 1.92
Conversion of the FhuA transport protein into a diffusion channel through the outer membrane of Escherichia coli. EMBO J (1993) 1.89
The multicatalytic proteinase (prosome) is ubiquitous from eukaryotes to archaebacteria. FEBS Lett (1989) 1.89
Isolation of Neisseria meningitidis mutants deficient in class 1 (porA) and class 3 (porB) outer membrane proteins. Infect Immun (1990) 1.87
Receptor for bacteriophage lambda of Escherichia coli forms larger pores in black lipid membranes than the matrix protein (porin). J Bacteriol (1979) 1.86
Clostridium perfringens iota toxin ADP-ribosylates skeletal muscle actin in Arg-177. FEBS Lett (1987) 1.85
Cloning of the mspA gene encoding a porin from Mycobacterium smegmatis. Mol Microbiol (1999) 1.84
Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of the holotoxin. J Biol Chem (1997) 1.83
Differential distribution of four hyperpolarization-activated cation channels in mouse brain. Biol Chem (1999) 1.82
The amino-terminal domain of Pseudomonas aeruginosa ExoS disrupts actin filaments via small-molecular-weight GTP-binding proteins. Mol Microbiol (1999) 1.81
Relaxation studies of ion transport systems in lipid bilayer membranes. Q Rev Biophys (1981) 1.81
The ATP-dependent HslVU protease from Escherichia coli is a four-ring structure resembling the proteasome. Nat Struct Biol (1997) 1.81
Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein. Infect Immun (2000) 1.78
Improving prevention systems in primary care practices: the Health Education and Research Trial (HEART) J Fam Pract (2000) 1.78
Pore-forming activity of the Tsx protein from the outer membrane of Escherichia coli. Demonstration of a nucleoside-specific binding site. J Biol Chem (1988) 1.72
The rate constants of valinomycin-mediated ion transport through thin lipid membranes. Biophys J (1971) 1.71
Voltage-induce capacitance relaxation of lipid bilayer membranes. Effects of membrane composition. Biochim Biophys Acta (1976) 1.71
Transmission of hepatitis C virus from a patient to an anesthesiology assistant to five patients. N Engl J Med (2000) 1.67
Concentrations of cyclic AMP-dependent protein kinase subunits in various tissues. J Biol Chem (1977) 1.67
Permeability of the cell wall of Mycobacterium smegmatis. Mol Microbiol (1994) 1.66
Molecular diversity of the calcium channel alpha2delta subunit. J Neurosci (1999) 1.63
Transport kinetics of hydrophobic ions in lipid bilayer membranes. Charge-pulse relaxation studies. Biochim Biophys Acta (1976) 1.62
Structure and function of cyclic nucleotide-gated channels. Rev Physiol Biochem Pharmacol (1999) 1.59
How do protons cross the membrane-solution interface? Kinetic studies on bilayer membranes exposed to the protonophore S-13 (5-chloro-3-tert-butyl-2'-chloro-4' nitrosalicylanilide). J Membr Biol (1987) 1.59
An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons. Proc Natl Acad Sci U S A (1998) 1.57
LcrV is a channel size-determining component of the Yop effector translocon of Yersinia. Mol Microbiol (2001) 1.56
Soluble guanylate cyclase purified from bovine lung contains heme and copper. FEBS Lett (1981) 1.55
Analysis of the SlyA-controlled expression, subcellular localization and pore-forming activity of a 34 kDa haemolysin (ClyA) from Escherichia coli K-12. Mol Microbiol (1999) 1.55
The peptide antibiotic subtilin acts by formation of voltage-dependent multi-state pores in bacterial and artificial membranes. Eur J Biochem (1989) 1.54
Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification. J Biol Chem (2000) 1.54