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P Tempst

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 SNAP receptors implicated in vesicle targeting and fusion. Nature 1993 18.57
2 Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol 2001 9.82
3 Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 1994 9.48
4 Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell 1990 9.24
5 A cellular gene encodes scrapie PrP 27-30 protein. Cell 1985 8.86
6 RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 1994 8.71
7 Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev 1999 7.58
8 Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 1998 6.79
9 DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell 1991 6.63
10 RSC, an essential, abundant chromatin-remodeling complex. Cell 1996 6.17
11 Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell 1997 5.83
12 MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet 1999 5.61
13 Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science 2001 5.25
14 COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 2001 5.19
15 Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol Cell 2001 5.04
16 The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell 1997 4.99
17 A human telomeric protein. Science 1995 4.77
18 Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature 1993 4.68
19 Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem 1999 4.56
20 Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell 1999 4.49
21 A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell 1994 4.47
22 Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature 1999 4.40
23 Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci U S A 1992 4.32
24 Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev 1991 4.28
25 I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell 1995 3.95
26 A Drosophila Polycomb group complex includes Zeste and dTAFII proteins. Nature 2001 3.90
27 A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol Cell 1999 3.80
28 SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell 1998 3.76
29 Rel-associated pp40: an inhibitor of the rel family of transcription factors. Science 1991 3.76
30 Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis. J Chromatogr A 1998 3.64
31 Cloning and characterization of PSF, a novel pre-mRNA splicing factor. Genes Dev 1993 3.63
32 Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits. EMBO J 1992 3.33
33 Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. Nature 1996 3.29
34 Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Proc Natl Acad Sci U S A 1998 3.18
35 A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J 2000 3.11
36 The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 1997 3.03
37 FK506 binding protein associated with the calcium release channel (ryanodine receptor). J Biol Chem 1992 3.02
38 The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev 1998 2.91
39 Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. Proc Natl Acad Sci U S A 1991 2.89
40 Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 2002 2.89
41 Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr Biol 1999 2.76
42 Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains. Mol Cell 1999 2.76
43 The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor. Mol Cell Biol 1994 2.71
44 Immobilized gallium(III) affinity chromatography of phosphopeptides. Anal Chem 1999 2.70
45 A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes Dev 1998 2.63
46 The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A 1993 2.63
47 A novel Rad24 checkpoint protein complex closely related to replication factor C. Curr Biol 2000 2.59
48 Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha. Nucleic Acids Res 1994 2.58
49 Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem 2000 2.47
50 Protein folding in the central cavity of the GroEL-GroES chaperonin complex. Nature 1996 2.46
51 PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol 2001 2.39
52 A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control. Mol Cell 2001 2.30
53 An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding. Proc Natl Acad Sci U S A 1995 2.26
54 Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. J Biol Chem 1997 2.17
55 Interleukin-3 signals through multiple isoforms of Stat5. EMBO J 1995 2.12
56 HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc Natl Acad Sci U S A 2008 2.10
57 Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). Mol Cell Biol 2002 2.06
58 Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. Cell 1999 2.04
59 An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells. Mol Cell Biol 2000 1.97
60 Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates. Proc Natl Acad Sci U S A 2001 1.93
61 Apidaecins: antibacterial peptides from honeybees. EMBO J 1989 1.90
62 Two actin-related proteins are shared functional components of the chromatin-remodeling complexes RSC and SWI/SNF. Mol Cell 1998 1.88
63 Purification of bovine bone morphogenetic protein by hydroxyapatite chromatography. Proc Natl Acad Sci U S A 1984 1.86
64 Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase. Proc Natl Acad Sci U S A 1997 1.78
65 Tuning of an electrospray ionization source for maximum peptide-ion transmission into a mass spectrometer. Anal Chem 2000 1.77
66 Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. J Biol Chem 1999 1.75
67 A v-SNARE implicated in intra-Golgi transport. J Cell Biol 1996 1.70
68 Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol Cell 2002 1.69
69 A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK. Science 1996 1.68
70 Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity. J Biol Chem 1999 1.67
71 Molecular cloning and characterization of the ryanodine receptor/junctional channel complex cDNA from skeletal muscle sarcoplasmic reticulum. Proc Natl Acad Sci U S A 1989 1.67
72 The Oms66 (p66) protein is a Borrelia burgdorferi porin. Infect Immun 1997 1.65
73 RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes. J Biol Chem 2001 1.65
74 Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction. J Biol Chem 2001 1.63
75 Requirement of a corepressor for Dr1-mediated repression of transcription. Genes Dev 1996 1.62
76 Functional and chemical characterization of Hymenoptaecin, an antibacterial polypeptide that is infection-inducible in the honeybee (Apis mellifera). J Biol Chem 1993 1.57
77 Co-translational domain folding as the structural basis for the rapid de novo folding of firefly luciferase. Nat Struct Biol 1999 1.54
78 Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching. Proc Natl Acad Sci U S A 1999 1.53
79 FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. J Cell Sci 2001 1.52
80 Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection. Infect Immun 1998 1.48
81 A microchemical facility for the analysis and synthesis of genes and proteins. Nature 1984 1.47
82 Identification of nucleotide-binding regions in the chaperonin proteins GroEL and GroES. Nature 1993 1.46
83 Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera). Eur J Biochem 1990 1.46
84 Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro. J Biol Chem 1997 1.43
85 Porin activity and sequence analysis of a 31-kilodalton Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp1). J Bacteriol 1995 1.41
86 Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide. Proc Natl Acad Sci U S A 1999 1.40
87 Methodical analysis of protein-nitrocellulose interactions to design a refined digestion protocol. Anal Biochem 1996 1.38
88 Apidaecin-type peptide antibiotics function through a non-poreforming mechanism involving stereospecificity. Biochem Biophys Res Commun 1994 1.36
89 Microbore reversed-phase high-performance liquid chromatographic purification of peptides for combined chemical sequencing-laser-desorption mass spectrometric analysis. J Chromatogr A 1994 1.34
90 Porin activity of the native and recombinant outer membrane protein Oms28 of Borrelia burgdorferi. J Bacteriol 1996 1.27
91 Activated ADP-ribosylation factor assembles distinct pools of actin on golgi membranes. J Biol Chem 2000 1.26
92 Detection of c-sis transcripts and synthesis of PDGF-like proteins by human osteosarcoma cells. Science 1984 1.26
93 T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity. EMBO J 2001 1.26
94 Induction of terminal differentiation in epithelial cells requires polymerization of hensin by galectin 3. J Cell Biol 2000 1.24
95 High-sensitivity sequencing of large proteins: partial structure of the rapamycin-FKBP12 target. Protein Sci 1994 1.24
96 Lethal effects of apidaecin on Escherichia coli involve sequential molecular interactions with diverse targets. J Biol Chem 1999 1.23
97 Acute transcriptional response of the honeybee peptide-antibiotics gene repertoire and required post-translational conversion of the precursor structures. J Biol Chem 1994 1.21
98 Identification of Rox3 as a component of mediator and RNA polymerase II holoenzyme. J Biol Chem 1997 1.21
99 Identification of CRKL as the constitutively phosphorylated 39-kD tyrosine phosphoprotein in chronic myelogenous leukemia cells. Blood 1994 1.20
100 ERS-24, a mammalian v-SNARE implicated in vesicle traffic between the ER and the Golgi. J Cell Biol 1997 1.17
101 Identification of a putative effector protein for rab11 that participates in transferrin recycling. Proc Natl Acad Sci U S A 1999 1.16
102 Biodiversity of apidaecin-type peptide antibiotics. Prospects of manipulating the antibacterial spectrum and combating acquired resistance. J Biol Chem 1994 1.15
103 Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros. J Clin Invest 1999 1.14
104 The Elp2 subunit of elongator and elongating RNA polymerase II holoenzyme is a WD40 repeat protein. J Biol Chem 2000 1.13
105 A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. Blood 1999 1.13
106 Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. J Biol Chem 1998 1.11
107 Helix pomatia lectin, an inducer of Drosophila immune response, binds to hemomucin, a novel surface mucin. J Biol Chem 1996 1.11
108 Sequence analysis and recombinant expression of a 28-kilodalton Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp2). J Bacteriol 1997 1.08
109 Photoaffinity labeling and mass spectrometry identify ribosomal protein S3 as a potential target for hybrid polar cytodifferentiation agents. J Biol Chem 1999 1.03
110 A multiprotein complex that interacts with RNA polymerase II elongator. J Biol Chem 2001 1.03
111 Surface topography analysis of the ryanodine receptor/junctional channel complex based on proteolysis sensitivity mapping. J Biol Chem 1990 1.02
112 The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme. Mol Cell Biol 2001 0.99
113 Aldehyde dehydrogenase is a positional marker in the retina. Development 1991 0.99
114 Apidaecin multipeptide precursor structure: a putative mechanism for amplification of the insect antibacterial response. EMBO J 1993 0.98
115 Primary structure of a molluscan egg-specific NADase, a second-messenger enzyme. Cell Regul 1991 0.98
116 Binding of defined regions of a polypeptide to GroEL and its implications for chaperonin-mediated protein folding. Nat Struct Biol 1995 0.96
117 Microscale structure analysis of a high-molecular-weight, hydrophobic membrane glycoprotein fraction with platelet-derived growth factor-dependent kinase activity. J Chromatogr 1986 0.95
118 A cell surface glycoprotein of rat basophilic leukemia cells close to the high affinity IgE receptor (Fc epsilon RI). Similarity to human melanoma differentiation antigen ME491. J Biol Chem 1991 0.94
119 Molecular cloning and characterization of (R)-3-hydroxybutyrate dehydrogenase from human heart. J Biol Chem 1992 0.93
120 Sequence analysis and characterization of a 40-kilodalton Borrelia hermsii glycerophosphodiester phosphodiesterase homolog. J Bacteriol 1997 0.93
121 Cyclin A-dependent phosphorylation of the ETS-related protein, MEF, restricts its activity to the G1 phase of the cell cycle. J Biol Chem 2001 0.92
122 Isolation and characterization of a corticotropin-releasing hormone-like peptide from human placenta. J Clin Endocrinol Metab 1988 0.90
123 DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma-membrane recruitment and endocytosis upon cell stimulation. Curr Biol 2000 0.90
124 Smooth muscle and brain inositol 1,4,5-trisphosphate receptors are structurally and functionally similar. J Biol Chem 1990 0.90
125 InJection adaptable fine ionization source ('JaFIS') for continuous flow nano-electrospray. Rapid Commun Mass Spectrom 1998 0.89
126 Prevention of experimental autoimmune arthritis with a peptide fragment of type II collagen. Eur J Immunol 1993 0.89
127 Distinct temporal patterns of defensin mRNA regulation during drug-induced differentiation of human myeloid leukemia cells. Blood 1996 0.89
128 Components of the protein synthesis and folding machinery are induced in vascular smooth muscle cells by hypertrophic and hyperplastic agents. Identification by comparative protein phenotyping and microsequencing. J Biol Chem 1995 0.88
129 Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei. J Biol Chem 2000 0.88
130 A glutathione S-transferase (GST) isozyme from broccoli with significant sequence homology to the mammalian theta-class of GSTs. Biochim Biophys Acta 1994 0.88
131 Single active-site histidine in D-xylose isomerase from Streptomyces violaceoruber. Identification by chemical derivatization and peptide mapping. Biochem J 1989 0.87
132 Enzymatic digestion of proteins in solution. Curr Protoc Protein Sci 2001 0.83
133 Differentiation-stimulated activity binds an ETS-like, essential regulatory element in the human promyelocytic defensin-1 promoter. J Biol Chem 1998 0.82
134 Separation of peptides by reverse-phase high-performance liquid chromatography using propyl- and cyanopropylsilyl supports. Anal Biochem 1984 0.81
135 Metal coordination centres of class II cytochromes c. Eur J Biochem 1982 0.81
136 The complete amino-acid sequence of the low-spin class II cytochrome c-556 from Agrobacterium tumefaciens strain B2a. Eur J Biochem 1983 0.81
137 Cytochromes c-556 from three genetic races of Agrobacterium. Purification and comparison of their properties. Eur J Biochem 1980 0.80
138 Characterization of a mastoparan-stimulated nucleotidase from bovine brain. Biochem J 1991 0.80
139 Peptide selection by an MHC H-2Kb class I molecule devoid of the central anchor ("C") pocket. J Immunol 1998 0.78
140 MUC-6 mucin is a major component of "blood group substance" from human ovarian cyst fluid. Biochim Biophys Acta 2000 0.78
141 Secretogranin I/chromogranin B is a heparin-binding adhesive protein. J Neurochem 1992 0.78
142 Purification, microsequencing, and immunolocalization of p36, a new interferon-alpha-induced protein that is associated with human lupus inclusions. J Biol Chem 1996 0.78
143 Metal chelates as reversible stains for detection of electroblotted proteins: application to protein microsequencing and immunoblotting. Anal Biochem 1994 0.77
144 A calcium-activated protease from Alzheimer's disease brain cleaves at the N-terminus of the amyloid beta-protein. Biochem Biophys Res Commun 1991 0.76
145 Identification and cloning of yeast phosphofructokinase 2. Eur J Biochem 1991 0.75
146 Strategies for handling polypeptides on a microscale. Methods Mol Biol 1997 0.75
147 Enhancing spot detection and reducing noise from digitized electrophoretic gel images using area processing filters. Electrophoresis 1993 0.75
148 A C-terminal haem-bound cytochrome c-556 from Agrobacterium tumefaciens, strain B-2a. Amino acid composition and N-terminal sequence analysis. FEBS Lett 1979 0.75
149 The amino acid sequence of cytochrome c-556 from Agrobacterium tumefaciens strain Apple 185. Eur J Biochem 1983 0.75
150 Sequence of the haem-binding region of cytochrome c-556 from Agrobacterium tumefaciens, strain B2a [proceedings]. Arch Int Physiol Biochim 1979 0.75
151 Drug-activated multiple pathways of defensin mRNA regulation in HL-60 cells are defined by reversed roles of participating protein kinases. Leuk Res 1998 0.75
152 [The coding according molecular mass of synthetic biomarkers under comprehensive testing of urine components: horizons of disease monitoring]. Klin Lab Diagn 2014 0.75
153 Regulation of post-Golgi vesicle production in an in vitro system. Cold Spring Harb Symp Quant Biol 1995 0.75
154 Characterizing proteins from 2-DE gels by internal sequence analysis of peptide fragments. Strategies for microsample handling. Methods Mol Biol 1999 0.75
155 Microflow-based automated chemistries: application to protein sequencing. Anal Chem 2001 0.75
156 Facile and sensitive assay for monitoring proteolytic activities with defined specificities: studies on amyloid beta-protein processing in Alzheimer's disease. Pept Res 1992 0.75