Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB.

PubWeight™: 3.29‹?› | Rank: Top 1%

🔗 View Article (PMID 8805703)

Published in Nature on September 19, 1996

Authors

M Ono1, S Bolland, P Tempst, J V Ravetch

Author Affiliations

1: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York 10021, USA.

Articles citing this

(truncated to the top 100)

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes Dev (1998) 3.40

Regulation of immune responses by mTOR. Annu Rev Immunol (2011) 3.08

PD-1 signaling in primary T cells. Immunol Rev (2009) 2.66

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci U S A (1998) 2.46

FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications. Nat Rev Immunol (2010) 2.44

Negative signaling by inhibitory receptors: the NK cell paradigm. Immunol Rev (2008) 2.40

The B-cell receptor signaling pathway as a therapeutic target in CLL. Blood (2012) 2.39

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation. EMBO J (1998) 2.36

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev (1999) 2.31

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J (1998) 2.29

Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med (1999) 2.23

A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Proc Natl Acad Sci U S A (1997) 2.11

A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med (1997) 2.05

The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci U S A (1998) 1.98

Fc receptors and their role in immune regulation and autoimmunity. J Clin Immunol (2005) 1.94

Deletion of fcgamma receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis. J Exp Med (1999) 1.92

The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. J Exp Med (1998) 1.88

Human FcγRIIA induces anaphylactic and allergic reactions. Blood (2011) 1.86

Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J Exp Med (1997) 1.85

Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE. J Exp Med (2006) 1.81

Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. Mol Cell Biol (2000) 1.68

Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma. Curr Mol Med (2008) 1.64

Calcium signalling and cell-fate choice in B cells. Nat Rev Immunol (2007) 1.64

Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG. J Exp Med (1999) 1.56

The inhibitory potential of Fc receptor homolog 4 on memory B cells. Proc Natl Acad Sci U S A (2003) 1.53

Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus. J Immunol (2007) 1.47

A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals. J Exp Med (1998) 1.43

A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice. J Exp Med (2000) 1.42

Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal. J Exp Med (1998) 1.41

Fcgamma receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: a novel murine model for autoimmune glomerular basement membrane disease. J Exp Med (2000) 1.39

CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. Mol Cell Biol (2006) 1.35

Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP). J Exp Med (2000) 1.34

Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity. Mol Cell Biol (2001) 1.32

5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells. Mol Cell Biol (2000) 1.31

Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity. J Exp Med (2002) 1.29

Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity (2011) 1.27

Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk. J Exp Med (2003) 1.25

Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells. EMBO J (1998) 1.25

Inhibitor and activator: dual functions for SHIP in immunity and cancer. Ann N Y Acad Sci (2010) 1.25

Antibody-mediated modulation of Cryptococcus neoformans infection is dependent on distinct Fc receptor functions and IgG subclasses. J Exp Med (1998) 1.24

Neisseria gonorrhoeae kills carcinoembryonic antigen-related cellular adhesion molecule 1 (CD66a)-expressing human B cells and inhibits antibody production. Infect Immun (2005) 1.24

T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses. Proc Natl Acad Sci U S A (2007) 1.23

A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation. Nat Med (2002) 1.21

The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1. Proc Natl Acad Sci U S A (1998) 1.20

A regulatory role for Src homology 2 domain-containing inositol 5'-phosphatase (SHIP) in phagocytosis mediated by Fc gamma receptors and complement receptor 3 (alpha(M)beta(2); CD11b/CD18). J Exp Med (2001) 1.20

Negative regulation of Fc epsilon RI-mediated degranulation by CD81. J Exp Med (1997) 1.18

Inhibitory receptors alter natural killer cell interactions with target cells yet allow simultaneous killing of susceptible targets. J Exp Med (1999) 1.17

SHIP limits immunoregulatory capacity in the T-cell compartment. Blood (2009) 1.15

Altered responsiveness to chemokines due to targeted disruption of SHIP. J Clin Invest (1999) 1.14

Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. PLoS Pathog (2014) 1.11

Differential roles for the inositol phosphatase SHIP in the regulation of macrophages and lymphocytes. Immunol Res (2009) 1.10

Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes. J Exp Med (1997) 1.08

Recruitment and phosphorylation of SH2-containing inositol phosphatase and Shc to the B-cell Fc gamma immunoreceptor tyrosine-based inhibition motif peptide motif. Mol Cell Biol (1997) 1.06

What goes up must come down: the emerging spectrum of inhibitory receptors. J Exp Med (1997) 1.03

Phosphoinositide phosphatases in a network of signalling reactions. Pflugers Arch (2007) 1.03

SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. J Exp Med (1999) 1.03

Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice. J Exp Med (2001) 1.02

Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung. J Allergy Clin Immunol (2006) 1.02

Distribution of the src-homology-2-domain-containing inositol 5-phosphatase SHIP-2 in both non-haemopoietic and haemopoietic cells and possible involvement of SHIP-2 in negative signalling of B-cells. Biochem J (1999) 1.00

Role of activatory Fc gamma RI and Fc gamma RIII and inhibitory Fc gamma RII in inflammation and cartilage destruction during experimental antigen-induced arthritis. Am J Pathol (2001) 1.00

Role of Fc gamma receptors in triggering host cell activation and cytokine release by Borrelia burgdorferi. Infect Immun (2001) 1.00

Negative signaling pathways of the killer cell inhibitory receptor and Fc gamma RIIb1 require distinct phosphatases. J Exp Med (1997) 0.99

The role of complement in the acquired immune response. Immunology (2000) 0.98

Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies. Front Immunol (2014) 0.98

An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. Nat Immunol (2010) 0.96

Inhibitory receptors abound? Proc Natl Acad Sci U S A (1997) 0.96

Antitumor activities of agonistic anti-TNFR antibodies require differential FcγRIIB coengagement in vivo. Proc Natl Acad Sci U S A (2013) 0.96

Visualization of negative signaling in B cells by quantitative confocal microscopy. Mol Cell Biol (2001) 0.96

Insulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of insulin receptor substrate expression. Mol Cell Biol (1999) 0.95

Differential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62. J Exp Med (1997) 0.95

The Role of FcRn in Antigen Presentation. Front Immunol (2014) 0.93

The IgG Fc receptor, FcgammaRIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma. Proc Natl Acad Sci U S A (2000) 0.93

FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation. Blood (2008) 0.93

Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3. Mol Cell Biol (2004) 0.92

Essential role for the C-terminal noncatalytic region of SHIP in FcgammaRIIB1-mediated inhibitory signaling. Mol Cell Biol (2000) 0.92

SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and phosphatidylinositol 3-kinase. Mol Cell Biol (1997) 0.91

FcR-like 2 Inhibition of B cell receptor-mediated activation of B cells. J Immunol (2010) 0.90

The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling. Front Immunol (2012) 0.90

The other side of immunoglobulin G: suppressor of inflammation. Clin Exp Immunol (2009) 0.89

FcgammaR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways. Blood (2006) 0.89

Inositol phospholipid signaling and the biology of natural killer cells. J Innate Immun (2011) 0.89

pp60c-src associates with the SH2-containing inositol-5-phosphatase SHIP1 and is involved in its tyrosine phosphorylation downstream of alphaIIbbeta3 integrin in human platelets. Biochem J (2000) 0.87

Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling. Immunol Rev (2015) 0.87

Mast cells and company. Front Immunol (2012) 0.87

Toll-like receptor 2 ligands regulate monocyte Fcγ receptor expression and function. J Biol Chem (2013) 0.87

Activation/Inhibition of mast cells by supra-optimal antigen concentrations. Cell Commun Signal (2013) 0.86

The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: potential molecular mechanisms. FEBS Lett (2010) 0.86

Genetics ignite focus on microglial inflammation in Alzheimer's disease. Mol Neurodegener (2015) 0.85

Regulation of hematopoietic cell function by inhibitory immunoglobulin G receptors and their inositol lipid phosphatase effectors. Immunol Rev (2008) 0.85

Chimeric human fcgamma-allergen fusion proteins in the prevention of allergy. Immunol Allergy Clin North Am (2007) 0.85

Role of inositol phospholipid signaling in natural killer cell biology. Front Immunol (2013) 0.85

Quorum sensing contributes to activated IgM-secreting B cell homeostasis. J Immunol (2012) 0.85

Intravenous immunoglobulin does not increase FcγRIIB expression levels on monocytes in children with immune thrombocytopenia. Clin Exp Immunol (2012) 0.84

Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome. J Leukoc Biol (2013) 0.84

Role of SHIP-1 in the adaptive immune responses to aeroallergen in the airway. PLoS One (2010) 0.84

FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling. Proc Natl Acad Sci U S A (2013) 0.83

Cross-presentation of IgG-containing immune complexes. Cell Mol Life Sci (2012) 0.83

Aberrant antibody affinity selection in SHIP-deficient B cells. Eur J Immunol (2012) 0.83

A role for SHIP in stem cell biology and transplantation. Curr Stem Cell Res Ther (2008) 0.83

Inhibition of the function of the FcgammaRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen. Immunology (2001) 0.82

Articles by these authors

SNAP receptors implicated in vesicle targeting and fusion. Nature (1993) 18.57

Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med (2000) 13.24

Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol (2001) 9.82

Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med (2001) 9.70

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell (1994) 9.48

Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell (1990) 9.24

Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature (1985) 9.18

A cellular gene encodes scrapie PrP 27-30 protein. Cell (1985) 8.86

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell (1994) 8.71

IgG Fc receptors. Annu Rev Immunol (2001) 8.63

FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell (1994) 7.66

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev (1999) 7.58

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science (1998) 6.79

DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell (1991) 6.63

RSC, an essential, abundant chromatin-remodeling complex. Cell (1996) 6.17

Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell (1997) 5.83

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet (1999) 5.61

Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science (2001) 5.25

Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature (1996) 5.25

COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A (2001) 5.19

Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol Cell (2001) 5.04

The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell (1997) 4.99

A human telomeric protein. Science (1995) 4.77

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature (1993) 4.68

Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor. Science (2001) 4.62

Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat Immunol (2000) 4.57

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem (1999) 4.56

Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell (1999) 4.49

A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell (1994) 4.47

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature (1999) 4.40

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci U S A (1992) 4.32

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev (1991) 4.28

Biochemical characterization of a gamma interferon-inducible cytokine (IP-10). J Exp Med (1987) 4.21

I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell (1995) 3.95

A Drosophila Polycomb group complex includes Zeste and dTAFII proteins. Nature (2001) 3.90

A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol Cell (1999) 3.80

SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell (1998) 3.76

Rel-associated pp40: an inhibitor of the rel family of transcription factors. Science (1991) 3.76

Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proc Natl Acad Sci U S A (1981) 3.73

Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis. J Chromatogr A (1998) 3.64

Cloning and characterization of PSF, a novel pre-mRNA splicing factor. Genes Dev (1993) 3.63

Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis. Immunity (2000) 3.55

Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits. EMBO J (1992) 3.33

Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Proc Natl Acad Sci U S A (1998) 3.18

A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J (2000) 3.11

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell (1997) 3.03

FK506 binding protein associated with the calcium release channel (ryanodine receptor). J Biol Chem (1992) 3.02

Human immunoglobulin D segments encoded in tandem multigenic families. Nature (1981) 2.99

Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science (1998) 2.95

Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. J Clin Invest (1983) 2.91

The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev (1998) 2.91

Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. Proc Natl Acad Sci U S A (1991) 2.89

Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science (2002) 2.89

Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors. Science (1986) 2.89

Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. Cell (1997) 2.77

Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr Biol (1999) 2.76

Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains. Mol Cell (1999) 2.76

The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor. Mol Cell Biol (1994) 2.71

Immobilized gallium(III) affinity chromatography of phosphopeptides. Anal Chem (1999) 2.70

A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes Dev (1998) 2.63

The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A (1993) 2.63

A novel Rad24 checkpoint protein complex closely related to replication factor C. Curr Biol (2000) 2.59

Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha. Nucleic Acids Res (1994) 2.58

Fc receptors are required in passive and active immunity to melanoma. Proc Natl Acad Sci U S A (1998) 2.50

Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem (2000) 2.47

A chromosomal rearrangement in a P. falciparum histidine-rich protein gene is associated with the knobless phenotype. Nature (1986) 2.46

Protein folding in the central cavity of the GroEL-GroES chaperonin complex. Nature (1996) 2.46

Genomic characterization of a gamma-interferon-inducible gene (IP-10) and identification of an interferon-inducible hypersensitive site. Mol Cell Biol (1987) 2.41

SHIP modulates immune receptor responses by regulating membrane association of Btk. Immunity (1998) 2.39

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol (2001) 2.39

A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control. Mol Cell (2001) 2.30

Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. J Clin Invest (1997) 2.29

An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding. Proc Natl Acad Sci U S A (1995) 2.26

Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med (1999) 2.23

Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. Science (1994) 2.18

Multiple immunoglobulin switch region homologies outside the heavy chain constant region locus. Nature (1981) 2.18

Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. J Biol Chem (1997) 2.17

Interleukin-3 signals through multiple isoforms of Stat5. EMBO J (1995) 2.12

Cloning and characterization of a mouse cysteine proteinase. J Biol Chem (1986) 2.12

A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signalling. Nature (1994) 2.11

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc Natl Acad Sci U S A (2008) 2.10

Large deletions result from breakage and healing of P. falciparum chromosomes. Cell (1988) 2.10

Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). Mol Cell Biol (2002) 2.06

Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. Cell (1999) 2.04

Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J Exp Med (1989) 2.01

Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3. Proc Natl Acad Sci U S A (1993) 1.99

An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells. Mol Cell Biol (2000) 1.97

Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates. Proc Natl Acad Sci U S A (2001) 1.93

Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements. Proc Natl Acad Sci U S A (1991) 1.93

Deletion of fcgamma receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis. J Exp Med (1999) 1.92

A single amino acid in the glycosyl phosphatidylinositol attachment domain determines the membrane topology of Fc gamma RIII. Nature (1989) 1.91

Apidaecins: antibacterial peptides from honeybees. EMBO J (1989) 1.90

Cytotoxic antibodies trigger inflammation through Fc receptors. Immunity (1995) 1.89

Two actin-related proteins are shared functional components of the chromatin-remodeling complexes RSC and SWI/SNF. Mol Cell (1998) 1.88

Purification of bovine bone morphogenetic protein by hydroxyapatite chromatography. Proc Natl Acad Sci U S A (1984) 1.86

Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice. J Exp Med (1996) 1.83

Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase. Proc Natl Acad Sci U S A (1997) 1.78

Tuning of an electrospray ionization source for maximum peptide-ion transmission into a mass spectrometer. Anal Chem (2000) 1.77

Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. J Biol Chem (1999) 1.75