Published in Acta Pharmacol Sin on August 09, 2010
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Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency. Autophagy (2015) 1.42
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Targeting autophagic pathways for cancer drug discovery. Chin J Cancer (2012) 0.91
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Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib. Autophagy (2014) 0.89
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Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway. Drug Des Devel Ther (2015) 0.86
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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell (2002) 11.65
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Regulation of translation initiation by FRAP/mTOR. Genes Dev (2001) 9.40
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Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol (2006) 9.17
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85
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Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol (2007) 8.29
The role of autophagy in cancer development and response to therapy. Nat Rev Cancer (2005) 8.18
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene (2004) 7.92
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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell (2005) 7.75
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The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol (2000) 7.48
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FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol (2008) 7.16
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell (2008) 7.14
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell (2007) 7.09
Autophagy as a cell death and tumor suppressor mechanism. Oncogene (2004) 6.92
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell (2008) 6.88
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci (2003) 6.50
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem (2009) 6.34
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Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol (2008) 5.52
Lysosomes and autophagy in cell death control. Nat Rev Cancer (2005) 5.47
Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem (2007) 5.21
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A (2004) 5.16
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res (2005) 5.07
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev (2004) 5.00
Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J Clin Invest (2008) 4.95
Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood (2007) 4.91
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Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol (2008) 4.47
siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem (2007) 4.33
The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem (2001) 4.14
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The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy (2005) 4.02
Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ (2006) 3.95
Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res (2005) 3.80
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Discovery and development of SAHA as an anticancer agent. Oncogene (2007) 3.58
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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci U S A (2001) 3.11
BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy (2007) 3.08
Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes. Traffic (2006) 2.98
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells. EMBO J (2009) 2.88
Stimulation of autophagy by the p53 target gene Sestrin2. Cell Cycle (2009) 2.72
Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae. Mol Biol Cell (2006) 2.63
Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy (2010) 2.62
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United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. Biochem Soc Trans (2003) 2.34
Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene (2005) 2.34
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem (2008) 2.31
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The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function. J Biol Chem (2008) 1.89
Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL. Autophagy (2009) 1.88
The anticancer drug imatinib induces cellular autophagy. Leukemia (2007) 1.84
Toward unraveling membrane biogenesis in mammalian autophagy. Curr Opin Cell Biol (2008) 1.83
Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability. Oncogene (2004) 1.77
Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains. Oncogene (1999) 1.76
Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells. Cell Death Differ (2000) 1.64
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Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol (2005) 6.47
Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial. Lancet Neurol (2008) 5.40
A high-throughput method to monitor the expression of microRNA precursors. Nucleic Acids Res (2004) 5.21
5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity. Bioorg Med Chem (2003) 3.13
Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization. Proc Natl Acad Sci U S A (2009) 2.59
Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem Pharmacol (2008) 2.56
Interactions among PIN-FORMED and P-glycoprotein auxin transporters in Arabidopsis. Plant Cell (2007) 2.52
Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain. Science (2010) 2.47
Circadian variation of blood pressure and the vascular response to asynchronous stress. Proc Natl Acad Sci U S A (2007) 2.39
The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. Mol Cell (2006) 2.24
eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206. Cancer Res (2011) 2.10
Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy (2009) 2.09
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Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study. Lancet Neurol (2008) 1.98
Elongation factor-2 kinase regulates autophagy in human glioblastoma cells. Cancer Res (2006) 1.89
A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A. Am J Med Genet A (2004) 1.79
Lower treatment blood pressure is associated with greatest reduction in hematoma growth after acute intracerebral hemorrhage. Hypertension (2010) 1.78
ABO3, a WRKY transcription factor, mediates plant responses to abscisic acid and drought tolerance in Arabidopsis. Plant J (2010) 1.74
ABCB19/PGP19 stabilises PIN1 in membrane microdomains in Arabidopsis. Plant J (2008) 1.74
Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells. Cancer Res (2003) 1.71
The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage. Cell Res (2012) 1.66
A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor. Blood (2014) 1.66
The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome. Blood (2011) 1.65
Suppressive oligodeoxynucleotides inhibit atherosclerosis in ApoE(-/-) mice through modulation of Th1/Th2 balance. J Mol Cell Cardiol (2008) 1.63
Genetic components of the circadian clock regulate thrombogenesis in vivo. Circulation (2008) 1.62
In vitro corrosion and biocompatibility of binary magnesium alloys. Biomaterials (2008) 1.62
Effect of stathmin on the sensitivity to antimicrotubule drugs in human breast cancer. Cancer Res (2002) 1.56
Circulating microRNAs: novel biomarkers for cardiovascular diseases. J Mol Med (Berl) (2011) 1.54
Exogenous silicon (Si) increases antioxidant enzyme activity and reduces lipid peroxidation in roots of salt-stressed barley (Hordeum vulgare L.). J Plant Physiol (2003) 1.53
Plant phenomics and high-throughput phenotyping: accelerating rice functional genomics using multidisciplinary technologies. Curr Opin Plant Biol (2013) 1.52
Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer. Clin Cancer Res (2011) 1.51
Viral quasi-species evolution during hepatitis Be antigen seroconversion. Gastroenterology (2007) 1.50
Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug. Blood (2010) 1.48
The Th17/Treg functional imbalance during atherogenesis in ApoE(-/-) mice. Cytokine (2009) 1.48
Transcription-dependent degradation of topoisomerase I-DNA covalent complexes. Mol Cell Biol (2003) 1.43
Reverse-phase protein array analysis to identify biomarker proteins in human pancreatic cancer. Dig Dis Sci (2013) 1.43
Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagy. Cancer Res (2009) 1.42
Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proc Natl Acad Sci U S A (2009) 1.41
RTE1 is a Golgi-associated and ETR1-dependent negative regulator of ethylene responses. Plant Physiol (2007) 1.39
Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma. J Transl Med (2011) 1.38
Identification of metastasis-associated proteins involved in gallbladder carcinoma metastasis by proteomic analysis and functional exploration of chloride intracellular channel 1. Cancer Lett (2009) 1.38
COX-2-derived prostacyclin modulates vascular remodeling. Circ Res (2005) 1.37
Microautophagy: lesser-known self-eating. Cell Mol Life Sci (2011) 1.35
MicroRNA-modulated autophagic signaling networks in cancer. Int J Biochem Cell Biol (2012) 1.35
Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action. Mol Cancer (2009) 1.35
Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway. Carcinogenesis (2009) 1.35
Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells. Hepatology (2012) 1.34
Receptor signal output mediated by the ETR1 N terminus is primarily subfamily I receptor dependent. Plant Physiol (2006) 1.34
Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration. Cytotechnology (2009) 1.34
MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis. Mol Cancer Ther (2011) 1.33
Temporal lobe epilepsy induces differential expression of hippocampal miRNAs including let-7e and miR-23a/b. Brain Res (2011) 1.33
Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res (2003) 1.33
Health care in China: improvement, challenges, and reform. Chest (2013) 1.31
Reversal of stathmin-mediated resistance to paclitaxel and vinblastine in human breast carcinoma cells. Mol Pharmacol (2007) 1.29
IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites. J Immunol (2005) 1.29
Hyaluronan and CD44 antagonize mitogen-dependent cyclin D1 expression in mesenchymal cells. J Cell Biol (2007) 1.25
Therapeutic targeting of autophagy in disease: biology and pharmacology. Pharmacol Rev (2013) 1.25
Requirements for the development of IL-4-producing T cells during intestinal nematode infections: what it takes to make a Th2 cell in vivo. Immunol Rev (2004) 1.24
Transposons inactivate biosynthesis of the nonribosomal peptide microcystin in naturally occurring Planktothrix spp. Appl Environ Microbiol (2006) 1.24
Tumor cell-microenvironment interaction models coupled with clinical validation reveal CCL2 and SNCG as two predictors of colorectal cancer hepatic metastasis. Clin Cancer Res (2009) 1.24
CADgene: a comprehensive database for coronary artery disease genes. Nucleic Acids Res (2010) 1.23
The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events. J Biol Chem (2007) 1.22
Hydrophilic Cu9S5 nanocrystals: a photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo. ACS Nano (2011) 1.21
Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signaling. Cytotechnology (2009) 1.21
Auxin minimum defines a developmental window for lateral root initiation. New Phytol (2011) 1.21
Upconversion luminescent materials: advances and applications. Chem Rev (2014) 1.19
Negative regulation of miR-145 by C/EBP-β through the Akt pathway in cancer cells. Nucleic Acids Res (2012) 1.19
The zebrafish Pard3 ortholog is required for separation of the eye fields and retinal lamination. Dev Biol (2004) 1.19
Regulation of the stability of P-glycoprotein by ubiquitination. Mol Pharmacol (2004) 1.19
Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway. Cancer Lett (2008) 1.19
Targeting apoptotic and autophagic pathways for cancer therapeutics. Cancer Lett (2010) 1.19
Controllable N-doping of graphene. Nano Lett (2010) 1.18
Laser speckle imaging of blood flow in microcirculation. Phys Med Biol (2004) 1.18
High-throughput measurement of rice tillers using a conveyor equipped with x-ray computed tomography. Rev Sci Instrum (2011) 1.18
Surface plasmon-coupled emission: what can directional fluorescence bring to the analytical sciences? Annu Rev Anal Chem (Palo Alto Calif) (2012) 1.17
Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis. Blood (2010) 1.17
The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus. J Immunol (2003) 1.17
Epidemiology and clinical presentation of the four human parainfluenza virus types. BMC Infect Dis (2013) 1.16
Factors associated with prehospital delays in the presentation of acute stroke in urban China. Stroke (2012) 1.16
sRNATarBase: a comprehensive database of bacterial sRNA targets verified by experiments. RNA (2010) 1.14
Plant lectins: potential antineoplastic drugs from bench to clinic. Cancer Lett (2009) 1.14
Involvement of CtBP1 in the transcriptional activation of the MDR1 gene in human multidrug resistant cancer cells. Biochem Pharmacol (2007) 1.14
AMD3100 is a potent antagonist at CXCR4(R334X) , a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome. J Cell Mol Med (2011) 1.14
Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells. Mol Cell (2012) 1.13
Arabidopsis P-glycoprotein19 participates in the inhibition of gravitropism by gravacin. Chem Biol (2007) 1.12
Low temperature of radiofrequency ablation at the target sites can facilitate rapid progression of residual hepatic VX2 carcinoma. J Transl Med (2010) 1.12
An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus. J Pathol (2005) 1.12
Evidence of oxidative attenuation of auxin signalling. J Exp Bot (2013) 1.12
Beclin-1: autophagic regulator and therapeutic target in cancer. Int J Biochem Cell Biol (2013) 1.11
Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics. Int J Biochem Cell Biol (2011) 1.11
EMMPRIN expression as a prognostic factor in radiotherapy of cervical cancer. Clin Cancer Res (2008) 1.11
The Arabidopsis concentration-dependent influx/efflux transporter ABCB4 regulates cellular auxin levels in the root epidermis. Plant J (2011) 1.10
Metabolic imaging of tumors using intrinsic and extrinsic fluorescent markers. Biosens Bioelectron (2004) 1.10
Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugs. Cancer Res (2007) 1.10