Published in Genes Dev on September 15, 2001
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell (2006) 3.08
Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J Cell Biol (2002) 2.97
Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Genes Dev (2002) 2.51
Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint. Genes Dev (2007) 2.32
An architectural map of the anaphase-promoting complex. Genes Dev (2006) 2.27
D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p. Genes Dev (2001) 2.20
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev (2006) 2.16
Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. EMBO J (2003) 2.14
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Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae. Genes Dev (2004) 2.11
Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint. PLoS One (2007) 2.08
Dual mode of degradation of Cdc25 A phosphatase. EMBO J (2002) 1.95
Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase. Genes Dev (2011) 1.95
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol Cell (2011) 1.87
Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins. Genes Dev (2001) 1.84
Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. Proc Natl Acad Sci U S A (2003) 1.77
Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property. Mol Cell Biol (2005) 1.67
Panta rhei: the APC/C at steady state. J Cell Biol (2013) 1.62
The roles of Fzy/Cdc20 and Fzr/Cdh1 in regulating the destruction of cyclin B in space and time. J Cell Biol (2002) 1.61
APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Mol Biol Cell (2001) 1.59
Cell cycle-dependent nuclear export of Cdh1p may contribute to the inactivation of APC/C(Cdh1). EMBO J (2002) 1.57
Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1. Mol Cell (2007) 1.53
Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol (2009) 1.51
Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. Mol Cell (2015) 1.49
How APC/C-Cdc20 changes its substrate specificity in mitosis. Nat Cell Biol (2011) 1.48
Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit. Mol Cell Biol (2005) 1.46
Endoreduplication mediated by the anaphase-promoting complex activator CCS52A is required for symbiotic cell differentiation in Medicago truncatula nodules. Plant Cell (2003) 1.44
Mammalian Cdh1/Fzr mediates its own degradation. EMBO J (2004) 1.42
Timing of APC/C substrate degradation is determined by fzy/fzr specificity of destruction boxes. EMBO J (2002) 1.38
Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. Genes Dev (2004) 1.34
The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis. Mol Biol Cell (2002) 1.33
Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding. Proc Natl Acad Sci U S A (2006) 1.33
Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos. Mol Cell Biol (2007) 1.32
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Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (2002) 1.26
Spatiotemporal regulation of the anaphase-promoting complex in mitosis. Nat Rev Mol Cell Biol (2015) 1.25
Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway. Mol Cell Biol (2004) 1.23
Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition. EMBO Rep (2005) 1.21
p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation. Mol Cell Biol (2005) 1.21
Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Mol Biol Cell (2009) 1.18
Structural insights into anaphase-promoting complex function and mechanism. Philos Trans R Soc Lond B Biol Sci (2011) 1.17
Acm1 is a negative regulator of the CDH1-dependent anaphase-promoting complex/cyclosome in budding yeast. Mol Cell Biol (2006) 1.17
Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity. Neuron (2009) 1.16
Xkid is degraded in a D-box, KEN-box, and A-box-independent pathway. Mol Cell Biol (2003) 1.16
Interplay between Cdh1 and JNK activity during the cell cycle. Nat Cell Biol (2010) 1.15
Human T-lymphotropic virus type 1 oncoprotein tax promotes unscheduled degradation of Pds1p/securin and Clb2p/cyclin B1 and causes chromosomal instability. Mol Cell Biol (2003) 1.15
Distinct sequence elements of cyclin B1 promote localization to chromatin, centrosomes, and kinetochores during mitosis. Mol Biol Cell (2007) 1.13
Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability. Genes Dev (2005) 1.13
Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. J Cell Biol (2005) 1.09
Unique D box and KEN box sequences limit ubiquitination of Acm1 and promote pseudosubstrate inhibition of the anaphase-promoting complex. J Biol Chem (2008) 1.08
Developmental role and regulation of cortex, a meiosis-specific anaphase-promoting complex/cyclosome activator. PLoS Genet (2007) 1.06
The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila. Development (2007) 1.04
The anaphase-promoting complex coordinates initiation of lens differentiation. Mol Biol Cell (2007) 1.03
State of the APC/C: organization, function, and structure. Crit Rev Biochem Mol Biol (2011) 1.02
Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1. Mol Cell Biol (2007) 1.00
Functional importance of the anaphase-promoting complex-Cdh1-mediated degradation of TMAP/CKAP2 in regulation of spindle function and cytokinesis. Mol Cell Biol (2007) 0.99
APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage. EMBO J (2014) 0.97
Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1. BMC Cell Biol (2004) 0.97
Degradation of the human mitotic checkpoint kinase Mps1 is cell cycle-regulated by APC-cCdc20 and APC-cCdh1 ubiquitin ligases. J Biol Chem (2010) 0.96
Regulation of Krüppel-like factor 4 by the anaphase promoting complex pathway is involved in TGF-beta signaling. J Biol Chem (2010) 0.96
Regulation of bovine papillomavirus replicative helicase e1 by the ubiquitin-proteasome pathway. J Virol (2002) 0.94
GPS-ARM: computational analysis of the APC/C recognition motif by predicting D-boxes and KEN-boxes. PLoS One (2012) 0.90
Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress. Mol Cell Biol (2010) 0.90
Regulated degradation of the APC coactivator Cdc20. Cell Div (2010) 0.90
Skp1-Cul1-F-box ubiquitin ligase (SCF(βTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry. J Biol Chem (2012) 0.87
Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint. Cell Div (2007) 0.87
Bovine papillomavirus replicative helicase E1 is a target of the ubiquitin ligase APC. J Virol (2004) 0.87
Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor. Oncogene (2010) 0.87
The four canonical tpr subunits of human APC/C form related homo-dimeric structures and stack in parallel to form a TPR suprahelix. J Mol Biol (2013) 0.86
In vivo characterization of the nonessential budding yeast anaphase-promoting complex/cyclosome components Swm1p, Mnd2p and Apc9p. Genetics (2005) 0.84
Id1 overexpression induces tetraploidization and multiple abnormal mitotic phenotypes by modulating aurora A. Mol Biol Cell (2008) 0.84
Assembly, activation, and substrate specificity of cyclin D1/Cdk2 complexes. Biochemistry (2013) 0.83
Insights into the cellular mechanism of the yeast ubiquitin ligase APC/C-Cdh1 from the analysis of in vivo degrons. Mol Biol Cell (2014) 0.82
Ama1p-activated anaphase-promoting complex regulates the destruction of Cdc20p during meiosis II. Mol Biol Cell (2010) 0.82
Phosphoproteomic Profiling Reveals Epstein-Barr Virus Protein Kinase Integration of DNA Damage Response and Mitotic Signaling. PLoS Pathog (2015) 0.81
Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate. Biol Open (2014) 0.80
The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation. FEBS Open Bio (2014) 0.79
The anaphase-promoting complex/cyclosome is required for anaphase progression in multinucleated Ashbya gossypii cells. Eukaryot Cell (2006) 0.79
Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain. J Mol Biol (2015) 0.75
The Ubp15 deubiquitinase promotes timely entry into S phase in Saccharomyces cerevisiae. Mol Biol Cell (2015) 0.75
Erratum to: Controlling the response to DNA damage by the APC/C-Cdh1. Cell Mol Life Sci (2016) 0.75
TGF-β activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth. Cell Cycle (2016) 0.75
The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex. Biol Open (2014) 0.75
Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic development in yeast. Cell Div (2013) 0.75
APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway. Biosci Rep (2016) 0.75
Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling to the cell cycle. J Biol Chem (2017) 0.75
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