Cdc42, dynein, and dynactin regulate MTOC reorientation independent of Rho-regulated microtubule stabilization.

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Published in Curr Biol on October 02, 2001

Authors

A F Palazzo1, H L Joseph, Y J Chen, D L Dujardin, A S Alberts, K K Pfister, R B Vallee, G G Gundersen

Author Affiliations

1: Department of Anatomy and Cell Biology, Columbia University, New York, NY 10032, USA.

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Molecular cloning of the retrograde transport motor cytoplasmic dynein (MAP 1C). Neuron (1993) 2.24

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Identity and polymerization-stimulatory activity of the nontubulin proteins associated with microtubules. Biochemistry (1977) 2.07

Stabilization of post-translational modification of microtubules during cellular morphogenesis. Bioessays (1991) 2.05

Distribution of microtubule-associated protein 2 in the nervous system of the rat studied by immunofluorescence. Neuroscience (1984) 2.04

Widespread cellular distribution of MAP-1A (microtubule-associated protein 1A) in the mitotic spindle and on interphase microtubules. J Cell Biol (1984) 2.03

Myelodysplastic syndrome and acute nonlymphocytic leukemia secondary to mitolactol treatment in patients with breast cancer. J Clin Oncol (1989) 2.02

Molecular characterization of the cAMP-dependent protein kinase bound to microtubule-associated protein 2. J Biol Chem (1982) 2.01

Dynein- and microtubule-mediated translocation of adenovirus serotype 5 occurs after endosomal lysis. Hum Gene Ther (2000) 1.97

A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2). J Cell Biol (1981) 1.97

Enhanced stability of microtubules enriched in detyrosinated tubulin is not a direct function of detyrosination level. J Cell Biol (1988) 1.96

Association of microtubule-associated protein 2 (MAP 2) with microtubules and intermediate filaments in cultured brain cells. J Cell Biol (1983) 1.93

Low molecular weight microtubule-associated proteins are light chains of microtubule-associated protein 1 (MAP 1). Proc Natl Acad Sci U S A (1983) 1.90

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Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin. J Biol Chem (2000) 1.82

Reversible assembly purification of microtubules without assembly-promoting agents and further purification of tubulin, microtubule-associated proteins, and MAP fragments. Methods Enzymol (1986) 1.82

Homology of the 74-kD cytoplasmic dynein subunit with a flagellar dynein polypeptide suggests an intracellular targeting function. J Cell Biol (1992) 1.81

Cytoplasmic dynein and dynactin are required for the transport of microtubules into the axon. J Cell Biol (1998) 1.80

Cytoskeletal architecture and immunocytochemical localization of microtubule-associated proteins in regions of axons associated with rapid axonal transport: the beta,beta'-iminodipropionitrile-intoxicated axon as a model system. J Cell Biol (1985) 1.78

An ATPase with properties expected for the organelle motor of the giant amoeba, Reticulomyxa. Nature (1988) 1.73

Microtubule-associated protein 1B: identification of a major component of the neuronal cytoskeleton. Proc Natl Acad Sci U S A (1985) 1.72

Subfractionation of Chlamydomonas 18 S dynein into two unique subunits containing ATPase activity. J Biol Chem (1984) 1.72

Distinct but overlapping sites within the cytoplasmic dynein heavy chain for dimerization and for intermediate chain and light intermediate chain binding. J Biol Chem (2000) 1.69

Removal of the projections from cytoplasmic microtubules in vitro by digestion with trypsin. J Biol Chem (1977) 1.65

Mechanisms of transition between double paroxysmal supraventricular tachycardias. J Cardiovasc Electrophysiol (2001) 1.62

Leukaemia in benzene workers: a retrospective cohort study. Br J Ind Med (1987) 1.62

Distribution of tyrosinated and nontyrosinated alpha-tubulin during mitosis. J Cell Biol (1986) 1.59

The prevalence and spectrum of alpha and beta thalassaemia in Guangdong Province: implications for the future health burden and population screening. J Clin Pathol (2004) 1.59

Microtubule arrays in differentiated cells contain elevated levels of a post-translationally modified form of tubulin. Eur J Cell Biol (1986) 1.59

Association of kinesin with characterized membrane-bounded organelles. Cell Motil Cytoskeleton (1992) 1.59

Ultrastructural colocalization of tyrosinated and detyrosinated alpha-tubulin in interphase and mitotic cells. J Cell Biol (1986) 1.57

Protein splicing of the yeast TFP1 intervening protein sequence: a model for self-excision. EMBO J (1993) 1.57

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Assembly and turnover of detyrosinated tubulin in vivo. J Cell Biol (1987) 1.55

Molecular genetics of kinesin light chains: generation of isoforms by alternative splicing. Proc Natl Acad Sci U S A (1991) 1.54

The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein. J Biol Chem (1996) 1.54

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Stable, detyrosinated microtubules function to localize vimentin intermediate filaments in fibroblasts. J Cell Biol (1995) 1.49

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A retrospective cohort study of leukemia and other cancers in benzene workers. Environ Health Perspect (1989) 1.44

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A binding site for SH3 domains targets dynamin to coated pits. J Biol Chem (1996) 1.42

Multiple distinct coiled-coils are involved in dynamin self-assembly. J Biol Chem (1999) 1.41

Five-color-based high-information-content fingerprinting of bacterial artificial chromosome clones using type IIS restriction endonucleases. Genomics (2001) 1.40