PubRank

Shaun P Jackson

Author PubWeight™ 78.05‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat Med 2009 3.57
2 Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 2005 2.35
3 Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth. Blood 2008 1.82
4 High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood 2010 1.75
5 Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J 2007 1.74
6 Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood 2009 1.74
7 Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function. Blood 2012 1.67
8 Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation. Blood 2006 1.63
9 Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood 2011 1.56
10 Shear-dependent tether formation during platelet translocation on von Willebrand factor. Blood 2002 1.42
11 Intercellular calcium communication regulates platelet aggregation and thrombus growth. J Cell Biol 2003 1.42
12 Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux. Circulation 2009 1.40
13 Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency. Blood 2006 1.37
14 The role of platelets in atherothrombosis. Hematology Am Soc Hematol Educ Program 2011 1.34
15 Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration. Clin Cancer Res 2008 1.30
16 Interaction between platelet glycoprotein Ibalpha and filamin-1 is essential for glycoprotein Ib/IX receptor anchorage at high shear. J Biol Chem 2001 1.30
17 SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets. J Biol Chem 2004 1.25
18 Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA. J Biol Chem 2003 1.24
19 Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow. J Biol Chem 2001 1.23
20 Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization. Blood 2006 1.21
21 A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood. Lab Chip 2009 1.16
22 Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction. Arterioscler Thromb Vasc Biol 2011 1.15
23 Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2. J Biol Chem 2003 1.13
24 Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets. J Biol Chem 2009 1.11
25 Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular injury. J Biol Chem 2009 1.10
26 Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin alpha(IIb)beta(3). Blood 2002 1.09
27 Pathophysiological levels of soluble P-selectin mediate adhesion of leukocytes to the endothelium through Mac-1 activation. Circ Res 2008 1.08
28 Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets. J Biol Chem 2007 1.04
29 A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists. Arterioscler Thromb Vasc Biol 2006 1.04
30 Platelet factor XIII and calpain negatively regulate integrin alphaIIbbeta3 adhesive function and thrombus growth. J Biol Chem 2004 1.04
31 The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Blood 2013 1.03
32 Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor. J Biol Chem 2006 1.03
33 RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear. J Biol Chem 2002 1.01
34 New insights into the haemostatic function of platelets. Br J Haematol 2009 1.01
35 The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis. J Mol Med (Berl) 2006 1.01
36 Shear induces a unique series of morphological changes in translocating platelets: effects of morphology on translocation dynamics. Arterioscler Thromb Vasc Biol 2005 1.01
37 Class I phosphoinositide 3-kinases. Int J Biochem Cell Biol 2003 0.99
38 Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha. Blood 2004 0.99
39 Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells. Nat Commun 2011 0.99
40 Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha. Biochem J 2005 0.98
41 Novel role for insulin as an autocrine growth factor for malignant brain tumour cells. Biochem J 2007 0.97
42 Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity. FEBS J 2007 0.97
43 A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance. Mol Cancer Res 2011 0.96
44 Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function. Blood 2012 0.95
45 A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. Blood 2006 0.94
46 PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading. Cell Signal 2010 0.94
47 Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket. Biochem J 2008 0.94
48 Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces. J Biol Chem 2009 0.92
49 Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation. J Biol Chem 2009 0.92
50 Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform. Blood 2007 0.90
51 Role of the intracellular domains of GPIb in controlling the adhesive properties of the platelet GPIb/V/IX complex. Blood 2003 0.89
52 Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading. Blood 2007 0.89
53 Importance of temporal flow gradients and integrin alphaIIbbeta3 mechanotransduction for shear activation of platelets. J Biol Chem 2005 0.89
54 Techniques to examine platelet adhesive interactions under flow. Methods Mol Biol 2004 0.88
55 Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene. Genesis 2010 0.88
56 Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors. Bioorg Med Chem 2007 0.87
57 Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels. Blood 2012 0.87
58 Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase C. Biochem J 2003 0.86
59 Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway. Am J Pathol 2010 0.86
60 An investigation on platelet transport during thrombus formation at micro-scale stenosis. PLoS One 2013 0.86
61 A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex. Blood 2008 0.84
62 The clot thickens--oxidized lipids and thrombosis. Nat Med 2007 0.81
63 The contribution of thrombin-induced platelet activation to thrombus growth is diminished under pathological blood shear conditions. Thromb Haemost 2011 0.80
64 Structural and hydrodynamic simulation of an acute stenosis-dependent thrombosis model in mice. J Biomech 2011 0.77
65 Are Erk, Btk, and PECAM-1 major players in GPIb signaling? The challenge of unraveling signaling events downstream of platelet GPIb. Blood 2007 0.76
66 Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice. J Biol Chem 2014 0.76
67 The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration. Cell Signal 2010 0.76
68 Is thrombin the problem or (dis)solution? Blood 2009 0.76
69 A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow. Methods Mol Biol 2012 0.75
70 SR-BI and fatty platelets. Blood 2010 0.75
71 Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263). Blood 2013 0.75
72 Antiplatelet therapy: present status and future prospects. Expert Opin Drug Discov 2007 0.75
73 Imaging signaling processes in platelets. Blood Cells Mol Dis 2006 0.75
74 Boosting platelet production. Nat Med 2008 0.75
75 Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nat Commun 2017 0.75
76 A multimode-TIRFM and microfluidic technique to examine platelet adhesion dynamics. Methods Mol Biol 2013 0.75