Published in Mol Cell Biol on July 01, 2004
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DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science (2011) 10.26
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol (2006) 5.74
Global and Hox-specific roles for the MLL1 methyltransferase. Proc Natl Acad Sci U S A (2005) 5.53
BAP1 loss defines a new class of renal cell carcinoma. Nat Genet (2012) 4.97
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Menin critically links MLL proteins with LEDGF on cancer-associated target genes. Cancer Cell (2008) 4.20
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Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. Genes Dev (2006) 2.20
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A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit. Mol Cell (2009) 1.94
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The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection. Proc Natl Acad Sci U S A (2007) 1.90
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Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients. Blood (2005) 1.81
WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket. J Biol Chem (2008) 1.77
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The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors. Proc Natl Acad Sci U S A (2009) 1.70
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proc Natl Acad Sci U S A (2006) 1.67
Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance. Nat Struct Mol Biol (2012) 1.64
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature (2012) 1.62
Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells. Blood (2013) 1.60
Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in Drosophila. Mol Cell Biol (2006) 1.60
Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. Mol Cell Biol (2007) 1.58
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Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias. J Biol Chem (2010) 1.56
c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development. Blood (2010) 1.55
The COMPASS family of H3K4 methylases in Drosophila. Mol Cell Biol (2011) 1.54
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. J Clin Invest (2010) 1.52
MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression. Proc Natl Acad Sci U S A (2008) 1.50
Global loss of Set1-mediated H3 Lys4 trimethylation is associated with silencing defects in Saccharomyces cerevisiae. J Biol Chem (2005) 1.46
Snapshots: chromatin control of viral infection. Virology (2013) 1.39
MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia. Cancer Cell (2017) 1.39
Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells. Cancer Res (2006) 1.36
Therapeutic targeting of MLL. Blood (2009) 1.36
The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation. Development (2010) 1.35
DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation. Cancer Res (2009) 1.34
An MLL-dependent network sustains hematopoiesis. Proc Natl Acad Sci U S A (2013) 1.34
MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription. Mol Cell Biol (2009) 1.33
Functional conservation of Asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene Asx. PLoS One (2009) 1.32
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Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A (2011) 1.28
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Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein. Mol Cell Biol (2005) 1.26
BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression. Mol Cell Biol (2008) 1.26
Species selectivity of mixed-lineage leukemia/trithorax and HCF proteolytic maturation pathways. Mol Cell Biol (2007) 1.26
MLL fusions: pathways to leukemia. Cancer Biol Ther (2009) 1.24
A role for Set1/MLL-related components in epigenetic regulation of the Caenorhabditis elegans germ line. PLoS Genet (2011) 1.22
A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem (2010) 1.21
Menin: a scaffold protein that controls gene expression and cell signaling. Trends Biochem Sci (2013) 1.21
Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark. Mol Cell Biol (2010) 1.21
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The PHD fingers of MLL block MLL fusion protein-mediated transformation. Blood (2008) 1.18
Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners. Proc Natl Acad Sci U S A (2011) 1.17
Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein. J Biol Chem (2011) 1.16
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The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res (2012) 1.15
Menin regulates the function of hematopoietic stem cells and lymphoid progenitors. Blood (2009) 1.15
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