Published in Proc Natl Acad Sci U S A on May 14, 2002
Zfp312 is required for subcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex. Proc Natl Acad Sci U S A (2005) 2.66
Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell (2006) 2.06
Not(ch) just development: Notch signalling in the adult brain. Nat Rev Neurosci (2011) 1.69
The amyloid-beta precursor protein: integrating structure with biological function. EMBO J (2005) 1.68
Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. Proc Natl Acad Sci U S A (2003) 1.55
Global profiling and molecular characterization of alternative splicing events misregulated in lung cancer. Mol Cell Biol (2010) 1.53
Proteolytic processing of Alzheimer's β-amyloid precursor protein. J Neurochem (2011) 1.50
A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor protein. Bioessays (2013) 1.47
BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci (2008) 1.42
Numb regulates cell-cell adhesion and polarity in response to tyrosine kinase signalling. EMBO J (2009) 1.24
Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J (2004) 1.18
The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains. Mol Neurodegener (2009) 1.12
Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis. J Biol Chem (2008) 1.08
JNK-interacting protein-1 promotes transcription of A beta protein precursor but not A beta precursor-like proteins, mechanistically different than Fe65. Proc Natl Acad Sci U S A (2003) 1.03
The Drosophila cell adhesion molecule klingon is required for long-term memory formation and is regulated by Notch. Proc Natl Acad Sci U S A (2008) 1.02
Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin. Mol Biol Cell (2007) 0.99
BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2. J Biol Chem (2009) 0.99
Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev (2004) 0.93
Numb regulates glioma stem cell fate and growth by altering epidermal growth factor receptor and Skp1-Cullin-F-box ubiquitin ligase activity. Stem Cells (2012) 0.93
Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance. Aging Cell (2012) 0.93
Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories. Neurobiol Aging (2008) 0.92
The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function. PLoS One (2011) 0.88
The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid. Neurochem Res (2006) 0.87
Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel. J Biol Chem (2009) 0.86
Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila. PLoS One (2008) 0.85
Norepinephrine transport-mediated gene expression in noradrenergic neurogenesis. BMC Genomics (2009) 0.85
The role of lipoprotein receptors on the physiological function of APP. Exp Brain Res (2011) 0.84
The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats. J Biol Chem (2012) 0.83
A TAG on to the neurogenic functions of APP. Cell Adh Migr (2008) 0.82
Epithelial-to-Mesenchymal Plasticity Harnesses Endocytic Circuitries. Front Oncol (2015) 0.82
An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss. PLoS One (2013) 0.81
CD74 interacts with APP and suppresses the production of Abeta. Mol Neurodegener (2009) 0.80
RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing. Transl Neurodegener (2012) 0.79
The association of cholesterol absorption gene Numb polymorphism with Coronary Artery Disease among Han Chinese and Uighur Chinese in Xinjiang, China. Lipids Health Dis (2015) 0.78
Novel adaptors of amyloid precursor protein intracellular domain and their functional implications. Genomics Proteomics Bioinformatics (2012) 0.78
Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development. Int Immunol (2009) 0.77
The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb. Neurobiol Dis (2016) 0.77
Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems. Alzheimers Res Ther (2012) 0.76
Postnatal dysregulation of Notch signal disrupts dendrite development of adult-born neurons in the hippocampus and contributes to memory impairment. Sci Rep (2016) 0.76
Numb and Alzheimer's disease: the current picture. Front Neurosci (2012) 0.76
Genetic variants of numb gene were associated with elevated total cholesterol level and low density lipoprotein cholesterol level in Chinese subjects, in Xinjiang, China. Diagn Pathol (2015) 0.75
APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins. Front Mol Neurosci (2017) 0.75
Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b. Cell Res (2016) 0.75
Numb deficiency in cerebellar Purkinje cells impairs synaptic expression of metabotropic glutamate receptor and motor coordination. Proc Natl Acad Sci U S A (2015) 0.75
Evaluation of APP695 Transgenic Mice Bone Marrow Mesenchymal Stem Cells Neural Differentiation for Transplantation. Biomed Res Int (2015) 0.75
Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. J Biol Chem (2016) 0.75
The role of Notch signaling in gastric carcinoma: molecular pathogenesis and novel therapeutic targets. Oncotarget (2017) 0.75
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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science (2001) 7.03
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Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science (1999) 2.71
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A portrait of Alzheimer secretases--new features and familiar faces. Science (2001) 2.42
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem (2001) 2.42
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Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development (1997) 1.82
Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain. J Biol Chem (1999) 1.81
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The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. J Neurochem (2001) 1.73
The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus. Proc Natl Acad Sci U S A (2001) 1.72
Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor. J Alzheimers Dis (2000) 1.61
A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor. J Biol Chem (2001) 1.55
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Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). J Biol Chem (2001) 1.40
Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1. Curr Biol (2000) 1.38
The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation. J Biol Chem (2000) 1.24
Identification and characterization of presenilin-independent Notch signaling. J Biol Chem (2001) 1.00
Binding partners of Alzheimer's disease proteins: are they physiologically relevant? Neurobiol Dis (2000) 0.97
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Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science (2005) 8.20
Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biol (2004) 7.33
Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations. Nature (2010) 6.26
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell (2006) 5.51
Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron (2009) 5.46
Origin of GABAergic neurons in the human neocortex. Nature (2002) 4.40
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Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron (2005) 3.83
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev (2003) 3.79
Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Neuron (2008) 3.57
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol (2006) 3.18
Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci (2007) 3.13
Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. Cell (2013) 2.94
Extraordinary neoteny of synaptic spines in the human prefrontal cortex. Proc Natl Acad Sci U S A (2011) 2.85
Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Nat Neurosci (2007) 2.70
Zfp312 is required for subcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex. Proc Natl Acad Sci U S A (2005) 2.66
Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2. Nat Cell Biol (2004) 2.58
Molecular and morphological heterogeneity of neural precursors in the mouse neocortical proliferative zones. J Neurosci (2006) 2.49
A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A (2003) 2.47
Phosphatidylserine receptor is required for clearance of apoptotic cells. Science (2003) 2.38
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron (2008) 2.31
Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus. Proc Natl Acad Sci U S A (2007) 2.31
SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons. Proc Natl Acad Sci U S A (2008) 2.26
Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science (2007) 2.21
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proc Natl Acad Sci U S A (2008) 2.17
Four-dimensional migratory coordinates of GABAergic interneurons in the developing mouse cortex. J Neurosci (2003) 2.12
Mitotic spindle rotation and mode of cell division in the developing telencephalon. Proc Natl Acad Sci U S A (2003) 2.06
Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell (2006) 2.06
Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J Biol Chem (2010) 2.06
JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 2.05
Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. J Neurosci (2004) 1.94
Selective depletion of molecularly defined cortical interneurons in human holoprosencephaly with severe striatal hypoplasia. Cereb Cortex (2009) 1.93
The first neurons of the human cerebral cortex. Nat Neurosci (2006) 1.91
Recessive LAMC3 mutations cause malformations of occipital cortical development. Nat Genet (2011) 1.89
Prenatal exposure to ultrasound waves impacts neuronal migration in mice. Proc Natl Acad Sci U S A (2006) 1.86
The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc Natl Acad Sci U S A (2007) 1.78
Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission. Neuron (2013) 1.74
Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p. Genes Dev (2013) 1.70
Not(ch) just development: Notch signalling in the adult brain. Nat Rev Neurosci (2011) 1.69
Timing of neurogenesis is a determinant of olfactory circuitry. Nat Neurosci (2011) 1.67
The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. J Biol Chem (2005) 1.67
TBR1 directly represses Fezf2 to control the laminar origin and development of the corticospinal tract. Proc Natl Acad Sci U S A (2011) 1.67
Glycogen synthase kinase-3beta modulates notch signaling and stability. Curr Biol (2002) 1.66
The stumpy gene is required for mammalian ciliogenesis. Proc Natl Acad Sci U S A (2008) 1.66
Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex. Development (2012) 1.65
Prolonged myelination in human neocortical evolution. Proc Natl Acad Sci U S A (2012) 1.64
Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA sequencing. Proc Natl Acad Sci U S A (2011) 1.60
Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. Nature (2009) 1.59
CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration, and survival of human prostate cancer cells. Cancer Res (2004) 1.55
Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. Proc Natl Acad Sci U S A (2003) 1.55
Cortical evolution: judge the brain by its cover. Neuron (2013) 1.54
The evolution of lineage-specific regulatory activities in the human embryonic limb. Cell (2013) 1.51
Abnormalities of thalamic volume and shape detected in fetally irradiated rhesus monkeys with high dimensional brain mapping. Biol Psychiatry (2002) 1.50
Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia. Cereb Cortex (2007) 1.48
Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1. J Biol Chem (2003) 1.45
Antibodies to cannabinoid type 1 receptor co-react with stomatin-like protein 2 in mouse brain mitochondria. Eur J Neurosci (2013) 1.45
Cis-regulatory control of corticospinal system development and evolution. Nature (2012) 1.43
Neuronal apoptosis is accompanied by amyloid beta-protein accumulation in the endoplasmic reticulum. J Alzheimers Dis (2002) 1.42
BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci (2008) 1.42
Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). J Biol Chem (2001) 1.40
Modes and mishaps of neuronal migration in the mammalian brain. J Neurosci (2008) 1.39
MEKK4 signaling regulates filamin expression and neuronal migration. Neuron (2006) 1.37
Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription. J Biol Chem (2002) 1.37
Gap junctions/hemichannels modulate interkinetic nuclear migration in the forebrain precursors. J Neurosci (2010) 1.37
AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization. Science (2011) 1.33
Midline radial glia translocation and corpus callosum formation require FGF signaling. Nat Neurosci (2006) 1.31
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Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. J Biol Chem (2002) 1.31
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POU-III transcription factors (Brn1, Brn2, and Oct6) influence neurogenesis, molecular identity, and migratory destination of upper-layer cells of the cerebral cortex. Cereb Cortex (2012) 1.29
Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex. Cell (2012) 1.28
Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role. Mol Neurodegener (2008) 1.28
Neocortical networks entrain neuronal circuits in cerebellar cortex. J Neurosci (2009) 1.27
Novel neuronal phenotypes from neural progenitor cells. J Neurosci (2004) 1.26
Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. Proc Natl Acad Sci U S A (2005) 1.22
β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia. EMBO Mol Med (2012) 1.20
DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics. Mol Autism (2014) 1.20
Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles. Neurobiol Aging (2009) 1.19
Renewed focus on the developing human neocortex. J Anat (2010) 1.18
A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss. J Neurosci (2013) 1.17
Origin, early commitment, migratory routes, and destination of cannabinoid type 1 receptor-containing interneurons. Cereb Cortex (2009) 1.17
CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/fractalkine in the bone marrow: potential role in prostate cancer bone tropism. Cancer Res (2008) 1.15
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis. J Neurosci (2010) 1.14
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The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains. Mol Neurodegener (2009) 1.12
Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo. PLoS One (2010) 1.11
Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO. J Neurovirol (2006) 1.11
PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2. J Alzheimers Dis (2001) 1.11
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JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration. J Neurochem (2008) 1.11