Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis.

PubWeight™: 1.14‹?› | Rank: Top 10%

🔗 View Article (PMC 2832944)

Published in J Biol Chem on January 14, 2010

Authors

Yoichiro Kamimura1, Peter N Devreotes

Author Affiliations

1: Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Articles citing this

Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis. J Cell Biol (2010) 1.64

Moving in the right direction: how eukaryotic cells migrate along chemical gradients. Semin Cell Dev Biol (2011) 1.15

Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes. Cell Mol Life Sci (2014) 1.15

Signaling mechanisms for chemotaxis. Dev Growth Differ (2011) 1.04

Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN. Mol Biol Cell (2010) 1.00

Delineating the core regulatory elements crucial for directed cell migration by examining folic-acid-mediated responses. J Cell Sci (2012) 0.96

Analysis of chemotaxis in Dictyostelium. Methods Mol Biol (2012) 0.96

Glycogen synthase kinase-3 is required for efficient Dictyostelium chemotaxis. Mol Biol Cell (2010) 0.94

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway. Biophys J (2016) 0.90

A PIP5 kinase essential for efficient chemotactic signaling. Curr Biol (2014) 0.87

Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility. Mol Biol Cell (2012) 0.85

TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing. J Cell Sci (2012) 0.82

Perspectives in PDK1 evolution: insights from photosynthetic and non-photosynthetic organisms. Plant Signal Behav (2012) 0.78

Chemotaxis: new role for Ras revealed. Protein Cell (2010) 0.77

Chemoattractant stimulation of TORC2 is regulated by receptor/G protein-targeted inhibitory mechanisms that function upstream and independently of an essential GEF/Ras activation pathway in Dictyostelium. Mol Biol Cell (2013) 0.77

PP2A/B56 and GSK3/Ras suppress PKB activity during Dictyostelium chemotaxis. Mol Biol Cell (2015) 0.76

Protein kinase B gene homologue pkbR1 performs one of its roles at first finger stage of Dictyostelium. Eukaryot Cell (2011) 0.75

Signaling network from GPCR to the actin cytoskeleton during chemotaxis. Bioarchitecture (2012) 0.75

Dual TORCs driven and B56 orchestrated Signaling Network guides eukaryotic cell migration. BMB Rep (2017) 0.75

Articles cited by this

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99

Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J (1996) 16.68

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol (1997) 15.32

Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell (2002) 6.36

Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell (2002) 6.06

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr Biol (1997) 5.66

PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol (2004) 5.10

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J (1999) 4.34

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J (2001) 3.58

Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19

PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nat Cell Biol (2006) 3.12

PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr Biol (2008) 3.06

TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell (2005) 2.76

Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Mol Biol Cell (2003) 2.56

PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev Cell (2007) 2.53

Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration. PLoS One (2008) 2.21

Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol Cell (2001) 2.07

A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev (1997) 1.82

Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis. J Cell Biol (2007) 1.80

Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol (2008) 1.63

A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium. Curr Biol (2000) 1.58

Chemotaxis: finding the way forward with Dictyostelium. Trends Cell Biol (2009) 1.55

Navigating signaling networks: chemotaxis in Dictyostelium discoideum. Curr Opin Genet Dev (2006) 1.43

Dissecting the role of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) signalling pathways. Cell Cycle (2008) 1.37

Assays for chemotaxis and chemoattractant-stimulated TorC2 activation and PKB substrate phosphorylation in Dictyostelium. Methods Mol Biol (2009) 0.95

Articles by these authors

Chemotaxis: signalling the way forward. Nat Rev Mol Cell Biol (2004) 4.96

Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature (2006) 4.09

Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys (2010) 3.76

PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr Biol (2008) 3.06

Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J Biol Chem (2004) 2.60

Cells navigate with a local-excitation, global-inhibition-biased excitable network. Proc Natl Acad Sci U S A (2010) 2.54

PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev Cell (2007) 2.53

Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A (2004) 2.52

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34

G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J Cell Biol (2007) 2.34

Navigating through models of chemotaxis. Curr Opin Cell Biol (2008) 2.19

Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis. Mol Biol Cell (2003) 2.19

Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15

Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc Natl Acad Sci U S A (2006) 1.96

Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells. Biophys J (2004) 1.91

Visualization of G protein betagamma dimers using bimolecular fluorescence complementation demonstrates roles for both beta and gamma in subcellular targeting. J Biol Chem (2004) 1.81

Chemoattractant signaling in dictyostelium discoideum. Annu Rev Cell Dev Biol (2004) 1.77

Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Mol Biol Cell (2006) 1.67

Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis. J Cell Biol (2010) 1.64

Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer. Science (2014) 1.64

An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration. Nat Cell Biol (2013) 1.34

Biased excitable networks: how cells direct motion in response to gradients. Curr Opin Cell Biol (2011) 1.24

Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development. Curr Biol (2002) 1.21

Leading-edge research: PtdIns(3,4,5)P3 and directed migration. Nat Cell Biol (2007) 1.20

Signaling pathways mediating chemotaxis in the social amoeba, Dictyostelium discoideum. Eur J Cell Biol (2006) 1.20

Moving in the right direction: how eukaryotic cells migrate along chemical gradients. Semin Cell Dev Biol (2011) 1.15

Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes. Cell Mol Life Sci (2014) 1.15

Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells. PLoS Comput Biol (2013) 1.10

Automated characterization of cell shape changes during amoeboid motility by skeletonization. BMC Syst Biol (2010) 1.08

tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis. Genes Dev (2008) 1.03

Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis. J Cell Biol (2002) 1.02

Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein. J Cell Sci (2006) 0.99

Analysis of chemotaxis in Dictyostelium. Methods Mol Biol (2012) 0.96

Moving forward: mechanisms of chemoattractant gradient sensing. Physiology (Bethesda) (2004) 0.95

Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion. Proc Natl Acad Sci U S A (2012) 0.93

Assessment of development and chemotaxis in Dictyostelium discoideum mutants. Methods Mol Biol (2011) 0.92

Extracellular cAMP inhibits proximal reabsorption: are plasma membrane cAMP receptors involved? Am J Physiol Renal Physiol (2002) 0.90

Different roles of membrane potentials in electrotaxis and chemotaxis of dictyostelium cells. Eukaryot Cell (2011) 0.88

Multiple host kinases contribute to Akt activation during Salmonella infection. PLoS One (2013) 0.79

Hippo on the move: tumor suppressor regulates adhesion and migration. Cell Cycle (2013) 0.78

Regulation of adenylyl cyclases by a region outside the minimally functional cytoplasmic domains. J Biol Chem (2001) 0.78

Analyzing chemotaxis using Dictyostelium discoideum as a model system. Methods Mol Biol (2004) 0.78

3D arrays for high throughput assay of cell migration and electrotaxis. Cell Biol Int (2013) 0.77

Ege A, a novel C2 domain containing protein, is essential for GPCR-mediated gene expression in dictyostelium. Dev Biol (2002) 0.76

QnAs with Peter N. Devreotes. Interview by Prashant Nair. Proc Natl Acad Sci U S A (2010) 0.75