Published in Biochemistry on July 02, 2002
A force-dependent state controls the coordination of processive myosin V. Proc Natl Acad Sci U S A (2005) 2.39
The prepower stroke conformation of myosin V. J Cell Biol (2002) 2.12
Myosin V from head to tail. Cell Mol Life Sci (2008) 1.76
The ATPase cycle mechanism of the DEAD-box rRNA helicase, DbpA. J Mol Biol (2007) 1.70
Kinetic and equilibrium analysis of the myosin ATPase. Methods Enzymol (2009) 1.66
Elastic lever-arm model for myosin V. Biophys J (2005) 1.62
How myosin VI coordinates its heads during processive movement. EMBO J (2007) 1.49
Myosin-Va transports the endoplasmic reticulum into the dendritic spines of Purkinje neurons. Nat Cell Biol (2010) 1.48
Electrostatic origin of the unidirectionality of walking myosin V motors. Proc Natl Acad Sci U S A (2013) 1.24
Myosin isoform determines the conformational dynamics and cooperativity of actin filaments in the strongly bound actomyosin complex. J Mol Biol (2009) 1.10
Human myosin Vc is a low duty ratio nonprocessive motor. J Biol Chem (2007) 1.07
Influence of lever structure on myosin 5a walking. Proc Natl Acad Sci U S A (2010) 1.05
Kinetic analysis of the guanine nucleotide exchange activity of TRAPP, a multimeric Ypt1p exchange factor. J Mol Biol (2009) 1.01
The Dictyostelium type V myosin MyoJ is responsible for the cortical association and motility of contractile vacuole membranes. J Cell Biol (2009) 0.97
Mechanochemical model for myosin V. Proc Natl Acad Sci U S A (2009) 0.97
How actin initiates the motor activity of Myosin. Dev Cell (2015) 0.97
Characterization of the pre-force-generation state in the actomyosin cross-bridge cycle. Proc Natl Acad Sci U S A (2008) 0.93
Switch II mutants reveal coupling between the nucleotide- and actin-binding regions in myosin V. Biophys J (2012) 0.91
Monte Carlo analysis of neck linker extension in kinesin molecular motors. PLoS Comput Biol (2010) 0.91
Functional adaptation of the switch-2 nucleotide sensor enables rapid processive translocation by myosin-5. FASEB J (2010) 0.88
Septin 9 Exhibits Polymorphic Binding to F-Actin and Inhibits Myosin and Cofilin Activity. J Mol Biol (2015) 0.85
Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport. Curr Biol (2014) 0.85
Full-length myosin Va exhibits altered gating during processive movement on actin. Proc Natl Acad Sci U S A (2012) 0.84
Magnesium impacts myosin V motor activity by altering key conformational changes in the mechanochemical cycle. Biochemistry (2013) 0.82
Biochemical and bioinformatic analysis of the myosin-XIX motor domain. Cytoskeleton (Hoboken) (2013) 0.82
Reverse conformational changes of the light chain-binding domain of myosin V and VI processive motor heads during and after hydrolysis of ATP by small-angle X-ray solution scattering. J Mol Biol (2009) 0.79
Strain Mediated Adaptation Is Key for Myosin Mechanochemistry: Discovering General Rules for Motor Activity. PLoS Comput Biol (2016) 0.77
EPR spectra and molecular dynamics agree that the nucleotide pocket of myosin V is closed and that it opens on binding actin. J Mol Biol (2011) 0.77
Global fit analysis of myosin-5b motility reveals thermodynamics of Mg2+-sensitive acto-myosin-ADP states. PLoS One (2013) 0.77
Myosin V passing over Arp2/3 junctions: branching ratio calculated from the elastic lever arm model. Biophys J (2008) 0.77
A branched kinetic scheme describes the mechanochemical coupling of Myosin Va processivity in response to substrate. Biophys J (2012) 0.77
Metal switch-controlled myosin II from Dictyostelium discoideum supports closure of nucleotide pocket during ATP binding coupled to detachment from actin filaments. J Biol Chem (2013) 0.75
Impact of the Motor and Tail Domains of Class III Myosins on Regulating the Formation and Elongation of Actin Protrusions. J Biol Chem (2016) 0.75
A subdomain interaction at the base of the lever allosterically tunes the mechanochemical mechanism of myosin 5a. PLoS One (2013) 0.75
Matrix elasticity directs stem cell lineage specification. Cell (2006) 43.00
Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. J Cell Biol (2004) 7.38
PTC124 targets genetic disorders caused by nonsense mutations. Nature (2007) 6.67
The mechanism of myosin VI translocation and its load-induced anchoring. Cell (2004) 3.85
Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol (2006) 3.78
A structural state of the myosin V motor without bound nucleotide. Nature (2003) 3.63
Three myosin V structures delineate essential features of chemo-mechanical transduction. EMBO J (2004) 3.21
Role of the lever arm in the processive stepping of myosin V. Proc Natl Acad Sci U S A (2002) 2.86
Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice. J Cell Biol (2002) 2.76
The structure of the myosin VI motor reveals the mechanism of directionality reversal. Nature (2005) 2.50
A model of myosin V processivity. J Biol Chem (2004) 2.49
Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nat Med (2008) 2.49
Myostatin activation in patients with advanced heart failure and after mechanical unloading. Eur J Heart Fail (2010) 2.40
A force-dependent state controls the coordination of processive myosin V. Proc Natl Acad Sci U S A (2005) 2.39
Relating biochemistry and function in the myosin superfamily. Curr Opin Cell Biol (2004) 2.31
Myosin VI steps via a hand-over-hand mechanism with its lever arm undergoing fluctuations when attached to actin. J Biol Chem (2004) 2.31
Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat. Hum Gene Ther (2008) 2.27
Myosin I can act as a molecular force sensor. Science (2008) 2.21
MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments. J Cell Biol (2002) 2.04
Cofilin increases the bending flexibility of actin filaments: implications for severing and cell mechanics. J Mol Biol (2008) 1.91
Cofilin increases the torsional flexibility and dynamics of actin filaments. J Mol Biol (2005) 1.89
Neovasculogenic therapy to augment perfusion and preserve viability in ischemic cardiomyopathy. Ann Thorac Surg (2006) 1.82
Full-length myosin VI dimerizes and moves processively along actin filaments upon monomer clustering. Mol Cell (2006) 1.80
A flexible domain is essential for the large step size and processivity of myosin VI. Mol Cell (2005) 1.78
Local cytoskeletal and organelle interactions impact molecular-motor- driven early endosomal trafficking. Curr Biol (2013) 1.76
Myo1c binds phosphoinositides through a putative pleckstrin homology domain. Mol Biol Cell (2006) 1.74
Myo1c binds tightly and specifically to phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate. Proc Natl Acad Sci U S A (2006) 1.72
Kinetic and equilibrium analysis of the myosin ATPase. Methods Enzymol (2009) 1.66
The structural basis for the large powerstroke of myosin VI. Cell (2007) 1.56
Cofilin tunes the nucleotide state of actin filaments and severs at bare and decorated segment boundaries. Curr Biol (2011) 1.55
Myosin IIb is unconventionally conventional. J Biol Chem (2003) 1.45
Interhead distance measurements in myosin VI via SHRImP support a simplified hand-over-hand model. Biophys J (2005) 1.43
Myosin VI dimerization triggers an unfolding of a three-helix bundle in order to extend its reach. Mol Cell (2009) 1.42
Magnesium regulates ADP dissociation from myosin V. J Biol Chem (2004) 1.42
Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb. Biochemistry (2004) 1.40
Viral expression of insulin-like growth factor-I enhances muscle hypertrophy in resistance-trained rats. J Appl Physiol (1985) (2004) 1.40
Visualization of the dynamics of fibrin clot growth 1 molecule at a time by total internal reflection fluorescence microscopy. Blood (2012) 1.39
The unique insert in myosin VI is a structural calcium-calmodulin binding site. Proc Natl Acad Sci U S A (2004) 1.38
Cargo binding induces dimerization of myosin VI. Proc Natl Acad Sci U S A (2009) 1.34
Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition. EMBO J (2007) 1.32
The unique insert at the end of the myosin VI motor is the sole determinant of directionality. Proc Natl Acad Sci U S A (2007) 1.30
Dynamics of myo1c (myosin-ibeta ) lipid binding and dissociation. J Biol Chem (2002) 1.29
Patterning, prestress, and peeling dynamics of myocytes. Biophys J (2004) 1.29
Functional role of loop 2 in myosin V. Biochemistry (2004) 1.29
Rescue of dystrophic skeletal muscle by PGC-1α involves a fast to slow fiber type shift in the mdx mouse. PLoS One (2012) 1.26
Age-related differences in lower-limb muscle cross-sectional area and torque production in boys with Duchenne muscular dystrophy. Arch Phys Med Rehabil (2010) 1.24
Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transport. Proc Natl Acad Sci U S A (2011) 1.23
Myosin VI undergoes a 180 degrees power stroke implying an uncoupling of the front lever arm. Proc Natl Acad Sci U S A (2009) 1.23
Skeletal muscles of ambulant children with Duchenne muscular dystrophy: validation of multicenter study of evaluation with MR imaging and MR spectroscopy. Radiology (2013) 1.22
Stromal cell-derived factor and granulocyte-monocyte colony-stimulating factor form a combined neovasculogenic therapy for ischemic cardiomyopathy. J Thorac Cardiovasc Surg (2005) 1.20
Adhesion-contractile balance in myocyte differentiation. J Cell Sci (2004) 1.20
Unregulated smooth-muscle myosin in human intestinal neoplasia. Proc Natl Acad Sci U S A (2008) 1.20
Calcium functionally uncouples the heads of myosin VI. J Biol Chem (2003) 1.18
Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry (2003) 1.17
Parallax: high accuracy three-dimensional single molecule tracking using split images. Nano Lett (2009) 1.13
Molecular extensibility of mini-dystrophins and a dystrophin rod construct. J Mol Biol (2005) 1.13
The kinetic mechanism of Myo1e (human myosin-IC). J Biol Chem (2002) 1.11
Mutation of smooth muscle myosin causes epithelial invasion and cystic expansion of the zebrafish intestine. Dev Cell (2005) 1.11
Biochemical and motile properties of Myo1b splice isoforms. J Biol Chem (2005) 1.11
Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice. PLoS One (2010) 1.10
Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells. Circ Res (2012) 1.10
Changes in inorganic phosphate and force production in human skeletal muscle after cast immobilization. J Appl Physiol (1985) (2004) 1.10
Structural and energetic analysis of activation by a cyclic nucleotide binding domain. J Mol Biol (2008) 1.10
Nonsense suppression activity of PTC124 (ataluren). Proc Natl Acad Sci U S A (2009) 1.09
Temperature dependence of nucleotide association and kinetic characterization of myo1b. Biochemistry (2006) 1.09
Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH). J Biol Chem (2010) 1.09
Noninvasive monitoring of gene correction in dystrophic muscle. Magn Reson Med (2005) 1.08
Viral gene transfer of the antiapoptotic factor Bcl-2 protects against chronic postischemic heart failure. Circulation (2002) 1.08
Myosin IC generates power over a range of loads via a new tension-sensing mechanism. Proc Natl Acad Sci U S A (2012) 1.08
Control of myosin-I force sensing by alternative splicing. Proc Natl Acad Sci U S A (2009) 1.08
A phase I trial of adeno-associated virus serotype 1-γ-sarcoglycan gene therapy for limb girdle muscular dystrophy type 2C. Brain (2012) 1.08
Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: mass spectrometry mapping of most exons and cooperative domain designs based on single molecule mechanics. Cytoskeleton (Hoboken) (2010) 1.08
A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells. PLoS Genet (2008) 1.07
Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping. Mol Ther (2011) 1.05
Blocking the development of postischemic cardiomyopathy with viral gene transfer of the apoptosis repressor with caspase recruitment domain. J Thorac Cardiovasc Surg (2003) 1.05
Chemical shift-based MRI to measure fat fractions in dystrophic skeletal muscle. Magn Reson Med (2013) 1.05
Cross-correlated TIRF/AFM reveals asymmetric distribution of force-generating heads along self-assembled, "synthetic" myosin filaments. Biophys J (2009) 1.05
Induction of angiogenesis and inhibition of apoptosis by hepatocyte growth factor effectively treats postischemic heart failure. J Card Surg (2005) 1.04
A possible effector role for the pleckstrin homology (PH) domain of dynamin. Proc Natl Acad Sci U S A (2009) 1.04
Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of Duchenne muscular dystrophy. Muscle Nerve (2010) 1.03
Calcium regulation of calmodulin binding to and dissociation from the myo1c regulatory domain. Biochemistry (2007) 1.03
Biophysics of actin filament severing by cofilin. FEBS Lett (2013) 1.03
Two single-headed myosin V motors bound to a tetrameric adapter protein form a processive complex. J Cell Biol (2011) 1.03
An actin-dependent conformational change in myosin. Nat Struct Biol (2003) 1.02
Membrane blebbing as an assessment of functional rescue of dysferlin-deficient human myotubes via nonsense suppression. J Appl Physiol (1985) (2010) 1.02
Myo1e binds anionic phospholipids with high affinity. Biochemistry (2010) 1.02
Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines. Hum Gene Ther (2011) 1.01
Correction of the dystrophic phenotype by in vivo targeting of muscle progenitor cells. Hum Gene Ther (2003) 1.01
Diaphragm displays early and progressive functional deficits in dysferlin-deficient mice. Muscle Nerve (2010) 1.00
Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy. J Biol Chem (2007) 1.00
Transendocardial delivery of AAV6 results in highly efficient and global cardiac gene transfer in rhesus macaques. Hum Gene Ther (2011) 0.99
Leupeptin-based inhibitors do not improve the mdx phenotype. Am J Physiol Regul Integr Comp Physiol (2010) 0.98
The post-rigor structure of myosin VI and implications for the recovery stroke. EMBO J (2007) 0.98
Is functional hypertrophy and specific force coupled with the addition of myonuclei at the single muscle fiber level? FASEB J (2011) 0.97