Published in Adv Cancer Res on January 01, 2003
Epigenetics of prostate cancer: beyond DNA methylation. J Cell Mol Med (2006) 1.12
Epigenetic modulators, modifiers and mediators in cancer aetiology and progression. Nat Rev Genet (2016) 1.07
The new field of epigenomics: implications for cancer and other common disease research. Cold Spring Harb Symp Quant Biol (2004) 0.98
A novel mammalian cell-based approach for the discovery of anticancer drugs with reduced cytotoxicity on non-dividing cells. Invest New Drugs (2004) 0.80
Cell type and context-specific function of PLAG1 for IGF2 P3 promoter activity. Int J Oncol (2012) 0.78
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54
Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. Mol Cell (2008) 9.76
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature (2002) 9.40
Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Nat Genet (2006) 8.99
Increased methylation variation in epigenetic domains across cancer types. Nat Genet (2011) 8.92
Comprehensive high-throughput arrays for relative methylation (CHARM). Genome Res (2008) 8.62
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature (2008) 7.64
Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science (2003) 6.85
Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17
Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature (2010) 6.06
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A (2006) 5.95
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics (2014) 5.93
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol (2013) 5.89
Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. Nat Genet (2009) 5.52
An integrated epigenetic and genetic approach to common human disease. Trends Genet (2004) 4.89
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci U S A (2002) 4.27
An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Science (2007) 4.00
Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. Am J Hum Genet (2002) 3.93
Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies. Int J Epidemiol (2012) 3.62
Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Nat Genet (2004) 3.56
A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. Genome Res (2002) 3.50
DNA methylation signatures within the human brain. Am J Hum Genet (2007) 3.50
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat Biotechnol (2011) 3.25
Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res (2002) 3.21
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat Struct Mol Biol (2011) 3.00
CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator. EMBO Rep (2005) 2.80
The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide. Genome Res (2004) 2.78
Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects. Am J Hum Genet (2002) 2.73
Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. Cancer Cell (2004) 2.73
Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science (2005) 2.72
BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A (2002) 2.62
Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity. Cancer Res (2002) 2.52
Reversible switching between epigenetic states in honeybee behavioral subcastes. Nat Neurosci (2012) 2.44
Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nat Rev Cancer (2013) 2.41
Epigenetics and assisted reproductive technology: a call for investigation. Am J Hum Genet (2004) 2.41
SNP-specific array-based allele-specific expression analysis. Genome Res (2008) 2.30
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance. Mol Cell Biol (2004) 2.24
The emerging science of epigenomics. Hum Mol Genet (2006) 2.22
Accurate genome-scale percentage DNA methylation estimates from microarray data. Biostatistics (2010) 2.11
CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide. Mol Cell Biol (2007) 2.07
Loss of imprinting of insulin growth factor II gene: a potential heritable biomarker for colon neoplasia predisposition. Gastroenterology (2004) 2.06
Redefining CpG islands using hidden Markov models. Biostatistics (2010) 2.03
Does CTCF mediate between nuclear organization and gene expression? Bioessays (2010) 2.02
Characterization of the RNA content of chromatin. Genome Res (2010) 1.99
Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients. Fertil Steril (2005) 1.87
Regulated noise in the epigenetic landscape of development and disease. Cell (2012) 1.79
Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Development (2010) 1.78
A nucleolar protein, H19 opposite tumor suppressor (HOTS), is a tumor growth inhibitor encoded by a human imprinted H19 antisense transcript. Proc Natl Acad Sci U S A (2011) 1.77
Significance analysis and statistical dissection of variably methylated regions. Biostatistics (2011) 1.74
Classification, incidence and survival analyses of children with CNS tumours diagnosed in Sweden 1984-2005. Acta Paediatr (2009) 1.65
An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region. Mol Cell Biol (2004) 1.62
Multiple nucleosome positioning sites regulate the CTCF-mediated insulator function of the H19 imprinting control region. Mol Cell Biol (2002) 1.49
Thyroid hormone-regulated enhancer blocking: cooperation of CTCF and thyroid hormone receptor. EMBO J (2003) 1.49
Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. PLoS One (2009) 1.45
Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells. Mol Cancer Ther (2007) 1.42
Regulation of the mammalian epigenome by long noncoding RNAs. Biochim Biophys Acta (2008) 1.42
Genome wide ChIP-chip analyses reveal important roles for CTCF in Drosophila genome organization. Dev Biol (2009) 1.39
Loss of imprinting of IGF2: a common epigenetic modifier of intestinal tumor risk. Cancer Res (2005) 1.39
Microdeletion of LIT1 in familial Beckwith-Wiedemann syndrome. Am J Hum Genet (2004) 1.38
A species-generalized probabilistic model-based definition of CpG islands. Mamm Genome (2009) 1.36
Epigenetics of imprinted long noncoding RNAs. Epigenetics (2009) 1.36
A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator. J Biol Chem (2002) 1.34
Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization. Genome Res (2013) 1.34
Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. Development (2008) 1.32
Kcnq1ot1/Lit1 noncoding RNA mediates transcriptional silencing by targeting to the perinucleolar region. Mol Cell Biol (2008) 1.31
DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth. Int J Epidemiol (2012) 1.30
Epigenetic specificity of loss of imprinting of the IGF2 gene in Wilms tumors. J Natl Cancer Inst (2007) 1.29
CTCF binds the proximal exonic region of hTERT and inhibits its transcription. Nucleic Acids Res (2005) 1.27
BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression. Mol Cell Biol (2008) 1.26
Heightened expression of CTCF in breast cancer cells is associated with resistance to apoptosis. Cancer Res (2005) 1.26
Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors. Nucleic Acids Res (2007) 1.23
Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing. Genome Res (2009) 1.22
Measuring cell-type specific differential methylation in human brain tissue. Genome Biol (2013) 1.19
DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation. Cancer Res (2008) 1.17
The KCNQ1OT1 imprinting control region and non-coding RNA: new properties derived from the study of Beckwith-Wiedemann syndrome and Silver-Russell syndrome cases. Hum Mol Genet (2011) 1.17
Genome-wide DNA methylation scan in major depressive disorder. PLoS One (2012) 1.17
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A (2007) 1.15
Bidirectional silencing and DNA methylation-sensitive methylation-spreading properties of the Kcnq1 imprinting control region map to the same regions. J Biol Chem (2003) 1.13
Long noncoding RNA-mediated maintenance of DNA methylation and transcriptional gene silencing. Development (2012) 1.11
Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression. Clin Cancer Res (2007) 1.10
Higher order chromatin organization in cancer. Semin Cancer Biol (2012) 1.09
Overlapping euchromatin/heterochromatin- associated marks are enriched in imprinted gene regions and predict allele-specific modification. Genome Res (2008) 1.06
Monoallelic expression and methylation of imprinted genes in human and mouse embryonic germ cell lineages. Proc Natl Acad Sci U S A (2002) 1.05
BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells. Nucleic Acids Res (2010) 1.04
Dynamic association of the mammalian insulator protein CTCF with centrosomes and the midbody. Exp Cell Res (2004) 1.03
Comprehensive high-throughput arrays for relative methylation (CHARM). Curr Protoc Hum Genet (2010) 1.02
Evolutionary diversification of SPANX-N sperm protein gene structure and expression. PLoS One (2007) 1.02
Characterization of novel and complex genomic aberrations in glioblastoma using a 32K BAC array. Neuro Oncol (2009) 1.02
Genetics and epigenetics--nature's pen-and-pencil set. N Engl J Med (2007) 1.02
The structural complexity of the human BORIS gene in gametogenesis and cancer. PLoS One (2010) 1.02