Published in Cancer Cell on March 01, 2003
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet (2006) 7.53
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol (2010) 6.67
Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer (2007) 6.58
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev (2004) 5.83
Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev (2011) 5.64
Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev (2012) 3.44
The thrombospondins. Int J Biochem Cell Biol (2004) 3.01
Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA (2010) 2.59
VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis. EMBO J (2004) 2.22
Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc Natl Acad Sci U S A (2003) 2.20
MicroRNA-210: a unique and pleiotropic hypoxamir. Cell Cycle (2010) 2.18
Computational expression deconvolution in a complex mammalian organ. BMC Bioinformatics (2006) 2.18
Thrombospondins in cancer. Cell Mol Life Sci (2008) 2.08
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol (2013) 2.03
Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol (2006) 1.95
Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation. Proc Natl Acad Sci U S A (2003) 1.90
Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch. Proc Natl Acad Sci U S A (2006) 1.89
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta. Genes Dev (2006) 1.87
Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis. Blood (2010) 1.81
Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene. Genes Dev (2006) 1.60
Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins. J Cell Biol (2005) 1.59
Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins. Blood (2009) 1.57
Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8. Proc Natl Acad Sci U S A (2008) 1.51
Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell. RNA (2009) 1.48
BRAF(V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression. Cancer Res (2011) 1.47
Decreased astrocytic thrombospondin-1 secretion after chronic ammonia treatment reduces the level of synaptic proteins: in vitro and in vivo studies. J Neurochem (2014) 1.45
"Myc'ed messages": myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron. PLoS Genet (2007) 1.45
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype. Oncogene (2008) 1.41
Tumor dormancy due to failure of angiogenesis: role of the microenvironment. Clin Exp Metastasis (2008) 1.38
Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells. Mol Biol Cell (2005) 1.35
Combining bevacizumab with temozolomide increases the antitumor efficacy of temozolomide in a human glioblastoma orthotopic xenograft model. Neoplasia (2008) 1.34
The problem of cancer dormancy: understanding the basic mechanisms and identifying therapeutic opportunities. Cell Cycle (2006) 1.34
The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications. Curr Genomics (2007) 1.33
The effect of thrombospondin-1 on breast cancer metastasis. Breast Cancer Res Treat (2008) 1.32
Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours. J Pathol (2010) 1.29
Thrombospondin-based antiangiogenic therapy. Microvasc Res (2007) 1.26
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3. J Biol Chem (2011) 1.20
Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21. J Exp Med (2010) 1.15
Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis. Mol Cancer (2009) 1.14
Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors. Mol Cancer (2010) 1.14
p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers. Cancer Res (2011) 1.14
Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1. Proc Natl Acad Sci U S A (2009) 1.12
Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma. Cancer Res (2007) 1.11
Wild-type NRas and KRas perform distinct functions during transformation. Mol Cell Biol (2007) 1.11
Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment. Cancer Res (2008) 1.09
Myc: the beauty and the beast. Genes Cancer (2010) 1.07
MicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma. Carcinogenesis (2011) 1.06
c-myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo. Development (2008) 1.05
Oncogenic ras-induced down-regulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cells. J Biol Chem (2009) 1.05
Transcriptomal profiling of the cellular transformation induced by Rho subfamily GTPases. Oncogene (2007) 1.05
Constitutive overexpression of pigment epithelium-derived factor inhibition of ocular melanoma growth and metastasis. Invest Ophthalmol Vis Sci (2009) 1.05
The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J Biol Chem (2009) 1.04
Contrasting effects of VEGF gene disruption in embryonic stem cell-derived versus oncogene-induced tumors. EMBO J (2003) 1.04
Expression of the type-1 repeats of thrombospondin-1 inhibits tumor growth through activation of transforming growth factor-beta. Am J Pathol (2004) 1.02
Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint. Mol Cell Biol (2011) 1.02
A C. elegans Myc-like network cooperates with semaphorin and Wnt signaling pathways to control cell migration. Dev Biol (2007) 1.02
Endogenous inhibitors of angiogenesis in malignant gliomas: nature's antiangiogenic therapy. Neuro Oncol (2005) 0.94
The role of the tumor microenvironment in regulating angiogenesis. Cold Spring Harb Perspect Med (2012) 0.93
Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression. Breast Cancer Res (2009) 0.93
Elongation factor ELL (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation. J Biol Chem (2009) 0.92
Tumour dormancy and clinical implications in breast cancer. Ecancermedicalscience (2013) 0.92
Cdk5-mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1. J Biol Chem (2008) 0.92
Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System. Clin Med Insights Oncol (2011) 0.92
Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis. Breast Cancer Res (2012) 0.91
Promoter-independent regulation of vimentin expression in mammary epithelial cells by val(12)ras and TGFbeta. Exp Cell Res (2007) 0.90
p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow. Proc Natl Acad Sci U S A (2005) 0.89
Synergism of BARF1 with Ras induces malignant transformation in primary primate epithelial cells and human nasopharyngeal epithelial cells. Neoplasia (2009) 0.89
Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism. Neoplasia (2012) 0.88
Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms. PLoS One (2010) 0.88
Posttranslational regulation of Myc by promyelocytic leukemia zinc finger protein. Int J Cancer (2009) 0.87
Proteomics analysis of H-RAS-mediated oncogenic transformation in a genetically defined human ovarian cancer model. Oncogene (2005) 0.86
Wiring the angiogenic switch: Ras, Myc, and Thrombospondin-1. Cancer Cell (2003) 0.85
Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS. PLoS One (2013) 0.83
E2F-1 directly regulates thrombospondin 1 expression. PLoS One (2010) 0.83
Autocrine stimulation of clear-cell renal carcinoma cell migration in hypoxia via HIF-independent suppression of thrombospondin-1. Sci Rep (2012) 0.83
A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton. Oncogene (2010) 0.82
Liver hyperplasia after tamoxifen induction of Myc in a transgenic medaka model. Dis Model Mech (2012) 0.82
Predictive and prognostic markers in colorectal cancer. Gastrointest Cancer Res (2007) 0.81
Efficacy of bevacizumab and chemotherapy in the first-line treatment of metastatic colorectal cancer: broadening KRAS-focused clinical view. BMC Gastroenterol (2015) 0.81
Concurrent quantification of proteome and phosphoproteome to reveal system-wide association of protein phosphorylation and gene expression. Mol Cell Proteomics (2009) 0.81
Immortalized cells as experimental models to study cancer. Cytotechnology (2004) 0.79
Screening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinoma. Proc Natl Acad Sci U S A (2015) 0.79
Platelet proteome and tumor dormancy: can platelets content serve as predictive biomarkers for exit of tumors from dormancy? Cancers (Basel) (2010) 0.79
Breast cancer metastasis and the lymphatic system. Oncol Lett (2015) 0.79
Significant gene expression differences in histologically "Normal" liver biopsies: Implications for control tissue. Hepatology (2008) 0.79
Induction of thrombospondin-1 partially mediates the anti-angiogenic activity of dexrazoxane. Br J Cancer (2009) 0.79
PPARgamma and Agonists against Cancer: Rational Design of Complementation Treatments. PPAR Res (2008) 0.78
Burkitt's lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a/Nop56 in oncogenesis. Oncogene (2013) 0.78
The effect of chemotherapeutic agents on tumor vasculature in subcutaneous and orthotopic human tumor xenografts. BMC Cancer (2015) 0.78
Aiding and ABT'ing Treatment for Glioblastoma. Cancer Biol Ther (2007) 0.77
Role of RAS mutation status as a prognostic factor for patients with advanced colorectal cancer treated with first-line chemotherapy based on fluoropyrimidines and oxaliplatin, with or without bevavizumab: A retrospective analysis. Mol Clin Oncol (2017) 0.75
Review of tumor dormancy therapy using traditional oriental herbal medicine. J Pharmacopuncture (2013) 0.75
Feeding sugar to tumors: with a supplement of miR? J Am Heart Assoc (2012) 0.75
Accomplishments in 2007 in biologic markers for gastrointestinal cancers. Gastrointest Cancer Res (2008) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
The basics of epithelial-mesenchymal transition. J Clin Invest (2009) 32.82
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature (2007) 21.53
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer (2009) 18.53
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 18.20
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet (2008) 17.67
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell (2008) 14.80
A perspective on cancer cell metastasis. Science (2011) 13.31
Retracted A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell (2009) 10.51
Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34
A progression puzzle. Nature (2002) 9.56
Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA (2003) 8.07
Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A (2004) 7.96
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res (2008) 7.91
Ras oncogenes: split personalities. Nat Rev Mol Cell Biol (2008) 7.91
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nat Biotechnol (2009) 6.76
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol (2010) 6.67
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A (2011) 5.53
Modelling the molecular circuitry of cancer. Nat Rev Cancer (2002) 5.43
Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A (2007) 5.24
Cancer stem cells: mirage or reality? Nat Med (2009) 5.20
The signals and pathways activating cellular senescence. Int J Biochem Cell Biol (2004) 5.00
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nat Med (2004) 4.98
Rules for making human tumor cells. N Engl J Med (2002) 4.84
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol (2010) 4.80
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell (2011) 4.79
Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol (2002) 4.77
Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat Genet (2005) 4.70
Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle (2006) 4.67
Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell (2007) 4.30
Species- and cell type-specific requirements for cellular transformation. Cancer Cell (2004) 4.25
Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol (2012) 3.98
Exploring a new twist on tumor metastasis. Cancer Res (2006) 3.96
The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med (2013) 3.96
Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell (2008) 3.95
Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene (2002) 3.80
Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell (2008) 3.75
The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Proc Natl Acad Sci U S A (2006) 3.64
Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell (2013) 3.61
Telomerase maintains telomere structure in normal human cells. Cell (2003) 3.29
Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice. Nat Rev Cancer (2003) 3.23
Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Res (2007) 3.04
The terminology of teratocarcinomas and teratomas. Nat Biotechnol (2007) 3.03
Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci U S A (2010) 3.03
The distal fallopian tube: a new model for pelvic serous carcinogenesis. Curr Opin Obstet Gynecol (2007) 3.02
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell (2012) 2.94
Telomeres: cancer to human aging. Annu Rev Cell Dev Biol (2006) 2.88
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci U S A (2002) 2.82
Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci U S A (2009) 2.75
Tumor-host interactions: a far-reaching relationship. J Clin Oncol (2010) 2.48
Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia (2010) 2.38
When cells get stressed: an integrative view of cellular senescence. J Clin Invest (2004) 2.37
A mouse model of human breast cancer metastasis to human bone. Cancer Res (2005) 2.24
Adaptation versus selection: the origins of metastatic behavior. Cancer Res (2007) 2.08
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci U S A (2011) 2.03
Micromanagers of malignancy: role of microRNAs in regulating metastasis. Trends Genet (2008) 2.03
Taking the study of cancer cell survival to a new dimension. Cell (2002) 2.03
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. J Clin Invest (2011) 1.96
Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discov (2011) 1.88
Loss of p63 expression is associated with tumor progression in bladder cancer. Am J Pathol (2002) 1.88
Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell (2013) 1.86
IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Dev Cell (2002) 1.79
Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Int J Cancer (2011) 1.79
Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells. FASEB J (2009) 1.79
Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet (2003) 1.78
Retracted Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis. Genes Dev (2009) 1.74
Cell plasticity and heterogeneity in cancer. Clin Chem (2012) 1.74
MicroRNAs in malignant progression. Cell Cycle (2007) 1.74
Retracted Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis. Cancer Res (2010) 1.73
Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. Cancer Discov (2012) 1.71
Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers. Cancer Res (2007) 1.66
Differentiation of NUT midline carcinoma by epigenomic reprogramming. Cancer Res (2011) 1.65
MicroRNAs: Crucial multi-tasking components in the complex circuitry of tumor metastasis. Cell Cycle (2009) 1.63
Human embryonic stem cell derivation from poor-quality embryos. Nat Biotechnol (2008) 1.60
Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol (2003) 1.59
Taxonomy of breast cancer based on normal cell phenotype predicts outcome. J Clin Invest (2014) 1.58
Microglandular hyperplasia: a model for the de novo emergence and evolution of endocervical reserve cells. Hum Pathol (2005) 1.52
miR-31: a crucial overseer of tumor metastasis and other emerging roles. Cell Cycle (2010) 1.51
The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions. Cancer Discov (2012) 1.45
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci U S A (2008) 1.41
Retracted Activation of miR-31 function in already-established metastases elicits metastatic regression. Genes Dev (2011) 1.40
An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell (2013) 1.36
Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Semin Cancer Biol (2010) 1.36
Phenotypic and functional characterization of human mammary stem/progenitor cells in long term culture. PLoS One (2009) 1.33
From whence will they come? - A perspective on the acute shortage of pathologists in biomedical research. J Vet Diagn Invest (2007) 1.32
A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells. Cancer Cell (2013) 1.29
Prediction of endometrial carcinoma by subjective endometrial intraepithelial neoplasia diagnosis. Mod Pathol (2005) 1.26
Roles for microRNAs in the regulation of cell adhesion molecules. J Cell Sci (2011) 1.25
Do-it-yourself (DIY) pathology. Nat Biotechnol (2008) 1.23
Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF. Cancer Res (2004) 1.21
Heterogeneity of stromal fibroblasts in tumors. Cancer Biol Ther (2007) 1.21
Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation. J Virol (2009) 1.20