Published in Acta Biochim Biophys Sin (Shanghai) on December 29, 2013
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Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nat Genet (2007) 4.99
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Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell (2011) 4.74
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol (2006) 4.54
ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell (2001) 4.38
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Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09
p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol (2007) 3.86
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p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol (2011) 3.70
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TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature (2010) 3.37
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Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene. Cell (1984) 3.05
The mitochondrial p53 pathway. Biochim Biophys Acta (2008) 2.98
p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat Cell Biol (2008) 2.81
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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol Cell Biol (2001) 2.69
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The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res (2004) 2.56
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Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep (2007) 1.96
Modulation of the vitamin D3 response by cancer-associated mutant p53. Cancer Cell (2010) 1.95
A Pin1/mutant p53 axis promotes aggressiveness in breast cancer. Cancer Cell (2011) 1.95
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc Natl Acad Sci U S A (2011) 1.87
Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis. Oncogene (2012) 1.85
In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute. Cell Death Differ (2008) 1.81
Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells. Mol Cancer Res (2011) 1.77
SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis. Cell Death Differ (2011) 1.76
CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. J Clin Invest (2007) 1.71
The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer. Biochem Biophys Res Commun (2010) 1.56
Tumour-associated mutant p53 drives the Warburg effect. Nat Commun (2013) 1.52
Tumor suppressor p53 meets microRNAs. J Mol Cell Biol (2011) 1.39
Mutant p53 drives invasion in breast tumors through up-regulation of miR-155. Oncogene (2012) 1.36
Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci U S A (2008) 1.36
Regulation of AIF expression by p53. Cell Death Differ (2006) 1.31
Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding. Mol Cell Biol (2003) 1.25
The role of TP53 in Cervical carcinogenesis. Hum Mutat (2003) 1.23
Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. J Clin Invest (2011) 1.21
Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity. Nat Commun (2011) 1.20
MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function. Cell Death Differ (2011) 1.18
DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model. J Exp Med (2007) 1.16
Promyelocytic leukemia protein is required for gain of function by mutant p53. Cancer Res (2009) 1.14
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MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell (2011) 4.56
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science (2010) 4.37
p53 regulates maternal reproduction through LIF. Nature (2007) 4.12
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci (2002) 3.64
Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat Med (2003) 3.21
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Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML. Cell Stem Cell (2012) 2.89
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev (2006) 2.66
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Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell (2010) 1.92
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc Natl Acad Sci U S A (2011) 1.87
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A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells. Cancer Res (2007) 1.67
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Mol Cell Biol (2004) 1.63
The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. Carcinogenesis (2002) 1.43
Tumor suppressor p53 meets microRNAs. J Mol Cell Biol (2011) 1.39
Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway. Genes Cancer (2010) 1.38
Identification of a biochemical link between energy intake and energy expenditure. J Clin Invest (2002) 1.29
p53: a new player in reproduction. Cell Cycle (2008) 1.20
p63 regulates glutaminase 2 expression. Cell Cycle (2013) 1.12
Enhanced ultraviolet emission and improved spatial distribution uniformity of ZnO nanorod array light-emitting diodes via Ag nanoparticles decoration. Nanoscale (2013) 1.09
LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway. Oncotarget (2014) 1.08
Regulation of female reproduction by p53 and its family members. FASEB J (2011) 1.08
Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci U S A (2012) 1.08
The Regulation of Multiple p53 Stress Responses is Mediated through MDM2. Genes Cancer (2012) 1.06
Tumor suppressor p53 and its mutants in cancer metabolism. Cancer Lett (2013) 1.04
Cloning and expression of a pivotal calcium metabolism regulator: calmodulin involved in shell formation from pearl oyster (Pinctada fucata). Comp Biochem Physiol B Biochem Mol Biol (2004) 1.01
Intracellular trafficking of a tagged and functional mammalian olfactory receptor. J Neurobiol (2002) 1.00
DNA damage, repair, and mutation induction by (+)-Syn and (-)-anti-dibenzo[a,l]pyrene-11,12-diol-13,14-epoxides in mouse cells. Cancer Res (2004) 0.98
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Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma. Oncotarget (2014) 0.91
Catalpol protects primary cultured astrocytes from in vitro ischemia-induced damage. Int J Dev Neurosci (2008) 0.91
The regulation of human reproduction by p53 and its pathway. Cell Cycle (2009) 0.90
Gene expression profiling of leukemia stem cells. Methods Mol Biol (2009) 0.89
2-(Substituted phenyl)-3,4-dihydroisoquinolin-2-iums as novel antifungal lead compounds: biological evaluation and structure-activity relationships. Molecules (2013) 0.88
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Preferential carcinogen-DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms. Biochemistry (2003) 0.86
Transformation from committed progenitor to leukemia stem cells. Ann N Y Acad Sci (2009) 0.83
A novel extracellular EF-hand protein involved in the shell formation of pearl oyster. Biochim Biophys Acta (2007) 0.83
Gene expression of primary human bronchial epithelial cells in response to coal dusts with different prevalence of coal workers' pneumoconiosis. J Toxicol Environ Health A (2003) 0.82
TAp63γ enhances nucleotide excision repair through transcriptional regulation of DNA repair genes. DNA Repair (Amst) (2011) 0.81
Support for mandatory health care worker influenza vaccination among allied health professionals, technical staff, and medical students. Am J Infect Control (2012) 0.80
Ionizing radiation sensitizes breast cancer cells to Bcl-2 inhibitor, ABT-737, through regulating Mcl-1. Radiat Res (2014) 0.80
Whole exome sequencing identifies a novel EMD mutation in a Chinese family with dilated cardiomyopathy. BMC Med Genet (2014) 0.77
Characterization of transgenic zebrafish lines that express GFP in the retina, pineal gland, olfactory bulb, hatching gland, and optic tectum. Gene Expr Patterns (2013) 0.77
PTEN, energy metabolism and tumor suppression. Acta Biochim Biophys Sin (Shanghai) (2012) 0.75
Dihydro-cryptopine. Acta Crystallogr Sect E Struct Rep Online (2012) 0.75
Mapping polycyclic aromatic hydrocarbon and aromatic amine-induced DNA damage in cancer-related genes at the sequence level. Int J Hyg Environ Health (2002) 0.75
Significant enhancement of yellow-green light emission of TiO2 thin films using Au localized surface plasmons: effect of dielectric MgO spacer layer thickness. J Nanosci Nanotechnol (2014) 0.75