Published in Curr Biol on July 01, 2003
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Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity. Proc Natl Acad Sci U S A (2009) 1.29
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Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J Neurosci (2010) 1.25
Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear. Hum Mol Genet (2008) 1.25
Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Dev Cell (2010) 1.25
Planar cell polarity: keeping hairs straight is not so simple. Cold Spring Harb Perspect Biol (2010) 1.24
The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis. Development (2007) 1.23
Primary cilia in planar cell polarity regulation of the inner ear. Curr Top Dev Biol (2008) 1.23
Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development. PLoS One (2012) 1.22
Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases. Neural Dev (2009) 1.21
The cell biology of planar cell polarity. J Cell Biol (2014) 1.19
Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes. Development (2012) 1.19
Line up and listen: Planar cell polarity regulation in the mammalian inner ear. Semin Cell Dev Biol (2009) 1.18
Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. Dev Cell (2009) 1.18
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Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS One (2008) 1.14
Gene-environment interactions, folate metabolism and the embryonic nervous system. Wiley Interdiscip Rev Syst Biol Med (2010) 1.14
Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation. Development (2008) 1.13
Distinct apical and basolateral mechanisms drive planar cell polarity-dependent convergent extension of the mouse neural plate. Dev Cell (2014) 1.12
Shaping the nervous system: role of the core planar cell polarity genes. Nat Rev Neurosci (2013) 1.11
Planar cell polarity signaling: coordination of cellular orientation across tissues. Wiley Interdiscip Rev Dev Biol (2013) 1.11
Alternative Wnt pathways and receptors. Cold Spring Harb Perspect Biol (2012) 1.09
Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility. Mol Cell Biol (2004) 1.09
The multiple-wing-hairs gene encodes a novel GBD-FH3 domain-containing protein that functions both prior to and after wing hair initiation. Genetics (2008) 1.08
A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment. Mamm Genome (2004) 1.07
The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. BMC Dev Biol (2010) 1.06
Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development (2008) 1.06
Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis. Hum Mutat (2011) 1.06
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When whorls collide: the development of hair patterns in frizzled 6 mutant mice. Development (2010) 1.06
The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells. EMBO Mol Med (2014) 1.05
Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis. Cell Rep (2012) 1.03
Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120-catenin. Development (2012) 1.00
Wnt signaling in vertebrate neural development and function. J Neuroimmune Pharmacol (2012) 1.00
The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled. Dev Biol (2012) 1.00
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Wnt-Frizzled/Planar Cell Polarity Signaling: Cellular Orientation by Facing the Wind (Wnt). Annu Rev Cell Dev Biol (2015) 0.98
The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling. J Biol Chem (2012) 0.98
Mutations in planar cell polarity gene SCRIB are associated with spina bifida. PLoS One (2013) 0.98
Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2. J Neurosci (2013) 0.97
Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat. BMC Neurosci (2008) 0.96
A balance of form and function: planar polarity and development of the vestibular maculae. Semin Cell Dev Biol (2013) 0.96
Mouse primitive streak forms in situ by initiation of epithelial to mesenchymal transition without migration of a cell population. Dev Dyn (2011) 0.95
Planar cell polarity in Drosophila. Organogenesis (2011) 0.95
Jxc1/Sobp, encoding a nuclear zinc finger protein, is critical for cochlear growth, cell fate, and patterning of the organ of corti. J Neurosci (2008) 0.94
Caenorhabditis elegans flamingo cadherin fmi-1 regulates GABAergic neuronal development. J Neurosci (2012) 0.93
Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear. Development (2012) 0.93
Identification of novel CELSR1 mutations in spina bifida. PLoS One (2014) 0.92
Current perspectives on the genetic causes of neural tube defects. Neurogenetics (2006) 0.92
Enabled (Xena) regulates neural plate morphogenesis, apical constriction, and cellular adhesion required for neural tube closure in Xenopus. Dev Biol (2007) 0.92
Mouse models for dissecting vertebrate planar cell polarity signaling in the inner ear. Brain Res (2009) 0.92
How to form and close the brain: insight into the mechanism of cranial neural tube closure in mammals. Cell Mol Life Sci (2012) 0.92
A search for factors specifying tonotopy implicates DNER in hair-cell development in the chick's cochlea. Dev Biol (2011) 0.92
The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain. Mol Cell Biol (2009) 0.91
Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet (2005) 4.76
Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet (2010) 4.37
The genetic basis of mammalian neurulation. Nat Rev Genet (2003) 4.14
Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. Nat Genet (2009) 3.72
An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science (2005) 3.61
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science (2007) 3.59
Sox2 is required for sensory organ development in the mammalian inner ear. Nature (2005) 3.58
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell (2013) 3.47
Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat Genet (2005) 3.39
The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation. Hum Mol Genet (2006) 3.06
Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans. Cell (2007) 3.06
An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Nat Genet (2009) 3.05
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science (2007) 3.05
Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31. Nat Genet (2003) 2.98
Wnt5a functions in planar cell polarity regulation in mice. Dev Biol (2007) 2.85
Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS. J Invest Dermatol (2013) 2.74
Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping Consortium. Dis Model Mech (2012) 2.73
EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids Res (2009) 2.72
FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder. Brain (2003) 2.55
Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development (2007) 2.45
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet (2011) 2.34
Beethoven, a mouse model for dominant, progressive hearing loss DFNA36. Nat Genet (2002) 2.31
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Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits. Curr Biol (2008) 2.27
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The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. Hum Mol Genet (2006) 2.14
Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circ Res (2005) 2.13
Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project. Mamm Genome (2012) 2.12
Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse. Hum Mol Genet (2003) 2.11
In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis (2005) 2.08
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol (2013) 2.04
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. Hum Mol Genet (2009) 1.93
Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization. Circ Res (2007) 1.85
A gene-driven ENU-based approach to generating an allelic series in any gene. Mamm Genome (2004) 1.82
Characterization of Usher syndrome type I gene mutations in an Usher syndrome patient population. Hum Genet (2005) 1.81
Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark. Hum Mol Genet (2003) 1.80
A gene-driven approach to the identification of ENU mutants in the mouse. Nat Genet (2002) 1.76
Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study. Physiol Genomics (2008) 1.76
Mouse Phenotype Database Integration Consortium: integration [corrected] of mouse phenome data resources. Mamm Genome (2007) 1.75
Loss of myosin VI reduces secretion and the size of the Golgi in fibroblasts from Snell's waltzer mice. EMBO J (2003) 1.74
Genetic analysis of the mouse brain proteome. Nat Genet (2002) 1.73
Multiple mutations in mouse Chd7 provide models for CHARGE syndrome. Hum Mol Genet (2005) 1.71
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Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia. Mol Cell Biol (2007) 1.66
A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice. Proc Natl Acad Sci U S A (2009) 1.66
Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea. J Physiol (2006) 1.65
Accessing data from the International Mouse Phenotyping Consortium: state of the art and future plans. Mamm Genome (2012) 1.63
Non-cell-autonomous roles for the planar cell polarity gene Vangl2 in development of the coronary circulation. Circ Res (2008) 1.60
Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Development (2003) 1.59
ENU mutagenesis, a way forward to understand gene function. Annu Rev Genomics Hum Genet (2008) 1.59
Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi: a role for MC1R in human fetal development. J Invest Dermatol (2012) 1.56
Folic acid prevents exencephaly in Cited2 deficient mice. Hum Mol Genet (2002) 1.55
Comprehensive sequence analysis of nine Usher syndrome genes in the UK National Collaborative Usher Study. J Med Genet (2011) 1.54
Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes. J Cell Sci (2004) 1.53
Fetal spina bifida in a mouse model: loss of neural function in utero. J Neurosurg (2007) 1.53
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Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes. PLoS Genet (2013) 1.50
Development of the vertebrate central nervous system: formation of the neural tube. Prenat Diagn (2009) 1.49
Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse. Nat Genet (2002) 1.48
Regeneration of hair follicles is modulated by flightless I (Flii) in a rodent vibrissa model. J Invest Dermatol (2010) 1.44
Sonic hedgehog and the molecular regulation of mouse neural tube closure. Development (2002) 1.44
Cordon-bleu is a conserved gene involved in neural tube formation. Dev Biol (2003) 1.44
Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome. Nat Genet (2011) 1.43
Novel ENU-induced eye mutations in the mouse: models for human eye disease. Hum Mol Genet (2002) 1.41
When clocks go bad: neurobehavioural consequences of disrupted circadian timing. PLoS Genet (2008) 1.41
Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. J Clin Invest (2009) 1.40
A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment. Nat Protoc (2010) 1.36
Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism. Hum Mol Genet (2008) 1.36
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Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function. Hum Mol Genet (2008) 1.33
miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells. Proc Natl Acad Sci U S A (2011) 1.32
Elongation of hair cell stereocilia is defective in the mouse mutant whirler. J Comp Neurol (2002) 1.31
Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium. Hum Mol Genet (2004) 1.30
The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Hum Mol Genet (2010) 1.30
A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse. J Neurosci (2003) 1.29
Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing. Genome Res (2008) 1.28
Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling. Development (2007) 1.27
Integrity of the methylation cycle is essential for mammalian neural tube closure. Birth Defects Res A Clin Mol Teratol (2006) 1.26