PubRank

David E Clapham

Author PubWeight™ 166.67‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 An introduction to TRP channels. Annu Rev Physiol 2006 7.52
2 The mitochondrial calcium uniporter is a highly selective ion channel. Nature 2004 6.97
3 TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet 2005 5.53
4 Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell 2006 5.03
5 A voltage-gated proton-selective channel lacking the pore domain. Nature 2006 4.89
6 Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol 2004 4.19
7 Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science 2009 3.96
8 The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol 2002 3.63
9 TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 2002 3.55
10 A unified nomenclature for the superfamily of TRP cation channels. Mol Cell 2002 2.99
11 Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature 2012 2.97
12 International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev 2010 2.66
13 Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature 2006 2.63
14 The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron 2003 2.61
15 Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science 2008 2.59
16 All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proc Natl Acad Sci U S A 2007 2.59
17 Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci 2006 2.58
18 The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Neuron 2006 2.50
19 Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci 2004 2.41
20 Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circ Res 2005 2.40
21 EMRE is an essential component of the mitochondrial calcium uniporter complex. Science 2013 2.39
22 TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell 2012 2.35
23 CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci U S A 2003 2.34
24 TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell 2010 2.32
25 Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J Biol Chem 2003 2.29
26 Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci 2005 2.09
27 International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev 2003 2.05
28 TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell 2012 2.03
29 Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A 2007 1.99
30 SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron 2004 1.97
31 TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci 2003 1.95
32 The cation selectivity filter of the bacterial sodium channel, NaChBac. J Gen Physiol 2002 1.94
33 A superfamily of voltage-gated sodium channels in bacteria. J Biol Chem 2003 1.84
34 Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proc Natl Acad Sci U S A 2009 1.80
35 TRP ion channels in the nervous system. Curr Opin Neurobiol 2004 1.78
36 KSper, a pH-sensitive K+ current that controls sperm membrane potential. Proc Natl Acad Sci U S A 2007 1.77
37 TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal 2009 1.75
38 The control of male fertility by spermatozoan ion channels. Annu Rev Physiol 2011 1.74
39 Essential role for TRPC5 in amygdala function and fear-related behavior. Cell 2009 1.72
40 International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev 2005 1.63
41 Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proc Natl Acad Sci U S A 2009 1.60
42 Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol 2009 1.51
43 Rheotaxis guides mammalian sperm. Curr Biol 2013 1.47
44 Real-time imaging of nuclear permeation by EGFP in single intact cells. Biophys J 2003 1.46
45 The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci 2012 1.45
46 CatSperbeta, a novel transmembrane protein in the CatSper channel complex. J Biol Chem 2007 1.43
47 MCU encodes the pore conducting mitochondrial calcium currents. Elife 2013 1.39
48 CACNA1H mutations in autism spectrum disorders. J Biol Chem 2006 1.35
49 The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A 2011 1.29
50 The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. Proc Natl Acad Sci U S A 2004 1.28
51 Phenotyping sensory nerve endings in vitro in the mouse. Nat Protoc 2009 1.27
52 A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol 2004 1.26
53 Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A 2013 1.25
54 Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. EMBO J 2006 1.25
55 Ion channels that control fertility in mammalian spermatozoa. Int J Dev Biol 2008 1.23
56 Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A 2011 1.19
57 Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nat Commun 2013 1.19
58 TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Proc Natl Acad Sci U S A 2008 1.17
59 A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun 2011 1.16
60 Mechanism of persistent protein kinase D1 translocation and activation. Dev Cell 2003 1.15
61 Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J Biol Chem 2006 1.14
62 POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. Proc Natl Acad Sci U S A 2011 1.12
63 Ancestral Ca2+ signaling machinery in early animal and fungal evolution. Mol Biol Evol 2011 1.12
64 Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. Proc Natl Acad Sci U S A 2013 1.10
65 TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Mol Cell Biol 2005 1.07
66 Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Dev Cell 2012 1.07
67 Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. PLoS One 2008 1.05
68 Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One 2008 1.01
69 TRP channels and mice deficient in TRP channels. Pflugers Arch 2005 1.00
70 TRPM7, the Mg(2+) inhibited channel and kinase. Adv Exp Med Biol 2011 0.99
71 Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption. Nano Lett 2010 0.99
72 The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation. J Gen Physiol 2013 0.97
73 Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation 2013 0.97
74 Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL. Nat Commun 2012 0.93
75 Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. J Gen Physiol 2013 0.92
76 Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh. Cell Res 2012 0.92
77 Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proc Natl Acad Sci U S A 2013 0.92
78 ATP-activated P2X2 current in mouse spermatozoa. Proc Natl Acad Sci U S A 2011 0.91
79 A STIMulus Package puts orai calcium channels to work. Cell 2009 0.91
80 Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. PLoS One 2012 0.90
81 Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. Proc Natl Acad Sci U S A 2012 0.89
82 Structural characterization of the mouse Girk genes. Gene 2002 0.88
83 Sperm patch-clamp. Methods Enzymol 2013 0.85
84 Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. J Neurosci 2014 0.85
85 The voltage-gated Na+ channel NaVBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4. Microbiology 2007 0.82
86 The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTP. Mol Cell Neurosci 2008 0.80
87 Modified herpes simplex virus delivery of enhanced GFP into the central nervous system. J Neurosci Methods 2002 0.77