Published in J Biol Chem on August 09, 2006
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J Clin Invest (2007) 2.19
From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs. Curr Opin Neurobiol (2007) 2.08
The transient receptor potential family of ion channels. Genome Biol (2011) 2.08
The thermo-TRP ion channel family: properties and therapeutic implications. Br J Pharmacol (2012) 1.39
Activation of the TRPV4 ion channel is enhanced by phosphorylation. J Biol Chem (2009) 1.30
Transient receptor potential (TRP) channels: a clinical perspective. Br J Pharmacol (2014) 1.25
Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system. Pharmacol Ther (2011) 1.24
TRPV channels and vascular function. Acta Physiol (Oxf) (2010) 1.16
Increased basal activity is a key determinant in the severity of human skeletal dysplasia caused by TRPV4 mutations. PLoS One (2011) 1.13
Function and regulation of TRP family channels in C. elegans. Pflugers Arch (2009) 1.09
TRP channels in neurogastroenterology: opportunities for therapeutic intervention. Br J Pharmacol (2011) 1.07
The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem (2010) 1.07
Forward genetic analysis reveals multiple gating mechanisms of TRPV4. J Biol Chem (2010) 1.04
The TRPV3 mutation associated with the hairless phenotype in rodents is constitutively active. Cell Calcium (2007) 1.02
Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain. FASEB J (2008) 0.99
Herbal compounds and toxins modulating TRP channels. Curr Neuropharmacol (2008) 0.99
Calcium influx pathways in breast cancer: opportunities for pharmacological intervention. Br J Pharmacol (2014) 0.96
ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1. Curr Neuropharmacol (2008) 0.93
TRP channels as candidates for hearing and balance abnormalities in vertebrates. Biochim Biophys Acta (2007) 0.92
Transient receptor potential channels as targets for phytochemicals. ACS Chem Neurosci (2014) 0.88
C. elegans TRP channels. Adv Exp Med Biol (2011) 0.83
Trafficking of ThermoTRP Channels. Membranes (Basel) (2014) 0.83
The TRPV4 cation channel: A molecule linking skin temperature and barrier function. Commun Integr Biol (2010) 0.82
TRPs and pain. Semin Immunopathol (2015) 0.80
Targeting TRP channels for chronic cough: from bench to bedside. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.80
TRPs in taste and chemesthesis. Handb Exp Pharmacol (2014) 0.80
Calcineurin/nuclear factor of activated T cells-coupled vanilliod transient receptor potential channel 4 ca2+ sparklets stimulate airway smooth muscle cell proliferation. Am J Respir Cell Mol Biol (2014) 0.79
Nociceptive and pro-inflammatory effects of dimethylallyl pyrophosphate via TRPV4 activation. Br J Pharmacol (2012) 0.79
TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells. Pflugers Arch (2015) 0.77
Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology. Evid Based Complement Alternat Med (2017) 0.75
Andrographis paniculata (Burm. f.) Wall. ex Nees: a review of ethnobotany, phytochemistry, and pharmacology. ScientificWorldJournal (2014) 0.75
Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. Front Pharmacol (2016) 0.75
An introduction to TRP channels. Annu Rev Physiol (2006) 7.52
The mitochondrial calcium uniporter is a highly selective ion channel. Nature (2004) 6.97
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet (2005) 5.53
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell (2006) 5.03
A voltage-gated proton-selective channel lacking the pore domain. Nature (2006) 4.89
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell (2006) 4.52
Small-molecule pheromones that control dauer development in Caenorhabditis elegans. Nat Chem Biol (2007) 4.26
Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol (2004) 4.19
A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans. Nature (2009) 4.05
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science (2009) 3.96
Bacterial protection of beetle-fungus mutualism. Science (2008) 3.69
The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol (2002) 3.63
D-amino acids trigger biofilm disassembly. Science (2010) 3.60
D-amino acids govern stationary phase cell wall remodeling in bacteria. Science (2009) 3.55
TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature (2002) 3.55
A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell (2003) 3.29
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature (2012) 2.97
The evolution of gene collectives: How natural selection drives chemical innovation. Proc Natl Acad Sci U S A (2008) 2.71
High-throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrob Agents Chemother (2006) 2.70
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature (2006) 2.63
The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron (2003) 2.61
Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science (2008) 2.59
All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proc Natl Acad Sci U S A (2007) 2.59
Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci (2006) 2.58
Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis. Nat Chem Biol (2009) 2.57
Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans. Science (2009) 2.55
The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Neuron (2006) 2.50
Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci (2004) 2.41
Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. Circ Res (2005) 2.40
Target identification using drug affinity responsive target stability (DARTS). Proc Natl Acad Sci U S A (2009) 2.40
EMRE is an essential component of the mitochondrial calcium uniporter complex. Science (2013) 2.39
Tyrosol is a quorum-sensing molecule in Candida albicans. Proc Natl Acad Sci U S A (2004) 2.39
A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components. Proc Natl Acad Sci U S A (2008) 2.35
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35
CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci U S A (2003) 2.34
TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell (2010) 2.32
Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J Biol Chem (2003) 2.29
Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A (2009) 2.22
The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proc Natl Acad Sci U S A (2007) 2.22
Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity. Proc Natl Acad Sci U S A (2002) 2.15
The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis. Nat Chem (2011) 2.12
Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci (2005) 2.09
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev (2003) 2.05
Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chem Biol (2010) 2.04
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A (2007) 1.99
Regulating alternative lifestyles in entomopathogenic bacteria. Curr Biol (2010) 1.97
SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron (2004) 1.97
Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A (2009) 1.96
TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci (2003) 1.95
The cation selectivity filter of the bacterial sodium channel, NaChBac. J Gen Physiol (2002) 1.94
Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA. Appl Environ Microbiol (2002) 1.89
A superfamily of voltage-gated sodium channels in bacteria. J Biol Chem (2003) 1.84
A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states. Science (2012) 1.82
Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proc Natl Acad Sci U S A (2009) 1.80
TRP ion channels in the nervous system. Curr Opin Neurobiol (2004) 1.78
KSper, a pH-sensitive K+ current that controls sperm membrane potential. Proc Natl Acad Sci U S A (2007) 1.77
TRPM1 forms ion channels associated with melanin content in melanocytes. Sci Signal (2009) 1.75
The control of male fertility by spermatozoan ion channels. Annu Rev Physiol (2011) 1.74
High-throughput screens for small-molecule inhibitors of Pseudomonas aeruginosa biofilm development. Antimicrob Agents Chemother (2007) 1.74
A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals. Elife (2012) 1.72
Essential role for TRPC5 in amygdala function and fear-related behavior. Cell (2009) 1.72
One pathway, many products. Nat Chem Biol (2007) 1.63
International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev (2005) 1.63
Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proc Natl Acad Sci U S A (2009) 1.60
Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria. Proc Natl Acad Sci U S A (2010) 1.59
Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. Proc Natl Acad Sci U S A (2003) 1.58
FeeM, an N-acyl amino acid synthase from an uncultured soil microbe: structure, mechanism, and acyl carrier protein binding. Structure (2006) 1.53
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol (2009) 1.51
New natural product families from an environmental DNA (eDNA) gene cluster. J Am Chem Soc (2002) 1.49
Rheotaxis guides mammalian sperm. Curr Biol (2013) 1.47
Real-time imaging of nuclear permeation by EGFP in single intact cells. Biophys J (2003) 1.46
The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci (2012) 1.45
A Bacillus subtilis sensor kinase involved in triggering biofilm formation on the roots of tomato plants. Mol Microbiol (2012) 1.45
Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp. Org Lett (2009) 1.45
CatSperbeta, a novel transmembrane protein in the CatSper channel complex. J Biol Chem (2007) 1.43
Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem (2009) 1.42
Production of α-galactosylceramide by a prominent member of the human gut microbiota. PLoS Biol (2013) 1.42
An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations. Org Lett (2009) 1.41
Retracted A self-produced trigger for biofilm disassembly that targets exopolysaccharide. Cell (2012) 1.41
Differential analysis of 2D NMR spectra: new natural products from a pilot-scale fungal extract library. Angew Chem Int Ed Engl (2007) 1.40
MCU encodes the pore conducting mitochondrial calcium currents. Elife (2013) 1.39
A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid. J Am Chem Soc (2006) 1.39
Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans. Science (2010) 1.36
CACNA1H mutations in autism spectrum disorders. J Biol Chem (2006) 1.35
Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem (2008) 1.34
Using the heat-shock response to discover anticancer compounds that target protein homeostasis. ACS Chem Biol (2011) 1.31
Liver-stage malaria parasites vulnerable to diverse chemical scaffolds. Proc Natl Acad Sci U S A (2012) 1.31
The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A (2011) 1.29
Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone. Proc Natl Acad Sci U S A (2010) 1.28
The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. Proc Natl Acad Sci U S A (2004) 1.28
Phenotyping sensory nerve endings in vitro in the mouse. Nat Protoc (2009) 1.27
A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol (2004) 1.26
Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A (2013) 1.25
Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. EMBO J (2006) 1.25
Roseobacticides: small molecule modulators of an algal-bacterial symbiosis. J Am Chem Soc (2011) 1.24