PubRank

Elisa Izaurralde

Author PubWeight™ 189.08‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet 2011 9.79
2 mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev 2006 8.78
3 P bodies: at the crossroads of post-transcriptional pathways. Nat Rev Mol Cell Biol 2007 7.96
4 Getting to the root of miRNA-mediated gene silencing. Cell 2008 7.17
5 GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay. Nat Struct Mol Biol 2008 5.57
6 A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. RNA 2005 5.15
7 Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature 2003 4.92
8 P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol Cell Biol 2007 4.90
9 Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species. Curr Opin Cell Biol 2005 4.45
10 Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat Struct Mol Biol 2004 4.38
11 Deadenylation is a widespread effect of miRNA regulation. RNA 2008 3.98
12 Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev 2007 3.92
13 Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. Mol Cell Biol 2006 3.80
14 Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J 2003 3.68
15 Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome. RNA 2005 3.11
16 SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol Cell 2004 3.05
17 An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature 2004 2.95
18 GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. Mol Cell 2011 2.80
19 Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila. Nature 2004 2.80
20 SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell 2005 2.71
21 Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Nat Struct Mol Biol 2004 2.70
22 The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nat Struct Mol Biol 2004 2.65
23 Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. RNA 2005 2.59
24 REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. J Cell Biol 2002 2.55
25 SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA 2008 2.54
26 The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. RNA 2009 2.37
27 The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha. Nat Struct Mol Biol 2004 2.36
28 The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release. Mol Cell Biol 2009 2.28
29 Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature 2005 2.27
30 mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Lett 2007 2.22
31 Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J 2006 2.16
32 A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. EMBO J 2007 2.11
33 A novel mode of RBD-protein recognition in the Y14-Mago complex. Nat Struct Biol 2003 2.11
34 The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. RNA 2009 2.11
35 A C-terminal silencing domain in GW182 is essential for miRNA function. RNA 2009 2.10
36 Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors. Trends Biochem Sci 2006 2.07
37 The interplay of nuclear mRNP assembly, mRNA surveillance and export. Trends Cell Biol 2003 2.03
38 An efficient protein complex purification method for functional proteomics in higher eukaryotes. Nat Biotechnol 2002 1.71
39 Genome-wide analysis of nuclear mRNA export pathways in Drosophila. EMBO J 2003 1.70
40 Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing. EMBO J 2010 1.64
41 The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition. EMBO Rep 2005 1.63
42 Complex genomic rearrangements lead to novel primate gene function. Genome Res 2005 1.62
43 Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proc Natl Acad Sci U S A 2011 1.56
44 Quality control of gene expression: a stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay. Genes Dev 2006 1.51
45 Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. PLoS Genet 2009 1.46
46 Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol 2009 1.44
47 Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Mol Cell 2009 1.43
48 The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res 2009 1.42
49 Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep 2010 1.39
50 Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu. Nat Rev Mol Cell Biol 2010 1.36
51 The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex. EMBO J 2011 1.29
52 The role of disordered protein regions in the assembly of decapping complexes and RNP granules. Genes Dev 2013 1.29
53 RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export. Mol Cell Biol 2004 1.26
54 A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Mol Cell Biol 2007 1.23
55 HPat provides a link between deadenylation and decapping in metazoa. J Cell Biol 2010 1.23
56 Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Mol Cell Biol 2008 1.22
57 The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic Acids Res 2012 1.19
58 Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15. Mol Cell Biol 2002 1.18
59 GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation. EMBO J 2013 1.17
60 CUP promotes deadenylation and inhibits decapping of mRNA targets. Genes Dev 2011 1.14
61 A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Nat Struct Mol Biol 2012 1.13
62 The role of GW182 proteins in miRNA-mediated gene silencing. Adv Exp Med Biol 2013 1.13
63 Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. EMBO Rep 2004 1.09
64 NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. RNA Biol 2013 1.09
65 DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proc Natl Acad Sci U S A 2009 1.08
66 SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes Dev 2010 1.08
67 The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Nucleic Acids Res 2012 1.07
68 The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. Genes Dev 2013 1.07
69 Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. Genes Dev 2014 1.04
70 The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic Acids Res 2012 1.03
71 The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. RNA 2008 1.02
72 Structure and assembly of the NOT module of the human CCR4-NOT complex. Nat Struct Mol Biol 2013 1.02
73 The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. EMBO J 2010 1.00
74 An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes Dev 2013 0.99
75 The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold. BMC Bioinformatics 2003 0.97
76 A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs. Cold Spring Harb Perspect Biol 2012 0.97
77 Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins. Mol Cell 2013 0.95
78 Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP. Nat Struct Mol Biol 2011 0.93
79 miRISC recruits decapping factors to miRNA targets to enhance their degradation. Nucleic Acids Res 2013 0.93
80 The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1. Nucleic Acids Res 2014 0.92
81 NMR assignment of the Drosophila Argonaute2 PAZ domain. J Biomol NMR 2004 0.91
82 RNAi: finding the elusive endonuclease. RNA 2004 0.88
83 A role for eIF4AII in microRNA-mediated mRNA silencing. Nat Struct Mol Biol 2013 0.79
84 Directing mRNA export. Nat Struct Mol Biol 2004 0.77
85 A tiny helper lightens the maternal load. Cell 2006 0.77
86 Making sense of nonsense. Nat Struct Mol Biol 2013 0.77
87 Delving into the diversity of silencing pathways. Symposium on MicroRNAs and siRNAs: biological functions and mechanisms. EMBO Rep 2007 0.75
88 Nucleus and gene expression. Curr Opin Cell Biol 2009 0.75