Published in Biochemistry on March 23, 2010
Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system. Circ Res (2012) 3.02
NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci U S A (2010) 2.36
The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4. J Biol Chem (2011) 2.20
Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases. Kidney Int (2011) 2.15
Redox signaling in cardiac myocytes. Free Radic Biol Med (2011) 1.62
Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling. Free Radic Biol Med (2011) 1.56
The NOX toolbox: validating the role of NADPH oxidases in physiology and disease. Cell Mol Life Sci (2012) 1.44
Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2. Free Radic Biol Med (2011) 1.27
Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation. Cell Death Differ (2014) 1.25
Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo. Free Radic Biol Med (2011) 1.22
NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases. Leukemia (2010) 1.20
Nox4: a hydrogen peroxide-generating oxygen sensor. Biochemistry (2014) 1.14
Hsp90 regulates NADPH oxidase activity and is necessary for superoxide but not hydrogen peroxide production. Antioxid Redox Signal (2011) 1.09
NADPH oxidases: novel therapeutic targets for neurodegenerative diseases. Trends Pharmacol Sci (2012) 1.08
From form to function: the role of Nox4 in the cardiovascular system. Front Physiol (2012) 1.07
Opposing actions of heat shock protein 90 and 70 regulate nicotinamide adenine dinucleotide phosphate oxidase stability and reactive oxygen species production. Arterioscler Thromb Vasc Biol (2012) 1.03
Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation. Free Radic Biol Med (2012) 1.02
NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling. Arterioscler Thromb Vasc Biol (2014) 0.98
Nox4 and diabetic nephropathy: with a friend like this, who needs enemies? Free Radic Biol Med (2013) 0.98
IGF-I increases the expression of fibronectin by Nox4-dependent Akt phosphorylation in renal tubular epithelial cells. Am J Physiol Cell Physiol (2011) 0.97
Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme. J Clin Biochem Nutr (2011) 0.94
Nox NADPH oxidases and the endoplasmic reticulum. Antioxid Redox Signal (2014) 0.94
Redox control of microglial function: molecular mechanisms and functional significance. Antioxid Redox Signal (2014) 0.90
Constitutive NADPH oxidase 4 activity resides in the composition of the B-loop and the penultimate C terminus. J Biol Chem (2012) 0.89
Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats. Am J Physiol Heart Circ Physiol (2013) 0.87
Endoplasmic Reticulum Stress and Associated ROS. Int J Mol Sci (2016) 0.86
Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions. Free Radic Biol Med (2015) 0.86
Prolonged fasting activates Nrf2 in post-weaned elephant seals. J Exp Biol (2013) 0.84
Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling. EMBO J (2016) 0.81
Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J Biol Chem (2013) 0.81
Redox signalling and cardioprotection: translatability and mechanism. Br J Pharmacol (2015) 0.81
Strategies Aimed at Nox4 Oxidase Inhibition Employing Peptides from Nox4 B-Loop and C-Terminus and p22 (phox) N-Terminus: An Elusive Target. Int J Hypertens (2013) 0.80
Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors. Medchemcomm (2013) 0.79
Central Nervous System Injury and Nicotinamide Adenine Dinucleotide Phosphate Oxidase: Oxidative Stress and Therapeutic Targets. J Neurotrauma (2016) 0.78
Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4. Oncotarget (2015) 0.78
NADPH oxidase in brain injury and neurodegenerative disorders. Mol Neurodegener (2017) 0.78
Redox processes inform multivariate transdifferentiation trajectories associated with TGFβ-induced epithelial-mesenchymal transition. Free Radic Biol Med (2014) 0.77
Myocardin-related Transcription Factor Regulates Nox4 Protein Expression: LINKING CYTOSKELETAL ORGANIZATION TO REDOX STATE. J Biol Chem (2015) 0.77
NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease. Proc Natl Acad Sci U S A (2015) 0.77
Detrimental role of pericyte Nox4 in the acute phase of brain ischemia. J Cereb Blood Flow Metab (2015) 0.76
Cytotoxic activities of substituted 3-(3,4,5-trimethoxybenzylidene)-1,3-dihydroindol-2-ones and studies on their mechanisms of action. Eur J Med Chem (2013) 0.75
Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase. BMC Evol Biol (2017) 0.75
Occludin controls HIV transcription in brain pericytes via regulation of SIRT-1 activation. FASEB J (2015) 0.75
Down-regulation of NOX2 activity in phagocytes mediated by ATM-kinase dependent phosphorylation. Free Radic Biol Med (2017) 0.75
Reactive Oxygen and Nitrogen Species in the Development of Pulmonary Hypertension. Antioxidants (Basel) (2017) 0.75
The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk. Antioxidants (Basel) (2017) 0.75
NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol (2004) 12.93
Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal (2005) 4.74
Identification of renox, an NAD(P)H oxidase in kidney. Proc Natl Acad Sci U S A (2000) 4.24
Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res (2001) 4.22
NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation. Biochem J (2007) 3.88
Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem (2004) 3.37
The superoxide-generating NADPH oxidase: structural aspects and activation mechanism. Cell Mol Life Sci (2002) 3.22
Regulation of ROS signal transduction by NADPH oxidase 4 localization. J Cell Biol (2008) 3.13
Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells. Circ Res (2009) 2.83
A novel superoxide-producing NAD(P)H oxidase in kidney. J Biol Chem (2001) 2.80
Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators. Mol Cell Biol (2004) 2.72
A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem (2001) 2.56
Molecular basis for Rac2 regulation of phagocyte NADPH oxidase. Nat Immunol (2001) 2.45
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem (2002) 2.41
Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas. J Biol Chem (1999) 2.37
A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science (2000) 2.36
NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem (2004) 2.36
Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes. Biochem J (1992) 2.32
Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase. Science (1992) 2.31
Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b. Proc Natl Acad Sci U S A (1988) 2.21
Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. J Biol Chem (2003) 2.12
Nox1-dependent reactive oxygen generation is regulated by Rac1. J Biol Chem (2006) 2.02
Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). J Biol Chem (2004) 1.86
Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation. J Biol Chem (2005) 1.85
Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases. Mol Cell Biol (2006) 1.80
The superoxide-generating oxidase of leucocytes. NADPH-dependent reduction of flavin and cytochrome b in solubilized preparations. Biochem J (1984) 1.80
Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages. Cell Immunol (1984) 1.73
Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. J Biol Chem (2003) 1.70
Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo. Free Radic Biol Med (2001) 1.60
Ferredoxin:NADP+ oxidoreductase is a subunit of the chloroplast cytochrome b6f complex. J Biol Chem (2001) 1.59
Separate roles for FMN and FAD in catalysis by liver microsomal NADPH-cytochrome P-450 reductase. J Biol Chem (1981) 1.56
Identification of structural elements in Nox1 and Nox4 controlling localization and activity. Antioxid Redox Signal (2009) 1.51
The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators. J Biol Chem (2005) 1.48
Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras. Int J Cancer (2008) 1.48
Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization. Mol Cell Biol (2009) 1.41
Some properties of hepatic reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase. Biochemistry (1973) 1.40
The p67(phox) activation domain regulates electron flow from NADPH to flavin in flavocytochrome b(558). J Biol Chem (1999) 1.36
Nox3 regulation by NOXO1, p47phox, and p67phox. J Biol Chem (2004) 1.29
Regulation of the neutrophil respiratory burst oxidase. Identification of an activation domain in p67(phox). J Biol Chem (1998) 1.26
Biophysical effect of amino acids on the prevention of protein aggregation. J Biochem (2002) 1.24
Purification and partial characterization of the b-type cytochrome from human polymorphonuclear leukocytes. J Biol Chem (1985) 1.23
A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox. J Clin Invest (1994) 1.18
Cytochrome b558, a component of the phagocyte NADPH oxidase, is a flavoprotein. Biochem Biophys Res Commun (1992) 1.16
NADPH oxidase subunit, gp91(phox) homologue, preferentially expressed in human colon epithelial cells. Gene (2000) 1.15
Oxidation of reduced diphosphopyridine nucleotide. J Biol Chem (1958) 1.12
The cytosolic activating factors p47phox and p67phox have distinct roles in the regulation of electron flow in NADPH oxidase. J Biol Chem (1995) 1.06
Solubilization of NADH-cytochrome b5 reductase from liver microsomes by lysosomal digestion. J Biochem (1970) 1.06
The superoxide-generating system of human neutrophils possesses a novel diaphorase activity. Evidence for distinct regulation of electron flow within NADPH oxidase by p67-phox and p47-phox. J Biol Chem (1994) 1.05
Purification and properties of the flavoenzyme D-lactate dehydrogenase from Megasphaera elsdenii. Biochemistry (1979) 1.04
The cytochrome b and flavin content and properties of the O2- -forming NADPH oxidase solubilized from activated neutrophils. Biochim Biophys Acta (1983) 1.00
Mutation at histidine 338 of gp91(phox) depletes FAD and affects expression of cytochrome b558 of the human NADPH oxidase. J Biol Chem (1998) 0.98
Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function. J Biol Chem (2003) 0.96
Leu505 of Nox2 is crucial for optimal p67phox-dependent activation of the flavocytochrome b558 during phagocytic NADPH oxidase assembly. J Leukoc Biol (2006) 0.92
Induction of NADPH-dependent diaphorase and nitric oxide synthase activity in aortic smooth muscle and cultured macrophages. Mol Pharmacol (1992) 0.90
Activation of the flavoprotein domain of gp91phox upon interaction with N-terminal p67phox (1-210) and the Rac complex. Biochemistry (2004) 0.85
Essential requirement of cytosolic phospholipase A(2) for stimulation of NADPH oxidase-associated diaphorase activity in granulocyte-like cells. J Biol Chem (2001) 0.85
Chimeric enzymes of cytochrome P450 oxidoreductase and neuronal nitric-oxide synthase reductase domain reveal structural and functional differences. J Biol Chem (2003) 0.85
Activation of NADPH oxidase 1 in tumour colon epithelial cells. Biochem J (2008) 0.83
Effects of flavin-binding motif amino acid mutations in the NADH-cytochrome b5 reductase catalytic domain on protein stability and catalysis. J Biochem (2001) 0.82
Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2003) 4.56
Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation (2002) 3.95
Regulation of Nox and Duox enzymatic activity and expression. Free Radic Biol Med (2007) 3.44
The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction. Mol Cell Biol (2004) 3.35
Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice. Circulation (2005) 3.12
Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury. Arterioscler Thromb Vasc Biol (2002) 3.10
Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy. Circ Res (2003) 2.50
Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes. BMC Evol Biol (2007) 2.29
Reactive oxygen generated by Nox1 triggers the angiogenic switch. Proc Natl Acad Sci U S A (2002) 2.29
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. J Clin Invest (2007) 2.22
The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4. J Biol Chem (2011) 2.20
Increased Nox1 and hydrogen peroxide in prostate cancer. Prostate (2005) 2.19
The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation. Cancer Res (2004) 2.12
Nox1-dependent reactive oxygen generation is regulated by Rac1. J Biol Chem (2006) 2.02
Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation. Arterioscler Thromb Vasc Biol (2009) 2.01
Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation. J Biol Chem (2005) 1.85
Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets. Antioxid Redox Signal (2009) 1.80
NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells. Am J Physiol Cell Physiol (2003) 1.73
Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells. Antioxid Redox Signal (2009) 1.64
Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits. Chem Biol (2012) 1.60
Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis. Dev Biol (2002) 1.57
Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest (2012) 1.57
NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. J Biol Chem (2003) 1.56
Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system. Blood (2002) 1.54
Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras. Int J Cancer (2008) 1.48
Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts. J Biol Chem (2010) 1.36
Symbiotic lactobacilli stimulate gut epithelial proliferation via Nox-mediated generation of reactive oxygen species. EMBO J (2013) 1.35
Identification and characterization of VPO1, a new animal heme-containing peroxidase. Free Radic Biol Med (2008) 1.33
Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling. Am J Physiol Heart Circ Physiol (2010) 1.31
NAD(P)H oxidases in rat basilar arterial endothelial cells. Stroke (2005) 1.31
Nox enzymes from fungus to fly to fish and what they tell us about Nox function in mammals. Free Radic Biol Med (2010) 1.30
Nox3 regulation by NOXO1, p47phox, and p67phox. J Biol Chem (2004) 1.29
Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2. Free Radic Biol Med (2011) 1.27
Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection. Hepatology (2010) 1.25
Association of gp91phox homolog Nox1 with anchorage-independent growth and MAP kinase-activation of transformed human keratinocytes. Oncogene (2003) 1.24
Redox-dependent expression of cyclin D1 and cell proliferation by Nox1 in mouse lung epithelial cells. Antioxid Redox Signal (2006) 1.22
NADPH oxidases in the gastrointestinal tract: a potential role of Nox1 in innate immune response and carcinogenesis. Antioxid Redox Signal (2006) 1.21
Redox regulation of interleukin-4 signaling. Immunity (2008) 1.20
Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes. BMC Evol Biol (2007) 1.17
Evidence for cancer-associated expression of NADPH oxidase 1 (Nox1)-based oxidase system in the human stomach. Free Radic Biol Med (2007) 1.16
Melan-A-specific cytotoxic T cells are associated with tumor regression and autoimmunity following treatment with anti-CTLA-4. Clin Cancer Res (2009) 1.16
Nox4: a hydrogen peroxide-generating oxygen sensor. Biochemistry (2014) 1.14
Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract. Semin Immunopathol (2008) 1.11
Nox regulation of smooth muscle contraction. Free Radic Biol Med (2007) 1.09
Interferon-gamma activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells. Am J Physiol Cell Physiol (2005) 1.07
Alternative mRNA splice forms of NOXO1: differential tissue expression and regulation of Nox1 and Nox3. Gene (2005) 1.05
Phosphatidylinositol (4,5)-bisphosphate modulates Nox5 localization via an N-terminal polybasic region. Mol Biol Cell (2008) 1.05
A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes. J Invest Dermatol (2004) 0.98
Nox5 forms a functional oligomer mediated by self-association of its dehydrogenase domain. Biochemistry (2011) 0.96
Microbicidal activity of vascular peroxidase 1 in human plasma via generation of hypochlorous acid. Infect Immun (2012) 0.95
A long, naturally presented immunodominant epitope from NY-ESO-1 tumor antigen: implications for cancer vaccine design. Cancer Res (2009) 0.94
Developmental memory capacity resources of typical children retrieving picture communication symbols using direct selection and visual linear scanning with fixed communication displays. J Speech Lang Hear Res (2006) 0.94
Tumor necrosis factor alpha activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells. Free Radic Biol Med (2008) 0.91
Nox4 B-loop creates an interface between the transmembrane and dehydrogenase domains. J Biol Chem (2010) 0.88
Nox1 expression determines cellular reactive oxygen and modulates c-fos-induced growth factor, interleukin-8, and Cav-1. Am J Pathol (2007) 0.87
Immunoediting and persistence of antigen-specific immunity in patients who have previously been vaccinated with NY-ESO-1 protein formulated in ISCOMATRIX™. Cancer Immunol Immunother (2011) 0.87
Combining MHC tetramer and intracellular cytokine staining for CD8(+) T cells to reveal antigenic epitopes naturally presented on tumor cells. J Immunol Methods (2008) 0.86
On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation. Free Radic Biol Med (2013) 0.86
Activation of the flavoprotein domain of gp91phox upon interaction with N-terminal p67phox (1-210) and the Rac complex. Biochemistry (2004) 0.85
NOX5 expression is increased in intramyocardial blood vessels and cardiomyocytes after acute myocardial infarction in humans. Am J Pathol (2012) 0.84
Activation of NADPH oxidase 1 in tumour colon epithelial cells. Biochem J (2008) 0.83
Effects of a soy protein diet on exercise-induced muscle protein catabolism in rats. Nutrition (2002) 0.83
Ecabet sodium inhibits Helicobacter pylori lipopolysaccharide-induced activation of NADPH oxidase 1 or apoptosis of guinea pig gastric mucosal cells. Am J Physiol Gastrointest Liver Physiol (2004) 0.82
Fine-mapping naturally occurring NY-ESO-1 antibody epitopes in melanoma patients' sera using short overlapping peptides and full-length recombinant protein. Mol Immunol (2013) 0.79
Spring brings breezes, wheezes, and pollen oxidases. J Clin Invest (2005) 0.78
The use of model systems to study biological functions of Nox/Duox enzymes. Biochem Soc Symp (2004) 0.78
Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid. Eur J Biochem (2002) 0.76
A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen. PLoS One (2012) 0.76
Superoxide generation by Nox1 in guinea pig gastric mucosal cells involves a component with p67(phox)-ability. Biol Pharm Bull (2004) 0.75