Published in J Biol Chem on September 08, 2003
Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell (2008) 4.26
The MRE11 complex: starting from the ends. Nat Rev Mol Cell Biol (2011) 3.83
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes. Mol Cell (2007) 2.30
Mre11 assembles linear DNA fragments into DNA damage signaling complexes. PLoS Biol (2004) 1.79
MRE11/RAD50/NBS1: complex activities. Chromosoma (2004) 1.79
DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining. Nucleic Acids Res (2004) 1.67
Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing. Int J Mol Sci (2009) 1.67
53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J (2009) 1.47
Nibrin functions in Ig class-switch recombination. Proc Natl Acad Sci U S A (2005) 1.41
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking. Proc Natl Acad Sci U S A (2013) 1.41
ATM activation in the presence of oxidative stress. Cell Cycle (2010) 1.40
The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A. Mol Cell Biol (2007) 1.38
Active role for nibrin in the kinetics of atm activation. Mol Cell Biol (2006) 1.27
Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. J Immunol (2010) 1.16
E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaks. Cell Cycle (2011) 1.15
ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. EMBO J (2014) 1.14
A glycine-arginine domain in control of the human MRE11 DNA repair protein. Mol Cell Biol (2008) 1.13
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. J Virol (2008) 1.08
Bacillus subtilis SbcC protein plays an important role in DNA inter-strand cross-link repair. BMC Mol Biol (2006) 1.07
RAD50 and NBS1 form a stable complex functional in DNA binding and tethering. Nucleic Acids Res (2009) 1.05
MRN and the race to the break. Chromosoma (2009) 1.04
The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. J Biol Chem (2010) 1.04
RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function? Chromosome Res (2009) 1.01
Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites. J Mol Biol (2008) 1.01
MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair. EMBO J (2009) 0.98
Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem (2013) 0.96
Recognition of double strand breaks by a mutator protein (MU2) in Drosophila melanogaster. PLoS Genet (2009) 0.93
Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways. Oncogene (2014) 0.91
The role of MRN in the S-phase DNA damage checkpoint is independent of its Ctp1-dependent roles in double-strand break repair and checkpoint signaling. Mol Biol Cell (2009) 0.90
The Nijmegen breakage syndrome gene and its role in genome stability. Chromosoma (2004) 0.89
Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET. Proc Natl Acad Sci U S A (2013) 0.89
NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks. Oncogene (2012) 0.89
Bcl2 inhibits recruitment of Mre11 complex to DNA double-strand breaks in response to high-linear energy transfer radiation. Nucleic Acids Res (2015) 0.88
At a crossroads: human DNA tumor viruses and the host DNA damage response. Future Virol (2011) 0.86
Mre11 modulates the fidelity of fusion between short telomeres in human cells. Nucleic Acids Res (2011) 0.86
ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex. EMBO J (2015) 0.83
The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changes. Exp Cell Res (2014) 0.82
Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair. Nucleic Acids Res (2012) 0.81
A tool for enhancement and scoring of DNA repair foci. Cytometry A (2009) 0.80
Hyperthermia alters the interaction of proteins of the Mre11 complex in irradiated cells. Cytometry A (2010) 0.80
Eukaryotic Rad50 functions as a rod-shaped dimer. Nat Struct Mol Biol (2017) 0.79
Structural studies of DNA end detection and resection in homologous recombination. Cold Spring Harb Perspect Biol (2014) 0.78
Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease. PLoS Genet (2014) 0.78
Replication fork integrity and intra-S phase checkpoint suppress gene amplification. Nucleic Acids Res (2015) 0.77
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet (2008) 16.17
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science (2005) 8.77
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
ATM activation by oxidative stress. Science (2010) 5.22
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science (2004) 4.58
Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol Cell (2007) 3.86
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol (2008) 3.07
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nat Genet (2009) 2.76
Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription. Mol Cell (2007) 2.71
ATP control of dynamic P1 ParA-DNA interactions: a key role for the nucleoid in plasmid partition. Mol Microbiol (2010) 2.65
Recorded scan times can limit the accuracy of sedimentation coefficients in analytical ultracentrifugation. Anal Biochem (2013) 2.57
Involvement of human MOF in ATM function. Mol Cell Biol (2005) 2.30
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes. Mol Cell (2007) 2.30
Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Cell (2003) 2.25
Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science (2008) 2.23
Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes. Am J Hum Genet (2006) 2.22
Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Cell (2007) 2.21
Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst (2008) 2.17
MicroRNAs and their isomiRs function cooperatively to target common biological pathways. Genome Biol (2011) 2.15
Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks. Nat Struct Mol Biol (2010) 2.14
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature (2008) 2.12
Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell (2010) 2.12
The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break. Cell (2008) 2.11
Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. Cancer Prev Res (Phila) (2008) 2.11
Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Clin Cancer Res (2008) 2.11
The TLR3 signaling complex forms by cooperative receptor dimerization. Proc Natl Acad Sci U S A (2008) 2.06
Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks. EMBO J (2010) 2.04
A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C. Science (2013) 2.00
Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3. Nature (2011) 1.99
Ultrafast and direct imprint of nanostructures in silicon. Nature (2002) 1.95
Wapl is an essential regulator of chromatin structure and chromosome segregation. Nature (2013) 1.92
The ATM protein kinase and cellular redox signaling: beyond the DNA damage response. Trends Biochem Sci (2011) 1.91
Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues. J Cell Biol (2009) 1.88
Tumor transcriptome sequencing reveals allelic expression imbalances associated with copy number alterations. PLoS One (2010) 1.85
Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2. Proc Natl Acad Sci U S A (2009) 1.82
Systematic evaluation of genetic variants in the inflammation pathway and risk of lung cancer. Cancer Res (2007) 1.82
Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. Mol Cell (2007) 1.77
Interaction of yeast RNA-binding proteins Nrd1 and Nab3 with RNA polymerase II terminator elements. RNA (2007) 1.72
Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR. Nature (2011) 1.70
Re: short telomere length, cancer survival, and cancer risk in 47 102 individuals. J Natl Cancer Inst (2013) 1.69
Prostate stem cell antigen: a Jekyll and Hyde molecule? Clin Cancer Res (2010) 1.65
Molecular architecture of a eukaryotic DNA transposase. Nat Struct Mol Biol (2005) 1.64
Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair. EMBO J (2004) 1.61
Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants. Cancer Prev Res (Phila) (2009) 1.57
Design of a novel peptide inhibitor of HIV fusion that disrupts the internal trimeric coiled-coil of gp41. J Biol Chem (2002) 1.57
Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer. J Clin Oncol (2006) 1.55
Global assessment of genetic variation influencing response to retinoid chemoprevention in head and neck cancer patients. Cancer Prev Res (Phila) (2011) 1.53
Solution structure of the 128 kDa enzyme I dimer from Escherichia coli and its 146 kDa complex with HPr using residual dipolar couplings and small- and wide-angle X-ray scattering. J Am Chem Soc (2010) 1.53
Efficient secretion of a folded protein domain by a monomeric bacterial autotransporter. Mol Microbiol (2005) 1.53
Structural and functional organization of the ESCRT-I trafficking complex. Cell (2006) 1.51
Genetic variations in the regulator of G-protein signaling genes are associated with survival in late-stage non-small cell lung cancer. PLoS One (2011) 1.51
Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP. Chem Biol (2010) 1.48
Genetic variants in MicroRNA biosynthesis pathways and binding sites modify ovarian cancer risk, survival, and treatment response. Cancer Res (2010) 1.48
53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J (2009) 1.47
Structure of a heparin-dependent complex of Hedgehog and Ihog. Proc Natl Acad Sci U S A (2006) 1.47
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature (2008) 1.47
Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. Cancer Res (2007) 1.47
RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination. Mol Cell (2007) 1.43
Active site sharing and subterminal hairpin recognition in a new class of DNA transposases. Mol Cell (2005) 1.42
Structural basis for DNA bridging by barrier-to-autointegration factor. Nat Struct Mol Biol (2005) 1.41
Overview of current methods in sedimentation velocity and sedimentation equilibrium analytical ultracentrifugation. Curr Protoc Protein Sci (2013) 1.41
ATM activation in the presence of oxidative stress. Cell Cycle (2010) 1.40
Repeated intracoronary infusion of peripheral blood stem cells with G-CSF in patients with refractory ischemic heart failure--a pilot study. Circ J (2011) 1.39
Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol Cell (2003) 1.38
The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae. J Cell Biol (2012) 1.38
The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting. Dev Cell (2007) 1.36
A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3. Hum Mol Genet (2011) 1.36
Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding. Biochemistry (2003) 1.35
MicroRNA expression signatures in Barrett's esophagus and esophageal adenocarcinoma. Clin Cancer Res (2009) 1.35
A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23. Hum Mol Genet (2011) 1.34
Solution NMR structure of the barrier-to-autointegration factor-Emerin complex. J Biol Chem (2007) 1.34
Genome-wide association study identifies multiple loci associated with bladder cancer risk. Hum Mol Genet (2013) 1.34
Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays. Int J Cancer (2009) 1.33
Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy. Clin Cancer Res (2003) 1.32
Projecting individualized probabilities of developing bladder cancer in white individuals. J Clin Oncol (2007) 1.30
Structure of colicin I receptor bound to the R-domain of colicin Ia: implications for protein import. EMBO J (2007) 1.27
Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy. J Natl Cancer Inst (2011) 1.27
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Res (2006) 1.26
Molecular activities of meiosis-specific proteins Hop2, Mnd1, and the Hop2-Mnd1 complex. J Biol Chem (2006) 1.25
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J Cell Biol (2008) 1.24
Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive. J Mol Biol (2003) 1.24
Visualization of transient ultra-weak protein self-association in solution using paramagnetic relaxation enhancement. J Am Chem Soc (2008) 1.24
Hybrid structural model of the complete human ESCRT-0 complex. Structure (2009) 1.23
Loss of ATM kinase activity leads to embryonic lethality in mice. J Cell Biol (2012) 1.23
The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae. DNA Repair (Amst) (2005) 1.22
Constitutive short telomere length of chromosome 17p and 12q but not 11q and 2p is associated with an increased risk for esophageal cancer. Cancer Prev Res (Phila) (2009) 1.22
Polymorphisms in inflammation genes and bladder cancer: from initiation to recurrence, progression, and survival. J Clin Oncol (2005) 1.22
Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway. J Biol Chem (2011) 1.21
The role of G beta gamma and domain interfaces in the activation of G protein-coupled receptor kinase 2. Biochemistry (2005) 1.21
Long-term tumor-free survival from treatment with the GFP-TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells. Oncogene (2002) 1.20
Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Res (2013) 1.20
Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9. J Biol Chem (2010) 1.19
The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1. EMBO J (2012) 1.19
The inner cavity of Escherichia coli DegP protein is not essential for molecular chaperone and proteolytic activity. J Bacteriol (2006) 1.19
Role of the PDZ domains in Escherichia coli DegP protein. J Bacteriol (2007) 1.19
The rad50 signature motif: essential to ATP binding and biological function. J Mol Biol (2004) 1.19
Genetic variations in the sonic hedgehog pathway affect clinical outcomes in non-muscle-invasive bladder cancer. Cancer Prev Res (Phila) (2010) 1.18