Published in Cell on April 19, 2007
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature (2009) 6.99
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J (2007) 5.31
Membrane scission by the ESCRT-III complex. Nature (2009) 4.66
Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. J Cell Biol (2008) 4.66
Membrane budding and scission by the ESCRT machinery: it's all in the neck. Nat Rev Mol Cell Biol (2010) 4.29
Molecular mechanism of multivesicular body biogenesis by ESCRT complexes. Nature (2010) 4.05
ESCRT complexes and the biogenesis of multivesicular bodies. Curr Opin Cell Biol (2008) 3.90
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
The ESCRT complexes. Crit Rev Biochem Mol Biol (2010) 2.23
Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science (2008) 2.23
Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Cell Host Microbe (2007) 2.18
Membrane fission reactions of the mammalian ESCRT pathway. Annu Rev Biochem (2013) 1.91
Membrane budding. Cell (2010) 1.65
A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae. Genetics (2008) 1.58
The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding. PLoS Pathog (2009) 1.55
How ubiquitin functions with ESCRTs. Traffic (2011) 1.51
No strings attached: the ESCRT machinery in viral budding and cytokinesis. J Cell Sci (2009) 1.50
Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis. Dev Cell (2009) 1.50
ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting. J Cell Biol (2009) 1.47
Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex. Dev Cell (2008) 1.40
MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulation. PLoS One (2007) 1.29
Hybrid structural model of the complete human ESCRT-0 complex. Structure (2009) 1.23
Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy. Proc Natl Acad Sci U S A (2011) 1.22
The role of cellular factors in promoting HIV budding. J Mol Biol (2011) 1.21
An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Mol Biol Cell (2008) 1.14
The ESCRT machinery: from the plasma membrane to endosomes and back again. Crit Rev Biochem Mol Biol (2014) 1.12
The ESCRT machinery. Curr Biol (2012) 1.11
Regulation of Tsg101 expression by the steadiness box: a role of Tsg101-associated ligase. Mol Biol Cell (2007) 1.10
The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. Structure (2012) 1.09
Proline-rich regions and motifs in trafficking: from ESCRT interaction to viral exploitation. Traffic (2011) 1.08
Solution structure of the ESCRT-I and -II supercomplex: implications for membrane budding and scission. Structure (2012) 1.06
Crystallographic and functional analysis of the ESCRT-I /HIV-1 Gag PTAP interaction. Structure (2010) 1.04
Structure and mechanism in membrane trafficking. Curr Opin Cell Biol (2010) 0.97
Recombinant protein complex expression in E. coli. Curr Protoc Protein Sci (2008) 0.95
Membrane protein targeting to the MVB/lysosome. Chem Rev (2009) 0.95
Multivesicular bodies in the enigmatic amoeboflagellate Breviata anathema and the evolution of ESCRT 0. J Cell Sci (2011) 0.95
Structural basis for membrane targeting by the MVB12-associated β-prism domain of the human ESCRT-I MVB12 subunit. Proc Natl Acad Sci U S A (2012) 0.94
Reverse-topology membrane scission by the ESCRT proteins. Nat Rev Mol Cell Biol (2016) 0.90
Global analysis of yeast endosomal transport identifies the vps55/68 sorting complex. Mol Biol Cell (2008) 0.90
Vesicle formation within endosomes: An ESCRT marks the spot. Commun Integr Biol (2012) 0.88
Wrapping up the bad news: HIV assembly and release. Retrovirology (2013) 0.88
Phosphoinositides in the mammalian endo-lysosomal network. Subcell Biochem (2012) 0.87
Differential physiological roles of ESCRT complexes in Caenorhabditis elegans. Mol Cells (2011) 0.87
Membrane-elasticity model of Coatless vesicle budding induced by ESCRT complexes. PLoS Comput Biol (2012) 0.87
A genomic-based approach combining in vivo selection in mice to identify a novel virulence gene in Leishmania. PLoS Negl Trop Dis (2008) 0.86
The circuitry of cargo flux in the ESCRT pathway. J Cell Biol (2009) 0.83
Genome evolution predicts genetic interactions in protein complexes and reveals cancer drug targets. Nat Commun (2013) 0.82
SProtP: a web server to recognize those short-lived proteins based on sequence-derived features in human cells. PLoS One (2011) 0.81
Chromatin modifying protein 1A (Chmp1A) of the endosomal sorting complex required for transport (ESCRT)-III family activates ataxia telangiectasia mutated (ATM) for PanC-1 cell growth inhibition. Cell Cycle (2011) 0.81
Calculation of the relative metastabilities of proteins in subcellular compartments of Saccharomyces cerevisiae. BMC Syst Biol (2009) 0.80
ESCRT regulates surface expression of the Kir2.1 potassium channel. Mol Biol Cell (2013) 0.80
The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex. J Cell Sci (2013) 0.79
Quantitative proteome analysis of temporally resolved phagosomes following uptake via key phagocytic receptors. Mol Cell Proteomics (2015) 0.77
Cancer Cell-derived Exosomes Induce Mitogen-activated Protein Kinase-dependent Monocyte Survival by Transport of Functional Receptor Tyrosine Kinases. J Biol Chem (2016) 0.77
Solution structure of the equine infectious anemia virus p9 protein: a rationalization of its different ALIX binding requirements compared to the analogous HIV-p6 protein. BMC Struct Biol (2009) 0.77
Bud-neck scaffolding as a possible driving force in ESCRT-induced membrane budding. Biophys J (2015) 0.76
HCRP-1 regulates cell migration and invasion via EGFR-ERK mediated up-regulation of MMP-2 with prognostic significance in human renal cell carcinoma. Sci Rep (2015) 0.75
Structural Stability of the coiled-coil domain of Tumor Susceptibility Gene (TSG)-101. Biochemistry (2017) 0.75
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
Proteome survey reveals modularity of the yeast cell machinery. Nature (2006) 20.77
BAR domains as sensors of membrane curvature: the amphiphysin BAR structure. Science (2003) 12.60
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell (2001) 12.00
Receptor downregulation and multivesicular-body sorting. Nat Rev Mol Cell Biol (2002) 10.12
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell (2001) 9.08
Calculation of hydrodynamic properties of globular proteins from their atomic-level structure. Biophys J (2000) 7.40
Retrovirus budding. Annu Rev Cell Dev Biol (2004) 7.16
Ubiquitin-binding domains. Nat Rev Mol Cell Biol (2005) 6.77
Molecular architecture and functional model of the endocytic AP2 complex. Cell (2002) 5.44
Ubiquitin-binding domains. Biochem J (2006) 5.32
The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Annu Rev Biophys Biomol Struct (2006) 5.21
Biological basket weaving: formation and function of clathrin-coated vesicles. Annu Rev Cell Dev Biol (2001) 4.72
Clathrin. Annu Rev Biochem (2000) 4.20
Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis. Nat Cell Biol (2002) 3.94
A protein's final ESCRT. Traffic (2005) 3.76
Vps27 recruits ESCRT machinery to endosomes during MVB sorting. J Cell Biol (2003) 3.68
Retrovirus budding. Virus Res (2004) 3.66
The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting. Nat Cell Biol (2002) 3.62
Role of ESCRT-I in retroviral budding. J Virol (2003) 3.36
ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes. Dev Cell (2004) 2.86
Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. Nat Struct Mol Biol (2006) 2.85
Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein. Nat Struct Biol (2002) 2.66
Endosomal and non-endosomal functions of ESCRT proteins. Trends Cell Biol (2006) 2.61
Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell (2002) 2.55
ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes. Cell (2006) 2.38
Protein transport from the late Golgi to the vacuole in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta (2005) 2.36
Structural basis for endosomal targeting by the Bro1 domain. Dev Cell (2005) 2.28
Did2 coordinates Vps4-mediated dissociation of ESCRT-III from endosomes. J Cell Biol (2006) 2.24
Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome. J Cell Biol (2003) 2.17
Ubiquitin recognition by the human TSG101 protein. Mol Cell (2004) 2.17
Multivalent endosome targeting by homodimeric EEA1. Mol Cell (2001) 2.03
Structure of the ESCRT-II endosomal trafficking complex. Nature (2004) 1.80
Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain. J Biol Chem (2005) 1.68
Structural insight into the ESCRT-I/-II link and its role in MVB trafficking. EMBO J (2007) 1.60
Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins. J Biol Chem (2004) 1.57
Structural and functional organization of the ESCRT-I trafficking complex. Cell (2006) 1.51
Efficient cargo sorting by ESCRT-I and the subsequent release of ESCRT-I from multivesicular bodies requires the subunit Mvb12. Mol Biol Cell (2006) 1.42
The crystal structure of the C-terminal domain of Vps28 reveals a conserved surface required for Vps20 recruitment. Traffic (2006) 1.39
New component of ESCRT-I regulates endosomal sorting complex assembly. J Cell Biol (2006) 1.35
Mvb12 is a novel member of ESCRT-I involved in cargo selection by the multivesicular body pathway. Mol Biol Cell (2006) 1.32
Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. J Biol Chem (2004) 1.28
An ESCRT into the endosome. Mol Cell (2002) 1.03
Ubiquitin-binding domains. Biochem J (2006) 5.32
Membrane scission by the ESCRT-III complex. Nature (2009) 4.66
VPS35 mutations in Parkinson disease. Am J Hum Genet (2011) 4.16
Molecular mechanism of multivesicular body biogenesis by ESCRT complexes. Nature (2010) 4.05
Retromer. Curr Opin Cell Biol (2008) 3.89
Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol Cell (2007) 3.86
Structural mechanism for sterol sensing and transport by OSBP-related proteins. Nature (2005) 3.22
Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. Nat Struct Mol Biol (2006) 2.85
A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. EMBO J (2003) 2.73
Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription. Mol Cell (2007) 2.71
ATP control of dynamic P1 ParA-DNA interactions: a key role for the nucleoid in plasmid partition. Mol Microbiol (2010) 2.65
Recorded scan times can limit the accuracy of sedimentation coefficients in analytical ultracentrifugation. Anal Biochem (2013) 2.57
Structure and catalytic mechanism of a SET domain protein methyltransferase. Cell (2002) 2.45
Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission. Proc Natl Acad Sci U S A (2011) 2.45
Structural basis for endosomal targeting by the Bro1 domain. Dev Cell (2005) 2.28
Functional architecture of the retromer cargo-recognition complex. Nature (2007) 2.26
Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Cell (2003) 2.25
Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science (2008) 2.23
Crystal structure and allosteric activation of protein kinase C βII. Cell (2011) 2.19
Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. Nat Struct Mol Biol (2008) 2.18
The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nat Struct Mol Biol (2006) 2.09
Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains. Nature (2002) 2.09
Beyond Tsg101: the role of Alix in 'ESCRTing' HIV-1. Nat Rev Microbiol (2007) 2.08
The TLR3 signaling complex forms by cooperative receptor dimerization. Proc Natl Acad Sci U S A (2008) 2.06
Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae. Nature (2012) 2.05
Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides. J Cell Biol (2006) 2.04
A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C. Science (2013) 2.00
Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3. Nature (2011) 1.99
Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Dev Cell (2010) 1.98
Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. J Virol (2007) 1.90
Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation. EMBO J (2009) 1.88
Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues. J Cell Biol (2009) 1.88
Structure of a lipid droplet protein; the PAT family member TIP47. Structure (2004) 1.85
Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2. Proc Natl Acad Sci U S A (2009) 1.82
Structure of the ESCRT-II endosomal trafficking complex. Nature (2004) 1.80
Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin. Cell (2004) 1.79
Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT. Nat Struct Biol (2003) 1.73
Interaction of yeast RNA-binding proteins Nrd1 and Nab3 with RNA polymerase II terminator elements. RNA (2007) 1.72
Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR. Nature (2011) 1.70
Structural basis for viral late-domain binding to Alix. Nat Struct Mol Biol (2007) 1.69
Molecular architecture of a eukaryotic DNA transposase. Nat Struct Mol Biol (2005) 1.64
Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair. EMBO J (2004) 1.61
Design of a novel peptide inhibitor of HIV fusion that disrupts the internal trimeric coiled-coil of gp41. J Biol Chem (2002) 1.57
Palmitoylation by the DHHC protein Pfa4 regulates the ER exit of Chs3. J Cell Biol (2006) 1.53
Solution structure of the 128 kDa enzyme I dimer from Escherichia coli and its 146 kDa complex with HPr using residual dipolar couplings and small- and wide-angle X-ray scattering. J Am Chem Soc (2010) 1.53
Efficient secretion of a folded protein domain by a monomeric bacterial autotransporter. Mol Microbiol (2005) 1.53
Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes. J Biol Chem (2003) 1.52
Structural and functional organization of the ESCRT-I trafficking complex. Cell (2006) 1.51
Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis. Dev Cell (2009) 1.50
Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP. Chem Biol (2010) 1.48
Structure of a heparin-dependent complex of Hedgehog and Ihog. Proc Natl Acad Sci U S A (2006) 1.47
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature (2008) 1.47
Normalization of nomenclature for peptide motifs as ligands of modular protein domains. FEBS Lett (2002) 1.46
An Alix fragment potently inhibits HIV-1 budding: characterization of binding to retroviral YPXL late domains. J Biol Chem (2006) 1.44
RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination. Mol Cell (2007) 1.43
Active site sharing and subterminal hairpin recognition in a new class of DNA transposases. Mol Cell (2005) 1.42
Structural basis for DNA bridging by barrier-to-autointegration factor. Nat Struct Mol Biol (2005) 1.41
Overview of current methods in sedimentation velocity and sedimentation equilibrium analytical ultracentrifugation. Curr Protoc Protein Sci (2013) 1.41
The ESCRT machinery at a glance. J Cell Sci (2009) 1.41
Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex. Dev Cell (2008) 1.40
VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo. EMBO J (2010) 1.40
The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae. J Cell Biol (2012) 1.38
Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol Cell (2003) 1.38
Quantitative mass spectrometry reveals a role for the GTPase Rho1p in actin organization on the peroxisome membrane. J Cell Biol (2004) 1.38
Regulators of yeast endocytosis identified by systematic quantitative analysis. J Cell Biol (2009) 1.37
A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy. Proc Natl Acad Sci U S A (2013) 1.37
Two-site recognition of phosphatidylinositol 3-phosphate by PROPPINs in autophagy. Mol Cell (2012) 1.37
The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting. Dev Cell (2007) 1.36
Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3. Nat Struct Biol (2003) 1.36
Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding. Biochemistry (2003) 1.35
Solution NMR structure of the barrier-to-autointegration factor-Emerin complex. J Biol Chem (2007) 1.34
Inp1p is a peroxisomal membrane protein required for peroxisome inheritance in Saccharomyces cerevisiae. J Cell Biol (2005) 1.29
The beginnings of mucin biosynthesis: the crystal structure of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1. Proc Natl Acad Sci U S A (2004) 1.28
Structure of colicin I receptor bound to the R-domain of colicin Ia: implications for protein import. EMBO J (2007) 1.27
Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1. Cell (2013) 1.26
Molecular activities of meiosis-specific proteins Hop2, Mnd1, and the Hop2-Mnd1 complex. J Biol Chem (2006) 1.25
A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2. J Virol (2007) 1.25
An endocytic mechanism for haemoglobin-iron acquisition in Candida albicans. Mol Microbiol (2008) 1.25
Visualization of transient ultra-weak protein self-association in solution using paramagnetic relaxation enhancement. J Am Chem Soc (2008) 1.24
Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. EMBO J (2012) 1.24
Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive. J Mol Biol (2003) 1.24
Hybrid structural model of the complete human ESCRT-0 complex. Structure (2009) 1.23
Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells. Mol Ther (2011) 1.23
Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy. Proc Natl Acad Sci U S A (2011) 1.22
Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase. Mol Cell (2004) 1.22
The role of G beta gamma and domain interfaces in the activation of G protein-coupled receptor kinase 2. Biochemistry (2005) 1.21
SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. Mol Biol Cell (2010) 1.20
In vitro reconstitution of the ordered assembly of the endosomal sorting complex required for transport at membrane-bound HIV-1 Gag clusters. Proc Natl Acad Sci U S A (2012) 1.19
The inner cavity of Escherichia coli DegP protein is not essential for molecular chaperone and proteolytic activity. J Bacteriol (2006) 1.19
Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9. J Biol Chem (2010) 1.19
Role of the PDZ domains in Escherichia coli DegP protein. J Bacteriol (2007) 1.19