Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice.

PubWeight™: 3.54‹?› | Rank: Top 1%

🔗 View Article (PMID 1448148)

Published in Nature on November 26, 1992

Authors

M M Matzuk1, M J Finegold, J G Su, A J Hsueh, A Bradley

Author Affiliations

1: Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030.

Articles citing this

(truncated to the top 100)

Ends-out, or replacement, gene targeting in Drosophila. Proc Natl Acad Sci U S A (2003) 5.55

Male reproductive health and environmental xenoestrogens. Environ Health Perspect (1996) 4.11

Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med (1996) 3.04

Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells. Proc Natl Acad Sci U S A (1998) 2.71

GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol (2003) 2.42

The mammalian ovary from genesis to revelation. Endocr Rev (2009) 2.31

Oxytocin is required for nursing but is not essential for parturition or reproductive behavior. Proc Natl Acad Sci U S A (1996) 2.31

Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. Proc Natl Acad Sci U S A (2005) 2.04

TEX14 is essential for intercellular bridges and fertility in male mice. Proc Natl Acad Sci U S A (2006) 2.01

20 years studying p53 functions in genetically engineered mice. Nat Rev Cancer (2009) 2.00

Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice. Proc Natl Acad Sci U S A (1996) 1.96

Mammary gland neoplasia in long-term rodent studies. Environ Health Perspect (1996) 1.94

GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet (2009) 1.83

Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc Natl Acad Sci U S A (2003) 1.79

Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility. Proc Natl Acad Sci U S A (2004) 1.73

Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Mol Cell Biol (2007) 1.72

Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility. Proc Natl Acad Sci U S A (2005) 1.71

Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes. Genome Res (2008) 1.66

The ovary: basic biology and clinical implications. J Clin Invest (2010) 1.65

Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors. Proc Natl Acad Sci U S A (1995) 1.64

Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice. Proc Natl Acad Sci U S A (1994) 1.60

Animal models of ovarian cancer. Reprod Biol Endocrinol (2003) 1.57

FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults. Proc Natl Acad Sci U S A (2007) 1.55

Glutathione synthesis is essential for mouse development but not for cell growth in culture. Proc Natl Acad Sci U S A (2000) 1.54

Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: phenotypic consequences of gene dosage imbalance. Mol Cell Biol (2003) 1.42

Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics (1998) 1.41

A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. J Cell Biol (2009) 1.39

MRG15 regulates embryonic development and cell proliferation. Mol Cell Biol (2005) 1.35

Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Mol Cell Biol (2007) 1.31

Targeting frequency for deletion vectors in embryonic stem cells. Mol Cell Biol (1994) 1.29

Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression. Carcinogenesis (2008) 1.26

COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast. Mol Cell Biol (2003) 1.26

Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice. Proc Natl Acad Sci U S A (2004) 1.24

Transforming growth factor β receptor type 1 is essential for female reproductive tract integrity and function. PLoS Genet (2011) 1.20

Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells. Cancer Res (2009) 1.19

The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle. Reprod Biol Endocrinol (2003) 1.18

Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development. Mol Endocrinol (2010) 1.17

IgA class switch in I alpha exon-deficient mice. Role of germline transcription in class switch recombination. J Clin Invest (1996) 1.17

Smad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors. Endocrinology (2009) 1.17

Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation, and male infertility. Proc Natl Acad Sci U S A (2007) 1.16

Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. Proc Natl Acad Sci U S A (2003) 1.13

Deficiency of growth differentiation factor 3 protects against diet-induced obesity by selectively acting on white adipose. Mol Endocrinol (2008) 1.11

Activin A, a product of fetal Leydig cells, is a unique paracrine regulator of Sertoli cell proliferation and fetal testis cord expansion. Proc Natl Acad Sci U S A (2010) 1.09

Conditional activin receptor type 1B (Acvr1b) knockout mice reveal hair loss abnormality. J Invest Dermatol (2010) 1.09

The power of mouse genetics to study spermatogenesis. J Androl (2009) 1.08

Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice. Mol Cell Biol (2003) 1.07

Insulin Receptor Substrate 1, the Hub Linking Follicle-stimulating Hormone to Phosphatidylinositol 3-Kinase Activation. J Biol Chem (2015) 1.05

Minireview: animal models and mechanisms of ovarian cancer development. Endocrinology (2012) 1.04

Receptors for anti-müllerian hormone on Leydig cells are responsible for its effects on steroidogenesis and cell differentiation. Proc Natl Acad Sci U S A (1998) 1.04

Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility. Mol Cell Biol (2005) 1.04

Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation. Mol Cell Biol (1997) 1.03

Targeted suppression of Has2 mRNA in mouse cumulus cell-oocyte complexes by adenovirus-mediated short-hairpin RNA expression. Mol Reprod Dev (2009) 1.01

Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells. Mol Endocrinol (2009) 1.00

Activin bioactivity affects germ cell differentiation in the postnatal mouse testis in vivo. Biol Reprod (2010) 1.00

Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma. Neoplasia (2009) 1.00

Treating cancer cachexia to treat cancer. Skelet Muscle (2011) 0.95

Activin betaC and betaE genes are not essential for mouse liver growth, differentiation, and regeneration. Mol Cell Biol (2000) 0.95

Conditional deletion of the retinoblastoma (Rb) gene in ovarian granulosa cells leads to premature ovarian failure. Mol Endocrinol (2008) 0.94

Selectable system for monitoring the instability of CTG/CAG triplet repeats in mammalian cells. Mol Cell Biol (2003) 0.94

Loss of inhibin alpha uncouples oocyte-granulosa cell dynamics and disrupts postnatal folliculogenesis. Dev Biol (2009) 0.94

Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. Proc Natl Acad Sci U S A (1998) 0.94

Normal reproductive function in InhBP/p120-deficient mice. Mol Cell Biol (2003) 0.93

Intertwining of Activin A and TGFβ Signaling: Dual Roles in Cancer Progression and Cancer Cell Invasion. Cancers (Basel) (2014) 0.92

Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. Oncogene (2011) 0.92

Activins and activin antagonists in hepatocellular carcinoma. World J Gastroenterol (2008) 0.92

Inhibin-A antagonizes TGFbeta2 signaling by down-regulating cell surface expression of the TGFbeta coreceptor betaglycan. Mol Endocrinol (2010) 0.91

Inhibin at 90: from discovery to clinical application, a historical review. Endocr Rev (2014) 0.91

Minireview: physiological and pathological actions of RAS in the ovary. Mol Endocrinol (2009) 0.91

YAP regulates cell proliferation, migration, and steroidogenesis in adult granulosa cell tumors. Endocr Relat Cancer (2014) 0.90

Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours. Br J Cancer (1996) 0.90

Overexpression of activin A in stage IV colorectal cancer. Gut (2001) 0.90

Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse. Biol Reprod (2009) 0.89

Developmentally regulated SMAD2 and SMAD3 utilization directs activin signaling outcomes. Dev Dyn (2009) 0.88

Transforming growth factor alpha (TGFα) regulates granulosa cell tumor (GCT) cell proliferation and migration through activation of multiple pathways. PLoS One (2012) 0.87

A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor beta (TGFbeta) ligands. J Biol Chem (2009) 0.87

Defective gonadotropin-dependent ovarian folliculogenesis and granulosa cell gene expression in inhibin-deficient mice. Endocrinology (2010) 0.86

Consequences of RAS and MAPK activation in the ovary: the good, the bad and the ugly. Mol Cell Endocrinol (2011) 0.86

Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice. Mol Cell Endocrinol (2008) 0.86

Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell. Mol Cell Biol (2002) 0.86

FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development. Mol Endocrinol (2015) 0.86

Tektin 3 is required for progressive sperm motility in mice. Mol Reprod Dev (2009) 0.85

TGFβ signaling promotes juvenile granulosa cell tumorigenesis by suppressing apoptosis. Mol Endocrinol (2014) 0.85

Distinct requirements for Ku in N nucleotide addition at V(D)J- and non-V(D)J-generated double-strand breaks. Nucleic Acids Res (2004) 0.85

PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice. Mol Cell Biol (2004) 0.85

Bone morphogenetic protein signaling transcription factor (SMAD) function in granulosa cells. Mol Cell Endocrinol (2011) 0.84

Inhibitory SMADs: potential regulators of ovarian function. Biol Reprod (2014) 0.84

Regulation of the ovarian reserve by members of the transforming growth factor beta family. Mol Reprod Dev (2012) 0.84

Krüppel-like factor 4 is involved in functional differentiation of testicular Sertoli cells. Dev Biol (2008) 0.83

Activins and inhibins: novel regulators of thymocyte development. Biochem Biophys Res Commun (2009) 0.83

Epithelial-mesenchymal crosstalk in Wolffian duct and fetal testis cord development. Genesis (2009) 0.83

Characterisation of prostate cancer lesions in heterozygous Men1 mutant mice. BMC Cancer (2010) 0.83

MrgX is not essential for cell growth and development in the mouse. Mol Cell Biol (2005) 0.82

Krüppel-like factor 4, a "pluripotency transcription factor" highly expressed in male postmeiotic germ cells, is dispensable for spermatogenesis in the mouse. Mech Dev (2009) 0.81

Isolation and characterization of renal cancer stem cells from patient-derived xenografts. Oncotarget (2016) 0.81

Transfection of rat ovarian surface epithelium with erb-B2/neu induces transformed phenotypes in vitro and the tumorigenic phenotype in vivo. Am J Pathol (1998) 0.81

New insights into ovarian function. Handb Exp Pharmacol (2010) 0.81

Activin-βC modulates cachexia by repressing the ubiquitin-proteasome and autophagic degradation pathways. J Cachexia Sarcopenia Muscle (2015) 0.81

Inhibin/activin subunits alpha, beta-A and beta-B are differentially expressed in normal human endometrium throughout the menstrual cycle. Histochem Cell Biol (2004) 0.81

Activin receptor signaling regulates prostatic epithelial cell adhesion and viability. Neoplasia (2009) 0.81

Presence of activin signal transduction in normal ovarian cells and epithelial ovarian carcinoma. Br J Cancer (2000) 0.80

Articles by these authors

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature (1992) 25.54

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science (1993) 14.91

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell (1991) 14.89

p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature (1999) 13.21

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev (2000) 11.49

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell (1990) 10.99

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (1995) 8.68

Prostate cancer in a transgenic mouse. Proc Natl Acad Sci U S A (1995) 8.16

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature (1992) 8.16

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature (1997) 8.04

Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science (2001) 7.17

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature (1993) 6.75

Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature (1984) 6.54

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat Genet (1996) 6.06

p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science (1995) 6.01

A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development (1999) 5.85

Impaired energy homeostasis in C/EBP alpha knockout mice. Science (1995) 5.68

Chromosome engineering in mice. Nature (1995) 5.48

Increased bone formation in osteocalcin-deficient mice. Nature (1996) 4.91

The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature (1999) 4.74

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector. Nature (1986) 4.73

Requirement for Wnt3 in vertebrate axis formation. Nat Genet (1999) 4.68

Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell (2001) 4.61

Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature (2001) 4.41

The severe and moderate phenotypes of heritable Mac-1, LFA-1 deficiency: their quantitative definition and relation to leukocyte dysfunction and clinical features. J Infect Dis (1985) 4.08

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene (1993) 4.03

Metastatic prostate cancer in a transgenic mouse. Cancer Res (1996) 4.02

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development (1996) 3.91

Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat Genet (1993) 3.85

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev (1995) 3.84

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature (1991) 3.83

Initial and cyclic recruitment of ovarian follicles. Endocr Rev (2000) 3.76

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev (1993) 3.60

Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci U S A (1993) 3.57

Gene targeting in embryonic stem cells. Methods Enzymol (1993) 3.41

Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet (1995) 3.29

Cancer predisposition caused by elevated mitotic recombination in Bloom mice. Nat Genet (2000) 3.28

Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells. Mol Cell Biol (1991) 3.25

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J (1998) 3.12

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Natl Acad Sci U S A (1999) 3.06

Genomic DNA microextraction: a method to screen numerous samples. Anal Biochem (1992) 3.05

Multiple defects and perinatal death in mice deficient in follistatin. Nature (1995) 2.96

The length of homology required for gene targeting in embryonic stem cells. Mol Cell Biol (1991) 2.75

Mouse ENU mutagenesis. Hum Mol Genet (1999) 2.72

Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells. Proc Natl Acad Sci U S A (1998) 2.71

Functional analysis of activins during mammalian development. Nature (1995) 2.71

The tumor suppressor p53. Biochim Biophys Acta (1993) 2.65

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell (1993) 2.62

Different phenotypes for mice deficient in either activins or activin receptor type II. Nature (1995) 2.62

Congenital heart disease in mice deficient for the DiGeorge syndrome region. Nature (1999) 2.60

Genetic background alters the spectrum of tumors that develop in p53-deficient mice. FASEB J (1993) 2.57

Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments. Cell (1993) 2.45

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc Natl Acad Sci U S A (1997) 2.45

CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice. Mol Cell Biol (1997) 2.44

Disruption of muscle architecture and myocardial degeneration in mice lacking desmin. J Cell Biol (1996) 2.44

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes Dev (1995) 2.41

The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Mol Endocrinol (2000) 2.37

Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat Med (2001) 2.33

A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature (1987) 2.33

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat Genet (1998) 2.32

Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol (1993) 2.32

DNA sequences similar to those of simian virus 40 in ependymomas and choroid plexus tumors of childhood. N Engl J Med (1992) 2.28

The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell (1992) 2.27

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc Natl Acad Sci U S A (1995) 2.27

Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients. Lancet (1998) 2.26

Clinical and pharmacological properties of ivermectin in rabbits and guinea pigs. Vet Rec (1992) 2.21

Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene (1994) 2.20

Effects of genetic background on tumorigenesis in p53-deficient mice. Mol Carcinog (1995) 2.18

Androgen-independent prostate cancer progression in the TRAMP model. Cancer Res (1997) 2.16

Apoptosis in testis germ cells: developmental changes in gonadotropin dependence and localization to selective tubule stages. Endocrinology (1995) 2.14

Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. Mol Endocrinol (1998) 2.13

The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages. Genes Dev (1995) 2.07

MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. J Biol Chem (2000) 2.05

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc Natl Acad Sci U S A (1998) 2.00

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev (1994) 1.99

Impaired vascular contractility and blood pressure homeostasis in the smooth muscle alpha-actin null mouse. FASEB J (2000) 1.91

Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1. Nature (1997) 1.89

Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. Proc Natl Acad Sci U S A (1994) 1.88

Engineering chromosomal rearrangements in mice. Nat Rev Genet (2001) 1.85

Müllerian-inhibiting substance function during mammalian sexual development. Cell (1994) 1.85

Hormonal regulation of the differentiation of cultured ovarian granulosa cells. Endocr Rev (1984) 1.85

Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice. J Virol (1990) 1.80

Oocyte maturation involves compartmentalization and opposing changes of cAMP levels in follicular somatic and germ cells: studies using selective phosphodiesterase inhibitors. Dev Biol (1996) 1.75

Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation. Genes Dev (1996) 1.75

Accumulation of PiZ alpha 1-antitrypsin causes liver damage in transgenic mice. J Clin Invest (1989) 1.72

The role and fate of DNA ends for homologous recombination in embryonic stem cells. Mol Cell Biol (1992) 1.71

Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applications. Mol Cell Biol (2000) 1.71

Randomized comparison of cisplatin/vincristine/fluorouracil and cisplatin/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: A report from the Children's Cancer Group and the Pediatric Oncology Group. J Clin Oncol (2000) 1.70

Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules. Mol Endocrinol (2001) 1.70

A randomized, controlled trial of routine early abdominal computed tomography in patients presenting with non-specific acute abdominal pain. Clin Radiol (2007) 1.70

Engineering a mouse balancer chromosome. Nat Genet (1999) 1.68

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Proc Natl Acad Sci U S A (1996) 1.62

Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes. J Immunol (1999) 1.61

A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice. Nucleic Acids Res (1999) 1.61

Involvement of apoptosis in ovarian follicular atresia and postovulatory regression. Endocrinology (1991) 1.61

A clone-array pooled shotgun strategy for sequencing large genomes. Genome Res (2001) 1.60

Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice. Proc Natl Acad Sci U S A (1994) 1.60