Published in J Biol Chem on October 22, 2003
PAK signalling during the development and progression of cancer. Nat Rev Cancer (2014) 2.21
PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. Biochem J (2005) 2.19
p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2). J Biol Chem (2012) 1.55
Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs. Structure (2007) 1.34
Optimizing molecular signatures for predicting prostate cancer recurrence. Prostate (2009) 1.22
Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Mol Cell Biol (2006) 1.16
P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion. J Biol Chem (2012) 1.07
Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors. J Cell Biol (2005) 1.07
PAK family kinases: Physiological roles and regulation. Cell Logist (2012) 1.06
P21 activated kinases: structure, regulation, and functions. Small GTPases (2014) 1.06
Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. J Neurochem (2007) 1.00
Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration. J Biol Chem (2009) 0.98
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proc Natl Acad Sci U S A (2012) 0.98
Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells. Prostate (2010) 0.97
PAK6 increase chemoresistance and is a prognostic marker for stage II and III colon cancer patients undergoing 5-FU based chemotherapy. Oncotarget (2015) 0.87
P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition. Biochim Biophys Acta (2015) 0.86
Approaches of targeting Rho GTPases in cancer drug discovery. Expert Opin Drug Discov (2015) 0.84
G-protein alpha-s and -12 subunits are involved in androgen-stimulated PI3K activation and androgen receptor transactivation in prostate cancer cells. Prostate (2011) 0.84
A PAK6-IQGAP1 complex promotes disassembly of cell-cell adhesions. Cell Mol Life Sci (2013) 0.84
Upregulation of p21-activated Kinase 6 in rat brain cortex after traumatic brain injury. J Mol Histol (2011) 0.84
PAK4-6 in cancer and neuronal development. Cell Logist (2012) 0.83
The activation of OR51E1 causes growth suppression of human prostate cancer cells. Oncotarget (2016) 0.79
Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6. PLoS One (2013) 0.78
Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain. J Neurochem (2015) 0.77
PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape. J Cell Sci (2015) 0.76
MicroRNA‑328 directly targets p21‑activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity. Mol Med Rep (2015) 0.75
Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight. Nutr Neurosci (2013) 0.75
Tumor Suppressive Function of p21-activated Kinase 6 in Hepatocellular Carcinoma. J Biol Chem (2015) 0.75
Putative miRNAs for the diagnosis of dyslexia, dyspraxia, and specific language impairment. Epigenetics (2013) 0.75
Liposome-mediated delivery of the p21 activated kinase-1 (PAK-1) inhibitor IPA-3 limits prostate tumor growth in vivo. Nanomedicine (2016) 0.75
Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. Nat Cell Biol (2002) 4.49
A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science (2006) 4.42
GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol (2005) 4.13
Regulation of the p300 HAT domain via a novel activation loop. Nat Struct Mol Biol (2004) 3.70
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature (2007) 3.57
Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat Cell Biol (2004) 3.12
Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol (2005) 2.66
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Mol Cell (2011) 2.61
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell (2007) 2.52
EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell (2009) 2.50
Regulation of leading edge microtubule and actin dynamics downstream of Rac1. J Cell Biol (2003) 2.41
Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase. Mol Cell (2004) 2.35
Linking beta-catenin to androgen-signaling pathway. J Biol Chem (2002) 2.27
GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA. Mol Biol Cell (2008) 2.24
Phosphatidylinositol 3-kinase/Akt stimulates androgen pathway through GSK3beta inhibition and nuclear beta-catenin accumulation. J Biol Chem (2002) 2.08
Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis. Curr Biol (2002) 2.01
14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin. Curr Biol (2002) 2.00
The androgen receptor negatively regulates the expression of c-Met: implications for a novel mechanism of prostate cancer progression. Cancer Res (2007) 1.99
Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1. J Biol Chem (2003) 1.99
Assay of Cdc42, Rac, and Rho GTPase activation by affinity methods. Methods Enzymol (2002) 1.99
Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks. Dev Cell (2007) 1.96
Roles and regulation of Wnt signaling and beta-catenin in prostate cancer. Cancer Lett (2005) 1.90
Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. Circ Res (2004) 1.88
GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol (2005) 1.81
Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis? Trends Cell Biol (2008) 1.80
p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. J Biol Chem (2004) 1.69
Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling. Mol Biol Cell (2006) 1.63
Reactive oxygen species regulate a slingshot-cofilin activation pathway. Mol Biol Cell (2009) 1.56
Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge. Mol Biol Cell (2009) 1.55
Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells. Cancer Res (2004) 1.53
Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J Biol Chem (2007) 1.52
IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition. Mol Cell Biol (2002) 1.51
Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood (2006) 1.49
Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. Oncogene (2005) 1.45
Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration. Mol Cell Biol (2003) 1.44
Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia. Proc Natl Acad Sci U S A (2007) 1.43
Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells. Mol Cell Biol (2011) 1.42
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection. J Cell Physiol (2008) 1.42
The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1. Mol Biol Cell (2008) 1.37
Regulation of hypoxic neuronal death signaling by neuroglobin. FASEB J (2008) 1.33
Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BB. Mol Biol Cell (2003) 1.29
Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domain. Mol Cell Biol (2007) 1.29
Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci Signal (2009) 1.29
Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. J Cell Biol (2011) 1.28
hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci. EMBO J (2003) 1.28
Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding. J Biol Chem (2007) 1.28
Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J Biol Chem (2008) 1.27
A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. ACS Chem Biol (2010) 1.26
Bacillus anthracis toxins inhibit human neutrophil NADPH oxidase activity. J Immunol (2006) 1.25
A promoting role of androgen receptor in androgen-sensitive and -insensitive prostate cancer cells. Nucleic Acids Res (2007) 1.22
p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling. J Biol Chem (2003) 1.22
The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity. J Biol Chem (2006) 1.22
c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells. Mol Biol Cell (2010) 1.20
Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function. J Leukoc Biol (2007) 1.17
Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation. Dev Cell (2008) 1.17
Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth. J Biol Chem (2002) 1.16
ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. J Biol Chem (2002) 1.13
Nod1 and nod2 are expressed in human and murine renal tubular epithelial cells and participate in renal ischemia reperfusion injury. J Immunol (2010) 1.13
hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes. Mol Endocrinol (2005) 1.11
Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2. J Immunol (2009) 1.10
The integrin beta tail is required and sufficient to regulate adhesion signaling to Rac1. J Cell Sci (2002) 1.09
Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species. J Biol Chem (2004) 1.09
Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism. J Biol Chem (2008) 1.08
Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast. Mol Cell Biol (2004) 1.07
LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin. Mol Cell Biol (2006) 1.07
Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. J Mol Biol (2008) 1.05
Identification of tyrosine kinases overexpressed in head and neck cancer. Arch Otolaryngol Head Neck Surg (2004) 1.04
Efficacy of c-Met inhibitor for advanced prostate cancer. BMC Cancer (2010) 1.03
Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions. Mol Biol Cell (2004) 1.03
Integrin-linked kinase regulates Bergmann glial differentiation during cerebellar development. Mol Cell Neurosci (2006) 1.02
The molecular basis for adhesion-mediated suppression of reactive oxygen species generation by human neutrophils. J Clin Invest (2003) 1.01
p21-activated kinase 2 in neutrophils can be regulated by phosphorylation at multiple sites and by a variety of protein phosphatases. J Immunol (2003) 1.01
Rac and Rap GTPase activation assays. Methods Mol Biol (2007) 1.00
Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. J Biol Chem (2001) 1.00
Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1. Biochem J (2009) 0.99
Innate immune responses during infection. Vaccine (2004) 0.97
Beta-catenin is involved in insulin-like growth factor 1-mediated transactivation of the androgen receptor. Mol Endocrinol (2004) 0.97
FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. J Biol Chem (2008) 0.96
Control of neutrophil pseudopods by fluid shear: role of Rho family GTPases. Am J Physiol Cell Physiol (2004) 0.96
The microtubule-associated Rho activating factor GEF-H1 interacts with exocyst complex to regulate vesicle traffic. Dev Cell (2012) 0.94
Isolation and characterization of cytoplasmic cofilin-actin rods. J Biol Chem (2009) 0.94
The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor. Nucleic Acids Res (2007) 0.94
Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation. Eur J Cell Biol (2010) 0.94
The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development. Mol Cell Biol (2007) 0.93
Phosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex. J Biol Chem (2003) 0.93
Retracted ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival. J Biol Chem (2005) 0.93
Xenopus p21-activated kinase 5 regulates blastomeres' adhesive properties during convergent extension movements. Dev Biol (2005) 0.92
Affinity-based assay of Rho guanosine triphosphatase activation. Methods Mol Biol (2006) 0.92
Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathway. J Biol Chem (2002) 0.92
Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression. PLoS Negl Trop Dis (2011) 0.92
A stable aspirin-triggered lipoxin A4 analog blocks phosphorylation of leukocyte-specific protein 1 in human neutrophils. J Immunol (2004) 0.90
Protein phosphorylation in neutrophils monitored with phosphospecific antibodies. J Immunol Methods (2003) 0.89
Modulation of myosin light-chain phosphorylation by p21-activated kinase 1 in Escherichia coli invasion of human brain microvascular endothelial cells. Infect Immun (2003) 0.87
Facilitation of Ca(2+)-dependent exocytosis by Rac1-GTPase in bovine chromaffin cells. J Physiol (2003) 0.87
Zimp7 and Zimp10, two novel PIAS-like proteins, function as androgen receptor coregulators. Nucl Recept Signal (2006) 0.87
Phosphorylation of RhoGDI by p21-activated kinase 1. Methods Enzymol (2006) 0.86
A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription. J Biol Chem (2010) 0.86
Conditional expression of the androgen receptor induces oncogenic transformation of the mouse prostate. J Biol Chem (2011) 0.86