Published in J Cell Sci on November 23, 2015
Structure, biochemistry, and biology of PAK kinases. Gene (2016) 0.77
Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer? Oncotarget (2016) 0.77
A guided tour into subcellular colocalization analysis in light microscopy. J Microsc (2006) 16.73
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell (2000) 4.21
PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. EMBO J (1998) 2.62
p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol (2002) 2.61
PAK signalling during the development and progression of cancer. Nat Rev Cancer (2014) 2.21
Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines. J Biol Chem (2001) 2.07
Delineation of the Cdc42/Rac-binding domain of p21-activated kinase. Biochemistry (1998) 2.06
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. Mol Cell (2002) 2.00
Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. Mol Biol Cell (2002) 1.72
AR and ER interaction with a p21-activated kinase (PAK6). Mol Endocrinol (2002) 1.60
Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. J Biol Chem (2001) 1.59
Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. EMBO J (2010) 1.45
The emerging importance of group II PAKs. Biochem J (2010) 1.42
Nuclear localization and chromatin targets of p21-activated kinase 1. J Biol Chem (2005) 1.34
The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation. J Biol Chem (1998) 1.28
Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain. Oncogene (2002) 1.27
Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling. J Biol Chem (2003) 1.24
Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. Prostate (2008) 1.24
PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion. J Cell Sci (2010) 1.17
Identification of an autoinhibitory domain of p21-activated protein kinase 5. J Biol Chem (2003) 1.15
Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B. Mol Biol Cell (2010) 1.14
Group I and II mammalian PAKs have different modes of activation by Cdc42. EMBO Rep (2012) 1.13
Role of p-21-activated kinases in cancer progression. Int Rev Cell Mol Biol (2014) 1.13
Identification of novel membrane-binding domains in multiple yeast Cdc42 effectors. Mol Biol Cell (2007) 1.07
P21 activated kinases: structure, regulation, and functions. Small GTPases (2014) 1.06
Nucleo-cytoplasmic shuttling of PAK4 modulates β-catenin intracellular translocation and signaling. Biochim Biophys Acta (2011) 1.05
Mbt, a Drosophila PAK protein, combines with Cdc42 to regulate photoreceptor cell morphogenesis. Development (2003) 1.02
Phosphoinositides are essential coactivators for p21-activated kinase 1. Mol Cell (2010) 1.00
Knockdown of p21-activated kinase 6 inhibits prostate cancer growth and enhances chemosensitivity to docetaxel. Urology (2009) 1.00
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proc Natl Acad Sci U S A (2012) 0.98
Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells. Prostate (2010) 0.97
A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation. J Biol Chem (2012) 0.97
The Drosophila p21 activated kinase Mbt regulates the actin cytoskeleton and adherens junctions to control photoreceptor cell morphogenesis. Mech Dev (2006) 0.95
Xenopus p21-activated kinase 5 regulates blastomeres' adhesive properties during convergent extension movements. Dev Biol (2005) 0.92
CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation. J Cell Biol (2015) 0.92
The Drosophila p21-activated kinase Mbt modulates DE-cadherin-mediated cell adhesion by phosphorylation of Armadillo. Biochem J (2008) 0.90
The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity. PLoS One (2015) 0.88
Signaling, Regulation, and Specificity of the Type II p21-activated Kinases. J Biol Chem (2015) 0.84
A PAK6-IQGAP1 complex promotes disassembly of cell-cell adhesions. Cell Mol Life Sci (2013) 0.84
PAK4-6 in cancer and neuronal development. Cell Logist (2012) 0.83
NMR binding and crystal structure reveal that intrinsically-unstructured regulatory domain auto-inhibits PAK4 by a mechanism different from that of PAK1. Biochem Biophys Res Commun (2013) 0.82
A bivalent dissectional analysis of the high-affinity interactions between Cdc42 and the Cdc42/Rac interactive binding domains of signaling kinases in Candida albicans. Biochemistry (2005) 0.81
The PAKs come of age: Celebrating 18 years of discovery. Cell Logist (2012) 0.80
IQGAP1: insights into the function of a molecular puppeteer. Mol Immunol (2015) 0.80
Direct interaction between AR and PAK6 in androgen-stimulated PAK6 activation. PLoS One (2013) 0.79
Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6. PLoS One (2013) 0.78
An oncogenic kinase: putting PAK5 forward. Expert Opin Ther Targets (2014) 0.76
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proc Natl Acad Sci U S A (2012) 0.98
Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity. Mol Cell (2013) 0.96