Published in Nat Genet on October 02, 2005
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
Repeatability of published microarray gene expression analyses. Nat Genet (2008) 8.24
Molecular networks as sensors and drivers of common human diseases. Nature (2009) 6.14
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet (2008) 5.80
Revealing the architecture of gene regulation: the promise of eQTL studies. Trends Genet (2008) 5.78
Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet (2010) 3.75
Identifying regulatory mechanisms using individual variation reveals key role for chromatin modification. Proc Natl Acad Sci U S A (2006) 3.68
Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations. PLoS Comput Biol (2007) 3.37
Regulation of gene expression in the mammalian eye and its relevance to eye disease. Proc Natl Acad Sci U S A (2006) 2.91
A network view of disease and compound screening. Nat Rev Drug Discov (2009) 2.90
Exploring the human genome with functional maps. Genome Res (2009) 2.69
Genetical genomics: spotlight on QTL hotspots. PLoS Genet (2008) 2.63
Moving toward a system genetics view of disease. Mamm Genome (2007) 2.38
Metabonomic, transcriptomic, and genomic variation of a population cohort. Mol Syst Biol (2010) 2.17
High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Res (2009) 1.83
A review of statistical methods for expression quantitative trait loci mapping. Mamm Genome (2006) 1.60
Microarray-based analysis of ventilator-induced lung injury. Proc Am Thorac Soc (2007) 1.58
Cis-regulatory variations: a study of SNPs around genes showing cis-linkage in segregating mouse populations. BMC Genomics (2006) 1.53
PPARG by dietary fat interaction influences bone mass in mice and humans. J Bone Miner Res (2008) 1.50
The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism. Cell Metab (2014) 1.47
Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans. PLoS Genet (2011) 1.40
SFP genotyping from affymetrix arrays is robust but largely detects cis-acting expression regulators. Genetics (2007) 1.38
Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice. Mamm Genome (2006) 1.33
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers. Mol Syst Biol (2012) 1.27
FastMap: fast eQTL mapping in homozygous populations. Bioinformatics (2008) 1.25
The PhenoGen informatics website: tools for analyses of complex traits. BMC Genet (2007) 1.25
Characterizing the role of miRNAs within gene regulatory networks using integrative genomics techniques. Mol Syst Biol (2011) 1.25
Harnessing gene expression to identify the genetic basis of drug resistance. Mol Syst Biol (2009) 1.24
Integrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network. Genome Res (2009) 1.17
Molecular signatures from omics data: from chaos to consensus. Biotechnol J (2012) 1.17
Intra- and inter-individual genetic differences in gene expression. Mamm Genome (2009) 1.16
Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction. Am J Clin Nutr (2008) 1.10
Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia (2008) 1.10
Using transcriptome profiling to characterize QTL regions on chicken chromosome 5. BMC Genomics (2009) 1.09
Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in mice. Genetics (2006) 1.07
Inferring causal genomic alterations in breast cancer using gene expression data. BMC Syst Biol (2011) 1.06
Adipocytes secrete leukotrienes: contribution to obesity-associated inflammation and insulin resistance in mice. Diabetes (2012) 1.06
Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains. Aging Cell (2010) 1.04
Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relationships. Mamm Genome (2006) 1.04
Regulatory network identification by genetical genomics: signaling downstream of the Arabidopsis receptor-like kinase ERECTA. Plant Physiol (2010) 1.03
Polyunsaturated fatty acids and cardiovascular disease: implications for nutrigenetics. J Nutrigenet Nutrigenomics (2009) 1.01
Identification of expression QTL (eQTL) of genes expressed in porcine M. longissimus dorsi and associated with meat quality traits. BMC Genomics (2010) 0.99
Diversification in the genetic architecture of gene expression and transcriptional networks in organ differentiation of Populus. Proc Natl Acad Sci U S A (2010) 0.99
A systems biology approach to understanding atherosclerosis. EMBO Mol Med (2010) 0.97
Integrating expression profiling and whole-genome association for dissection of fat traits in a porcine model. J Lipid Res (2011) 0.96
Genetic contribution of the leukotriene pathway to coronary artery disease. Hum Genet (2011) 0.96
Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas. Nat Commun (2013) 0.95
Serious limitations of the QTL/microarray approach for QTL gene discovery. BMC Biol (2010) 0.95
Exon and junction microarrays detect widespread mouse strain- and sex-bias expression differences. BMC Genomics (2008) 0.94
Genome-wide co-expression analysis in multiple tissues. PLoS One (2008) 0.93
Metabolomics and atherosclerosis. Curr Atheroscler Rep (2010) 0.93
Novel integrative genomics strategies to identify genes for complex traits. Anim Genet (2006) 0.92
A high-fat diet induces bone loss in mice lacking the Alox5 gene. Endocrinology (2011) 0.91
Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes. Neuroscience (2007) 0.91
Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation. Circulation (2012) 0.91
Genomic networks of hybrid sterility. PLoS Genet (2014) 0.90
Systems biology and its potential role in radiobiology. Radiat Environ Biophys (2007) 0.90
Integrative analysis using module-guided random forests reveals correlated genetic factors related to mouse weight. PLoS Comput Biol (2013) 0.89
Genetic polymorphisms associated with acute lung injury. Pharmacogenomics (2009) 0.88
Heritability and genetic basis of protein level variation in an outbred population. Genome Res (2014) 0.88
Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice. J Lipid Res (2011) 0.88
A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot. Mamm Genome (2006) 0.87
A wild derived quantitative trait locus on mouse chromosome 2 prevents obesity. BMC Genet (2010) 0.86
The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages. Genome Res (2013) 0.86
An efficient method to identify differentially expressed genes in microarray experiments. Bioinformatics (2008) 0.84
Robust detection and genotyping of single feature polymorphisms from gene expression data. PLoS Comput Biol (2009) 0.84
Combining QTL data for HDL cholesterol levels from two different species leads to smaller confidence intervals. Heredity (Edinb) (2010) 0.84
Systems analysis of bone. Wiley Interdiscip Rev Syst Biol Med (2010) 0.84
Genetic regulation of bone metabolism in the chicken: similarities and differences to Mammalian systems. PLoS Genet (2015) 0.83
Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders. Front Pharmacol (2014) 0.83
Understanding quantitative genetics in the systems biology era. Int J Biol Sci (2009) 0.82
Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross. PLoS Genet (2016) 0.82
Genetic influences on brain gene expression in rats selected for tameness and aggression. Genetics (2014) 0.82
Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice. Physiol Genomics (2009) 0.82
Genomic insights into early-onset obesity. Genome Med (2010) 0.81
Optimal design of genetic studies of gene expression with two-color microarrays in outbred crosses. Genetics (2008) 0.81
Systems genetics: a novel approach to dissect the genetic basis of osteoporosis. Curr Osteoporos Rep (2012) 0.81
Systematic detection of epistatic interactions based on allele pair frequencies. PLoS Genet (2012) 0.81
Expression quantitative trait loci infer the regulation of isoflavone accumulation in soybean (Glycine max L. Merr.) seed. BMC Genomics (2014) 0.80
Generating a robust statistical causal structure over 13 cardiovascular disease risk factors using genomics data. J Biomed Inform (2016) 0.80
Polygenic molecular architecture underlying non-sexual cell aggregation in budding yeast. DNA Res (2013) 0.80
Body composition and gene expression QTL mapping in mice reveals imprinting and interaction effects. BMC Genet (2013) 0.80
Biomarkers for combat-related PTSD: focus on molecular networks from high-dimensional data. Eur J Psychotraumatol (2014) 0.79
Association studies of ALOX5 and bone mineral density in healthy adults. Osteoporos Int (2007) 0.79
Association of PLA2G4A with myocardial infarction is modulated by dietary PUFAs. Am J Clin Nutr (2012) 0.78
Genome-wide Mapping of Copy Number Variations Using SNP Arrays. Transfus Med Hemother (2009) 0.78
Partial restoration of macrophage alteration from diet-induced obesity in response to Porphyromonas gingivalis infection. PLoS One (2013) 0.77
A three step network based approach (TSNBA) to finding disease molecular signature and key regulators: a case study of IL-1 and TNF-alpha stimulated inflammation. PLoS One (2014) 0.77
Molecular and neurologic responses to chronic alcohol use. Handb Clin Neurol (2014) 0.76
Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer. Genome Med (2016) 0.75
Identifying genes for neurobehavioural traits in rodents: progress and pitfalls. Dis Model Mech (2017) 0.75
Association of ALOX15 gene polymorphisms with obesity-related phenotypes in Chinese nuclear families with male offspring. Acta Pharmacol Sin (2012) 0.75
5-lipoxygenase-activating protein as a modulator of olanzapine-induced lipid accumulation in adipocyte. J Lipids (2013) 0.75
Relating quantitative variation within a behavior to variation in transcription. Evolution (2017) 0.75
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Genetics of gene expression surveyed in maize, mouse and man. Nature (2003) 22.17
Genetics of gene expression and its effect on disease. Nature (2008) 21.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science (2003) 16.80
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet (2005) 11.40
The origin of the Haitian cholera outbreak strain. N Engl J Med (2010) 9.85
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med (2013) 9.44
Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N Engl J Med (2011) 9.37
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66
Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45
Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet (2006) 5.82
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet (2008) 5.80
Dark matter in the genome: evidence of widespread transcription detected by microarray tiling experiments. Trends Genet (2005) 4.56
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell (2013) 4.45
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33
Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A (2002) 4.23
Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med (2004) 4.06
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature (2012) 4.01
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet (2011) 3.92
A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res (2010) 3.81
Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet (2010) 3.75
Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. JAMA (2008) 3.64
Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet (2010) 3.63
Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome (2007) 3.59
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51
Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing. Nat Biotechnol (2012) 3.39
Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology (2008) 3.38
Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations. PLoS Comput Biol (2007) 3.37
Microarray standard data set and figures of merit for comparing data processing methods and experiment designs. Bioinformatics (2003) 3.33
Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res (2008) 3.26
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Comparative analysis of proteome and transcriptome variation in mouse. PLoS Genet (2011) 3.23
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Epidemiology (2011) 3.15
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science (2002) 3.13
Correction for hidden confounders in the genetic analysis of gene expression. Proc Natl Acad Sci U S A (2010) 3.08
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet (2011) 3.07
Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes (2008) 3.05
Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci U S A (2006) 3.03
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab (2013) 3.01
A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort. Genome Res (2011) 3.00
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97
The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arterioscler Thromb Vasc Biol (2006) 2.90
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet (2004) 2.86
Global survey of genomic imprinting by transcriptome sequencing. Curr Biol (2008) 2.80
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J Lipid Res (2004) 2.72
Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res (2002) 2.69
A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients. Cancer Res (2005) 2.65