Published in Nat Protoc on January 01, 2007
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell (2011) 5.27
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature (2012) 2.96
Asymmetrically modified nucleosomes. Cell (2012) 2.79
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Blood (2010) 2.71
H3K36 methylation antagonizes PRC2-mediated H3K27 methylation. J Biol Chem (2011) 2.63
In vivo residue-specific histone methylation dynamics. J Biol Chem (2009) 2.33
Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Mol Cell (2009) 2.27
One-pot shotgun quantitative mass spectrometry characterization of histones. J Proteome Res (2009) 2.13
Lysine succinylation and lysine malonylation in histones. Mol Cell Proteomics (2012) 1.95
Retracted Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature (2010) 1.92
Examining histone posttranslational modification patterns by high-resolution mass spectrometry. Methods Enzymol (2012) 1.83
Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia. Nat Genet (2013) 1.77
Pitfalls in histone propionylation during bottom-up mass spectrometry analysis. Proteomics (2015) 1.62
Oncogene-induced cellular senescence elicits an anti-Warburg effect. Proteomics (2013) 1.50
Breaking the histone code with quantitative mass spectrometry. Expert Rev Proteomics (2011) 1.39
H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions. Genome Biol (2012) 1.33
Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency. Nat Cell Biol (2013) 1.33
Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry. J Proteome Res (2010) 1.29
Quantitative assessment of chromatin immunoprecipitation grade antibodies directed against histone modifications reveals patterns of co-occurring marks on histone protein molecules. Mol Cell Proteomics (2012) 1.27
Identification and verification of lysine propionylation and butyrylation in yeast core histones using PTMap software. J Proteome Res (2009) 1.25
Loss of BAP1 function leads to EZH2-dependent transformation. Nat Med (2015) 1.21
A model for mitotic inheritance of histone lysine methylation. EMBO Rep (2011) 1.20
Differences in specificity and selectivity between CBP and p300 acetylation of histone H3 and H3/H4. Biochemistry (2013) 1.17
Acetylation of vertebrate H2A.Z and its effect on the structure of the nucleosome. Biochemistry (2009) 1.17
Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates. BMC Biol (2009) 1.17
Histone methyltransferase G9a contributes to H3K27 methylation in vivo. Cell Res (2010) 1.14
Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3. Proc Natl Acad Sci U S A (2012) 1.12
A novel approach for untargeted post-translational modification identification using integer linear optimization and tandem mass spectrometry. Mol Cell Proteomics (2010) 1.11
EpiProfile Quantifies Histone Peptides With Modifications by Extracting Retention Time and Intensity in High-resolution Mass Spectra. Mol Cell Proteomics (2015) 1.09
Stable-isotope-labeled histone peptide library for histone post-translational modification and variant quantification by mass spectrometry. Mol Cell Proteomics (2014) 1.08
Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries. Nat Methods (2014) 1.08
The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer. Oncogene (2012) 1.07
Sequential Window Acquisition of all Theoretical Mass Spectra (SWATH) Analysis for Characterization and Quantification of Histone Post-translational Modifications. Mol Cell Proteomics (2015) 1.06
Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites. Nat Commun (2013) 1.06
Quantitating the specificity and selectivity of Gcn5-mediated acetylation of histone H3. PLoS One (2013) 1.05
Recombinant antibodies to histone post-translational modifications. Nat Methods (2013) 1.05
Combinatorial chromatin modification patterns in the human genome revealed by subspace clustering. Nucleic Acids Res (2011) 1.03
Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs. J Biol Chem (2011) 1.00
Symmetrical modification within a nucleosome is not required globally for histone lysine methylation. EMBO Rep (2011) 0.99
Modulation of 14-3-3 interaction with phosphorylated histone H3 by combinatorial modification patterns. Cell Cycle (2008) 0.99
Mass spectrometry-based proteomics for the analysis of chromatin structure and dynamics. Int J Mol Sci (2013) 0.97
Comparing and combining capillary electrophoresis electrospray ionization mass spectrometry and nano-liquid chromatography electrospray ionization mass spectrometry for the characterization of post-translationally modified histones. Mol Cell Proteomics (2013) 0.96
An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol (2016) 0.96
Quantitative proteomics reveals direct and indirect alterations in the histone code following methyltransferase knockdown. Mol Biosyst (2010) 0.94
Trimethylation of histone H3 lysine 4 impairs methylation of histone H3 lysine 9: regulation of lysine methyltransferases by physical interaction with their substrates. Epigenetics (2010) 0.94
Identification of lysine 37 of histone H2B as a novel site of methylation. PLoS One (2011) 0.94
Proteomic interrogation of human chromatin. PLoS One (2011) 0.93
The histone code of Toxoplasma gondii comprises conserved and unique posttranslational modifications. MBio (2013) 0.93
Changing the selectivity of p300 by acetyl-CoA modulation of histone acetylation. ACS Chem Biol (2014) 0.92
Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression. Mol Cell Proteomics (2015) 0.92
Identification and interrogation of combinatorial histone modifications. Front Genet (2013) 0.91
Mass spectrometric quantification of histone post-translational modifications by a hybrid chemical labeling method. Mol Cell Proteomics (2015) 0.89
Analysis of Histone Modifications from Tryptic Peptides of Deuteroacetylated Isoforms. Int J Mass Spectrom (2012) 0.89
Drawbacks in the use of unconventional hydrophobic anhydrides for histone derivatization in bottom-up proteomics PTM analysis. Proteomics (2015) 0.87
H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression programs during ESC differentiation. PLoS Genet (2013) 0.87
Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigenetics. J Am Chem Soc (2014) 0.87
Unambiguous determination of isobaric histone modifications by reversed-phase retention time and high-mass accuracy. Anal Biochem (2009) 0.87
ChIP-less analysis of chromatin states. Epigenetics Chromatin (2014) 0.87
Revealing histone variant induced changes via quantitative proteomics. Crit Rev Biochem Mol Biol (2011) 0.86
Phosphorylation and arginine methylation mark histone H2A prior to deposition during Xenopus laevis development. Epigenetics Chromatin (2014) 0.86
Collective mass spectrometry approaches reveal broad and combinatorial modification of high mobility group protein A1a. J Am Soc Mass Spectrom (2010) 0.86
Proteomics of protein post-translational modifications implicated in neurodegeneration. Transl Neurodegener (2014) 0.86
FLEXIQinase, a mass spectrometry-based assay, to unveil multikinase mechanisms. Nat Methods (2012) 0.86
Chemical and biochemical approaches in the study of histone methylation and demethylation. Med Res Rev (2012) 0.85
The Dynamic Regulatory Genome of Capsaspora and the Origin of Animal Multicellularity. Cell (2016) 0.85
Modern approaches for investigating epigenetic signaling pathways. J Appl Physiol (1985) (2010) 0.84
A quantitative multiplexed mass spectrometry assay for studying the kinetic of residue-specific histone acetylation. Methods (2014) 0.84
Proteomics in epigenetics: new perspectives for cancer research. Brief Funct Genomics (2013) 0.84
Characterization of histone post-translational modifications during virus infection using mass spectrometry-based proteomics. Methods (2015) 0.84
A chemical proteomics approach for global analysis of lysine monomethylome profiling. Mol Cell Proteomics (2014) 0.84
Histone H1 phosphorylation in breast cancer. J Proteome Res (2014) 0.83
Building the Connectivity Map of epigenetics: chromatin profiling by quantitative targeted mass spectrometry. Methods (2014) 0.83
Mass spectrometric analysis of histone proteoforms. Annu Rev Anal Chem (Palo Alto Calif) (2014) 0.83
Comprehending dynamic protein methylation with mass spectrometry. Curr Opin Chem Biol (2013) 0.82
C-terminal phosphorylation of murine testis-specific histone H1t in elongating spermatids. J Proteome Res (2008) 0.82
A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme. J Biol Chem (2015) 0.81
Quantitative proteomics reveals that the specific methyltransferases Txr1p and Ezl2p differentially affect the mono-, di- and trimethylation states of histone H3 lysine 27 (H3K27). Mol Cell Proteomics (2012) 0.81
Accelerated identification of proteins by mass spectrometry by employing covalent pre-gel staining with Uniblue A. PLoS One (2012) 0.81
A Comprehensive Guide for Performing Sample Preparation and Top-Down Protein Analysis. Proteomes (2017) 0.81
Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth. Mol Cancer (2014) 0.80
Analyses of Histone Proteoforms Using Front-end Electron Transfer Dissociation-enabled Orbitrap Instruments. Mol Cell Proteomics (2016) 0.79
PUB-NChIP--"in vivo biotinylation" approach to study chromatin in proximity to a protein of interest. Genome Res (2012) 0.79
Site-specific human histone H3 methylation stability: fast K4me3 turnover. Proteomics (2014) 0.78
Epiproteomics: quantitative analysis of histone marks and codes by mass spectrometry. Curr Opin Chem Biol (2016) 0.78
Quantitative proteomics reveals histone modifications in crosstalk with H3 lysine 27 methylation. Mol Cell Proteomics (2014) 0.78
Profiling post-translational modifications of histones in human monocyte-derived macrophages. Proteome Sci (2015) 0.78
Heavy methyl-SILAC labeling coupled with liquid chromatography and high-resolution mass spectrometry to study the dynamics of site-specific histone methylation. Methods Mol Biol (2013) 0.78
Molecular epigenetics in the management of ovarian cancer: are we investigating a rational clinical promise? Front Oncol (2014) 0.78
Expression, purification and proteomic analysis of recombinant histone H4 acetylated at lysine 16. Proteomics (2013) 0.78
Cis-existence of H3K27me3 and H3K36me2 in mouse embryonic stem cells revealed by specific ions of isobaric modification chromatogram. Stem Cell Res Ther (2015) 0.77
Bioinformatic and proteomic analysis of bulk histones reveals PTM crosstalk and chromatin features. J Proteome Res (2014) 0.77
Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1. Elife (2016) 0.77
Progress in epigenetic histone modification analysis by mass spectrometry for clinical investigations. Expert Rev Proteomics (2015) 0.77
A quantitative analysis of histone methylation and acetylation isoforms from their deuteroacetylated derivatives: application to a series of knockout mutants. J Mass Spectrom (2013) 0.77
Mapping of Post-translational Modifications of Transition Proteins, TP1 and TP2, and Identification of Protein Arginine Methyltransferase 4 and Lysine Methyltransferase 7 as Methyltransferase for TP2. J Biol Chem (2015) 0.77
Quantification of histone modifications using ¹⁵N metabolic labeling. Methods (2013) 0.77
Systems Level Analysis of Histone H3 Post-translational Modifications (PTMs) Reveals Features of PTM Crosstalk in Chromatin Regulation. Mol Cell Proteomics (2016) 0.76
An integrative analysis of post-translational histone modifications in the marine diatom Phaeodactylum tricornutum. Genome Biol (2015) 0.76
Multiplexed data independent acquisition (MSX-DIA) applied by high resolution mass spectrometry improves quantification quality for the analysis of histone peptides. Proteomics (2016) 0.76
Quantitative proteomic analysis of histone modifications in decitabine sensitive and resistant leukemia cell lines. Clin Proteomics (2016) 0.76
Translating the histone code. Science (2001) 56.77
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell (2003) 11.33
Histone modifications in transcriptional regulation. Curr Opin Genet Dev (2002) 8.10
Cellular memory and the histone code. Cell (2002) 7.30
Histone H3.3 is enriched in covalent modifications associated with active chromatin. Proc Natl Acad Sci U S A (2004) 4.88
Novel linear quadrupole ion trap/FT mass spectrometer: performance characterization and use in the comparative analysis of histone H3 post-translational modifications. J Proteome Res (2004) 4.32
Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. Curr Biol (2001) 4.17
PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state. Mol Cell (2006) 3.20
Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem (2005) 3.00
Identification of novel histone post-translational modifications by peptide mass fingerprinting. Chromosoma (2003) 2.67
Shotgun annotation of histone modifications: a new approach for streamlined characterization of proteins by top down mass spectrometry. J Am Chem Soc (2004) 2.36
Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications. Nucleic Acids Res (2004) 2.28
A combination of different mass spectroscopic techniques for the analysis of dynamic changes of histone modifications. Proteomics (2004) 1.56
Resetting the epigenetic histone code in the MRL-lpr/lpr mouse model of lupus by histone deacetylase inhibition. J Proteome Res (2005) 1.41
Comprehensive phosphoprotein analysis of linker histone H1 from Tetrahymena thermophila. Mol Cell Proteomics (2006) 1.26
Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry. Proc Natl Acad Sci U S A (2004) 13.14
Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae. Nat Biotechnol (2002) 8.37
Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell (2003) 6.44
Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature (2005) 6.40
A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature (2002) 6.19
Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Mol Cell Biol (2002) 5.42
Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry. Proc Natl Acad Sci U S A (2007) 5.09
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature (2011) 4.44
Novel linear quadrupole ion trap/FT mass spectrometer: performance characterization and use in the comparative analysis of histone H3 post-translational modifications. J Proteome Res (2004) 4.32
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature (2011) 4.23
Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr Biol (2004) 4.20
Organismal differences in post-translational modifications in histones H3 and H4. J Biol Chem (2006) 3.84
Gene silencing: trans-histone regulatory pathway in chromatin. Nature (2002) 3.77
Protein identification using sequential ion/ion reactions and tandem mass spectrometry. Proc Natl Acad Sci U S A (2005) 3.77
Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc Natl Acad Sci U S A (2003) 3.75
Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. Cell (2008) 3.09
A neutral loss activation method for improved phosphopeptide sequence analysis by quadrupole ion trap mass spectrometry. Anal Chem (2004) 3.08
Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem (2005) 3.00
Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry. Anal Chem (2006) 2.89
The utility of ETD mass spectrometry in proteomic analysis. Biochim Biophys Acta (2006) 2.85
Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal (2010) 2.79
Partial agonists activate PPARgamma using a helix 12 independent mechanism. Structure (2007) 2.57
MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding. J Biol Chem (2003) 2.53
Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini. Proc Natl Acad Sci U S A (2007) 2.43
N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis. Nat Cell Biol (2007) 2.36
Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1. J Biol Chem (2006) 2.32
The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. Curr Biol (2004) 2.31
The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist. Mol Pharmacol (2009) 2.30
Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications. Nucleic Acids Res (2004) 2.28
O-GlcNAc regulates FoxO activation in response to glucose. J Biol Chem (2008) 2.27
Electron transfer dissociation of peptide anions. J Am Soc Mass Spectrom (2005) 2.26
RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena. Genes Dev (2007) 2.26
Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation. Curr Biol (2005) 2.20
Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites. J Biol Chem (2002) 2.01
Genomic and functional evolution of the Drosophila melanogaster sperm proteome. Nat Genet (2006) 1.97
Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. J Biol Chem (2002) 1.96
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. Nature (2010) 1.95
Characterization of histones and their post-translational modifications by mass spectrometry. Curr Opin Chem Biol (2006) 1.92
Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes. Proc Natl Acad Sci U S A (2005) 1.91
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proc Natl Acad Sci U S A (2012) 1.89
Methods for analyzing peptides and proteins on a chromatographic timescale by electron-transfer dissociation mass spectrometry. Nat Protoc (2008) 1.87
Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins. Curr Biol (2010) 1.86
Post-acquisition ETD spectral processing for increased peptide identifications. J Am Soc Mass Spectrom (2009) 1.86
HD desktop: an integrated platform for the analysis and visualization of H/D exchange data. J Am Soc Mass Spectrom (2008) 1.82
Proteome-wide prediction of acetylation substrates. Proc Natl Acad Sci U S A (2009) 1.81
A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose. J Biol Chem (2008) 1.76
Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets. Proc Natl Acad Sci U S A (2012) 1.75
Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry. Mol Cell Proteomics (2009) 1.72
A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev (2006) 1.70
Tandem mass spectrometry for peptide and protein sequence analysis. Biotechniques (2005) 1.70