Published in Genet Epidemiol on September 01, 2003
Using linkage genome scans to improve power of association in genome scans. Am J Hum Genet (2006) 5.67
Recent developments in genomewide association scans: a workshop summary and review. Am J Hum Genet (2005) 3.76
Optimal two-stage genotyping designs for genome-wide association scans. Genet Epidemiol (2006) 3.41
Design and analysis issues in genome-wide somatic mutation studies of cancer. Genomics (2008) 1.95
Evaluating statistical significance in two-stage genomewide association studies. Am J Hum Genet (2006) 1.95
Flexible design for following up positive findings. Am J Hum Genet (2007) 1.94
Methods for investigating gene-environment interactions in candidate pathway and genome-wide association studies. Annu Rev Public Health (2010) 1.88
Calibrating the performance of SNP arrays for whole-genome association studies. PLoS Genet (2008) 1.86
Genome-Wide Significance Levels and Weighted Hypothesis Testing. Stat Sci (2009) 1.81
Two-stage designs in case-control association analysis. Genetics (2006) 1.65
ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio. Am J Respir Crit Care Med (2011) 1.62
BCL2 genetic variants are associated with acute kidney injury in septic shock*. Crit Care Med (2012) 1.61
Genome-wide association studies of cancer. J Clin Oncol (2010) 1.45
A network of dopaminergic gene variations implicated as risk factors for schizophrenia. Hum Mol Genet (2007) 1.43
Quantitative trait locus study design from an information perspective. Genetics (2005) 1.26
Optimal two-stage design for case-control association analysis incorporating genotyping errors. Ann Hum Genet (2008) 1.12
Multifactor dimensionality reduction-phenomics: a novel method to capture genetic heterogeneity with use of phenotypic variables. Am J Hum Genet (2007) 1.11
Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PLoS One (2012) 1.11
Methodological issues in detecting gene-gene interactions in breast cancer susceptibility: a population-based study in Ontario. BMC Med (2007) 1.08
Probability that a two-stage genome-wide association study will detect a disease-associated snp and implications for multistage designs. Ann Hum Genet (2008) 1.07
Methodological Issues in Multistage Genome-wide Association Studies. Stat Sci (2009) 1.06
IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist. Am J Respir Crit Care Med (2013) 1.03
Detecting multiple associations in genome-wide studies. Hum Genomics (2006) 0.99
Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin. J Med Genet (2012) 0.97
Optimal DNA pooling-based two-stage designs in case-control association studies. Hum Hered (2008) 0.97
The cost effectiveness of duplicate genotyping for testing genetic association. Ann Hum Genet (2009) 0.92
Including additional controls from public databases improves the power of a genome-wide association study. Hum Hered (2011) 0.86
Efficiency of genomic selection using Bayesian multi-marker models for traits selected to reflect a wide range of heritabilities and frequencies of detected quantitative traits loci in mice. BMC Genet (2012) 0.86
Multistage designs in the genomic era: providing balance in complex disease studies. Genet Epidemiol (2007) 0.85
A modified forward multiple regression in high-density genome-wide association studies for complex traits. Genet Epidemiol (2009) 0.85
Optimal screening for promising genes in 2-stage designs. Biostatistics (2008) 0.85
Multifactor dimensionality reduction as a filter-based approach for genome wide association studies. Front Genet (2011) 0.83
Prioritize and select SNPs for association studies with multi-stage designs. J Comput Biol (2008) 0.82
Two-phase and family-based designs for next-generation sequencing studies. Front Genet (2013) 0.82
Robust joint analysis allowing for model uncertainty in two-stage genetic association studies. BMC Bioinformatics (2011) 0.80
Joint analysis for genome-wide association studies in family-based designs. PLoS One (2011) 0.79
Marker selection for whole-genome association studies with two-stage designs using dense single-nucleotide polymorphisms. BMC Proc (2007) 0.79
Accounting for selection and correlation in the analysis of two-stage genome-wide association studies. Biostatistics (2016) 0.79
Genome-wide association tests by two-stage approaches with unified analysis of families and unrelated individuals. BMC Proc (2007) 0.78
Two-stage analysis strategy for identifying the IgM quantitative trait locus. BMC Proc (2007) 0.78
Incorporation of genetic model parameters for cost-effective designs of genetic association studies using DNA pooling. BMC Genomics (2007) 0.78
Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: the Singapore Chinese health study. PLoS One (2014) 0.78
Two-stage family-based designs for sequencing studies. BMC Proc (2014) 0.77
Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk. Am J Transplant (2015) 0.76
Improved minimum cost and maximum power two stage genome-wide association study designs. PLoS One (2012) 0.75
Rhegmatogenous retinal detachment in Scotland: research design and methodology. BMC Ophthalmol (2009) 0.75
MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping. Age (Dordr) (2012) 0.75
Optimal 2-stage design with given power in association studies. Biostatistics (2008) 0.75
Using Ascertainment for Targeted Resequencing to Increase Power to Identify Causal Variants. Stat Interface (2011) 0.75
A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet (2007) 4.46
Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci U S A (2010) 3.78
Improved power by use of a weighted score test for linkage disequilibrium mapping. Am J Hum Genet (2006) 3.36
Adding further power to the Haseman and Elston method for detecting linkage in larger sibships: weighting sums and differences. Hum Hered (2003) 3.33
Choosing an optimal method to combine P-values. Stat Med (2009) 3.15
The genetic basis of complex traits: rare variants or "common gene, common disease"? Methods Mol Biol (2007) 3.01
A unified association analysis approach for family and unrelated samples correcting for stratification. Am J Hum Genet (2008) 3.00
Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. Am J Hum Genet (2003) 2.92
Detecting rare variants for complex traits using family and unrelated data. Genet Epidemiol (2010) 2.80
Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence. Hum Mol Genet (2005) 2.80
Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis. Am J Hum Genet (2004) 2.36
Linkage analysis of a complex disease through use of admixed populations. Am J Hum Genet (2004) 2.21
Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes. Am J Hum Genet (2008) 2.20
Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence. Am J Hum Genet (2005) 2.18
A powerful method of combining measures of association and Hardy-Weinberg disequilibrium for fine-mapping in case-control studies. Stat Med (2006) 2.18
Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions. Bioinformatics (2006) 2.08
Whole genome scan for obstructive sleep apnea and obesity in African-American families. Am J Respir Crit Care Med (2004) 2.03
The Family Investigation of Nephropathy and Diabetes (FIND): design and methods. J Diabetes Complications (2005) 1.87
Self-reported race and genetic admixture. N Engl J Med (2006) 1.85
A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. Proc Natl Acad Sci U S A (2003) 1.84
The meaning of interaction. Hum Hered (2010) 1.83
EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet (2009) 1.82
A whole-genome scan for obstructive sleep apnea and obesity. Am J Hum Genet (2002) 1.81
Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND). Diabetes (2007) 1.79
Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND). Diabetes (2007) 1.61
A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies. Am J Hum Genet (2008) 1.57
Improving power in contrasting linkage-disequilibrium patterns between cases and controls. Am J Hum Genet (2007) 1.55
A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study. Am J Hum Genet (2003) 1.53
A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population. BMC Genet (2003) 1.50
Log-linear model-based multifactor dimensionality reduction method to detect gene gene interactions. Bioinformatics (2007) 1.44
Genetics of the apnea hypopnea index in Caucasians and African Americans: I. Segregation analysis. Genet Epidemiol (2002) 1.44
Detecting rare and common variants for complex traits: sibpair and odds ratio weighted sum statistics (SPWSS, ORWSS). Genet Epidemiol (2011) 1.43
Sampling correction in linkage analysis. Genet Epidemiol (2004) 1.43
Genome scan of M. tuberculosis infection and disease in Ugandans. PLoS One (2008) 1.41
Plasma aldosterone is independently associated with the metabolic syndrome. Hypertension (2006) 1.40
Are linkage analysis and the collection of family data dead? Prospects for family studies in the age of genome-wide association. Hum Hered (2007) 1.39
Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients. Cancer Res (2009) 1.38
Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence. Hum Mol Genet (2005) 1.36
Pleiotropic effects of a chromosome 3 locus on speech-sound disorder and reading. Am J Hum Genet (2004) 1.36
A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African Americans. Am J Hum Genet (2006) 1.31
Heritability of the severity of diabetic retinopathy: the FIND-Eye study. Invest Ophthalmol Vis Sci (2008) 1.29
Statistical interaction in human genetics: how should we model it if we are looking for biological interaction? Nat Rev Genet (2010) 1.28
Two-level Haseman-Elston regression for general pedigree data analysis. Genet Epidemiol (2005) 1.28
Identification of a major locus for age-related cortical cataract on chromosome 6p12-q12 in the Beaver Dam Eye Study. Proc Natl Acad Sci U S A (2004) 1.27
The power of independent types of genetic information to detect association in a case-control study design. Genet Epidemiol (2008) 1.24
CYP3A5 and ABCB1 genes influence blood pressure and response to treatment, and their effect is modified by salt. Hypertension (2007) 1.23
Adaptive two-stage analysis of genetic association in case-control designs. Hum Hered (2007) 1.23
Single-marker and two-marker association tests for unphased case-control genotype data, with a power comparison. Genet Epidemiol (2010) 1.22
A partial least-square approach for modeling gene-gene and gene-environment interactions when multiple markers are genotyped. Genet Epidemiol (2009) 1.18
A sarcoidosis genetic linkage consortium: the sarcoidosis genetic analysis (SAGA) study. Sarcoidosis Vasc Diffuse Lung Dis (2005) 1.18
Two-marker association tests yield new disease associations for coronary artery disease and hypertension. Hum Genet (2011) 1.16
Higher offspring survival among Tibetan women with high oxygen saturation genotypes residing at 4,000 m. Proc Natl Acad Sci U S A (2004) 1.16
Heritability analysis of cytokines as intermediate phenotypes of tuberculosis. J Infect Dis (2003) 1.16
Regression models for linkage: issues of traits, covariates, heterogeneity, and interaction. Hum Hered (2003) 1.15
Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. Biol Psychiatry (2008) 1.13
Heritability of renal function in hypertensive families of African descent in the Seychelles (Indian Ocean). Kidney Int (2005) 1.13
Detecting genetic interactions for quantitative traits with U-statistics. Genet Epidemiol (2011) 1.13
The structure of linkage disequilibrium at the DBH locus strongly influences the magnitude of association between diallelic markers and plasma dopamine beta-hydroxylase activity. Am J Hum Genet (2003) 1.11
Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study. Am J Hum Genet (2008) 1.10
Mapping susceptibility loci for alcohol consumption using number of grams of alcohol consumed per day as a phenotype measure. BMC Genet (2003) 1.10
In silico gene prioritization by integrating multiple data sources. PLoS One (2011) 1.10
GW433908/ritonavir once daily in antiretroviral therapy-naive HIV-infected patients: absence of protease resistance at 48 weeks. AIDS (2004) 1.08
Haplotype-based quantitative trait mapping using a clustering algorithm. BMC Bioinformatics (2006) 1.07
Robust asymptotic sampling theory for correlations in pedigrees. Stat Med (2003) 1.07
Genomewide linkage scan for diabetic renal failure and albuminuria: the FIND study. Am J Nephrol (2011) 1.07
Evidence for a major gene influence on tumor necrosis factor-alpha expression in tuberculosis: path and segregation analysis. Hum Hered (2005) 1.05
Association of vitamin D receptor gene variants, adiposity and colon cancer. Carcinogenesis (2008) 1.05
Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans. Biol Psychiatry (2006) 1.05
Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes. Hum Genet (2007) 1.04
Complement factor H and hemicentin-1 in age-related macular degeneration and renal phenotypes. Hum Mol Genet (2007) 1.03
The distribution of long range admixture linkage disequilibrium in an African-American population. Hum Hered (2002) 1.03
A modified revisited Haseman-Elston method to further improve power. Hum Hered (2004) 1.02
A framework for structural equation models in general pedigrees. Hum Hered (2011) 1.02
Structural equation model-based genome scan for the metabolic syndrome. BMC Genet (2003) 1.02
High heritability of ambulatory blood pressure in families of East African descent. Hypertension (2005) 1.02
A cautionary note on the use of Mendelian randomization to infer causation in observational epidemiology. Int J Epidemiol (2007) 1.01
Fine mapping functional sites or regions from case-control data using haplotypes of multiple linked SNPs. Ann Hum Genet (2005) 1.01
A likelihood ratio-based Mann-Whitney approach finds novel replicable joint gene action for type 2 diabetes. Genet Epidemiol (2012) 1.00
Identification of gene-gene interactions in the presence of missing data using the multifactor dimensionality reduction method. Genet Epidemiol (2009) 1.00
The affected-/discordant-sib-pair design can guarantee validity of multipoint model-free linkage analysis of incomplete pedigrees when there is marker-marker disequilibrium. Am J Hum Genet (2006) 1.00
Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data. BMC Syst Biol (2012) 1.00
Evaluation of removable statistical interaction for binary traits. Stat Med (2012) 0.99
Distribution and magnitude of type I error of model-based multipoint lod scores: implications for multipoint mod scores. Genet Epidemiol (2006) 0.98
Immunoglobulin allotypes influence IgG antibody responses to hepatitis C virus envelope proteins E1 and E2. Hum Immunol (2008) 0.97
Nonparametric disequilibrium mapping of functional sites using haplotypes of multiple tightly linked single-nucleotide polymorphism markers. Genetics (2003) 0.97
Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peak. Genet Epidemiol (2006) 0.97
A non-parametric method for building predictive genetic tests on high-dimensional data. Hum Hered (2011) 0.96
A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer. Am J Epidemiol (2007) 0.96
Genetic markers of IgG influence the outcome of infection with hepatitis C virus. J Infect Dis (2008) 0.95
Genome scan for loci predisposing to anxiety disorders using a novel multivariate approach: strong evidence for a chromosome 4 risk locus. Am J Hum Genet (2006) 0.94
Genome-wide linkage scan for genes affecting longitudinal trends in systolic blood pressure. BMC Genet (2003) 0.93
Linkage analysis of plasma dopamine β-hydroxylase activity in families of patients with schizophrenia. Hum Genet (2011) 0.92
Capability of common SNPs to tag rare variants. BMC Proc (2011) 0.92
Using the optimal robust receiver operating characteristic (ROC) curve for predictive genetic tests. Biometrics (2009) 0.91
Comparison of microsatellites, single-nucleotide polymorphisms (SNPs) and composite markers derived from SNPs in linkage analysis. BMC Genet (2005) 0.91
Heritability and intrafamilial aggregation of arterial characteristics. J Hypertens (2008) 0.91
Examination of association with candidate genes for diabetic nephropathy in a Mexican American population. Clin J Am Soc Nephrol (2010) 0.91
Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility. PLoS One (2013) 0.91
A variance component based multi-marker association test using family and unrelated data. BMC Genet (2013) 0.90