Published in Hum Mol Genet on March 24, 2005
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet (2006) 13.16
Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet (2006) 7.90
A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet (2007) 4.46
A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet (2008) 3.25
Genome-wide and candidate gene association study of cigarette smoking behaviors. PLoS One (2009) 3.00
Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B Neuropsychiatr Genet (2009) 2.86
Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. Mol Psychiatry (2008) 2.49
Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Hum Mol Genet (2009) 2.35
Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. Hum Mol Genet (2008) 2.12
Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking. Addiction (2008) 1.91
A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. Biol Psychiatry (2008) 1.88
Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Biol Psychiatry (2011) 1.76
Association of CHRN genes with "dizziness" to tobacco. Am J Med Genet B Neuropsychiatr Genet (2010) 1.70
New insights into the genetics of addiction. Nat Rev Genet (2009) 1.70
Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. Am J Med Genet B Neuropsychiatr Genet (2009) 1.68
Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. Am J Med Genet B Neuropsychiatr Genet (2010) 1.48
ADHD and smoking: from genes to brain to behavior. Ann N Y Acad Sci (2008) 1.46
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Genes Brain Behav (2010) 1.35
Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. Genet Epidemiol (2012) 1.34
Significant association of DRD1 with nicotine dependence. Hum Genet (2007) 1.33
Genetics and smoking cessation improving outcomes in smokers at risk. Am J Prev Med (2007) 1.33
Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers. Hum Mol Genet (2008) 1.29
The genetic components of alcohol and nicotine co-addiction: from genes to behavior. Curr Drug Abuse Rev (2008) 1.25
Nicotinic acetylcholine receptor variation and response to smoking cessation therapies. Pharmacogenet Genomics (2013) 1.24
Bupropion efficacy for smoking cessation is influenced by the DRD2 Taq1A polymorphism: analysis of pooled data from two clinical trials. Nicotine Tob Res (2007) 1.21
Genetics of nicotine dependence and pharmacotherapy. Biochem Pharmacol (2007) 1.21
Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. Hum Genet (2011) 1.19
Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence. Neuropsychopharmacology (2010) 1.17
Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence. Neuropsychopharmacology (2010) 1.17
Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning. Neurobiol Learn Mem (2007) 1.16
Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research. Behav Brain Res (2008) 1.14
Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. Biol Psychiatry (2008) 1.13
Identification of pharmacogenetic markers in smoking cessation therapy. Am J Med Genet B Neuropsychiatr Genet (2008) 1.12
Genome-wide association analyses suggested a novel mechanism for smoking behavior regulated by IL15. Mol Psychiatry (2009) 1.09
Meta-analysis of 15 genome-wide linkage scans of smoking behavior. Biol Psychiatry (2010) 1.08
Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation. Neuropsychopharmacology (2009) 1.03
Association of candidate genes with antisocial drug dependence in adolescents. Drug Alcohol Depend (2008) 1.01
Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. Hum Genet (2006) 1.01
Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations. PLoS One (2009) 1.00
GENES AS INSTRUMENTS FOR STUDYING RISK BEHAVIOR EFFECTS: AN APPLICATION TO MATERNAL SMOKING AND OROFACIAL CLEFTS. Health Serv Outcomes Res Methodol (2011) 0.98
Association of CHRNA4 polymorphisms with smoking behavior in two populations. Am J Med Genet B Neuropsychiatr Genet (2011) 0.96
Genetic interaction between alpha4 and beta2 subunits of high affinity nicotinic receptor: analysis in schizophrenia. Exp Brain Res (2006) 0.96
Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patch. Cancer Epidemiol Biomarkers Prev (2009) 0.96
Genetics of smoking and depression. Hum Genet (2012) 0.95
A CHRNA5 allele related to nicotine addiction and schizophrenia. Genes Brain Behav (2011) 0.92
Evaluation of the brief wisconsin inventory of smoking dependence motives in african-american and European-american heavy smokers. Front Psychiatry (2012) 0.92
Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. Hum Genet (2012) 0.92
Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence. Transl Psychiatry (2015) 0.90
The Role of the Habenula in Nicotine Addiction. J Addict Res Ther (2011) 0.90
Multivariate dimensionality reduction approaches to identify gene-gene and gene-environment interactions underlying multiple complex traits. PLoS One (2014) 0.89
The necessity of α4* nicotinic receptors in nicotine-driven behaviors: dissociation between reinforcing and motor effects of nicotine. Neuropsychopharmacology (2011) 0.89
Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder. Genes Brain Behav (2007) 0.88
Smoking and body weight: evidence using genetic instruments. Econ Hum Biol (2011) 0.88
Neuroimaging, genetics and the treatment of nicotine addiction. Behav Brain Res (2008) 0.87
Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes. Pharmacogenomics J (2011) 0.87
No evidence for association between 19 cholinergic genes and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet (2007) 0.87
A unified GMDR method for detecting gene-gene interactions in family and unrelated samples with application to nicotine dependence. Hum Genet (2013) 0.86
Nominal association with CHRNA4 variants and nicotine dependence. Genes Brain Behav (2013) 0.86
Associations of nicotine intake measures with CHRN genes in Finnish smokers. Nicotine Tob Res (2011) 0.86
Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population. Nicotine Tob Res (2009) 0.85
Cognitive effects of nicotine: genetic moderators. Addict Biol (2010) 0.85
Genetics of drug dependence. Dialogues Clin Neurosci (2010) 0.85
Inhibition of the nicotinic acetylcholine receptors by cobra venom α-neurotoxins: is there a perspective in lung cancer treatment? PLoS One (2011) 0.85
A faster pedigree-based generalized multifactor dimensionality reduction method for detecting gene-gene interactions. Stat Interface (2011) 0.84
Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers. Drug Alcohol Depend (2013) 0.84
Breakout session: Gender and ethnic disparities in pain management. Clin Orthop Relat Res (2011) 0.84
Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. Genes Brain Behav (2015) 0.84
Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations. Hum Genet (2013) 0.83
The contribution of rare and common variants in 30 genes to risk nicotine dependence. Mol Psychiatry (2014) 0.82
Biomarkers of postoperative delirium and cognitive dysfunction. Front Aging Neurosci (2015) 0.82
Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (CHRNA4 and CHRNB2) with schizophrenia in the Japanese population. J Neural Transm (Vienna) (2008) 0.82
ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. PLoS One (2011) 0.80
Born to Lead? A Twin Design and Genetic Association Study of Leadership Role Occupancy. Leadersh Q (2012) 0.80
Joint associations of 61 genetic variants in the nicotinic acetylcholine receptor genes with subclinical atherosclerosis in American Indians: a gene-family analysis. Circ Cardiovasc Genet (2012) 0.80
Association of the CHRNA4 neuronal nicotinic receptor subunit gene with frequency of binge drinking in young adults. Alcohol Clin Exp Res (2014) 0.79
Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependence. Hum Genet (2013) 0.79
Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction. BMC Syst Biol (2015) 0.78
Nicotinic receptor contributions to smoking: insights from human studies and animal models. Curr Addict Rep (2015) 0.78
The nicotinic acetylcholine receptor alpha 4 subunit contains a functionally relevant SNP Haplotype. BMC Genet (2015) 0.77
Chromosome 20 shows linkage with DSM-IV nicotine dependence in Finnish adult smokers. Nicotine Tob Res (2011) 0.76
Assessing the impact of nicotine dependence genes on the risk of facial clefts: An example of the use of national registry and biobank data. Nor Epidemiol (2015) 0.76
Nicotinic acetylcholine receptor subunits α4 and α5 associated with smoking behaviour and lung cancer are regulated by upstream open reading frames. PLoS One (2013) 0.76
Association of Common Polymorphisms in the Nicotinic Acetylcholine Receptor Alpha4 Subunit Gene with an Electrophysiological Endophenotype in a Large Population-Based Sample. PLoS One (2016) 0.76
Genetic Association of CHRNB3 and CHRNA6 Gene Polymorphisms with Nicotine Dependence Syndrome Scale in Korean Population. Psychiatry Investig (2014) 0.76
The DYX2 locus and neurochemical signaling genes contribute to speech sound disorder and related neurocognitive domains. Genes Brain Behav (2015) 0.75
Ethnic-specific genetic association of variants in the corticotropin-releasing hormone receptor 1 gene with nicotine dependence. Biomed Res Int (2015) 0.75
CHRNA4 rs1044396 is associated with smoking cessation in varenicline therapy. Front Genet (2015) 0.75
Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence. Genes (Basel) (2016) 0.75
Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions. Mol Psychiatry (2016) 0.75
Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. Am J Med Genet B Neuropsychiatr Genet (2016) 0.75
CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation. Nicotine Tob Res (2016) 0.75
Clinical whole-exome sequencing for the diagnosis of mendelian disorders. N Engl J Med (2013) 15.85
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med (2006) 10.97
Optimal two-stage genotyping in population-based association studies. Genet Epidemiol (2003) 6.01
Oral topiramate for treatment of alcohol dependence: a randomised controlled trial. Lancet (2003) 4.79
A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet (2007) 4.46
A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. Addiction (2003) 4.37
Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet (2010) 3.91
Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci U S A (2010) 3.78
Improved power by use of a weighted score test for linkage disequilibrium mapping. Am J Hum Genet (2006) 3.36
Adding further power to the Haseman and Elston method for detecting linkage in larger sibships: weighting sums and differences. Hum Hered (2003) 3.33
Choosing an optimal method to combine P-values. Stat Med (2009) 3.15
The genetic basis of complex traits: rare variants or "common gene, common disease"? Methods Mol Biol (2007) 3.01
A unified association analysis approach for family and unrelated samples correcting for stratification. Am J Hum Genet (2008) 3.00
Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. Am J Hum Genet (2003) 2.92
Detecting rare variants for complex traits using family and unrelated data. Genet Epidemiol (2010) 2.80
Blood pressure and mortality in U.S. veterans with chronic kidney disease: a cohort study. Ann Intern Med (2013) 2.74
Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis. Am J Hum Genet (2004) 2.36
Linkage analysis of a complex disease through use of admixed populations. Am J Hum Genet (2004) 2.21
Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes. Am J Hum Genet (2008) 2.20
Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence. Am J Hum Genet (2005) 2.18
A powerful method of combining measures of association and Hardy-Weinberg disequilibrium for fine-mapping in case-control studies. Stat Med (2006) 2.18
Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions. Bioinformatics (2006) 2.08
Whole genome scan for obstructive sleep apnea and obesity in African-American families. Am J Respir Crit Care Med (2004) 2.03
Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. Proc Natl Acad Sci U S A (2004) 1.95
Comparative survival of dialysis patients in the United States after coronary angioplasty, coronary artery stenting, and coronary artery bypass surgery and impact of diabetes. Circulation (2002) 1.91
Outcomes associated with microalbuminuria: effect modification by chronic kidney disease. J Am Coll Cardiol (2013) 1.89
Preoperative statin administration is associated with lower mortality and decreased need for postoperative hemodialysis in patients undergoing coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth (2009) 1.88
The associations between race and geographic area and quality-of-care indicators in patients approaching ESRD. Clin J Am Soc Nephrol (2013) 1.87
The Family Investigation of Nephropathy and Diabetes (FIND): design and methods. J Diabetes Complications (2005) 1.87
Hyponatremia, hypernatremia, and mortality in patients with chronic kidney disease with and without congestive heart failure. Circulation (2012) 1.86
Self-reported race and genetic admixture. N Engl J Med (2006) 1.85
A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. Proc Natl Acad Sci U S A (2003) 1.84
The meaning of interaction. Hum Hered (2010) 1.83
EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet (2009) 1.82
A whole-genome scan for obstructive sleep apnea and obesity. Am J Hum Genet (2002) 1.81
Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND). Diabetes (2007) 1.79
Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking. Am J Psychiatry (2011) 1.69
Long-term survival of dialysis patients in the United States with prosthetic heart valves: should ACC/AHA practice guidelines on valve selection be modified? Circulation (2002) 1.63
Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND). Diabetes (2007) 1.61
Topiramate for the treatment of methamphetamine addiction: a multi-center placebo-controlled trial. Addiction (2012) 1.59
A survey of oral and maxillofacial surgeons' tobacco-use-related knowledge, attitudes and intervention behaviors. J Am Dent Assoc (2008) 1.58
A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies. Am J Hum Genet (2008) 1.57
Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers. Am J Med Genet B Neuropsychiatr Genet (2005) 1.55
Improving power in contrasting linkage-disequilibrium patterns between cases and controls. Am J Hum Genet (2007) 1.55
A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study. Am J Hum Genet (2003) 1.53
A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population. BMC Genet (2003) 1.50
Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. Am J Med Genet B Neuropsychiatr Genet (2010) 1.48
Log-linear model-based multifactor dimensionality reduction method to detect gene gene interactions. Bioinformatics (2007) 1.44
Genetics of the apnea hypopnea index in Caucasians and African Americans: I. Segregation analysis. Genet Epidemiol (2002) 1.44
Identification of viral infections in the prostate and evaluation of their association with cancer. BMC Cancer (2010) 1.44
Sampling correction in linkage analysis. Genet Epidemiol (2004) 1.43
Detecting rare and common variants for complex traits: sibpair and odds ratio weighted sum statistics (SPWSS, ORWSS). Genet Epidemiol (2011) 1.43
Genetic research and smoking behavior. JAMA (2007) 1.42
Genome scan of M. tuberculosis infection and disease in Ugandans. PLoS One (2008) 1.41
Plasma aldosterone is independently associated with the metabolic syndrome. Hypertension (2006) 1.40
The 5A's vs 3A's plus proactive quitline referral in private practice dental offices: preliminary results. Tob Control (2007) 1.40
Are linkage analysis and the collection of family data dead? Prospects for family studies in the age of genome-wide association. Hum Hered (2007) 1.39
Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients. Cancer Res (2009) 1.38
Differential allelic expression of dopamine D1 receptor gene (DRD1) is modulated by microRNA miR-504. Biol Psychiatry (2009) 1.37
Pleiotropic effects of a chromosome 3 locus on speech-sound disorder and reading. Am J Hum Genet (2004) 1.36
Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence. Hum Mol Genet (2005) 1.36
Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. Neuropsychopharmacology (2006) 1.36
Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. Genet Epidemiol (2012) 1.34
Significant association of DRD1 with nicotine dependence. Hum Genet (2007) 1.33
The relationship of age, race, and ethnicity with survival in dialysis patients. Clin J Am Soc Nephrol (2013) 1.32
Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample. Neuropsychopharmacology (2008) 1.31
A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African Americans. Am J Hum Genet (2006) 1.31