Cbl-b in T-cell activation.

PubWeight™: 0.88‹?›

🔗 View Article (PMID 20458601)

Published in Semin Immunopathol on February 21, 2010

Authors

Magdalena Paolino1, Josef M Penninger

Author Affiliations

1: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohrgasse 3, 1030, Vienna, Austria. magdalena.paolino@imba.oeaw.ac.at

Articles cited by this

(truncated to the top 100)

Mechanisms underlying ubiquitination. Annu Rev Biochem (2001) 18.87

The immunological synapse: a molecular machine controlling T cell activation. Science (1999) 17.41

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (1995) 16.19

Three-dimensional segregation of supramolecular activation clusters in T cells. Nature (1998) 14.14

Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol (2001) 8.68

Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science (2001) 8.31

T cell activation. Annu Rev Immunol (2009) 7.40

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature (1992) 7.15

T cell anergy. Annu Rev Immunol (2001) 7.15

T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity (2006) 6.93

NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol (2005) 6.25

T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science (1999) 6.24

Calcium signalling in lymphocyte activation and disease. Nat Rev Immunol (2007) 5.62

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J Cell Biol (2002) 4.89

Ubiquitin and ubiquitin-like proteins as multifunctional signals. Nat Rev Mol Cell Biol (2005) 4.88

Ubiquitylation in innate and adaptive immunity. Nature (2009) 4.60

Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins. Annu Rev Biochem (2001) 4.54

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature (1993) 4.26

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol (2004) 4.21

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat Immunol (2003) 4.17

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature (2000) 4.08

Transcriptional mechanisms underlying lymphocyte tolerance. Cell (2002) 4.04

Cbl-b regulates the CD28 dependence of T-cell activation. Nature (2000) 3.89

Partners in transcription: NFAT and AP-1. Oncogene (2001) 3.83

Egr-2 and Egr-3 are negative regulators of T cell activation. Nat Immunol (2005) 3.74

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. Nat Immunol (2000) 3.58

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J Immunol (1991) 3.47

Phosphorylation of the CARMA1 linker controls NF-kappaB activation. Immunity (2005) 3.36

Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. Genes Dev (1997) 3.29

The Cbl interactome and its functions. Nat Rev Mol Cell Biol (2005) 3.27

CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nat Rev Immunol (2004) 3.17

Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. Immunity (2007) 3.14

CD28-mediated co-stimulation: a quantitative support for TCR signalling. Nat Rev Immunol (2003) 3.12

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness. J Immunol (1987) 2.85

Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity (2004) 2.76

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation. Nat Immunol (2002) 2.64

Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling. Nature (1994) 2.63

Immunity by ubiquitylation: a reversible process of modification. Nat Rev Immunol (2005) 2.56

Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells. Nat Med (2008) 2.52

Calcium signaling in lymphocytes. Curr Opin Immunol (2008) 2.38

T cell antigen receptor signaling and immunological synapse stability require myosin IIA. Nat Immunol (2009) 2.17

Ubiquitin ligases and the immune response. Annu Rev Immunol (2004) 2.14

The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality. Immunity (2008) 2.13

Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nat Immunol (2001) 2.02

ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation. Nat Immunol (2004) 1.99

Tuning immune responses: diversity and adaptation of the immunological synapse. Nat Rev Immunol (2005) 1.98

E3 ubiquitin ligases as T cell anergy factors. Nat Immunol (2004) 1.96

T cell activation and the cytoskeleton. Annu Rev Immunol (2000) 1.94

TCR affinity and negative regulation limit autoimmunity. Nat Med (2004) 1.94

Regulation of TGF-beta family signaling by E3 ubiquitin ligases. Cancer Sci (2008) 1.79

Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat Genet (2002) 1.63

Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo. J Immunol (2006) 1.62

SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. J Immunol (2003) 1.58

Common themes in the assembly and architecture of activating immune receptors. Nat Rev Immunol (2007) 1.54

Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice. J Immunol (2004) 1.50

Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity (2000) 1.44

Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells. J Biol Chem (2000) 1.41

Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination. J Immunol (2002) 1.39

Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3. Eur J Immunol (2008) 1.35

Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene. Oncogene (1995) 1.35

Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses. Nat Immunol (2006) 1.34

Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1. Proc Natl Acad Sci U S A (2009) 1.34

Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice. Diabetes (2007) 1.33

SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms. Immunity (2006) 1.33

T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Mol Cell Biol (2008) 1.30

Ablation of Cbl-b provides protection against transplanted and spontaneous tumors. J Clin Invest (2007) 1.29

Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells. J Exp Med (2007) 1.28

The molecular signature of CD8+ T cells undergoing deletional tolerance. Blood (2009) 1.27

Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance. J Exp Med (2009) 1.24

Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol (2008) 1.23

E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury. Nat Med (2007) 1.22

Protein kinase B (Akt) regulation and function in T lymphocytes. Semin Immunol (2002) 1.21

CARMA1 is required for Akt-mediated NF-kappaB activation in T cells. Mol Cell Biol (2006) 1.21

Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B. J Immunol (2007) 1.16

Dok-1 and Dok-2 are negative regulators of T cell receptor signaling. Int Immunol (2007) 1.14

Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. J Immunol (2004) 1.13

cbl-3: a new mammalian cbl family protein. Oncogene (1999) 1.13

PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. Sci Signal (2009) 1.12

Beyond the RING: CBL proteins as multivalent adapters. Oncogene (2001) 1.11

Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins. Blood (2008) 1.10

Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity (2007) 1.06

Comparative genomic organization of the cbl genes. Gene (2003) 1.05

Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells. Eur J Immunol (2004) 1.04

The yins of T cell activation. Sci STKE (2005) 1.03

Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. Oncogene (1999) 1.02

From T-cell activation signals to signaling control of anti-cancer immunity. Immunol Rev (2007) 0.98

Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b. Blood (2003) 0.97

The sound of silence: modulating anergy in T lymphocytes. Curr Opin Immunol (2007) 0.96

Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b. J Immunol (2005) 0.96

Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b. J Biol Chem (2003) 0.96

Cbl-b regulates antigen-induced TCR down-regulation and IFN-gamma production by effector CD8 T cells without affecting functional avidity. J Immunol (2007) 0.95

Cbl-3-deficient mice exhibit normal epithelial development. Mol Cell Biol (2003) 0.95

Cutting edge: requirement for TRAF6 in the induction of T cell anergy. J Immunol (2008) 0.95

Evidence for repression of IL-2 gene activation in anergic T cells. J Immunol (1999) 0.95

Molecular controls of antigen receptor clustering and autoimmunity. Trends Cell Biol (2001) 0.94

Control of virus-specific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection. J Virol (2008) 0.91

Molecular cloning and characterization of a novel cbl-family gene, cbl-c. Gene (1999) 0.90

The ubiquitin E3 ligase Cbl-b in T cells tolerance and tumor immunity. Cell Cycle (2007) 0.84

E3 ubiquitin ligases in T-cell tolerance. Eur J Immunol (2009) 0.84

Molecular motors involved in T cell receptor clusterings. J Leukoc Biol (2001) 0.82

Articles by these authors

(truncated to the top 100)

Cerebral organoids model human brain development and microcephaly. Nature (2013) 9.07

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37

Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med (2011) 5.66

Regulation of cancer cell migration and bone metastasis by RANKL. Nature (2006) 5.27

Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature (2002) 5.02

Mitogen-activated protein kinases in apoptosis regulation. Oncogene (2004) 4.76

An immunosurveillance mechanism controls cancer cell ploidy. Science (2012) 4.35

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35

The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol (2007) 4.12

Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature (2006) 4.09

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature (2010) 4.01

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell (2007) 3.82

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature (2002) 3.74

RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med (2005) 3.68

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity (2003) 3.36

RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol (2001) 3.27

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med (2005) 3.26

The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell (2013) 3.19

AIF deficiency compromises oxidative phosphorylation. EMBO J (2004) 3.19

Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19

Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature (2005) 3.09

Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med (2006) 3.09

Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat Med (2013) 2.93

RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med (2007) 2.91

Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell (2010) 2.91

The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol (2004) 2.90

The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity (2008) 2.81

Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity (2004) 2.76

Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell (2011) 2.69

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest (2003) 2.68

The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity (2003) 2.67

The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity (2008) 2.57

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature (2012) 2.53

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet (2011) 2.47

Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science (2009) 2.47

T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med (2006) 2.38

A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell (2010) 2.37

A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell (2010) 2.27

Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging. Stroke (2012) 2.18

RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci (2008) 2.10

Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nat Med (2003) 2.04

Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease. Kidney Int (2008) 1.99

Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium. Immunity (2012) 1.94

TCR affinity and negative regulation limit autoimmunity. Nat Med (2004) 1.94

Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron (2004) 1.89

Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology (2009) 1.83

Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med (2011) 1.79

Cardiac regulation by phosphoinositide 3-kinases and PTEN. Cardiovasc Res (2009) 1.78

Human recombinant ACE2 reduces the progression of diabetic nephropathy. Diabetes (2009) 1.78

Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity (2002) 1.77

Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation (2010) 1.77

High precision quantitative proteomics using iTRAQ on an LTQ Orbitrap: a new mass spectrometric method combining the benefits of all. J Proteome Res (2009) 1.75

Lineage-committed osteoclast precursors circulate in blood and settle down into bone. J Bone Miner Res (2011) 1.74

Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res (2007) 1.74

Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling. Circ Res (2006) 1.71

AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Oncogene (2004) 1.68

Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2. Mol Cell Biol (2006) 1.67

PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas. Nat Med (2012) 1.67

Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell (2012) 1.65

Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells. Circ Res (2008) 1.65

DREAM is a critical transcriptional repressor for pain modulation. Cell (2002) 1.63

Complete cardiac regeneration in a mouse model of myocardial infarction. Aging (Albany NY) (2012) 1.60

Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. EMBO J (2006) 1.59

Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol Cell Biol (2005) 1.58

The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med (2007) 1.55

Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. Am J Pathol (2007) 1.55

Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways. Regul Pept (2013) 1.54

Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension. Hypertension (2009) 1.52

Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway. J Biochem (2008) 1.52

MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol (2004) 1.51

Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis. Science (2003) 1.51

Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis. J Exp Med (2003) 1.46

Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease. J Mol Med (Berl) (2014) 1.45

Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2. Hypertension (2010) 1.45

Central control of fever and female body temperature by RANKL/RANK. Nature (2009) 1.42

Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. J Exp Med (2003) 1.42

Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. J Biol Chem (2011) 1.42

CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature (2013) 1.41

Mitochondria, AIF and caspases--rivaling for cell death execution. Nat Cell Biol (2003) 1.40

Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res (2007) 1.40

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat Med (2005) 1.39

Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation (2003) 1.36

Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol (2005) 1.36

Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. Am J Pathol (2006) 1.35

The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J Exp Med (2004) 1.35

RANKL/RANK-beyond bones. J Mol Med (Berl) (2011) 1.34

Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo. Blood (2007) 1.33

Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. Am J Physiol Heart Circ Physiol (2008) 1.32

AIF: not just an apoptosis-inducing factor. Ann N Y Acad Sci (2009) 1.31

p110gamma and p110delta phosphoinositide 3-kinase signaling pathways synergize to control development and functions of murine NK cells. Immunity (2007) 1.30

T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Mol Cell Biol (2008) 1.30

Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ Heart Fail (2009) 1.29

Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells. J Exp Med (2007) 1.28

CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med (2012) 1.28

Essential role for collectrin in renal amino acid transport. Nature (2006) 1.26

Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal. Proc Natl Acad Sci U S A (2006) 1.24

Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9. J Immunol (2008) 1.23

Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med (2005) 1.22

The role of ACE2 in cardiovascular physiology. Trends Cardiovasc Med (2003) 1.21

Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions. J Immunol (2011) 1.18