Published in Nat Immunol on June 10, 2002
The genomic landscape of histone modifications in human T cells. Proc Natl Acad Sci U S A (2006) 6.09
Epigenetic control of T-helper-cell differentiation. Nat Rev Immunol (2009) 5.72
MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94
Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med (2003) 4.68
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity (2010) 4.52
Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma. Nat Immunol (2007) 3.72
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci U S A (2007) 3.32
Interleukin 2 plays a central role in Th2 differentiation. Proc Natl Acad Sci U S A (2004) 2.98
Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J Clin Immunol (2003) 2.93
Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity (2007) 2.88
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Metabolic checkpoints in activated T cells. Nat Immunol (2012) 2.47
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Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo. J Exp Med (2003) 2.27
Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development. EMBO J (2006) 2.21
Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells. Proc Natl Acad Sci U S A (2004) 2.21
Genetics and epigenetics of rheumatoid arthritis. Nat Rev Rheumatol (2013) 2.20
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Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity (2008) 2.04
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Histone hyperacetylated domains across the Ifng gene region in natural killer cells and T cells. Proc Natl Acad Sci U S A (2005) 1.73
The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. Nat Immunol (2010) 1.72
T-bet: a bridge between innate and adaptive immunity. Nat Rev Immunol (2013) 1.70
Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates. Immunity (2011) 1.65
IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. J Exp Med (2005) 1.64
Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. Immunity (2008) 1.62
An epigenetic silencing pathway controlling T helper 2 cell lineage commitment. Nature (2012) 1.60
Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription. J Immunol (2006) 1.55
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Programming CD8+ T cells for effective immunotherapy. Curr Opin Immunol (2006) 1.51
IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines. J Immunol (2009) 1.51
A default pathway of memory CD8 T cell differentiation after dendritic cell immunization is deflected by encounter with inflammatory cytokines during antigen-driven proliferation. J Immunol (2009) 1.50
GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. EMBO J (2004) 1.50
Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. J Clin Invest (2006) 1.49
Constitutive NF-kappaB and NFAT activation in aggressive B-cell lymphomas synergistically activates the CD154 gene and maintains lymphoma cell survival. Blood (2005) 1.49
T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent. J Exp Med (2006) 1.49
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc Natl Acad Sci U S A (2005) 1.45
Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells. Blood (2007) 1.43
Murine neonatal CD4+ cells are poised for rapid Th2 effector-like function. J Immunol (2007) 1.41
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Lung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction. Respir Res (2006) 1.39
Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. J Immunol (2010) 1.39
Epigenetic regulation of immune cell functions during post-septic immunosuppression. Epigenetics (2011) 1.38
Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12Rbeta2 expression during human Th1 cell differentiation. EMBO J (2007) 1.36
Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. Nat Rev Immunol (2012) 1.36
Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development. Proc Natl Acad Sci U S A (2004) 1.36
Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3. Proc Natl Acad Sci U S A (2004) 1.34
Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation. EMBO J (2007) 1.34
Genome wide transcriptional analysis of resting and IL2 activated human natural killer cells: gene expression signatures indicative of novel molecular signaling pathways. BMC Genomics (2007) 1.30
T-cell memory differentiation: insights from transcriptional signatures and epigenetics. Immunology (2013) 1.29
BRG1-mediated chromatin remodeling regulates differentiation and gene expression of T helper cells. Mol Cell Biol (2008) 1.28
T-bet's ability to regulate individual target genes requires the conserved T-box domain to recruit histone methyltransferase activity and a separate family member-specific transactivation domain. Mol Cell Biol (2007) 1.28
Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance. J Exp Med (2009) 1.24
Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation. Proc Natl Acad Sci U S A (2004) 1.23
T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site. Proc Natl Acad Sci U S A (2005) 1.22
Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein. Gastroenterology (2007) 1.21
PU.1 regulates TCR expression by modulating GATA-3 activity. J Immunol (2009) 1.20
Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE. J Clin Invest (2006) 1.19
Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression. Mol Syst Biol (2010) 1.19
Beyond genetics: epigenetic code in chronic kidney disease. Kidney Int (2010) 1.18
Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation. J Exp Med (2008) 1.18
Dynamic BRG1 recruitment during T helper differentiation and activation reveals distal regulatory elements. Mol Cell Biol (2011) 1.17
Thymic selection pathway regulates the effector function of CD4 T cells. J Exp Med (2007) 1.15
Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease. Nat Rev Immunol (2016) 1.15
Histone/protein deacetylases and T-cell immune responses. Blood (2012) 1.14
Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA. J Mol Biol (2008) 1.14
MicroRNA-221-222 regulate the cell cycle in mast cells. J Immunol (2009) 1.14
Cutting edge: Ikaros is a regulator of Th2 cell differentiation. J Immunol (2009) 1.12
Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy. J Autoimmun (2010) 1.10
Epigenomics of T cell activation, differentiation, and memory. Curr Opin Immunol (2010) 1.10
Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation. Proc Natl Acad Sci U S A (2004) 1.10
Application of ChIP-Seq and related techniques to the study of immune function. Immunity (2011) 1.09
Biochemical signaling pathways for memory T cell recall. Semin Immunol (2009) 1.07
Molecular mechanisms by which T-bet regulates T-helper cell commitment. Immunol Rev (2010) 1.07
Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice. Blood (2005) 1.01
Transcriptional regulation of T cell tolerance. Semin Immunol (2007) 1.00
Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma. Proc Natl Acad Sci U S A (2010) 1.00
Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population. PLoS One (2011) 1.00
CREB, ATF, and AP-1 transcription factors regulate IFN-gamma secretion by human T cells in response to mycobacterial antigen. J Immunol (2008) 0.99
Genetic and epigenetic networks controlling T helper 1 cell differentiation. Immunology (2009) 0.98
T cell directives for transcriptional regulation in asthma. Springer Semin Immunopathol (2003) 0.98
GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells. Blood (2007) 0.98
Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice. J Biol Chem (2008) 0.97
Impaired CD4+ T-cell proliferation and effector function correlates with repressive histone methylation events in a mouse model of severe sepsis. Eur J Immunol (2010) 0.96
Impaired proteasome function activates GATA3 in T cells and upregulates CTLA-4: relevance for Sézary syndrome. J Invest Dermatol (2012) 0.96
Effector CD4 cell tolerization is mediated through functional inactivation and involves preferential impairment of TNF-alpha and IFN-gamma expression potentials. Cell Immunol (2003) 0.95
Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation. Adv Immunol (2013) 0.94
Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization. J Immunol (2010) 0.94
IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18. Proc Natl Acad Sci U S A (2010) 0.93
Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation. J Immunol (2008) 0.93
Lck mediates Th2 differentiation through effects on T-bet and GATA-3. J Immunol (2010) 0.92
CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements. J Immunol (2009) 0.92
T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production. Cytokine (2015) 0.92
NF45 and NF90 regulate HS4-dependent interleukin-13 transcription in T cells. J Biol Chem (2010) 0.91
Recruitment of histone deacetylase 4 by transcription factors represses interleukin-5 transcription. Biochem J (2006) 0.91
Calcium-dependent transcription of cytokine genes in T lymphocytes. Pflugers Arch (2007) 0.91
Control of IL-4 expression in T helper 1 and 2 cells. Immunology (2008) 0.90
Cytotoxic T-lymphocyte antigen-4 inhibits GATA-3 but not T-bet mRNA expression during T helper cell differentiation. Immunology (2006) 0.89
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 19.08
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature (2006) 14.78
Regulation of the germinal center response by microRNA-155. Science (2007) 12.25
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol (2003) 11.17
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature (2010) 8.87
Orai1 is an essential pore subunit of the CRAC channel. Nature (2006) 8.60
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43
Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell (2007) 8.42
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One (2010) 8.10
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature (2011) 7.43
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol (2003) 7.06
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity (2004) 6.72
Aberrant T cell differentiation in the absence of Dicer. J Exp Med (2005) 6.58
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity (2004) 6.43
Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol (2001) 6.30
Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol (2006) 6.10
Regulation of hepatic lipogenesis by the transcription factor XBP1. Science (2008) 6.02
Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med (2004) 5.13
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol (2010) 5.11
MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94
Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol (2006) 4.81
Homeostasis and inflammation in the intestine. Cell (2010) 4.60
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol (2010) 4.56
Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe (2010) 4.54
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity (2010) 4.52
Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci U S A (2003) 4.47
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science (2006) 4.46
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol (2004) 4.21
Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle (2009) 4.14
The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol (2008) 4.09
Transcriptional mechanisms underlying lymphocyte tolerance. Cell (2002) 4.04
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol (2008) 3.98
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J (2005) 3.92
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science (2002) 3.91
An epigenetic view of helper T cell differentiation. Nat Immunol (2003) 3.87
Biochemical and functional characterization of Orai proteins. J Biol Chem (2007) 3.87
NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol (2006) 3.70
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science (2005) 3.65
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature (2006) 3.61
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature (2007) 3.55
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science (2009) 3.47
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res (2004) 3.24
Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci U S A (2003) 3.23
The role of Th1/Th2 polarization in mucosal immunity. Nat Med (2002) 3.19
Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol (2006) 3.19
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat Rev Mol Cell Biol (2013) 3.18
Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. Science (2008) 3.17
Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med (2002) 3.16
Critical roles for transcription factor GATA-3 in thymocyte development. Immunity (2003) 3.15
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A (2011) 3.07
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell (2009) 3.07
The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol (2002) 3.05
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev (2009) 3.03
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. J Exp Med (2009) 3.01
T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood (2005) 2.95
NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol (2010) 2.77
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature (2013) 2.76
STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity. N Engl J Med (2009) 2.72
Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science (2006) 2.70
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat Immunol (2010) 2.68
T-bet regulates IgG class switching and pathogenic autoantibody production. Proc Natl Acad Sci U S A (2002) 2.63
A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison. J Biol Chem (2003) 2.59
The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol Rev (2011) 2.50
Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol (2008) 2.50
Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity (2002) 2.47
Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. Mol Cell (2009) 2.47
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood (2011) 2.47
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol (2004) 2.38
Calcium signaling in lymphocytes. Curr Opin Immunol (2008) 2.38
T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci U S A (2003) 2.34
Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest (2004) 2.31
An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry. Nature (2013) 2.31
NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest (2008) 2.29
A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med (2008) 2.26
Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium (2007) 2.23
Chaperone-mediated autophagy is required for tumor growth. Sci Transl Med (2011) 2.21
Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes. Mol Cell (2004) 2.20
A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients. J Exp Med (2005) 2.20
The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response. Immunol Rev (2003) 2.20
STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nat Struct Mol Biol (2009) 2.15
The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J Exp Med (2007) 2.12
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci U S A (2004) 2.12
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev (2012) 2.10
Signaling pathways in Th2 development. Immunol Rev (2004) 2.10
Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proc Natl Acad Sci U S A (2010) 2.10
T-bet in disease. Nat Immunol (2011) 2.09
ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia. J Allergy Clin Immunol (2009) 2.09
Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J (2007) 2.07