PubRank

Dafna Bar-Sagi

Author PubWeight™ 118.28‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer 2011 6.45
2 Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature 2013 4.71
3 Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nat Genet 2006 4.68
4 Redox-dependent downregulation of Rho by Rac. Nat Cell Biol 2003 4.46
5 Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell 2004 4.23
6 Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell 2012 4.16
7 Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nat Cell Biol 2007 3.68
8 Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell 2003 3.66
9 Modulation of signalling by Sprouty: a developing story. Nat Rev Mol Cell Biol 2004 3.46
10 The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol 2002 3.08
11 Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol 2002 3.00
12 Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol 2008 2.82
13 Regulating the regulator: post-translational modification of RAS. Nat Rev Mol Cell Biol 2011 2.81
14 In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. J Clin Invest 2009 2.53
15 Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature 2007 2.43
16 Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell 2004 2.38
17 Role of boundary conditions in an experimental model of epithelial wound healing. Am J Physiol Cell Physiol 2006 2.01
18 An orthosteric inhibitor of the Ras-Sos interaction. Nat Chem Biol 2011 1.91
19 MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med 2012 1.82
20 Differential modification of Ras proteins by ubiquitination. Mol Cell 2006 1.80
21 Regulation of ras signaling dynamics by Sos-mediated positive feedback. Curr Biol 2006 1.70
22 Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell 2010 1.58
23 A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci U S A 2006 1.57
24 hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl. Curr Biol 2003 1.52
25 Ras/MAPK signaling from endomembranes. Mol Oncol 2009 1.51
26 A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology 2006 1.48
27 Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes Dev 2003 1.48
28 Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin Cancer Res 2008 1.43
29 The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proc Natl Acad Sci U S A 2008 1.42
30 Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor. J Leukoc Biol 2009 1.37
31 Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene. Radiat Res 2003 1.35
32 The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins. Proc Natl Acad Sci U S A 2002 1.33
33 The structural basis for the transition from Ras-GTP to Ras-GDP. Proc Natl Acad Sci U S A 2002 1.32
34 Design, synthesis, and biological evaluation of new-generation taxoids. J Med Chem 2008 1.29
35 Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination. Curr Biol 2010 1.27
36 Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis. Nat Commun 2012 1.26
37 Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells. Cancer Res 2004 1.23
38 The two hats of SOS. Sci STKE 2002 1.22
39 Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc Natl Acad Sci U S A 2010 1.22
40 VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression. Cancer Res 2012 1.21
41 Structure of the G60A mutant of Ras: implications for the dominant negative effect. J Biol Chem 2005 1.21
42 Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless. Proc Natl Acad Sci U S A 2005 1.20
43 Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems. Methods Enzymol 2006 1.19
44 Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between. Cell Res 2005 1.13
45 Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless. Structure 2003 1.12
46 Spatial regulation of EGFR signaling by Sprouty2. Curr Biol 2007 1.09
47 EZH2 couples pancreatic regeneration to neoplastic progression. Genes Dev 2012 1.07
48 Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy. Biol Blood Marrow Transplant 2002 1.05
49 Regulation of sprouty stability by Mnk1-dependent phosphorylation. Mol Cell Biol 2006 1.03
50 Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. Blood 2009 1.03
51 Fibronectin growth factor-binding domains are required for fibroblast survival. J Invest Dermatol 2010 1.02
52 Regulation of RAS oncogenicity by acetylation. Proc Natl Acad Sci U S A 2012 1.02
53 Allosteric gating of Son of sevenless activity by the histone domain. Proc Natl Acad Sci U S A 2010 0.98
54 The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation. Mol Cell Biol 2002 0.98
55 Ras and Rac as activators of reactive oxygen species (ROS). Methods Mol Biol 2002 0.98
56 Signaling endosomes: seeing is believing. Curr Opin Cell Biol 2010 0.95
57 Characterization of a Ras mutant with identical GDP- and GTP-bound structures . Biochemistry 2009 0.89
58 Spry2 expression correlates with BRAF mutation in thyroid cancer. Surgery 2010 0.88
59 Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. J Clin Invest 2013 0.88
60 Autoinhibition of Sos by intramolecular interactions. Front Biosci 2002 0.84
61 Ras oncogene and inflammation: partners in crime. Cell Cycle 2005 0.83
62 Microdissection and culture of murine pancreatic ductal epithelial cells. Methods Mol Biol 2013 0.81
63 Analysis of Ras:RasGEF interactions by phage display and static multi-angle light scattering. Methods 2005 0.81
64 Clinical and therapeutic implications of Sprouty2 feedback dysregulation in BRAF V600E-mutation-positive papillary thyroid cancer. Surgery 2013 0.79
65 Perturbation of cytoskeleton dynamics by the opposing effects of Rac1 and Rac1b. Small GTPases 2010 0.79
66 Raf-1 and squamous cell carcinoma: Rok-ing the boat. Cancer Cell 2009 0.78
67 Mapping cellular routes of Ras: a ubiquitin trail. Cell Cycle 2006 0.77
68 Escorting Ras. Small GTPases 2012 0.76
69 Biochemical and biophysical analyses of Ras modification by ubiquitin. Methods Enzymol 2008 0.75