Published in Proc Natl Acad Sci U S A on May 26, 2006
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers. Nature (2008) 5.98
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol (2010) 5.35
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol Med (2009) 4.68
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell (2011) 4.41
BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat Rev Cancer (2011) 3.85
Purified human BRCA2 stimulates RAD51-mediated recombination. Nature (2010) 3.45
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell (2012) 3.26
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51. Cell (2009) 2.49
Homologous recombination and its regulation. Nucleic Acids Res (2012) 2.44
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. Nat Struct Mol Biol (2010) 2.37
Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. Nat Struct Mol Biol (2010) 2.07
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins. Cold Spring Harb Perspect Biol (2015) 1.73
Unraveling the mechanism of BRCA2 in homologous recombination. Nat Struct Mol Biol (2011) 1.59
The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry. Curr Biol (2009) 1.51
Structural basis for recruitment of BRCA2 by PALB2. EMBO Rep (2009) 1.50
Replication stress and cancer. Nat Rev Cancer (2015) 1.43
The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange. Proc Natl Acad Sci U S A (2009) 1.30
Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians. Crit Rev Biochem Mol Biol (2010) 1.30
Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication. Nat Struct Mol Biol (2011) 1.29
Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms. Proc Natl Acad Sci U S A (2011) 1.28
Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity. Cancer Res (2013) 1.22
BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage. Nucleic Acids Res (2007) 1.18
Trypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombination. Mol Microbiol (2008) 1.15
Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint. PLoS Genet (2008) 1.13
Dss1 interaction with Brh2 as a regulatory mechanism for recombinational repair. Mol Cell Biol (2007) 1.11
A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization. Nat Struct Mol Biol (2013) 1.04
Modification of the DNA damage response by therapeutic CDK4/6 inhibition. J Biol Chem (2012) 1.03
Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor. Nat Struct Mol Biol (2014) 1.03
Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains. PLoS Genet (2011) 1.02
DNA-binding Domain within the Brh2 N Terminus Is the Primary Interaction Site for Association with DNA. J Biol Chem (2009) 0.98
Presynaptic filament dynamics in homologous recombination and DNA repair. Crit Rev Biochem Mol Biol (2011) 0.93
BRCA2: Shining light on the regulation of DNA-binding selectivity by RAD51. Cell Cycle (2009) 0.90
Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity. PLoS Comput Biol (2011) 0.88
Functional redundancy of exon 12 of BRCA2 revealed by a comprehensive analysis of the c.6853A>G (p.I2285V) variant. Hum Mutat (2009) 0.86
BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells. J Cell Biol (2014) 0.85
Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics. Nucleic Acids Res (2012) 0.81
BRCA2: one small step for DNA repair, one giant protein purified. Yale J Biol Med (2013) 0.79
Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity. Oncotarget (2015) 0.79
Functions of alternative replication protein A in initiation and elongation. Biochemistry (2010) 0.77
Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity. Nucleic Acids Res (2016) 0.77
Roles of C-Terminal Region of Yeast and Human Rad52 in Rad51-Nucleoprotein Filament Formation and ssDNA Annealing. PLoS One (2016) 0.76
Current status of and perspectives regarding neoadjuvant chemoradiotherapy for locally advanced esophageal squamous cell carcinoma. Surg Today (2015) 0.75
A second DNA binding site in human BRCA2 promotes homologous recombination. Nat Commun (2016) 0.75
Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev (2017) 0.75
Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells. J Clin Invest (2017) 0.75
Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol Mol Biol Rev (1999) 19.25
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu Rev Biochem (1997) 9.83
Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell (2002) 9.61
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev (1999) 9.50
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature (1997) 8.04
BRCA2 is required for homology-directed repair of chromosomal breaks. Mol Cell (2001) 6.75
Recombinant replication protein A: expression, complex formation, and functional characterization. J Biol Chem (1994) 6.41
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science (2002) 6.32
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev (2001) 5.60
Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. Mol Cell (2001) 5.59
Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations. Genes Dev (1998) 4.68
Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes. Proc Natl Acad Sci U S A (1995) 4.60
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. Nature (2002) 4.22
BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo. Cancer Res (1999) 4.16
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction. Nature (2005) 4.08
Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol Cell Biol (2004) 3.96
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci U S A (2005) 3.93
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature (2005) 3.90
Rad51 recombinase and recombination mediators. J Biol Chem (2003) 3.86
Breast and ovarian cancer. N Engl J Med (2003) 3.84
RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2. J Biol Chem (1997) 3.26
Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences. EMBO J (2001) 3.21
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc Natl Acad Sci U S A (1998) 2.85
Homologous repair of DNA damage and tumorigenesis: the BRCA connection. Oncogene (2002) 2.73
From RPA to BRCA2: lessons from single-stranded DNA binding by the OB-fold. Curr Opin Struct Biol (2004) 2.48
Structure of the single-strand annealing domain of human RAD52 protein. Proc Natl Acad Sci U S A (2002) 2.24
Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Mol Cell Biol (2002) 2.14
Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide. J Biol Chem (2006) 2.01
Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form. Mol Cell (2002) 1.98
ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair. J Biol Chem (2002) 1.97
BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis. Mol Cell (2002) 1.96
Biallelic BRCA2 mutations are associated with multiple malignancies in childhood including familial Wilms tumour. J Med Genet (2005) 1.94
RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair. Mol Cell Biol (2005) 1.74
BRCA2 BRC motifs bind RAD51-DNA filaments. Proc Natl Acad Sci U S A (2005) 1.68
Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemia. Blood (2004) 1.67
Brca2 is involved in meiosis in Arabidopsis thaliana as suggested by its interaction with Dmc1. EMBO J (2004) 1.56
BRCA2 deficiency in mice leads to meiotic impairment and infertility. Development (2003) 1.55
Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations. Proc Natl Acad Sci U S A (1999) 1.54
The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans. Oncogene (2002) 1.46
Shared genetic susceptibility to breast cancer, brain tumors, and Fanconi anemia. J Natl Cancer Inst (2003) 1.42
Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2. Mol Cell (2003) 1.33
Replication protein A interactions with DNA: differential binding of the core domains and analysis of the DNA interaction surface. Biochemistry (2003) 1.28
Brh2-Dss1 interplay enables properly controlled recombination in Ustilago maydis. Mol Cell Biol (2005) 1.22
Structural analysis of the chicken BRCA2 gene facilitates identification of functional domains and disease causing mutations. Hum Mol Genet (2002) 0.99
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell (2010) 8.70
Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell (2006) 7.33
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol (2010) 5.35
The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J. Nat Genet (2005) 4.92
Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair. PLoS Genet (2008) 4.71
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell (2011) 4.41
Positional stability of single double-strand breaks in mammalian cells. Nat Cell Biol (2007) 4.35
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev (2007) 4.16
Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol Cell Biol (2004) 3.96
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci U S A (2005) 3.93
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature (2005) 3.90
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell (2012) 3.26
A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation. Cell (2011) 3.08
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol (2008) 3.07
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med (2002) 2.86
Chromosomal translocations induced at specified loci in human stem cells. Proc Natl Acad Sci U S A (2009) 2.73
Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation. Nat Struct Mol Biol (2010) 2.65
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet (2012) 2.63
Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells. Eur J Immunol (2002) 2.57
Distinct properties of the XY pseudoautosomal region crucial for male meiosis. Science (2011) 2.43
DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation. PLoS Genet (2011) 2.22
Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase. Methods Enzymol (2006) 2.21
BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science (2011) 2.17
Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. PLoS Genet (2009) 2.15
Androgen receptor signaling regulates DNA repair in prostate cancers. Cancer Discov (2013) 2.15
Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Mol Cell Biol (2002) 2.14
Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage. Mol Cell Biol (2005) 2.13
Collaboration and competition between DNA double-strand break repair pathways. FEBS Lett (2010) 2.11
Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70. Nat Cell Biol (2007) 2.10
Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J (2006) 2.09
The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage. J Cell Biol (2010) 2.06
Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science (2004) 2.03
Modeling oncogenic translocations: distinct roles for double-strand break repair pathways in translocation formation in mammalian cells. DNA Repair (Amst) (2006) 2.03
Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Proc Natl Acad Sci U S A (2005) 2.03
Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Res (2005) 2.02
ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair. J Biol Chem (2002) 1.97
E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks. Proc Natl Acad Sci U S A (2008) 1.97
Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability. Oncogene (2004) 1.95
An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway. Nat Struct Mol Biol (2010) 1.92
Chromosomal translocation mechanisms at intronic alu elements in mammalian cells. Mol Cell (2005) 1.84
A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining. J Clin Invest (2008) 1.82
Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair. Nature (2011) 1.80
Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks. Oncogene (2004) 1.79
A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair. Blood (2005) 1.78
Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes Dev (2004) 1.77
Homeostatic control of recombination is implemented progressively in mouse meiosis. Nat Cell Biol (2012) 1.73
An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. Nucleic Acids Res (2002) 1.70
Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J (2003) 1.68
ATM controls meiotic double-strand-break formation. Nature (2011) 1.68
The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis. Dev Biol (2011) 1.67
Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice. Physiol Genomics (2003) 1.65
Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks. Mol Cell Biol (2003) 1.65
ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes. PLoS Genet (2008) 1.61
A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation. J Clin Invest (2005) 1.59
I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks. Methods Mol Biol (2012) 1.59
Mouse TRIP13/PCH2 is required for recombination and normal higher-order chromosome structure during meiosis. PLoS Genet (2010) 1.54
The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection. Nature (2012) 1.53
Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Nucleic Acids Res (2002) 1.52
Cancer translocations in human cells induced by zinc finger and TALE nucleases. Genome Res (2013) 1.44
Numerical constraints and feedback control of double-strand breaks in mouse meiosis. Genes Dev (2013) 1.43
Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1. Nat Cell Biol (2011) 1.40
Measuring recombination proficiency in mouse embryonic stem cells. Methods Mol Biol (2005) 1.39
Limiting the persistence of a chromosome break diminishes its mutagenic potential. PLoS Genet (2009) 1.38
DNA double-strand breaks and gamma-H2AX signaling in the testis. Biol Reprod (2003) 1.36
RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res (2012) 1.36
BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks. Mol Cell Biol (2003) 1.34
Evolutionary conservation of meiotic DSB proteins: more than just Spo11. Genes Dev (2010) 1.33
Homologous recombination deficiency leads to profound genetic instability in cells derived from Xrcc2-knockout mice. Cancer Res (2003) 1.32
Alternative pathways for the repair of RAG-induced DNA breaks. Mol Cell Biol (2006) 1.32
Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. J Biol Chem (2005) 1.31
Artesunate derived from traditional Chinese medicine induces DNA damage and repair. Cancer Res (2008) 1.31
Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice. Hum Mol Genet (2002) 1.29
Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication. Nat Struct Mol Biol (2011) 1.29
Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase. Proc Natl Acad Sci U S A (2013) 1.27
A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure. EMBO J (2012) 1.24
Selective targeting of homologous DNA recombination repair by gemcitabine. Int J Radiat Oncol Biol Phys (2003) 1.23
Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow. Blood (2002) 1.23
Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context. J Biol Chem (2011) 1.23
Comprehensive, fine-scale dissection of homologous recombination outcomes at a hot spot in mouse meiosis. Mol Cell (2010) 1.21
The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells. Carcinogenesis (2005) 1.21
Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity. J Biol Chem (2010) 1.19
DNA damage responses by human ELG1 in S phase are important to maintain genomic integrity. Cell Cycle (2009) 1.18
Chinese hamster cell mutant, V-C8, a model for analysis of Brca2 function. Mutat Res (2006) 1.17
Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. PLoS Genet (2010) 1.16
Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks. Oncogene (2002) 1.15
Inducibility of nuclear Rad51 foci after DNA damage distinguishes all Fanconi anemia complementation groups from D1/BRCA2. Mutat Res (2005) 1.15
A dual role for UVRAG in maintaining chromosomal stability independent of autophagy. Dev Cell (2012) 1.13