PubRank

Charles Boone

Author PubWeight™ 319.91‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Global mapping of the yeast genetic interaction network. Science 2004 21.34
2 The genetic landscape of a cell. Science 2010 16.52
3 Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 2005 10.41
4 Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature 2007 9.25
5 Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell 2005 7.21
6 A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules. Science 2001 7.08
7 Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol 2003 6.79
8 An empirical framework for binary interactome mapping. Nat Methods 2008 6.59
9 Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell 2006 6.42
10 Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol 2003 5.60
11 Role of formins in actin assembly: nucleation and barbed-end association. Science 2002 5.47
12 Exploration of essential gene functions via titratable promoter alleles. Cell 2004 5.21
13 Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell 2005 4.95
14 Synthetic genetic array analysis in Saccharomyces cerevisiae. Methods Mol Biol 2006 4.45
15 A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol Cell 2003 4.04
16 Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell 2006 4.03
17 Identification of a bacterial type III effector family with G protein mimicry functions. Cell 2006 3.47
18 A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A 2002 3.46
19 Combining biological networks to predict genetic interactions. Proc Natl Acad Sci U S A 2004 3.18
20 A specificity map for the PDZ domain family. PLoS Biol 2008 3.16
21 The synthetic genetic interaction spectrum of essential genes. Nat Genet 2005 3.06
22 eSGA: E. coli synthetic genetic array analysis. Nat Methods 2008 3.01
23 Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast. Nat Cell Biol 2002 2.95
24 Genotype to phenotype: a complex problem. Science 2010 2.92
25 Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol Microbiol 2003 2.84
26 Formin leaky cap allows elongation in the presence of tight capping proteins. Curr Biol 2003 2.69
27 Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network. J Biol 2005 2.68
28 Quantitative analysis of fitness and genetic interactions in yeast on a genome scale. Nat Methods 2010 2.67
29 The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast. Nat Genet 2007 2.58
30 Functional genomics and proteomics: charting a multidimensional map of the yeast cell. Trends Cell Biol 2003 2.46
31 Systematic mapping of genetic interaction networks. Annu Rev Genet 2009 2.43
32 Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 2012 2.40
33 Identifying transcription factor functions and targets by phenotypic activation. Proc Natl Acad Sci U S A 2006 2.39
34 RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J 2005 2.34
35 Identification of protein complexes required for efficient sister chromatid cohesion. Mol Biol Cell 2004 2.34
36 Formins: signaling effectors for assembly and polarization of actin filaments. J Cell Sci 2003 2.31
37 Signature-tagged mutagenesis: barcoding mutants for genome-wide screens. Nat Rev Genet 2006 2.30
38 Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast. Nat Cell Biol 2002 2.27
39 Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol 2011 2.26
40 Mechanism of formin-induced nucleation of actin filaments. Biochemistry 2003 2.18
41 Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA. Nature 2009 2.14
42 Elg1 forms an alternative RFC complex important for DNA replication and genome integrity. EMBO J 2003 2.03
43 Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Proc Natl Acad Sci U S A 2008 2.01
44 Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p. Nat Cell Biol 2004 1.94
45 Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation. J Cell Biol 2008 1.92
46 Systematic exploration of synergistic drug pairs. Mol Syst Biol 2011 1.89
47 Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. Genes Dev 2011 1.89
48 The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Mol Cell Biol 2006 1.79
49 High-resolution genetic mapping with ordered arrays of Saccharomyces cerevisiae deletion mutants. Genetics 2002 1.78
50 Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins. PLoS Biol 2009 1.78
51 Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell. Nat Biotechnol 2011 1.77
52 Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway. Mol Biol Cell 2004 1.76
53 Synthetic genetic array (SGA) analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Methods Enzymol 2010 1.73
54 Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation. Proc Natl Acad Sci U S A 2005 1.72
55 Global gene deletion analysis exploring yeast filamentous growth. Science 2012 1.67
56 The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol 2007 1.66
57 The interaction network of the chaperonin CCT. EMBO J 2008 1.63
58 An integrated approach to characterize genetic interaction networks in yeast metabolism. Nat Genet 2011 1.62
59 A network of multi-tasking proteins at the DNA replication fork preserves genome stability. PLoS Genet 2005 1.61
60 Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. EMBO J 2004 1.59
61 Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae. Genetics 2003 1.57
62 Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers. Nat Methods 2008 1.56
63 Global map of SUMO function revealed by protein-protein interaction and genetic networks. Mol Cell 2009 1.55
64 The origin recognition complex links replication, sister chromatid cohesion and transcriptional silencing in Saccharomyces cerevisiae. Genetics 2004 1.49
65 Identifying specificity profiles for peptide recognition modules from phage-displayed peptide libraries. Nat Protoc 2007 1.49
66 Mrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage. Mol Cell Biol 2004 1.48
67 Problems with co-funding in Canada. Science 2005 1.48
68 An interactional network of genes involved in chitin synthesis in Saccharomyces cerevisiae. BMC Genet 2005 1.47
69 The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast. Genome Res 2008 1.44
70 DRYGIN: a database of quantitative genetic interaction networks in yeast. Nucleic Acids Res 2009 1.41
71 Synthetic lethal analysis implicates Ste20p, a p21-activated potein kinase, in polarisome activation. Mol Biol Cell 2003 1.37
72 Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis. J Cell Biol 2010 1.36
73 Bringing order to protein disorder through comparative genomics and genetic interactions. Genome Biol 2011 1.34
74 Ybp2 associates with the central kinetochore of Saccharomyces cerevisiae and mediates proper mitotic progression. PLoS One 2008 1.31
75 Identification of a novel lysophospholipid acyltransferase in Saccharomyces cerevisiae. J Biol Chem 2007 1.28
76 Charting the genetic interaction map of a cell. Curr Opin Biotechnol 2010 1.28
77 Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways. J Biol Chem 2008 1.26
78 Genetic dissection of parallel sister-chromatid cohesion pathways. Genetics 2007 1.26
79 Putting genetic interactions in context through a global modular decomposition. Genome Res 2011 1.24
80 The yeast Shu complex couples error-free post-replication repair to homologous recombination. Mol Microbiol 2009 1.22
81 Shifted Transversal Design smart-pooling for high coverage interactome mapping. Genome Res 2009 1.22
82 Genetic interactions reveal the evolutionary trajectories of duplicate genes. Mol Syst Biol 2010 1.22
83 The GTPase Arf1p and the ER to Golgi cargo receptor Erv14p cooperate to recruit the golgin Rud3p to the cis-Golgi. J Cell Biol 2004 1.21
84 Systems-level antimicrobial drug and drug synergy discovery. Nat Chem Biol 2013 1.19
85 Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle. Mol Biol Cell 2007 1.18
86 Interaction between a Ras and a Rho GTPase couples selection of a growth site to the development of cell polarity in yeast. Mol Biol Cell 2003 1.16
87 Fus1p interacts with components of the Hog1p mitogen-activated protein kinase and Cdc42p morphogenesis signaling pathways to control cell fusion during yeast mating. Genetics 2004 1.13
88 Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops. Nat Commun 2013 1.13
89 Inorganic phosphate deprivation causes tRNA nuclear accumulation via retrograde transport in Saccharomyces cerevisiae. Genetics 2007 1.12
90 Genetic interaction networks: toward an understanding of heritability. Annu Rev Genomics Hum Genet 2013 1.10
91 Trans-Golgi network and endosome dynamics connect ceramide homeostasis with regulation of the unfolded protein response and TOR signaling in yeast. Mol Biol Cell 2008 1.10
92 Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae. Genome Biol 2012 1.09
93 Rex1p deficiency leads to accumulation of precursor initiator tRNAMet and polyadenylation of substrate RNAs in Saccharomyces cerevisiae. Nucleic Acids Res 2008 1.07
94 Chemical-genetic approaches for exploring the mode of action of natural products. Prog Drug Res 2008 1.04
95 Yeast genomics and proteomics in drug discovery and target validation. Prog Cell Cycle Res 2003 1.04
96 A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Mol Syst Biol 2013 1.03
97 Functional analysis with a barcoder yeast gene overexpression system. G3 (Bethesda) 2012 1.02
98 Combining functional genomics and chemical biology to identify targets of bioactive compounds. Curr Opin Chem Biol 2010 1.02
99 Reconstitution and protein composition analysis of endocytic actin patches. Curr Biol 2010 1.01
100 The future of model organisms in human disease research. Nat Rev Genet 2011 1.00
101 An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease. J Biol Chem 2011 0.99
102 Protein complexes are central in the yeast genetic landscape. PLoS Comput Biol 2011 0.99
103 Global analysis of SUMO chain function reveals multiple roles in chromatin regulation. J Cell Biol 2013 0.98
104 Mapping the functional yeast ABC transporter interactome. Nat Chem Biol 2013 0.98
105 ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Traffic 2008 0.98
106 Actin filament elongation in Arp2/3-derived networks is controlled by three distinct mechanisms. Dev Cell 2013 0.97
107 Pol32 is required for Pol zeta-dependent translesion synthesis and prevents double-strand breaks at the replication fork. Mutat Res 2007 0.96
108 Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. isolated from a marine sediment. Org Lett 2011 0.96
109 A comparative genomic approach for identifying synthetic lethal interactions in human cancer. Cancer Res 2013 0.95
110 Conserved rules govern genetic interaction degree across species. Genome Biol 2012 0.95
111 A picture is worth a thousand words: genomics to phenomics in the yeast Saccharomyces cerevisiae. FEBS Lett 2009 0.94
112 SH3 interactome conserves general function over specific form. Mol Syst Biol 2013 0.94
113 ORFeomics: correcting the wiggle in worm genes. Nat Genet 2003 0.94
114 Histone modifications influence mediator interactions with chromatin. Nucleic Acids Res 2011 0.94
115 Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells. PLoS Genet 2008 0.94
116 Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. Mol Biol Cell 2008 0.93
117 Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Genome Res 2012 0.93
118 Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase. J Biol Chem 2011 0.92
119 The Saccharomyces cerevisiae homolog of p24 is essential for maintaining the association of p150Glued with the dynactin complex. Genetics 2008 0.92
120 The DNA damage response pathway contributes to the stability of chromosome III derivatives lacking efficient replicators. PLoS Genet 2010 0.91
121 Genetic and molecular interactions of the Erv41p-Erv46p complex involved in transport between the endoplasmic reticulum and Golgi complex. J Cell Sci 2006 0.90
122 Network evolution: rewiring and signatures of conservation in signaling. PLoS Comput Biol 2012 0.88
123 The TFIIH subunit Tfb3 regulates cullin neddylation. Mol Cell 2011 0.87
124 Genetic interactions of MAF1 identify a role for Med20 in transcriptional repression of ribosomal protein genes. PLoS Genet 2008 0.86
125 Genetic variation in Saccharomyces cerevisiae: circuit diversification in a signal transduction network. Genetics 2012 0.86
126 Old drugs, new tricks: using genetically sensitized yeast to reveal drug targets. Cell 2004 0.86
127 SGAM: an array-based approach for high-resolution genetic mapping in Saccharomyces cerevisiae. Methods Mol Biol 2009 0.85
128 PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae. Nucleic Acids Res 2011 0.85
129 Nutrients and the Pkh1/2 and Pkc1 protein kinases control mRNA decay and P-body assembly in yeast. J Biol Chem 2010 0.85
130 Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression. PLoS One 2013 0.84
131 Identification of Saccharomyces cerevisiae spindle pole body remodeling factors. PLoS One 2010 0.84
132 Mms1 and Mms22 stabilize the replisome during replication stress. Mol Biol Cell 2011 0.84
133 Playing tag with the yeast proteome. Nat Biotechnol 2003 0.83
134 Functional genomics of intracellular peptide recognition domains with combinatorial biology methods. Curr Opin Chem Biol 2003 0.83
135 Chemical-genomic profiling: systematic analysis of the cellular targets of bioactive molecules. Bioorg Med Chem 2011 0.82
136 Global linkage map connects meiotic centromere function to chromosome size in budding yeast. G3 (Bethesda) 2013 0.81
137 Synthetic genetic array analysis for global mapping of genetic networks in yeast. Methods Mol Biol 2014 0.81
138 From worm genetic networks to complex human diseases. Nat Genet 2006 0.79
139 Regulatory circuitry governing morphogenesis in Saccharomyces cerevisiae and Candida albicans. Cell Cycle 2012 0.79
140 Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines. Mol Cancer 2013 0.78
141 Genomic approaches for identifying DNA damage response pathways in S. cerevisiae. Methods Enzymol 2006 0.78
142 Exploring the conservation of synthetic lethal genetic interaction networks. Commun Integr Biol 2009 0.78
143 New azole antifungal agents with novel modes of action: synthesis and biological studies of new tridentate ligands based on pyrazole and triazole. Eur J Med Chem 2011 0.77
144 Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome. Mol Biosyst 2011 0.77
145 You too can play with an edge. Nat Methods 2009 0.77
146 Drug-sensitive DNA polymerase δ reveals a role for mismatch repair in checkpoint activation in yeast. Genetics 2011 0.76
147 The awesome power of synergy from chemical-chemical profiling. Chem Biol 2010 0.75
148 Network Biology editorial 2013. Mol Biosyst 2013 0.75
149 Mapping interactomes with high coverage and efficiency using the shifted transversal design. Methods Mol Biol 2012 0.75
150 Public-academic partnerships: tools for mental health agencies to evaluate research protocols. Psychiatr Serv 2010 0.75
151 Focus on chemical biology in Asia. Mol Biosyst 2013 0.75
152 Fostering interdisciplinary biology. Mol Biosyst 2012 0.75
153 Simplifying the author and reader experience. Mol Biosyst 2012 0.75
154 From chemical genomics to personalized medicine--tackling the genotype to phenotype problem. Mol Biosyst 2010 0.75
155 Beyond the genome: from genomics to systems biology. Curr Opin Microbiol 2004 0.75