Published in RNA on August 01, 2004
MicroInspector: a web tool for detection of miRNA binding sites in an RNA sequence. Nucleic Acids Res (2005) 2.87
EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3. Cancer Res (2008) 2.46
A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites. Nucleic Acids Res (2005) 2.27
Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs. Nucleic Acids Res (2009) 1.21
MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature (1998) 72.56
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell (1993) 64.62
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature (2000) 39.31
Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 38.75
The nuclear RNase III Drosha initiates microRNA processing. Nature (2003) 35.49
RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev (2001) 26.16
MicroRNA targets in Drosophila. Genome Biol (2003) 23.59
Asymmetry in the assembly of the RNAi enzyme complex. Cell (2003) 22.18
Functional siRNAs and miRNAs exhibit strand bias. Cell (2003) 19.15
MicroRNA-directed cleavage of HOXB8 mRNA. Science (2004) 18.33
The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev Biol (1999) 17.82
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science (2002) 17.04
Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol (2003) 16.63
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell (2002) 14.37
Rational siRNA design for RNA interference. Nat Biotechnol (2004) 14.16
Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell (2004) 13.51
A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans. Nature (2003) 12.93
Identification of Drosophila MicroRNA targets. PLoS Biol (2003) 12.72
Identification of virus-encoded microRNAs. Science (2004) 12.56
Control of leaf morphogenesis by microRNAs. Nature (2003) 11.36
The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell (2000) 10.92
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev (2002) 10.71
R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science (2003) 9.53
Establishment and maintenance of a heterochromatin domain. Science (2002) 9.34
Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD. Cell (1999) 9.01
RNAi-mediated targeting of heterochromatin by the RITS complex. Science (2004) 8.73
A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature (2004) 8.67
Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature (2004) 7.63
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol (2003) 6.90
A resource for large-scale RNA-interference-based screens in mammals. Nature (2004) 6.36
A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila. Cell (2004) 5.69
Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Curr Biol (2002) 5.66
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature (2004) 5.57
RNA interference in adult mice. Nature (2002) 5.33
Structure and conserved RNA binding of the PAZ domain. Nature (2003) 5.28
The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell (2002) 5.07
Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature (2003) 4.92
RISC assembly defects in the Drosophila RNAi mutant armitage. Cell (2004) 4.88
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci U S A (2004) 4.85
microRNAs: runts of the genome assert themselves. Curr Biol (2003) 4.75
RISC is a 5' phosphomonoester-producing RNA endonuclease. Genes Dev (2004) 4.73
Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization. Proc Natl Acad Sci U S A (2000) 4.54
Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi. Nature (2003) 4.09
Retracted Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing. Science (2003) 3.98
A viral protein suppresses RNA silencing and binds silencing-generated, 21- to 25-nucleotide double-stranded RNAs. EMBO J (2002) 3.95
Viral RNA silencing suppressors inhibit the microRNA pathway at an intermediate step. Genes Dev (2004) 3.78
The RNA-induced silencing complex is a Mg2+-dependent endonuclease. Curr Biol (2004) 3.68
High throughput virus-induced gene silencing implicates heat shock protein 90 in plant disease resistance. EMBO J (2003) 3.25
Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). RNA (2004) 3.16
Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage. Structure (2001) 2.40
Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants. Science (2003) 2.34
Improving the efficiency of RNA interference in mammals. Nat Rev Genet (2004) 2.13
Quelling in Neurospora crassa. Adv Genet (2002) 1.25
Pattern formation during C. elegans vulval induction. Curr Top Dev Biol (2001) 1.09
Experimental RNomics: a global approach to identifying small nuclear RNAs and their targets in different model organisms. Methods Mol Biol (2004) 1.02
SVISS - a novel transient gene silencing system for gene function discovery and validation in tobacco plants. Plant J (2002) 0.91
Origins and Mechanisms of miRNAs and siRNAs. Cell (2009) 20.77
Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell (2004) 13.51
CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA. Science (2008) 11.82
CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea. Nat Rev Genet (2010) 7.47
Self versus non-self discrimination during CRISPR RNA-directed immunity. Nature (2010) 5.89
A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila. Cell (2004) 5.69
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc Natl Acad Sci U S A (2013) 3.53
Silencing by small RNAs is linked to endosomal trafficking. Nat Cell Biol (2009) 3.25
Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis. Mol Cell (2013) 2.52
A role for ubiquitin in the spliceosome assembly pathway. Nat Struct Mol Biol (2008) 2.12
Molecular requirements for RNA-induced silencing complex assembly in the Drosophila RNA interference pathway. J Biol Chem (2005) 1.62
Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. RNA (2006) 1.43
An inside job for siRNAs. Mol Cell (2008) 1.29
RNAi: RISC gets loaded. Cell (2005) 1.15
Short interfering RNA strand selection is independent of dsRNA processing polarity during RNAi in Drosophila. Curr Biol (2006) 1.11
Microbiology: slicer for DNA. Nature (2010) 1.10
Invasive DNA, chopped and in the CRISPR. Structure (2009) 0.99
ATP modulates siRNA interactions with an endogenous human Dicer complex. RNA (2005) 0.95
Meiosis-induced alterations in transcript architecture and noncoding RNA expression in S. cerevisiae. RNA (2012) 0.86
Methods in Enzymology. The use of CRISPR/Cas9, ZFNs, and TALENs in generating site-specific genome alterations. Preface. Methods Enzymol (2014) 0.84
Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis. Proc Natl Acad Sci U S A (2011) 0.83
Proteomics identification of Drosophila small interfering RNA-associated factors. Mol Cell Proteomics (2010) 0.81
R2D2 leads the silencing trigger to mRNA's death star. Cell (2003) 0.78
Thermodynamic and structural characterization of 2'-nitrogen-modified RNA duplexes. Nucleic Acids Res (2004) 0.77
Separation of Drosophila RNA silencing complexes by native gel electrophoresis. Methods Mol Biol (2005) 0.76
A fork in the road for microRNAs. Nat Struct Mol Biol (2007) 0.76
Quit stalling or you'll be silenced. Cell (2013) 0.75
The Making of an siRNA. Mol Cell (2004) 0.75
Type II-C CRISPR-Cas9 Biology, Mechanism and Application. ACS Chem Biol (2017) 0.75