Published in Cell on March 05, 2010
An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. EMBO J (2010) 2.51
A Tetrahymena Piwi bound to mature tRNA 3' fragments activates the exonuclease Xrn2 for RNA processing in the nucleus. Mol Cell (2012) 1.65
Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proc Natl Acad Sci U S A (2011) 1.56
Regulation of small RNA stability: methylation and beyond. Cell Res (2012) 1.33
Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells. Nucleic Acids Res (2011) 1.15
Argonaute and the nuclear RNAs: new pathways for RNA-mediated control of gene expression. Nucleic Acid Ther (2012) 1.10
Biased transcription and selective degradation of small RNAs shape the pattern of DNA elimination in Tetrahymena. Genes Dev (2012) 1.10
A highly conserved protein of unknown function in Sinorhizobium meliloti affects sRNA regulation similar to Hfq. Nucleic Acids Res (2011) 1.08
The MicroRNA Biology of the Mammalian Nucleus. Mol Ther Nucleic Acids (2014) 1.05
Untangling the web: the diverse functions of the PIWI/piRNA pathway. Mol Reprod Dev (2013) 0.98
Programmed DNA elimination in Tetrahymena: a small RNA-mediated genome surveillance mechanism. Adv Exp Med Biol (2011) 0.97
Tetrahymena thermophila, a unicellular eukaryote with separate germline and somatic genomes. Res Microbiol (2011) 0.97
A Tetrahymena Hsp90 co-chaperone promotes siRNA loading by ATP-dependent and ATP-independent mechanisms. EMBO J (2015) 0.89
Tetrahymena thermophila JMJD3 homolog regulates H3K27 methylation and nuclear differentiation. Eukaryot Cell (2012) 0.89
Gene network landscape of the ciliate Tetrahymena thermophila. PLoS One (2011) 0.88
Keeping the soma free of transposons: programmed DNA elimination in ciliates. J Biol Chem (2011) 0.88
Small-RNA-Mediated Genome-wide trans-Recognition Network in Tetrahymena DNA Elimination. Mol Cell (2015) 0.88
DNA rearrangements directed by non-coding RNAs in ciliates. Wiley Interdiscip Rev RNA (2011) 0.88
Developmentally programmed, RNA-directed genome rearrangement in Tetrahymena. Dev Growth Differ (2011) 0.85
Structure of the germline genome of Tetrahymenathermophila and relationship to the massively rearranged somatic genome. Elife (2016) 0.84
The zinc finger protein Zfr1p is localized specifically to conjugation junction and required for sexual development in Tetrahymena thermophila. PLoS One (2012) 0.84
Genome-wide analysis of genetic and epigenetic control of programmed DNA deletion. Nucleic Acids Res (2014) 0.83
Phosphorylation of an HP1-like Protein Regulates Heterochromatin Body Assembly for DNA Elimination. Dev Cell (2015) 0.83
Loading and pre-loading processes generate a distinct siRNA population in Tetrahymena. Biochem Biophys Res Commun (2013) 0.80
Nuclear Noncoding RNAs and Genome Stability. Mol Cell (2016) 0.79
LIA4 encodes a chromoshadow domain protein required for genomewide DNA rearrangements in Tetrahymena thermophila. Eukaryot Cell (2014) 0.79
Targeted Gene Disruption by Ectopic Induction of DNA Elimination in Tetrahymena. Genetics (2015) 0.78
RNAi in fission yeast finds new targets and new ways of targeting at the nuclear periphery. Genes Dev (2012) 0.77
Phosphorylation of an HP1-like protein is a prerequisite for heterochromatin body formation in Tetrahymena DNA elimination. Proc Natl Acad Sci U S A (2016) 0.77
Role of class III phosphatidylinositol 3-kinase during programmed nuclear death of Tetrahymena thermophila. Autophagy (2013) 0.77
Intercepting noncoding messages between germline and soma. Genes Dev (2012) 0.75
snRNA 3' End Processing by a CPSF73-Containing Complex Essential for Development in Arabidopsis. PLoS Biol (2016) 0.75
DRH1, a p68-related RNA helicase, is required for chromosome breakage in Tetrahymena. Biol Open (2016) 0.75
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science (2002) 17.04
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell (2005) 9.35
Small RNAs as guardians of the genome. Cell (2009) 8.88
Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol (2005) 6.64
Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell (2005) 6.47
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell (2008) 6.35
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature (2008) 5.78
Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena. Cell (2002) 5.78
DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev (2008) 5.58
Slicer function of Drosophila Argonautes and its involvement in RISC formation. Genes Dev (2005) 5.29
Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell (2007) 5.26
An ARGONAUTE4-containing nuclear processing center colocalized with Cajal bodies in Arabidopsis thaliana. Cell (2006) 5.22
Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells. Nat Struct Mol Biol (2006) 4.93
RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol Cell (2002) 4.90
The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center. Cell (2006) 4.82
piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells. Development (2000) 4.54
RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing. Nat Genet (2004) 4.23
Cleavage of the siRNA passenger strand during RISC assembly in human cells. EMBO Rep (2006) 4.15
Slicer and the argonautes. Nat Chem Biol (2007) 3.99
An Argonaute transports siRNAs from the cytoplasm to the nucleus. Science (2008) 3.86
Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. Nat Struct Mol Biol (2006) 3.46
Methylation of histone h3 at lysine 9 targets programmed DNA elimination in tetrahymena. Cell (2002) 3.16
Programmed DNA deletion as an RNA-guided system of genome defense. Science (2003) 3.02
Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Cell (2009) 2.98
Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing. EMBO J (2007) 2.79
A Dicer-like protein in Tetrahymena has distinct functions in genome rearrangement, chromosome segregation, and meiotic prophase. Genes Dev (2004) 2.75
RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena. Genes Dev (2007) 2.26
Conjugation-specific small RNAs in Tetrahymena have predicted properties of scan (scn) RNAs involved in genome rearrangement. Genes Dev (2004) 2.19
Two classes of endogenous small RNAs in Tetrahymena thermophila. Genes Dev (2005) 2.08
Nongenic, bidirectional transcription precedes and may promote developmental DNA deletion in Tetrahymena thermophila. Genes Dev (2001) 2.08
Germ line transcripts are processed by a Dicer-like protein that is essential for developmentally programmed genome rearrangements of Tetrahymena thermophila. Mol Cell Biol (2005) 2.06
QIP, a putative exonuclease, interacts with the Neurospora Argonaute protein and facilitates conversion of duplex siRNA into single strands. Genes Dev (2007) 1.88
Study of an RNA helicase implicates small RNA-noncoding RNA interactions in programmed DNA elimination in Tetrahymena. Genes Dev (2008) 1.82
Parental expression of the chromodomain protein Pdd1p is required for completion of programmed DNA elimination and nuclear differentiation. Mol Cell (1999) 1.78
2'-O-methylation stabilizes Piwi-associated small RNAs and ensures DNA elimination in Tetrahymena. RNA (2009) 1.76
A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe. Genes Dev (2004) 1.69
A novel family of mobile genetic elements is limited to the germline genome in Tetrahymena thermophila. Nucleic Acids Res (2002) 1.41
RDE-1 slicer activity is required only for passenger-strand cleavage during RNAi in Caenorhabditis elegans. Nat Struct Mol Biol (2009) 1.35
Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila. Genes Dev (2009) 1.34
A non-long terminal repeat retrotransposon family is restricted to the germ line micronucleus of the ciliated protozoan Tetrahymena thermophila. Eukaryot Cell (2004) 1.12
Two GW repeat proteins interact with Tetrahymena thermophila argonaute and promote genome rearrangement. Mol Cell Biol (2009) 0.97
Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena. Cell (2002) 5.78
Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol (2006) 5.44
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
The tree of eukaryotes. Trends Ecol Evol (2005) 3.98
A Dicer-like protein in Tetrahymena has distinct functions in genome rearrangement, chromosome segregation, and meiotic prophase. Genes Dev (2004) 2.75
Small RNAs in genome rearrangement in Tetrahymena. Curr Opin Genet Dev (2004) 2.56
A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. Proc Natl Acad Sci U S A (2002) 2.46
Pulmonary hypertension as a prognostic indicator at the initial evaluation in idiopathic pulmonary fibrosis. Respiration (2012) 2.23
Search for cancer markers from endometrial tissues using differentially labeled tags iTRAQ and cICAT with multidimensional liquid chromatography and tandem mass spectrometry. J Proteome Res (2005) 2.22
Conjugation-specific small RNAs in Tetrahymena have predicted properties of scan (scn) RNAs involved in genome rearrangement. Genes Dev (2004) 2.19
Microarray analyses of gene expression during the Tetrahymena thermophila life cycle. PLoS One (2009) 2.11
Histone H3 lysine 9 methylation is required for DNA elimination in developing macronuclei in Tetrahymena. Proc Natl Acad Sci U S A (2004) 2.10
A unified phylogeny-based nomenclature for histone variants. Epigenetics Chromatin (2012) 1.82
Study of an RNA helicase implicates small RNA-noncoding RNA interactions in programmed DNA elimination in Tetrahymena. Genes Dev (2008) 1.82
Discovery and verification of head-and-neck cancer biomarkers by differential protein expression analysis using iTRAQ labeling, multidimensional liquid chromatography, and tandem mass spectrometry. Mol Cell Proteomics (2008) 1.76
2'-O-methylation stabilizes Piwi-associated small RNAs and ensures DNA elimination in Tetrahymena. RNA (2009) 1.76
Quantitative proteomic analysis in metastatic renal cell carcinoma reveals a unique set of proteins with potential prognostic significance. Mol Cell Proteomics (2012) 1.72
Phosphorylation and an ATP-dependent process increase the dynamic exchange of H1 in chromatin. J Cell Biol (2002) 1.55
Problems with co-funding in Canada. Science (2005) 1.48
Lung-Dominant Connective Tissue Disease: Clinical, Radiologic, and Histologic Features. Chest (2015) 1.48
Phosphorylation motifs regulating the stability and function of myocyte enhancer factor 2A. J Biol Chem (2003) 1.44
Robust method for proteome analysis by MS/MS using an entire translated genome: demonstration on the ciliome of Tetrahymena thermophila. J Proteome Res (2005) 1.42
Multiple reaction monitoring of mTRAQ-labeled peptides enables absolute quantification of endogenous levels of a potential cancer marker in cancerous and normal endometrial tissues. J Proteome Res (2008) 1.42
A domesticated piggyBac transposase plays key roles in heterochromatin dynamics and DNA cleavage during programmed DNA deletion in Tetrahymena thermophila. Mol Biol Cell (2010) 1.42
Tetrahymena thermophila contains a conventional gamma-tubulin that is differentially required for the maintenance of different microtubule-organizing centers. J Cell Biol (2002) 1.42
Refined annotation and assembly of the Tetrahymena thermophila genome sequence through EST analysis, comparative genomic hybridization, and targeted gap closure. BMC Genomics (2008) 1.40
Effects of pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis. Respirology (2008) 1.32
Noninvasive ventilation in acute exacerbation of idiopathic pulmonary fibrosis. Intern Med (2010) 1.28
Efficiency of nano-electrospray ionization. J Am Soc Mass Spectrom (2005) 1.25
Tetrahymena thermophila. Curr Biol (2005) 1.25
Endometrial carcinoma biomarker discovery and verification using differentially tagged clinical samples with multidimensional liquid chromatography and tandem mass spectrometry. Mol Cell Proteomics (2007) 1.25
Deposition and function of histone H3 variants in Tetrahymena thermophila. Mol Cell Biol (2006) 1.22
Glutamylation on alpha-tubulin is not essential but affects the assembly and functions of a subset of microtubules in Tetrahymena thermophila. Eukaryot Cell (2008) 1.20
Protein kinase A represses skeletal myogenesis by targeting myocyte enhancer factor 2D. Mol Cell Biol (2008) 1.18
Genome-Scale Analysis of Programmed DNA Elimination Sites in Tetrahymena thermophila. G3 (Bethesda) (2011) 1.16
iTRAQ-multidimensional liquid chromatography and tandem mass spectrometry-based identification of potential biomarkers of oral epithelial dysplasia and novel networks between inflammation and premalignancy. J Proteome Res (2009) 1.16
Epigenetics of ciliates. Cold Spring Harb Perspect Biol (2013) 1.14
Absolute quantification of potential cancer markers in clinical tissue homogenates using multiple reaction monitoring on a hybrid triple quadrupole/linear ion trap tandem mass spectrometer. Anal Chem (2009) 1.14
Differential protein expressions in renal cell carcinoma: new biomarker discovery by mass spectrometry. J Proteome Res (2009) 1.13
Both carboxy-terminal tails of alpha- and beta-tubulin are essential, but either one will suffice. Curr Biol (2002) 1.13
A non-long terminal repeat retrotransposon family is restricted to the germ line micronucleus of the ciliated protozoan Tetrahymena thermophila. Eukaryot Cell (2004) 1.12
Quantitative proteomic analysis reveals potential diagnostic markers and pathways involved in pathogenesis of renal cell carcinoma. Oncotarget (2014) 1.11
The Tetrahymena thermophila phagosome proteome. Eukaryot Cell (2006) 1.11
Biased transcription and selective degradation of small RNAs shape the pattern of DNA elimination in Tetrahymena. Genes Dev (2012) 1.10
Gaseous bradykinin and its singly, doubly, and triply protonated forms: a first-principles study. J Phys Chem B (2006) 1.10
Different effects of Tetrahymena IFT172 domains on anterograde and retrograde intraflagellar transport. Mol Biol Cell (2008) 1.09
Tetrahymena IFT122A is not essential for cilia assembly but plays a role in returning IFT proteins from the ciliary tip to the cell body. J Cell Sci (2008) 1.08
Ion mobility spectrometer with radial collisional focusing. Anal Chem (2005) 1.04
Nuclear S100A7 is associated with poor prognosis in head and neck cancer. PLoS One (2010) 1.04
Elimination of foreign DNA during somatic differentiation in Tetrahymena thermophila shows position effect and is dosage dependent. Eukaryot Cell (2005) 1.04
Exploring the mitochondrial proteome of the ciliate protozoon Tetrahymena thermophila: direct analysis by tandem mass spectrometry. J Mol Biol (2007) 1.03
Heterogeneous ribonucleoprotein K is a marker of oral leukoplakia and correlates with poor prognosis of squamous cell carcinoma. Int J Cancer (2009) 1.03
Cell context-specific effects of the beta-tubulin glycylation domain on assembly and size of microtubular organelles. Mol Biol Cell (2004) 1.03
mTRAQ-based quantification of potential endometrial carcinoma biomarkers from archived formalin-fixed paraffin-embedded tissues. Proteomics (2010) 1.02
The nonessential H2A N-terminal tail can function as an essential charge patch on the H2A.Z variant N-terminal tail. Mol Cell Biol (2003) 1.02
RNA polymerase II localizes in Tetrahymena thermophila meiotic micronuclei when micronuclear transcription associated with genome rearrangement occurs. Eukaryot Cell (2004) 1.02
Diversity of penicillin-binding proteins. Resistance factor FmtA of Staphylococcus aureus. J Biol Chem (2007) 1.01
Prognostic significance of head-and-neck cancer biomarkers previously discovered and identified using iTRAQ-labeling and multidimensional liquid chromatography-tandem mass spectrometry. J Proteome Res (2008) 1.00
Protein expression profiling of endometrial malignancies reveals a new tumor marker: chaperonin 10. J Proteome Res (2004) 0.99
S100A7 overexpression is a predictive marker for high risk of malignant transformation in oral dysplasia. Int J Cancer (2013) 0.99
Analysis of expressed sequence tags (ESTs) in the ciliated protozoan Tetrahymena thermophila. J Eukaryot Microbiol (2002) 0.99
Centromeric histone H3 is essential for vegetative cell division and for DNA elimination during conjugation in Tetrahymena thermophila. Mol Cell Biol (2006) 0.98
Identification of proteins secreted by head and neck cancer cell lines using LC-MS/MS: Strategy for discovery of candidate serological biomarkers. Proteomics (2011) 0.98
Programmed DNA elimination in Tetrahymena: a small RNA-mediated genome surveillance mechanism. Adv Exp Med Biol (2011) 0.97
Two GW repeat proteins interact with Tetrahymena thermophila argonaute and promote genome rearrangement. Mol Cell Biol (2009) 0.97
Identification of secreted proteins during skeletal muscle development. J Proteome Res (2007) 0.97
14-3-3 zeta as novel molecular target for cancer therapy. Expert Opin Ther Targets (2012) 0.96
Mutational analyses reveal a novel function of the nucleotide-binding domain of gamma-tubulin in the regulation of basal body biogenesis. J Cell Biol (2005) 0.96
Genomic and proteomic evidence for a second family of dense core granule cargo proteins in Tetrahymena thermophila. J Eukaryot Microbiol (2005) 0.96
Interstitial pneumonia associated with MPO-ANCA: clinicopathological features of nine patients. Respir Med (2012) 0.96
Crizotinib-induced acute interstitial lung disease in a patient with EML4-ALK positive non-small cell lung cancer and chronic interstitial pneumonia. Acta Oncol (2013) 0.95
Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila. Mol Cell Biol (2007) 0.95
Small interfering RNA targeting 14-3-3ζ increases efficacy of chemotherapeutic agents in head and neck cancer cells. Mol Cancer Ther (2010) 0.94
Identification of novel molecular targets for endometrial cancer using a drill-down LC-MS/MS approach with iTRAQ. PLoS One (2011) 0.93
MRE11 and COM1/SAE2 are required for double-strand break repair and efficient chromosome pairing during meiosis of the protist Tetrahymena. Chromosoma (2010) 0.93
Acute exacerbation of idiopathic pulmonary fibrosis: high-resolution CT scores predict mortality. Eur Radiol (2011) 0.92
Pathologically proved nonspecific interstitial pneumonia: CT pattern analysis as compared with usual interstitial pneumonia CT pattern. Radiology (2014) 0.92
Proteomic analysis of the proliferative and secretory phases of the human endometrium: protein identification and differential protein expression. Proteomics (2005) 0.91
Regulation of transcription by H1 phosphorylation in Tetrahymena is position independent and requires clustered sites. Proc Natl Acad Sci U S A (2002) 0.91