PLUNC: a multifunctional surfactant of the airways.

Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways. Proc Natl Acad Sci U S A (2013) 1.20

Influenza-induced type I interferon enhances susceptibility to gram-negative and gram-positive bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol (2015) 0.96

Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. Am J Physiol Lung Cell Mol Physiol (2013) 0.93

Decreased PLUNC expression in nasal polyps is associated with multibacterial colonization in chronic rhinosinusitis patients. Eur Arch Otorhinolaryngol (2013) 0.86

Retracted Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways. FASEB J (2012) 0.85

Ovocalyxin-36 is a pattern recognition protein in chicken eggshell membranes. PLoS One (2013) 0.83

Mammalian short palate lung and nasal epithelial clone 1 (SPLUNC1) in pH-dependent airway hydration. Int J Biochem Cell Biol (2014) 0.82

Short palate, lung, and nasal epithelial clone-1 is a tightly regulated airway sensor in innate and adaptive immunity. Am J Respir Cell Mol Biol (2013) 0.80

A novel siderophore system is essential for the growth of Pseudomonas aeruginosa in airway mucus. Sci Rep (2015) 0.79

Structural characterization of the pulmonary innate immune protein SPLUNC1 and identification of lipid ligands. FASEB J (2014) 0.77

Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1. Biochemistry (2016) 0.77

"SP-G", a putative new surfactant protein--tissue localization and 3D structure. PLoS One (2012) 0.75

Interleukin-13 Inhibits Lipopolysaccharide-Induced BPIFA1 Expression in Nasal Epithelial Cells. PLoS One (2015) 0.75

SPLUNC1 Is a Significant Marker in Pleural Effusion from Lung Cancer Compared to Tuberculosis. Monoclon Antib Immunodiagn Immunother (2015) 0.75

PLUNC proteins positivity in patients with chronic rhinosinusitis: a case-control study. ScientificWorldJournal (2014) 0.75

MicroRNA-200b regulates distal airway development by maintaining epithelial integrity. Sci Rep (2017) 0.75

A simple method for displaying the hydropathic character of a protein. J Mol Biol (1982) 150.65

Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes. J Biol Chem (1978) 4.61

Rhamnolipids mediate detachment of Pseudomonas aeruginosa from biofilms. Mol Microbiol (2005) 2.40

Function of surfactant proteins B and C. Annu Rev Physiol (2001) 2.03

PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. Hum Mol Genet (2002) 1.95

Function and regulation of SPLUNC1 protein in Mycoplasma infection and allergic inflammation. J Immunol (2007) 1.85

Multiple roles of biosurfactants in structural biofilm development by Pseudomonas aeruginosa. J Bacteriol (2007) 1.66

Surfactant displaces particles toward the epithelium in airways and alveoli. Respir Physiol (1990) 1.60

Temporal-spatial distribution of SP-B and SP-C proteins and mRNAs in developing respiratory epithelium of human lung. J Histochem Cytochem (1994) 1.58

Innate immune functions of the airway epithelium. Contrib Microbiol (2008) 1.57

Identification of human whole saliva protein components using proteomics. Proteomics (2004) 1.51

Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts. J Biol Chem (2002) 1.47

Antimicrobial polypeptides. J Leukoc Biol (2003) 1.46

PLUNC is a novel airway surfactant protein with anti-biofilm activity. PLoS One (2010) 1.44

Bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP): structure, function and regulation in host defence against Gram-negative bacteria. Biochem Soc Trans (2003) 1.44

Isolation and characterization of a phospholipid transfer protein (LTP-II) from human plasma. J Lipid Res (1988) 1.41

Extracellular lining of bronchioles after perfusion-fixation of rat lungs for electron microscopy. Anat Rec (1971) 1.40

Purification and characterization of PLUNC from human tracheobronchial secretions. Am J Respir Cell Mol Biol (2003) 1.32

Pseudomonas aeruginosa rhamnolipids disperse Bordetella bronchiseptica biofilms. FEMS Microbiol Lett (2005) 1.29

The multifunctional host defense peptide SPLUNC1 is critical for homeostasis of the mammalian upper airway. PLoS One (2010) 1.26

Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting. Proteomics (2002) 1.24

Phylogenetic and evolutionary analysis of the PLUNC gene family. Protein Sci (2004) 1.23

Comparative proteomics of nasal fluid in seasonal allergic rhinitis. J Proteome Res (2006) 1.16

PLUNC is a secreted product of neutrophil granules. J Leukoc Biol (2008) 1.13

In vivo determination of surface tension in the horse trachea and in vitro model studies. Respir Physiol (1997) 1.13

Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage fluid with two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight. Electrophoresis (2001) 1.12

Latherin: a surfactant protein of horse sweat and saliva. PLoS One (2009) 1.10

PLUNC (palate, lung and nasal epithelial clone) proteins in human nasal lavage fluid. Biochem Soc Trans (2003) 1.09

The influence of Lactobacillus acidophilus-derived surfactants on staphylococcal adhesion and biofilm formation. Folia Microbiol (Praha) (2008) 1.08

Isolation and characterization of latherin, a surface-active protein from horse sweat. Biochem J (1986) 1.06

Plunc, a member of the secretory gland protein family, is up-regulated in nasal respiratory epithelium after olfactory bulbectomy. J Biol Chem (2002) 1.05

Molecular biology and pathophysiological aspects of plasma cholesteryl ester transfer protein. Biochim Biophys Acta (2000) 1.03

Conductive airway surfactant: surface-tension function, biochemical composition, and possible alveolar origin. Am J Respir Cell Mol Biol (1997) 0.97

Biochemical characterization and surfactant properties of horse allergens. Eur J Biochem (2001) 0.85

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell (2008) 11.24

Bacterial biofilms: an emerging link to disease pathogenesis. Annu Rev Microbiol (2003) 7.29

Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science (2008) 6.28

DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele-specific demethylation. Cell (2006) 6.11

Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A (2005) 5.05

Self-generated diversity produces "insurance effects" in biofilm communities. Proc Natl Acad Sci U S A (2004) 4.54

Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria. Science (2011) 3.66

Current prospects for RNA interference-based therapies. Nat Rev Genet (2011) 3.63

Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med (2010) 3.36

Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol (2002) 3.13

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature (2012) 2.94

Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature (2011) 2.94

A novel host defense system of airways is defective in cystic fibrosis. Am J Respir Crit Care Med (2006) 2.61

A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Nat Immunol (2013) 2.60

Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. J Bacteriol (2005) 2.59

Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A (2002) 2.56

The porcine lung as a potential model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 2.53

Cytokine-mediated regulation of antimicrobial proteins. Nat Rev Immunol (2008) 2.46

Rhamnolipids mediate detachment of Pseudomonas aeruginosa from biofilms. Mol Microbiol (2005) 2.40

The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity. J Clin Invest (2007) 2.26

Rieske business: structure-function of Rieske non-heme oxygenases. Biochem Biophys Res Commun (2005) 2.24

Direct sampling of cystic fibrosis lungs indicates that DNA-based analyses of upper-airway specimens can misrepresent lung microbiota. Proc Natl Acad Sci U S A (2012) 2.22

Left atrial thrombus predicts transient ischemic attack in patients with atrial fibrillation. Am Heart J (2003) 2.22

Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed. J Clin Invest (2008) 2.21

The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. J Biol Chem (2001) 2.20

ExsD is a negative regulator of the Pseudomonas aeruginosa type III secretion regulon. Mol Microbiol (2002) 2.18

Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A (2014) 2.17

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc Natl Acad Sci U S A (2011) 2.12

The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Sci Transl Med (2011) 2.01

Endogenous oxidative stress produces diversity and adaptability in biofilm communities. Proc Natl Acad Sci U S A (2008) 2.00

Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. Am J Respir Crit Care Med (2010) 1.94

Ebola virus glycoprotein 1: identification of residues important for binding and postbinding events. J Virol (2007) 1.93

Evolving stealth: genetic adaptation of Pseudomonas aeruginosa during cystic fibrosis infections. Proc Natl Acad Sci U S A (2006) 1.93

Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms. J Clin Microbiol (2004) 1.91

Correlation between beta-defensin expression and induction profiles in gingival keratinocytes. Mol Immunol (2004) 1.90

Antimicrobial peptides in animals and their role in host defences. Int J Antimicrob Agents (2003) 1.84

[beta]-defensins in lung host defense. Annu Rev Physiol (2002) 1.80

Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2. Am J Physiol Lung Cell Mol Physiol (2004) 1.64

Utility and distribution of conserved noncoding sequences in the grasses. Proc Natl Acad Sci U S A (2002) 1.61

The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. Am J Physiol Lung Cell Mol Physiol (2010) 1.61

Innate immune functions of the airway epithelium. Contrib Microbiol (2008) 1.57

Haemophilus influenzae forms biofilms on airway epithelia: implications in cystic fibrosis. Am J Respir Crit Care Med (2006) 1.56

Bacterial neuraminidase facilitates mucosal infection by participating in biofilm production. J Clin Invest (2006) 1.54

Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6. Hum Mol Genet (2008) 1.50

WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Mol Cell (2010) 1.50

Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization. J Am Chem Soc (2011) 1.48

The extracellular matrix protects Pseudomonas aeruginosa biofilms by limiting the penetration of tobramycin. Environ Microbiol (2013) 1.47

miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production. Am J Respir Crit Care Med (2014) 1.45

Lentivirus vectors pseudotyped with filoviral envelope glycoproteins transduce airway epithelia from the apical surface independently of folate receptor alpha. J Virol (2003) 1.45

Delayed wound healing in diabetic (db/db) mice with Pseudomonas aeruginosa biofilm challenge: a model for the study of chronic wounds. Wound Repair Regen (2010) 1.44

PLUNC is a novel airway surfactant protein with anti-biofilm activity. PLoS One (2010) 1.44

Dynamics and biological relevance of DNA demethylation in Arabidopsis antibacterial defense. Proc Natl Acad Sci U S A (2013) 1.40

Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylation. Infect Immun (2002) 1.40

Targeting a bacterial stress response to enhance antibiotic action. Proc Natl Acad Sci U S A (2009) 1.39

Single-copy genes define a conserved order between rice and wheat for understanding differences caused by duplication, deletion, and transposition of genes. Funct Integr Genomics (2006) 1.38

Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase subunit, FBXL2, to regulate surfactant homeostasis. Mol Cell Biol (2011) 1.37

The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. J Am Soc Nephrol (2013) 1.35

piggyBac transposase tools for genome engineering. Proc Natl Acad Sci U S A (2013) 1.35

Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. J Clin Invest (2013) 1.30

Pseudomonas aeruginosa acquires biofilm-like properties within airway epithelial cells. Infect Immun (2005) 1.30

F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. Nat Immunol (2012) 1.28

CCL20 is an inducible product of human airway epithelia with innate immune properties. Am J Respir Cell Mol Biol (2003) 1.28

Use of an efflux pump inhibitor to determine the prevalence of efflux pump-mediated fluoroquinolone resistance and multidrug resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2005) 1.27

Masking of a nuclear signal motif by monoubiquitination leads to mislocalization and degradation of the regulatory enzyme cytidylyltransferase. Mol Cell Biol (2009) 1.27

Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection. J Virol (2014) 1.25

Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins. J Immunol (2003) 1.24

Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein. Virology (2011) 1.22

Lipids including cholesteryl linoleate and cholesteryl arachidonate contribute to the inherent antibacterial activity of human nasal fluid. J Immunol (2008) 1.22

Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange. Nat Struct Mol Biol (2010) 1.21

Integration site choice of a feline immunodeficiency virus vector. J Virol (2006) 1.20

Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors. J Virol (2009) 1.20

Calmodulin binds and stabilizes the regulatory enzyme, CTP: phosphocholine cytidylyltransferase. J Biol Chem (2007) 1.20

Conditions associated with the cystic fibrosis defect promote chronic Pseudomonas aeruginosa infection. Am J Respir Crit Care Med (2014) 1.19

Mucin-Pseudomonas aeruginosa interactions promote biofilm formation and antibiotic resistance. Mol Microbiol (2006) 1.19

Measles virus preferentially transduces the basolateral surface of well-differentiated human airway epithelia. J Virol (2002) 1.18

Persistent gene expression in mouse nasal epithelia following feline immunodeficiency virus-based vector gene transfer. J Virol (2005) 1.18

Expression and activity of beta-defensins and LL-37 in the developing human lung. J Immunol (2005) 1.17

F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. Blood (2012) 1.16

In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins. J Virol (2002) 1.16

Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission. J Immunol (2008) 1.15

Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. J Virol (2009) 1.15

Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer. Blood (2005) 1.14

ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol (2005) 1.14

Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides. Protein Eng (2002) 1.14

Rac1-mediated mitochondrial H2O2 generation regulates MMP-9 gene expression in macrophages via inhibition of SP-1 and AP-1. J Biol Chem (2010) 1.14

Emerging therapies targeting the ubiquitin proteasome system in cancer. J Clin Invest (2014) 1.13

The NMDA receptor NR1 C1 region bound to calmodulin: structural insights into functional differences between homologous domains. Structure (2007) 1.13

PLUNC is a secreted product of neutrophil granules. J Leukoc Biol (2008) 1.13

14-3-3 binding and phosphorylation of neuroglobin during hypoxia modulate six-to-five heme pocket coordination and rate of nitrite reduction to nitric oxide. J Biol Chem (2011) 1.12

Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells. J Biol Chem (2008) 1.12

Expression of beta-defensins in gingival health and in periodontal disease. J Oral Pathol Med (2004) 1.12

Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth. Proc Natl Acad Sci U S A (2010) 1.12

Stx2-specific human monoclonal antibodies protect mice against lethal infection with Escherichia coli expressing Stx2 variants. Infect Immun (2003) 1.12

A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia A. Mol Ther (2011) 1.11

MD-2-dependent pulmonary immune responses to inhaled lipooligosaccharides: effect of acylation state. Am J Respir Cell Mol Biol (2008) 1.11

CFTR DeltaF508 mutation has minimal effect on the gene expression profile of differentiated human airway epithelia. Am J Physiol Lung Cell Mol Physiol (2005) 1.09