|
1
|
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.
|
Lancet
|
2002
|
8.57
|
|
2
|
Mepolizumab and exacerbations of refractory eosinophilic asthma.
|
N Engl J Med
|
2009
|
8.36
|
|
3
|
Mast-cell infiltration of airway smooth muscle in asthma.
|
N Engl J Med
|
2002
|
6.52
|
|
4
|
Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma.
|
Am J Respir Crit Care Med
|
2013
|
4.95
|
|
5
|
Evidence of a role of tumor necrosis factor alpha in refractory asthma.
|
N Engl J Med
|
2006
|
4.83
|
|
6
|
Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma.
|
Thorax
|
2007
|
2.37
|
|
7
|
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.
|
J Allergy Clin Immunol
|
2012
|
2.24
|
|
8
|
Induced sputum inflammatory mediator concentrations in chronic cough.
|
Am J Respir Crit Care Med
|
2003
|
1.98
|
|
9
|
The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle.
|
Am J Respir Crit Care Med
|
2005
|
1.95
|
|
10
|
TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis.
|
J Allergy Clin Immunol
|
2002
|
1.92
|
|
11
|
Increased sputum and bronchial biopsy IL-13 expression in severe asthma.
|
J Allergy Clin Immunol
|
2008
|
1.92
|
|
12
|
IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma.
|
Am J Respir Crit Care Med
|
2010
|
1.91
|
|
13
|
Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer.
|
J Clin Oncol
|
2005
|
1.87
|
|
14
|
Airway hyperresponsiveness is dissociated from airway wall structural remodeling.
|
J Allergy Clin Immunol
|
2008
|
1.76
|
|
15
|
Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma.
|
Am J Respir Crit Care Med
|
2006
|
1.53
|
|
16
|
Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis.
|
J Allergy Clin Immunol
|
2004
|
1.52
|
|
17
|
C3a, mast cells, and asthma.
|
FASEB J
|
2005
|
1.42
|
|
18
|
Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma.
|
J Allergy Clin Immunol
|
2011
|
1.38
|
|
19
|
Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-beta 1.
|
J Immunol
|
2008
|
1.34
|
|
20
|
Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.
|
FASEB J
|
2006
|
1.30
|
|
21
|
Functional transient receptor potential melastatin 7 channels are critical for human mast cell survival.
|
J Immunol
|
2007
|
1.30
|
|
22
|
Clinical, radiologic, and induced sputum features of chronic obstructive pulmonary disease in nonsmokers: a descriptive study.
|
Am J Respir Crit Care Med
|
2002
|
1.27
|
|
23
|
Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6.
|
J Immunol
|
2008
|
1.23
|
|
24
|
KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation.
|
Am J Respir Cell Mol Biol
|
2007
|
1.20
|
|
25
|
Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes.
|
Thorax
|
2010
|
1.19
|
|
26
|
Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis.
|
J Allergy Clin Immunol
|
2007
|
1.17
|
|
27
|
The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells.
|
J Allergy Clin Immunol
|
2004
|
1.15
|
|
28
|
Differential expression of CCR3 and CXCR3 by human lung and bone marrow-derived mast cells: implications for tissue mast cell migration.
|
J Leukoc Biol
|
2005
|
1.14
|
|
29
|
The reclassification of asthma based on subphenotypes.
|
Curr Opin Allergy Clin Immunol
|
2007
|
1.14
|
|
30
|
Activation of human mast cells through the platelet-activating factor receptor.
|
J Allergy Clin Immunol
|
2010
|
1.08
|
|
31
|
Inhibition of human mast cell proliferation and survival by tamoxifen in association with ion channel modulation.
|
J Allergy Clin Immunol
|
2003
|
1.05
|
|
32
|
Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor.
|
Eur J Immunol
|
2007
|
1.04
|
|
33
|
The relationship between clinical outcomes and medication adherence in difficult-to-control asthma.
|
Thorax
|
2012
|
1.04
|
|
34
|
The tissue microlocalisation and cellular expression of CD163, VEGF, HLA-DR, iNOS, and MRP 8/14 is correlated to clinical outcome in NSCLC.
|
PLoS One
|
2011
|
1.01
|
|
35
|
Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1.
|
J Immunol
|
2006
|
1.00
|
|
36
|
Beta2-adrenoceptor regulation of the K+ channel iKCa1 in human mast cells.
|
FASEB J
|
2005
|
0.99
|
|
37
|
Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin.
|
J Immunol
|
2010
|
0.96
|
|
38
|
CRACM/Orai ion channel expression and function in human lung mast cells.
|
J Allergy Clin Immunol
|
2012
|
0.96
|
|
39
|
Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma.
|
Thorax
|
2011
|
0.95
|
|
40
|
Functional KCa3.1 K+ channels are required for human fibrocyte migration.
|
J Allergy Clin Immunol
|
2011
|
0.95
|
|
41
|
Chemokine receptor expression in tumour islets and stroma in non-small cell lung cancer.
|
BMC Cancer
|
2010
|
0.95
|
|
42
|
IgE alone promotes human lung mast cell survival through the autocrine production of IL-6.
|
BMC Immunol
|
2008
|
0.94
|
|
43
|
CCL11 and GM-CSF differentially use the Rho GTPase pathway to regulate motility of human eosinophils in a three-dimensional microenvironment.
|
J Immunol
|
2008
|
0.92
|
|
44
|
A novel FcεRIβ-chain truncation regulates human mast cell proliferation and survival.
|
FASEB J
|
2010
|
0.89
|
|
45
|
Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration.
|
Eur J Immunol
|
2008
|
0.89
|
|
46
|
A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells.
|
Immunity
|
2013
|
0.89
|
|
47
|
Inflammatory and satellite cells in the quadriceps of patients with COPD and response to resistance training.
|
Chest
|
2012
|
0.88
|
|
48
|
CADM1 is a key receptor mediating human mast cell adhesion to human lung fibroblasts and airway smooth muscle cells.
|
PLoS One
|
2013
|
0.88
|
|
49
|
Ca(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model.
|
Am J Respir Cell Mol Biol
|
2012
|
0.88
|
|
50
|
Chemokine concentrations and mast cell chemotactic activity in BAL fluid in patients with eosinophilic bronchitis and asthma, and in normal control subjects.
|
Chest
|
2006
|
0.86
|
|
51
|
Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent.
|
Respir Res
|
2014
|
0.86
|
|
52
|
Mast cells in lung inflammation.
|
Adv Exp Med Biol
|
2011
|
0.86
|
|
53
|
Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation.
|
PLoS One
|
2012
|
0.85
|
|
54
|
Mast cell fibroblastoid differentiation mediated by airway smooth muscle in asthma.
|
J Immunol
|
2010
|
0.85
|
|
55
|
K(Ca)3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma.
|
PLoS One
|
2013
|
0.84
|
|
56
|
Tumour necrosis factor-alpha expression in tumour islets confers a survival advantage in non-small cell lung cancer.
|
BMC Cancer
|
2010
|
0.83
|
|
57
|
Human lung mast cell heterogeneity.
|
Thorax
|
2009
|
0.83
|
|
58
|
CADM1 is expressed as multiple alternatively spliced functional and dysfunctional isoforms in human mast cells.
|
Mol Immunol
|
2012
|
0.82
|
|
59
|
Detection of an activating c-kit mutation by real-time PCR in patients with anaphylaxis.
|
Mutat Res
|
2005
|
0.81
|
|
60
|
The re-emergence of the mast cell as a pivotal cell in asthma pathogenesis.
|
Curr Allergy Asthma Rep
|
2005
|
0.81
|
|
61
|
CADM1 isoforms differentially regulate human mast cell survival and homotypic adhesion.
|
Cell Mol Life Sci
|
2012
|
0.81
|
|
62
|
The contribution of Orai(CRACM)1 and Orai(CRACM)2 channels in store-operated Ca2+ entry and mediator release in human lung mast cells.
|
PLoS One
|
2013
|
0.81
|
|
63
|
In search of the fibrotic epithelial cell: opportunities for a collaborative network.
|
Thorax
|
2011
|
0.80
|
|
64
|
Leukotriene B4 production in healthy subjects carrying variants of the arachidonate 5-lipoxygenase-activating protein gene associated with a risk of myocardial infarction.
|
Clin Sci (Lond)
|
2007
|
0.80
|
|
65
|
Counterregulation of beta(2)-adrenoceptor function in human mast cells by stem cell factor.
|
J Allergy Clin Immunol
|
2009
|
0.79
|
|
66
|
Novel immunogenic peptides elicit systemic anaphylaxis in mice: implications for peptide vaccines.
|
J Immunol
|
2011
|
0.79
|
|
67
|
Adenosine potentiates human lung mast cell tissue plasminogen activator activity.
|
J Immunol
|
2010
|
0.79
|
|
68
|
Mast cell infiltration of airway smooth muscle in asthma.
|
Respir Med
|
2007
|
0.77
|
|
69
|
Multigene family isoform profiling from blood cell lineages.
|
BMC Genomics
|
2002
|
0.76
|
|
70
|
Asthma exacerbations: prevention is better than cure.
|
Ther Clin Risk Manag
|
2005
|
0.75
|
|
71
|
Mannitol and AMP do not induce bronchoconstriction in eosinophilic bronchitis: further evidence for dissociation between airway inflammation and bronchial hyperresponsiveness.
|
Respirology
|
2010
|
0.75
|